Dioxins

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Sat, 07/18/2020 - 08:02
by Weihao Hong, Wenzhao Cheng, Tingjin Zheng, Nan Jiang, Ruian Xu Establishing latent infection but retaining the capability to reactivate in certain circumstance is an ingenious tactic for retroviruses to persist in vivo while evading host immune surveillance. Many evidences indicate that Human T-cell leukemia virus type 1 (HTLV-1) is not completely silent in vivo. However, signals that trigger...
Mon, 07/13/2020 - 22:12
Polychlorinated dibenzo‐p‐dioxins (PCDDs) are hypothesized to exert their toxic effects in wildlife and humans via endocrine disruption. However, very scanty information is available on the underlying molecular interactions that trigger this disruption. In this study, molecular docking simulation was used to predict the susceptibility of 12 nuclear receptors to disruption via PCDD bindings....
Wed, 07/08/2020 - 18:02
Cleft palate (CP), a congenital defect in the oral and maxillofacial regions, is difficult to detect prenatally. This study investigated the correlation between differentially expressed proteins in serum and CP induced by all-trans retinoic acid (atRA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. We studied 80 mice in the following groups: male mice (male; n = 6), nonpregnant female...
Tue, 07/07/2020 - 02:03
In order to assess environmental exposure-associated human health risk of dioxin compounds for the population in the vicinity of a municipal solid waste incinerator (MSWI) in Shanghai, the atmospheric samples (n = 24) and soils samples (n = 96) were collected and analyzed to obtain the concentration level, pollution characteristics and seasonal changes of dioxin compounds in environmental medias...
Tue, 05/19/2020 - 03:39
Polychlorinated biphenyls (PCBs) are a class of persistent organic environmental pollutants with a total of 209 homologs. The homolog 2,3′,4,4′,5‐pentachlorobiphenyl (PCB118) is one of the most important dioxin‐like PCBs and is highly toxic. PCB118 can accumulate in human tissues, serum and breast milk, which leads to direct exposure of the fetus during development. In the present study, pregnant...
Sat, 05/09/2020 - 03:36
Concentrations and sources of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), dioxin-like polychlorinated biphenyls (dl-PCBs), and polycyclic aromatic hydrocarbons (PAHs) in a rural atmosphere near industrial zones in Jiangsu, China were determined and the associated risks were assessed. The concentrations of ΣPCDD/Fs, ΣPCBs, and ΣPAHs ranged from 11.9–57.7 pg·m−3, 0.58–2.71 pg m−3...
Tue, 05/05/2020 - 03:37
Epidemiological evidence links polychlorinated biphenyls (PCBs) to skeletal toxicity, however mechanisms whereby PCBs affect bone are poorly studied. In this study, coplanar PCB 126 (5 μmol/kg) or corn oil vehicle was administered to N = 5 and 6 male and female, wild type (WT) or AhR −/− rats via intraperitoneal injection. Animals were sacrificed after 4 weeks. Bone length was measured; bone...
Thu, 04/30/2020 - 03:48
Author(s): A.M. Api, F. Belmonte, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G.A. Burton, J. Buschmann, M.A. Cancellieri, M.L. Dagli, M. Date, W. Dekant, C. Deodhar, A.D. Fryer, S. Gadhia, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, D.C. Liebler Summary: The existing information supports the use of this material as described in this safety assessment. 4H-1,3-Benzodioxin, hexahydro-4-methyl-...
Fri, 04/17/2020 - 03:27
Exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) through food, water, and air occurred during the life, which may change telomere length (TL) in peripheral blood leukocytes. The present study was designed to investigate the association between TL and serum levels of PCBs and OCPs in Tehran male’s population. Whole blood samples were randomly taken from 300 adult...
Wed, 04/15/2020 - 03:31
Previously an increased risk for monoclonal gammopathy of undetermined significance (MGUS), a precursor of multiple myeloma (MM), was reported among Vietnam veterans exposed to Agent Orange and its contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Dysregulated expression of certain microRNAs (miRNAs) was demonstrated in MGUS and MM. Given the important role of miRNAs in cellular homeostasis...
