Dioxins

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Wed, 05/12/2021 - 10:02
Sphingomonas wittichii RW1 is one of a few strains known to grow on the related compounds dibenzofuran (DBF) and dibenzo-p-dioxin (DXN) as the sole source of carbon. Previous work by others (B. Happe, L. D. Eltis, H. Poth, R. Hedderich, and K. N. Timmis, J Bacteriol 175:7313–7320, 1993, https://doi.org/10.1128/jb.175.22.7313-7320.1993) showed that purified DbfB had significant ring cleavage...
Fri, 04/16/2021 - 06:09
Author(s): Anh T.N. Dao, Miriam Smits, Ha T.C. Dang, Abraham Brouwer, Tjalf E. de Boer White-rot fungus Rigidoporus sp. FMD21 is a lignin-modifying enzyme producing fungus that can degrade dioxin. Extracellular enzymes from FMD21 include laccase and manganese peroxidase which are promising enzymes for myco-remediation because of their wide substrate specificity and mild catalysis conditions. The...
Thu, 04/15/2021 - 04:02
The aim of the present study was to evaluate the contamination levels of some classes of persistent organic pollutants (POPs) in free-range hen eggs and to estimate the related human dietary exposure in a Site of National Interest (SNI), characterized by a serious state of environmental pollution (Bussi sul Tirino area, central Italy). For these purposes, 17 samples of free-range hen eggs...
Sat, 02/27/2021 - 12:00
Hydroxylated chalcones are phytochemicals which are biosynthetic precursors of flavonoids and their 1,3-diaryl-prop-2-en-1-one structure is used as a scaffold for drug development. In this study, the structure-dependent activation of aryl hydrocarbon receptor (AhR)-responsive CYP1A1, CYP1B1, and UGT1A1 genes was investigated in Caco2 colon cancer cells and in non-transformed young adult mouse...
Tue, 02/16/2021 - 02:03
Air samples were collected around industrial parks in Jiangsu, China, to allow the concentrations, profiles, and risk assessment of polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs), polychlorinated naphthalenes (PCNs), and metals to be investigated. The concentrations of ΣPBDD/Fs and ΣPCNs were 1324.26–2080.98 fg/m3 (11.35–42.57 fg I-TEQ/m3) and 10,404.9–29,322.9 fg/m3 (1.32–7.19 fg I...
Fri, 01/29/2021 - 12:01
Regulatory agencies have derived noncancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin based on reduced sperm counts relying on single studies from a large body of evidence. Techniques such as meta-regression allow for greater use of the available data while simultaneously providing important information regarding the uncertainty associated with the underlying evidence base when...
Wed, 01/27/2021 - 06:09
Author(s): Min-Kyung Cho, Jae-Gon Park, Hisato Iwata, Eun-Young Kim The chicken (Gallus gallus), which has three aryl hydrocarbon receptor (AHR) isoforms (ckAHR1, ckAHR2, and ckAHR1β) and two AHR nuclear translocator (ARNT) isoforms (ckARNT1 and ckARNT2), is highly sensitive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and can serve as an avian model to gain an understanding of the mechanism...
Wed, 01/27/2021 - 06:08
Author(s): Tran Thi Ai My, Nguyen Duy Dat, Kersten Van Langenhove, Michael S. Denison, Hoang Thai Long, Marc Elskens In this study, an AhR-responsive reporter-gene cell-based bioassay CALUX was used to assess the biological potency of dioxins and dioxin-like PCBs (dl-PCBs) in top soil samples collected from a former airbase (A-So) and remote regions from urban and agricultural areas in Thua Thien...
Sun, 01/24/2021 - 06:11
Author(s): Z. Wang, H.J. van der Fels-Klerx, A. G. J. M. Oude Lansink, HJ (Ine) van der Fels-Klerx Food safety monitoring is essential for hazard identification in food chain, but its application may be limited due to costly analytical methods and (inefficient) sampling procedures. The objective of this study was to design cost-effective monitoring schemes for food safety contaminants along the...
Sun, 01/24/2021 - 02:03
Electric arc furnaces (EAFs) in steelmaking plants are a major source of dioxins. Preheating of steelmaking raw materials is widely used in EAFs to reduce energy consumption. Few studies have investigated emissions of dioxin-like polychlorinated biphenyls (PCBs) from EAFs, and the PCB emission levels and characteristics during preheating are unknown. In this study, PCB concentrations and...
