Heavy Metals

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Fri, 10/11/2019 - 03:41
by Shan Lu, Zhongyun Dong Proliferating cell nuclear antigen (PCNA) is essential for DNA replication and repair, and cell growth and survival. Previously, we identified a novel class of small molecules that bind directly to PCNA, stabilize PCNA trimer structure, reduce chromatin-associated PCNA, selectively inhibit tumor cell growth, and induce apoptosis. The purpose of this study was to...
Fri, 10/11/2019 - 03:37
Author(s): Diana Matos, Carina Sá, Paulo Cardoso, Adília Pires, Sílvia M. Rocha, Etelvina FigueiraAbstractRhizobia have a significant agronomic and environmental role and are eminent contributors to soil fertility. However, this group of microorganisms are affected by various environmental stresses, such as Cd contamination. High Cd concentrations change bacterial metabolism. During this...
Fri, 10/11/2019 - 03:37
Author(s): Florian Zindler, Franziska Beedgen, Diana Brandt, Madeleine Steiner, Daniel Stengel, Lisa Baumann, Thomas BraunbeckAbstractIn (eco)toxicology, there is a critical need for efficient methods to evaluate the neurotoxic potential of environmental chemicals. Recent studies proposed analysis of early coiling activity in zebrafish embryos as a powerful tool for the identification of...
Thu, 10/10/2019 - 03:37
Author(s): Surbhi Dabral, Yashaswee, Ajit Varma, Devendra Kumar Choudhary, Rajeev Nayan Bahuguna, Manoj NathAbstractPiriformospora indica is known for plant growth promotion and abiotic stress alleviation potential in several agricultural crops. However, a systemic analysis is warranted to explore potential application of this important fungus to augment heavy metal tolerance in rice. The present...
Wed, 10/09/2019 - 03:29
A hydroponic experiment was carried out to study the accumulation characteristics of copper (Cu) and lead (Pb) combined pollution in three ornamental plants. The results showed that these tested ornamental plants had higher tolerance to Cu–Pb combined pollution and could effectively accumulate the heavy metals. The Cu and Pb concentrations were higher in the roots of the ornamental plants than...
Wed, 10/09/2019 - 03:29
Detoxification of the highly toxic cadmium element is essential for the survival of living organisms. Pseudomonas putida CadR, a MerR family transcriptional regulator, has been reported to exhibit an ultraspecific response to the cadmium ion. Our crystallographic and spectroscopic studies reveal that the extra cadmium selectivity of CadR is mediated...
Sun, 10/06/2019 - 03:36
Author(s): Yakui Chen, Qifa Zhu, Xiangzhou Dong, Weiwei Huang, Chenyu Du, Diannan LuAbstractA novel strain Serratia marcescens HB-4 with high Cadmium adsorption capacity was isolated from heavy metal contaminated soil in Hunan province, China. S. marcescens HB-4 reduced the concentration of Cd present in wastewater to less than 0.1 mg/L when the inlet stream contained no higher than 5.0 mg/L Cd....
Sun, 10/06/2019 - 03:36
Author(s): M.O. Ibiwoye, Q. Matthews, K. Travers, J.D. FosterSummaryClinical and experimental studies have demonstrated the neurotoxic and behavioural effects of cadmium. However, the exact pathophysiological mechanism(s) of cadmium neurotoxicity on the human central nervous system (CNS) is not completely understood. A rat blood–brain barrier (BBB) endothelial marker, the endothelial barrier...
Sat, 10/05/2019 - 03:30
The use of pedunculate oak (Quercus robur L.), along with other tree species, for the afforestation of heavy metal contaminated lands is an attractive prospect. Little, however, is known of Q. robur tolerance and its antioxidative system response to heavy metal exposure. The main objective of the study was to determine the cadmium-induced changes in antioxidative system of pedunculate oak in an...
Fri, 10/04/2019 - 03:40
Author(s): Cristina García-Florentino, Maite Maguregui, Chiara Ciantelli, Alessandro Sardella, Alessandra Bonazza, Ignasi Queralt, Jose Antonio Carrero, Claudio Natali, Héctor Morillas, Juan Manuel Madariaga, Gorka AranaAbstractConstruction materials affected by black crusts (BCs) can be subjected to restoration, demolition, recycling or even to their management as waste products. Therefore, the...
Thu, 10/03/2019 - 03:37
Author(s): Xiaoxia Dong, Fan Yang, Shuping Yang, Changzhou YanAbstractCanna indica L. is a promising species for heavy metal phytoremediation due to its fast growth rate and large biomass. However, few studies have investigated cadmium (Cd) tolerance mechanisms. In the present study, Canna plants were cultivated under hydroponic conditions with increasing Cd concentrations (0, 5, 10, 15 mg/L). We...
Wed, 10/02/2019 - 03:35
Honey, pineapple, chilli pepper, and onion extracts were investigated for their ability to inhibit enzymatic browning in sweet potatoes. Honey had the highest inhibition (41.39%–48.0%), comparable with l‐ascorbic acid. Heated onion extract increased polyphenol oxidase (PPO) inhibition by 2.5‐fold when 4‐methylcatechol was used as substrate. However, percentage inhibition decreased drastically (7....