Sun, 04/12/2020 - 03:32
Author(s): Yuchang Tao, Xiaozhuan Liu, Lingling Cui, Xinxin Liu, Yao Chen, Zhidong He, Mengmeng Ji, Zhan Gao, Ning Li, Zhongxiao Wan, Zengli Yu As a common birth defect, Cleft palate can be caused by the disturbance during the developmental process of the palatal shelves. The 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) is a well-known environmental teratogenic agent for cleft palate and Aryl...
Thu, 04/09/2020 - 03:36
Author(s): Yunyun Deng, Pingan Peng, Lijuan Jia, Haowen Yin, Jianfang Hu, Wanlian Mao Atmospheric bulk deposition samples were gathered month by month throughout a year at two sites in vicinity of a MSWI in Shanghai, to carry out an investigation on the atmospheric bulk deposition fluxes and seasonal variations of polychlorinated dibenzo-p-dioxinsand dibenzofurans (PCDD/Fs). The atmospheric bulk...
Wed, 04/01/2020 - 03:34
To discover natural-product-based pesticides, 7β-oxycarbonylandrographolide derivatives were stereoselectively constructed from a labdane diterpenoid andrographolide. Among them, 2′-(n)Pr-1′,3′-dioxin-7β-oxy(m-Cl)benzoylandrographolide (IIc), 2′-(n)Pr-1′,3′-dioxin-7β-oxyacetylandrographolide (IIf), 2′-(p-Me)Ph-1′,3′-dioxin-7β-oxy(o-Cl)benzoylandrographolide (Vb), and 2′-(p-Me)Ph-1′,3′-dioxin-7β-...
Wed, 04/01/2020 - 03:34
by Lucille Rey-Cadilhac, Ronan Cariou, Anne Ferlay, Catherine Jondreville, Carole Delavaud, Yannick Faulconnier, Sébastien Alcouffe, Pascal Faure, Philippe Marchand, Bruno Le Bizec, Stefan Jurjanz, Sylvain Lerch Food safety crises involving persistent organic pollutants [POPs, e.g. dioxins, polychlorinated biphenyls (PCBs), organochlorine pesticides] lead to systematic slaughter of livestock to...
Wed, 04/01/2020 - 03:34
by Sylvain Lerch, Lucille Rey-Cadilhac, Ronan Cariou, Yannick Faulconnier, Catherine Jondreville, Denis Roux, Gaud Dervilly-Pinel, Bruno Le Bizec, Stefan Jurjanz, Anne Ferlay Food safety crises involving persistent organic pollutants (POPs) lead to systematic slaughter of livestock to prevent contaminants from entering the food chain. Therefore, there is a need to develop strategies to depurate...
Wed, 04/01/2020 - 03:32
Author(s): Kailun Yu, Xiuli Zhang, Xuemei Tan, Mengmeng Ji, Yao Chen, Zhongxiao Wan, Zengli Yu 2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), one of the key endocrine disruptors, has been shown to cause reproductive and developmental disorders. Our previous studies have primarily focused on TCDD induced impairment of ovarian follicular development in female F1 rats. It is unknown whether TCDD exposure...
Mon, 03/23/2020 - 03:33
Author(s): Marion Hulin, Véronique Sirot, Paule Vasseur, Aurelie Mahe, Jean-Charles Leblanc, Julien Jean, Philippe Marchand, Anaïs Venisseau, Bruno LE. Bizec, Gilles Riviere A total diet study (TDS) was conducted between 2010 and 2016 to characterize the health risk related to chemical residues in food of French not breastfed children under three years of age (infant TDS). Among the targeted...
Fri, 03/20/2020 - 03:31
Author(s): Keqi Hu, Hang Yu, Zihuan Li, Guifang Jin, Hansi Jia, Meiqi Song, Yungang Liu Polychlorinated biphenyls (PCBs) are persistent organic pollutants with human carcinogenicity. Many lower chlorinated and non-dioxin-like PCBs have been observed to be mutagenic following activation by human CYP2E1, while activation of dioxin-like (DL-) PCBs by this enzyme has never been evidenced. In this...
Sat, 03/07/2020 - 03:25
The levels of persistent organic pollutants, polychlorinated biphenyls (PCBs), were investigated in influent, effluent, and sludge of five wastewater treatment plants (WWTPs) in Jordan. Concentrations of 12 dioxin-like PCBs were determined. The extraction of PCBs from wastewater samples was done by solvent extraction using dichloromethane/hexane 1:1 mixture. The concentrated extracts were...