Mon, 01/11/2021 - 12:01
Chemical modifications of proteins, DNA, and RNA moieties play critical roles in regulating gene expression. Emerging evidence suggests the RNA modifications (epitranscriptomics) have substantive roles in basic biological processes. One of the most common modifications in mRNA and noncoding RNAs is N6-methyladenosine (m6A). In a subset of mRNAs, m6A sites are preferentially enriched near stop...
Sat, 12/05/2020 - 06:19
Author(s): Xuejing Shen, Qiuting Yang, Jia Shen, Lili Yang, Minxiang Wang, Yuanping Yang, Guorui Liu The amount of steel produced using electric arc furnaces (EAFs) has been increasing in recent years. In this study, stack gases from EAFs in steelmaking plants were analyzed to determine if they are also dominant sources of polybrominated dibenzo-p-dioxin and dibenzofuran (PBDD/F) emissions in...
Tue, 12/01/2020 - 12:01
Over the last 2 decades, the zebrafish (Danio rerio) has emerged as a stellar model for unraveling molecular signaling events mediated by the aryl hydrocarbon receptor (AHR), an important ligand-activated receptor found in all eumetazoan animals. Zebrafish have 3 AHRs—AHR1a, AHR1b, and AHR2, and studies have demonstrated the diversity of both the endogenous and toxicological functions of the...
Tue, 12/01/2020 - 12:01
Congenital heart disease (CHD), the leading birth defect worldwide, has a largely unknown etiology, likely to result from complex interactions between genetic and environmental factors during heart development, at a time when the heart adapts to diverse physiological and pathophysiological conditions. Crucial among these is the regulation of cardiomyocyte development and postnatal maturation,...
Thu, 08/13/2020 - 22:13
ABSTRACT Background The manila clam Ruditapes philippinarum and the wedge clam Donax trunculus are economic bivalve species which constitute an important part of the natural bivalve beds in the Marmara Sea, Turkey. Toxic chemicals such as, dioxins, dioxin‐like polychlorinated biphenyls (PCBs), polycyclic hydrocarbons (PAHs), and toxic metals are recognized as important health risk factors that...
Sat, 07/18/2020 - 08:02
Establishing latent infection but retaining the capability to reactivate in certain circumstance is an ingenious tactic for retroviruses to persist in vivo while evading host immune surveillance. Many evidences indicate that Human T-cell leukemia virus type 1 (HTLV-1) is not completely silent in vivo. However, signals that trigger HTLV-1 latency-reactivation switching remain poorly understood....
Mon, 07/13/2020 - 22:12
Polychlorinated dibenzo‐p‐dioxins (PCDDs) are hypothesized to exert their toxic effects in wildlife and humans via endocrine disruption. However, very scanty information is available on the underlying molecular interactions that trigger this disruption. In this study, molecular docking simulation was used to predict the susceptibility of 12 nuclear receptors to disruption via PCDD bindings....
Wed, 07/08/2020 - 18:02
Cleft palate (CP), a congenital defect in the oral and maxillofacial regions, is difficult to detect prenatally. This study investigated the correlation between differentially expressed proteins in serum and CP induced by all-trans retinoic acid (atRA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. We studied 80 mice in the following groups: male mice (male; n = 6), nonpregnant female...
Tue, 07/07/2020 - 02:03
In order to assess environmental exposure-associated human health risk of dioxin compounds for the population in the vicinity of a municipal solid waste incinerator (MSWI) in Shanghai, the atmospheric samples (n = 24) and soils samples (n = 96) were collected and analyzed to obtain the concentration level, pollution characteristics and seasonal changes of dioxin compounds in environmental medias...
Tue, 05/19/2020 - 03:39
Polychlorinated biphenyls (PCBs) are a class of persistent organic environmental pollutants with a total of 209 homologs. The homolog 2,3′,4,4′,5‐pentachlorobiphenyl (PCB118) is one of the most important dioxin‐like PCBs and is highly toxic. PCB118 can accumulate in human tissues, serum and breast milk, which leads to direct exposure of the fetus during development. In the present study, pregnant...