Wed, 03/04/2020 - 03:59
Author(s): Yan Bao, Lei Zhang, Xin Liu, Lei Shi, Jingguang Li, Guimin Meng, Yunfeng Zhao, Yongning Wu Serum and breast milk are both important biological samples to evaluate body burden of dioxin-like compounds which include polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs). We collected maternal serum at early...
Sat, 02/22/2020 - 03:29
Landfills are repository for complex microbial diversity responsible for bio-degradation of solid waste. To elucidate this complexity, samples from three different landfill sites of North India (sample V: Bhalswa near Karnal byepass road, New Delhi, India; sample T: Chandigarh, India and sample S3: Una, H.P., India) were analyzed using metagenomic approach. Selected landfill sites had different...
Sat, 02/08/2020 - 03:25
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental contaminant in the environment. The developmental period is more sensitive to TCDD and there is a possibility that maternal exposure to TCDD may affect in adulthood. Adult female Wistar rats were exposed to 0.5, 1.0, and 2.0 µg/kg TCDD during the critical stage of organogenesis, that is, on GD15. The results revealed a...
Wed, 02/05/2020 - 03:33
Author(s): Jinzhong Yang, Haibin Yu, Zhen Xie, Yufei Yang, Xiaoyan Zheng, Jingxing Zhang, Qifei Huang, Tao Wen, Jianyuan WangAbstractThe thermal processes of cement kilns are sources of polybrominated dibenzofurans and dioxins (PBDD/Fs); however, when co-processing decabromodiphenyl ether (BDE-209) soil in cement kilns, very few reports have investigated the mechanism of PBDD/Fs formation from...
Thu, 01/30/2020 - 03:28
Seaweed is a source of protein that can help overcome the anticipated challenges of a growing world population and the current challenges for finding alternatives for animal proteins in the Western diet. Thus far, data on the safety of seaweed for feed and food purposes in the Western world are scattered. This study aimed to review the available knowledge on the presence of food safety hazards in...
Wed, 01/22/2020 - 03:25
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental pollutant and also a strong teratogen for cleft palate (CP). But up to now, the underlying molecular mechanisms of TCDD-induced CP are largely unknown. More recently, accumulating evidences are revealing important roles of long noncoding RNAs (lncRNAs) in all kinds of diseases including CP. However, the role and molecular...
Fri, 01/10/2020 - 03:23
Endocrine disrupting chemicals (EDCs) are defined as exogenous substances that can alter the development and functioning of the endocrine system. The Wnt signaling pathway is an evolutionarily conserved pathway consisting of proteins that transmit cell-to-cell receptors through cell surface receptors, regulating important aspects of cell migration, polarity, neural formation, and organogenesis,...
Tue, 01/07/2020 - 03:26
Polychlorinated biphenyls (PCBs) are highly persistent and ubiquitously distributed environmental pollutants. Based on their chemical structure, PCBs are classified into non-ortho-substituted and ortho-substituted congeners. Non-ortho-substituted PCBs are structurally similar to dioxin and their toxic effects and mode of action are well-established. In contrast, very little is known about the...
Sat, 01/04/2020 - 03:35
Author(s): Zheng Peng, Roland Weber, Yong Ren, Jianwei Wang, Yangzhao Sun, Lifang WangAbstractA recycling and disposal technology for municipal solid waste incinerator (MSWI) fly ash using high temperature sintering process was evaluated in an industrial scale facility with daily disposal capacity of 100 t/d. The emission, mass balance and distribution characteristics of polychlorinated dibenzo-p...
Sun, 12/29/2019 - 03:34
Author(s): Xiaozhuan Liu, Xue Li, Yuchang Tao, Ning Li, Mengmeng Ji, Xiuli Zhang, Yao Chen, Zhidong He, Kailun Yu, Zengli YuAbstractExposure to environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes cleft palate at high rates, but little is known about the underlying biological mechanisms. In the present study, we cultured osteoblasts from human fetal palate mesenchymal cells (...
Thu, 11/28/2019 - 04:00
Author(s): Lili Yang, Fen Jin, Guorui Liu, Yang Xu, Minghui Zheng, Cui Li, Yuanping YangAbstractWe collected surface sediments from the Chaobai river, the dominant source of drinking water for Beijing, China, to assess the status of contamination by polychlorinated biphenyls and evaluate their sources. Total concentrations of polychlorinated biphenyls in the sediments ranged from 0.125 to 70.6 ng...
Tue, 11/26/2019 - 03:26
Context-specific GEnome-scale metabolic Network REconstructions (GENREs) provide a means to understand cellular metabolism at a deeper level of physiological detail. Here, we use transcriptomics data from chemically-exposed rat hepatocytes to constrain a GENRE of rat hepatocyte metabolism and predict biomarkers of liver toxicity using the Transcriptionally Inferred Metabolic Biomarker Response...
Tue, 11/26/2019 - 03:26
The aryl hydrocarbon receptor (AhR) activation has been shown to alter proliferation, apoptosis, or differentiation of adult rat liver progenitors. Here, we investigated the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated AhR activation on a human model of bipotent liver progenitors, undifferentiated HepaRG cells. We used both intact undifferentiated HepaRG cells, and the cells with...
Fri, 11/15/2019 - 03:32
Author(s): Yuting Chen, Yifan Wu, Weiwei Xiao, Hansi Jia, Hansruedi Glatt, Ming Shi, Yungang LiuAbstractPolychlorinated biphenyls (PCBs) are persistent organic pollutants and human carcinogens. It was reported that rat CYP1A1 and catfish CYP1A can hydroxylate 3,3',4,4',5-pentachlorobiphenyl (PCB 126) and 3,3',4,4'-tetrachlorobiphenyl (PCB 77), while potential roles of other CYP1 enzymes in the...
Fri, 11/08/2019 - 03:33
Author(s): Chenyang Xu, Jicheng Hu, Jing Wu, Baokai Wei, Zhenlei Zhu, Liwen Yang, Tingting Zhou, Jun JinAbstractSeventeen soil samples collected in an industrial park located in Ningxia Province, Northwestern China were analyzed for polychlorinated naphthalenes (PCNs), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), and polychlorinated biphenyls (PCBs). The PCN, PCDD/F, and PCB...
Wed, 10/30/2019 - 03:35
Author(s): Jelena Maric, Teresa Berdugo Vilches, Sébastien Pissot, Isabele Cañete Vela, Marianne Gyllenhammar, Martin SeemannAbstractEmissions of dioxins and furans during the gasification of Automotive Shredder Residue (ASR) were investigated. The experimental work was carried out in a Dual Fluidized Bed (DFB) system, which consists of a 2–4-MWth gasifier that is fluidized with steam, and an...
Sat, 10/26/2019 - 03:50
by Khushbu Salian, Vladimir Strezov, Tim J. Evans, Mark Taylor, Peter F. Nelson Industrial sources, including iron ore sintering, municipal waste incineration and non-ferrous metal processing have been prominent emitters of dioxins to the environment. With the expanding industrial sectors, many international conventions were established in order to reduce the emission of dioxins in the past two...
Sat, 10/19/2019 - 03:40
Author(s): Kailun Yu, Zengli YuAbstract2,3,7,8-Tetrachlorobenze-p-dioxin (TCDD), one of representive Endocrine Disrupting Chemicals (EDCs), has potential adverse effects on human health. Direct exposure to TCDD has been implicated in ovarian follicles development and functions deficits in adulthood. However, it is rarely reported whether indirect exposure to TCDD can cause similar negative impact...
Fri, 10/18/2019 - 03:39
Author(s): Annette Petersen, Bodil Hamborg Jensen, Nathalie Michelle Löbl, Elsa Nielsen, Lea Bredsdorff, Sisse Fagt, Tue Christensen, Julie BobergAbstractThis study shows that dietary habits have an impact on contaminant exposures. A tool was developed to calculate chemical exposures for different Danish population groups. First, the tool divided the individuals into quartiles using a previously...
Fri, 10/18/2019 - 03:29
The Aryl Hydrocarbon Receptor (AhR) is a transcription factor that, when activated by ligand-binding, has been shown to regulate the immune response. Pertussis Toxin (PTX) is a virulence factor found in Bordetella pertussis, a human respiratory pathogen that causes whooping cough. PTX promotes colonization and disease promotion by triggering a heightened inflammatory response. The role of AhR in...