Sat, 05/09/2020 - 03:36
Concentrations and sources of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), dioxin-like polychlorinated biphenyls (dl-PCBs), and polycyclic aromatic hydrocarbons (PAHs) in a rural atmosphere near industrial zones in Jiangsu, China were determined and the associated risks were assessed. The concentrations of ΣPCDD/Fs, ΣPCBs, and ΣPAHs ranged from 11.9–57.7 pg·m−3, 0.58–2.71 pg m−3...
Tue, 05/05/2020 - 03:37
Epidemiological evidence links polychlorinated biphenyls (PCBs) to skeletal toxicity, however mechanisms whereby PCBs affect bone are poorly studied. In this study, coplanar PCB 126 (5 μmol/kg) or corn oil vehicle was administered to N = 5 and 6 male and female, wild type (WT) or AhR −/− rats via intraperitoneal injection. Animals were sacrificed after 4 weeks. Bone length was measured; bone...
Thu, 04/30/2020 - 03:48
Author(s): A.M. Api, F. Belmonte, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G.A. Burton, J. Buschmann, M.A. Cancellieri, M.L. Dagli, M. Date, W. Dekant, C. Deodhar, A.D. Fryer, S. Gadhia, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, D.C. Liebler Summary: The existing information supports the use of this material as described in this safety assessment. 4H-1,3-Benzodioxin, hexahydro-4-methyl-...
Fri, 04/17/2020 - 03:27
Exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) through food, water, and air occurred during the life, which may change telomere length (TL) in peripheral blood leukocytes. The present study was designed to investigate the association between TL and serum levels of PCBs and OCPs in Tehran male’s population. Whole blood samples were randomly taken from 300 adult...
Wed, 04/15/2020 - 03:31
Previously an increased risk for monoclonal gammopathy of undetermined significance (MGUS), a precursor of multiple myeloma (MM), was reported among Vietnam veterans exposed to Agent Orange and its contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Dysregulated expression of certain microRNAs (miRNAs) was demonstrated in MGUS and MM. Given the important role of miRNAs in cellular homeostasis...
Sun, 04/12/2020 - 03:32
Author(s): Yuchang Tao, Xiaozhuan Liu, Lingling Cui, Xinxin Liu, Yao Chen, Zhidong He, Mengmeng Ji, Zhan Gao, Ning Li, Zhongxiao Wan, Zengli Yu As a common birth defect, Cleft palate can be caused by the disturbance during the developmental process of the palatal shelves. The 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) is a well-known environmental teratogenic agent for cleft palate and Aryl...
Thu, 04/09/2020 - 03:36
Author(s): Yunyun Deng, Pingan Peng, Lijuan Jia, Haowen Yin, Jianfang Hu, Wanlian Mao Atmospheric bulk deposition samples were gathered month by month throughout a year at two sites in vicinity of a MSWI in Shanghai, to carry out an investigation on the atmospheric bulk deposition fluxes and seasonal variations of polychlorinated dibenzo-p-dioxinsand dibenzofurans (PCDD/Fs). The atmospheric bulk...
Wed, 04/01/2020 - 03:34
To discover natural-product-based pesticides, 7β-oxycarbonylandrographolide derivatives were stereoselectively constructed from a labdane diterpenoid andrographolide. Among them, 2′-(n)Pr-1′,3′-dioxin-7β-oxy(m-Cl)benzoylandrographolide (IIc), 2′-(n)Pr-1′,3′-dioxin-7β-oxyacetylandrographolide (IIf), 2′-(p-Me)Ph-1′,3′-dioxin-7β-oxy(o-Cl)benzoylandrographolide (Vb), and 2′-(p-Me)Ph-1′,3′-dioxin-7β-...
Wed, 04/01/2020 - 03:34
by Lucille Rey-Cadilhac, Ronan Cariou, Anne Ferlay, Catherine Jondreville, Carole Delavaud, Yannick Faulconnier, Sébastien Alcouffe, Pascal Faure, Philippe Marchand, Bruno Le Bizec, Stefan Jurjanz, Sylvain Lerch Food safety crises involving persistent organic pollutants [POPs, e.g. dioxins, polychlorinated biphenyls (PCBs), organochlorine pesticides] lead to systematic slaughter of livestock to...
Wed, 04/01/2020 - 03:34
by Sylvain Lerch, Lucille Rey-Cadilhac, Ronan Cariou, Yannick Faulconnier, Catherine Jondreville, Denis Roux, Gaud Dervilly-Pinel, Bruno Le Bizec, Stefan Jurjanz, Anne Ferlay Food safety crises involving persistent organic pollutants (POPs) lead to systematic slaughter of livestock to prevent contaminants from entering the food chain. Therefore, there is a need to develop strategies to depurate...
Wed, 04/01/2020 - 03:32
Author(s): Kailun Yu, Xiuli Zhang, Xuemei Tan, Mengmeng Ji, Yao Chen, Zhongxiao Wan, Zengli Yu 2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), one of the key endocrine disruptors, has been shown to cause reproductive and developmental disorders. Our previous studies have primarily focused on TCDD induced impairment of ovarian follicular development in female F1 rats. It is unknown whether TCDD exposure...
Mon, 03/23/2020 - 03:33
Author(s): Marion Hulin, Véronique Sirot, Paule Vasseur, Aurelie Mahe, Jean-Charles Leblanc, Julien Jean, Philippe Marchand, Anaïs Venisseau, Bruno LE. Bizec, Gilles Riviere A total diet study (TDS) was conducted between 2010 and 2016 to characterize the health risk related to chemical residues in food of French not breastfed children under three years of age (infant TDS). Among the targeted...
Fri, 03/20/2020 - 03:31
Author(s): Keqi Hu, Hang Yu, Zihuan Li, Guifang Jin, Hansi Jia, Meiqi Song, Yungang Liu Polychlorinated biphenyls (PCBs) are persistent organic pollutants with human carcinogenicity. Many lower chlorinated and non-dioxin-like PCBs have been observed to be mutagenic following activation by human CYP2E1, while activation of dioxin-like (DL-) PCBs by this enzyme has never been evidenced. In this...
Sat, 03/07/2020 - 03:25
The levels of persistent organic pollutants, polychlorinated biphenyls (PCBs), were investigated in influent, effluent, and sludge of five wastewater treatment plants (WWTPs) in Jordan. Concentrations of 12 dioxin-like PCBs were determined. The extraction of PCBs from wastewater samples was done by solvent extraction using dichloromethane/hexane 1:1 mixture. The concentrated extracts were...
Wed, 03/04/2020 - 03:59
Author(s): Yan Bao, Lei Zhang, Xin Liu, Lei Shi, Jingguang Li, Guimin Meng, Yunfeng Zhao, Yongning Wu Serum and breast milk are both important biological samples to evaluate body burden of dioxin-like compounds which include polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs). We collected maternal serum at early...
Sat, 02/22/2020 - 03:29
Landfills are repository for complex microbial diversity responsible for bio-degradation of solid waste. To elucidate this complexity, samples from three different landfill sites of North India (sample V: Bhalswa near Karnal byepass road, New Delhi, India; sample T: Chandigarh, India and sample S3: Una, H.P., India) were analyzed using metagenomic approach. Selected landfill sites had different...
Sat, 02/08/2020 - 03:25
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental contaminant in the environment. The developmental period is more sensitive to TCDD and there is a possibility that maternal exposure to TCDD may affect in adulthood. Adult female Wistar rats were exposed to 0.5, 1.0, and 2.0 µg/kg TCDD during the critical stage of organogenesis, that is, on GD15. The results revealed a...
Wed, 02/05/2020 - 03:33
Author(s): Jinzhong Yang, Haibin Yu, Zhen Xie, Yufei Yang, Xiaoyan Zheng, Jingxing Zhang, Qifei Huang, Tao Wen, Jianyuan WangAbstractThe thermal processes of cement kilns are sources of polybrominated dibenzofurans and dioxins (PBDD/Fs); however, when co-processing decabromodiphenyl ether (BDE-209) soil in cement kilns, very few reports have investigated the mechanism of PBDD/Fs formation from...
Thu, 01/30/2020 - 03:28
Seaweed is a source of protein that can help overcome the anticipated challenges of a growing world population and the current challenges for finding alternatives for animal proteins in the Western diet. Thus far, data on the safety of seaweed for feed and food purposes in the Western world are scattered. This study aimed to review the available knowledge on the presence of food safety hazards in...