Tue, 10/15/2019 - 03:34
Aflatoxins (AFs) as potent food contaminants are highly detrimental to human and animal health. The production of such biological toxins is influenced by environmental factors including pollutants, such as dioxins. Here, we report the biological feedback of an active AF-producer strain of A. flavus upon in vitro exposure to the most toxic congener of dioxins, the 2,3,7,8-tetrachlorinated dibenzo-...
Sat, 10/05/2019 - 03:41
by Karina Orlowska, Sylwia Swigonska, Agnieszka Sadowska, Monika Ruszkowska, Anna Nynca, Tomasz Molcan, Agata Zmijewska, Renata E. Ciereszko 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic man-made chemical compound contaminating the environment and affecting human/animal health and reproduction. Intracellular TCDD action usually involves the activation of aryl hydrocarbon receptor (AhR)....
Sat, 09/28/2019 - 03:28
Author(s): Fang Du, Ting Zhao, Hong-Chen Ji, Ying-Biao Luo, Fen Wang, Guang-Hua Mao, Wei-Wei Feng, Yao Chen, Xiang-Yang Wu, Liu-Qing YangAbstractPolychlorinated biphenyls (PCBs) would do serious damage to multiple systems, while coplanar polychlorinated biphenyls, the most toxic member of the family, has been widely taken into consideration. In this study, ICR mice were fed with different doses...
Sun, 09/22/2019 - 03:22
The aryl hydrocarbon receptor (AHR) mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced toxicity that can lead to chloracne in humans. A characteristic of chloracne, in contrast to acne vulgaris, is shrinkage or loss of sebaceous glands. Acne vulgaris, on the other hand, is often accompanied by excessive sebum production. Here, we examined the role of AHR in lipid synthesis in human...
Sat, 09/21/2019 - 03:32
Author(s): Shuang Song, Xin Zhou, Chenqi Guo, Haiyan Zhang, Tao Zeng, Yidong Xie, Jinsong Liu, Chaofei Zhu, Xingrong SunAbstractTypical thermal processes are common sources of polychlorinated, polybrominated and mixed polybrominated/chlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs, and PBCDD/Fs); however, very few reports have investigated their coemission. To clarify the...
Sat, 09/21/2019 - 03:32
Author(s): Congcong Zhang, Xiaoxiu Li, Zhiguang ZhouAbstractThe mass concentrations, toxic equivalent quantity (TEQ) concentrations and congener profiles of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the stack flue gas and ambient air of municipal solid waste incinerator (MSWI) were monitored in this study to evaluate the levels, emission characteristics, seasonal variation...
Sat, 09/21/2019 - 03:31
Author(s): Nassim Zeinali, Ibukun Oluwoye, Mohammednoor Altarawneh, Bogdan Z. DlugogorskiAbstractPolychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) remain of particular concern owing to their extensive toxicity towards health and accumulation in the environment. Atmospheric oxidation (by ambient oxygen molecules) of this class of persistent environmental pollutants has little to...
Fri, 09/20/2019 - 03:36
A sensitive and reproducible screening analytical method is here proposed for the determination of six non dioxin-like polychlorinated biphenyls (NDL-PCBs, congener 28, 52, 101, 138, 153, 180) in chicken eggs based on accelerated solvent extraction (ASE) procedure for the fat extraction and determination, a solid phase extraction (SPE) sample clean-up process, and a gas chromatography – electron...
Fri, 09/20/2019 - 03:32
Increasing interest in characterizing risk assessment uncertainty is highlighted by recent recommendations from the National Academy of Sciences. In this paper we demonstrate the utility of applying qualitative and quantitative methods for assessing uncertainty to enhance risk‐based decision‐making for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. The approach involved deconstructing the reference dose (...
Fri, 09/20/2019 - 03:32
2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) is a well‐known environmental contaminant that produces a wide variety of adverse effects in humans. Catalpol, a major bioactive compound enriched in the dried root of Rehmannia glutinosa, is a major iridoid glycoside that alleviates bone loss. However, the detailed mechanisms underlying the effects of catalpol remain unclear. The present study evaluated...

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