Wed, 01/22/2020 - 03:25
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental pollutant and also a strong teratogen for cleft palate (CP). But up to now, the underlying molecular mechanisms of TCDD-induced CP are largely unknown. More recently, accumulating evidences are revealing important roles of long noncoding RNAs (lncRNAs) in all kinds of diseases including CP. However, the role and molecular...
Fri, 01/10/2020 - 03:23
Endocrine disrupting chemicals (EDCs) are defined as exogenous substances that can alter the development and functioning of the endocrine system. The Wnt signaling pathway is an evolutionarily conserved pathway consisting of proteins that transmit cell-to-cell receptors through cell surface receptors, regulating important aspects of cell migration, polarity, neural formation, and organogenesis,...
Tue, 01/07/2020 - 03:26
Polychlorinated biphenyls (PCBs) are highly persistent and ubiquitously distributed environmental pollutants. Based on their chemical structure, PCBs are classified into non-ortho-substituted and ortho-substituted congeners. Non-ortho-substituted PCBs are structurally similar to dioxin and their toxic effects and mode of action are well-established. In contrast, very little is known about the...
Sat, 01/04/2020 - 03:35
Author(s): Zheng Peng, Roland Weber, Yong Ren, Jianwei Wang, Yangzhao Sun, Lifang WangAbstractA recycling and disposal technology for municipal solid waste incinerator (MSWI) fly ash using high temperature sintering process was evaluated in an industrial scale facility with daily disposal capacity of 100 t/d. The emission, mass balance and distribution characteristics of polychlorinated dibenzo-p...
Sun, 12/29/2019 - 03:34
Author(s): Xiaozhuan Liu, Xue Li, Yuchang Tao, Ning Li, Mengmeng Ji, Xiuli Zhang, Yao Chen, Zhidong He, Kailun Yu, Zengli YuAbstractExposure to environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes cleft palate at high rates, but little is known about the underlying biological mechanisms. In the present study, we cultured osteoblasts from human fetal palate mesenchymal cells (...
Thu, 11/28/2019 - 04:00
Author(s): Lili Yang, Fen Jin, Guorui Liu, Yang Xu, Minghui Zheng, Cui Li, Yuanping YangAbstractWe collected surface sediments from the Chaobai river, the dominant source of drinking water for Beijing, China, to assess the status of contamination by polychlorinated biphenyls and evaluate their sources. Total concentrations of polychlorinated biphenyls in the sediments ranged from 0.125 to 70.6 ng...
Tue, 11/26/2019 - 03:26
Context-specific GEnome-scale metabolic Network REconstructions (GENREs) provide a means to understand cellular metabolism at a deeper level of physiological detail. Here, we use transcriptomics data from chemically-exposed rat hepatocytes to constrain a GENRE of rat hepatocyte metabolism and predict biomarkers of liver toxicity using the Transcriptionally Inferred Metabolic Biomarker Response...
Tue, 11/26/2019 - 03:26
The aryl hydrocarbon receptor (AhR) activation has been shown to alter proliferation, apoptosis, or differentiation of adult rat liver progenitors. Here, we investigated the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated AhR activation on a human model of bipotent liver progenitors, undifferentiated HepaRG cells. We used both intact undifferentiated HepaRG cells, and the cells with...
Fri, 11/15/2019 - 03:32
Author(s): Yuting Chen, Yifan Wu, Weiwei Xiao, Hansi Jia, Hansruedi Glatt, Ming Shi, Yungang LiuAbstractPolychlorinated biphenyls (PCBs) are persistent organic pollutants and human carcinogens. It was reported that rat CYP1A1 and catfish CYP1A can hydroxylate 3,3',4,4',5-pentachlorobiphenyl (PCB 126) and 3,3',4,4'-tetrachlorobiphenyl (PCB 77), while potential roles of other CYP1 enzymes in the...
Fri, 11/08/2019 - 03:33
Author(s): Chenyang Xu, Jicheng Hu, Jing Wu, Baokai Wei, Zhenlei Zhu, Liwen Yang, Tingting Zhou, Jun JinAbstractSeventeen soil samples collected in an industrial park located in Ningxia Province, Northwestern China were analyzed for polychlorinated naphthalenes (PCNs), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), and polychlorinated biphenyls (PCBs). The PCN, PCDD/F, and PCB...

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