Tue, 10/01/2019 - 03:39
Author(s): Gabriela M. Chiocchetti, Teresa Latorre, María Jesús Clemente, Carlos Jadán-Piedra, Vicenta Devesa, Dinoraz VélezAbstractMushrooms can accumulate toxic trace elements. The objectives of the present study are to evaluate levels of mercury, cadmium, lead, and arsenic in dried mushrooms, to determine the effect of cooking on the contents of these elements, and to evaluate their...
Tue, 10/01/2019 - 03:38
Author(s): Bulat Kuluev, Elena Mikhaylova, Alexander Ermoshin, Svetlana Veselova, Anastasia Tugbaeva, Gulnar Gumerova, Karina Gainullina, Evgenia ZaikinaAbstractA small family of ARGOS genes encodes transmembrane proteins that act as negative regulators of ethylene signaling. Recent studies show that ARGOS genes are involved in the regulation of plant growth under the influence of stress factors...
Tue, 10/01/2019 - 03:30
Animal venoms are promising sources of novel drug leads, but their translational potential is hampered by the low success rate of earlier biodiscovery programs, in part reflecting the narrow selection of targets for investigation. To increase the number of lead candidates, here we discuss a phylogeny-guided approach for the rational selection of venomous taxa, using tarantulas (family...
Mon, 09/30/2019 - 17:10
Actinomycetes are remarkable producers of compounds essential for human and veterinary medicine as well as for agriculture. The genomes of those microorganisms possess several sets of genes (biosynthetic gene cluster (BGC)) encoding pathways for the production of the valuable secondary metabolites. A significant proportion of the identified BGCs in actinomycetes encode pathways for the...
Mon, 09/30/2019 - 17:10
For the past few decades, there has been limited progress in the development of novel antibacterials. Previously, we postulated that the gut microbiota of animals residing in polluted environments are a forthcoming supply of antibacterials. Among various species, the water monitor lizard is an interesting species that feeds on organic waste and the carcass of wild animals. Gut microbiota of the...
Mon, 09/30/2019 - 17:04
Author(s): Jie Zhang, Liang Li, Liping Huang, Manman Zhang, Ziyan Chen, Qingsong Zheng, Haiyan Zhao, Xi Chen, Mingyi Jiang, Mingpu TanAbstractThe plant-specific NAC transcription factors play diverse roles in various stress signaling. Alternative splicing is particularly prevalent in plants under stress. However, the investigation of cadmium (Cd) on the differential expression of the splice...
Mon, 09/30/2019 - 17:03
Author(s): Xu Yang, Rongkai Lin, Wenyuan Zhang, Yongkang Xu, Xin Wei, Chen Zhuo, Junhao Qin, Huashou LiAbstractSalt-tolerant rice cultivar (sea rice) is a research hotspot worldwide due to its high yield in high salinity soil. However, knowledge regarding the cadmium (Cd) effects on the growth of sea rice is limited. To determine the short-term and long-term impact of Cd stress, relatively low/...
Mon, 09/30/2019 - 16:54
ABSTRACT The opportunistic pathogenic fungus Candida albicans can cause devastating infections in immunocompromised patients. Its ability to undergo a morphogenetic transition from yeast to filamentous forms allows it to penetrate tissues and damage tissues, and the expression of genes associated with a number of pathogenetic mechanisms is also coordinately regulated with the yeast-to-hypha...
Sun, 09/29/2019 - 03:29
Author(s): Arthur Vinicius Sousa Silva, Lilian D. Moura Torquato, Glauber CruzAbstractThe replacement of fossil fuels by renewable sources has been discussed globally, because fossil fuels account for a large portion of the pollutant emissions into the atmosphere. Several cities along the Brazilian coast produce a variety of fish types, generating a large amount of waste, including viscera and...
Sat, 09/28/2019 - 03:28
Author(s): Subrata Banik, Mahmuda Akter, Serene Ezra Corpus Bondad, Takeshi Saito, Toshiyuki Hosokawa, Masaaki KurasakiAbstractCarvacrol is a monoterpenic phenol found in essential oils, is considered a safe food additive, and possesses various therapeutic properties. Numerous studies have also deciphered the protective role of carvacrol on various cytotoxicities. We clarify the effects of...
Thu, 09/26/2019 - 03:22
Cadmium (Cd) is an environmental pollutant of considerable interest throughout the world and potentially a neurotoxicant. Our recent data indicate that Cd exposure induces impairment of hippocampus-dependent learning and memory in mice. However, the underlying mechanisms for this defect are not known. The goal of this study was to determine if Cd inhibits adult neurogenesis and to identify...
Wed, 09/25/2019 - 03:34
Author(s): Mengyao Mu, Hongjing Zhao, Yu Wang, Juanjuan Liu, Dongxue Fei, Mingwei XingAbstractArsenic and copper are naturally occurring element. Contamination from natural processes and anthropogenic activities can be discovered all over the world and their unique interactions with the environment lead to widespread toxicity. When the content was excessive, the organism would be hurt seriously....
Wed, 09/25/2019 - 03:34
Author(s): Aneta Spyra, Anna Cieplok, Małgorzata Strzelec, Agnieszka BabczyńskaAbstractIn this study we focused on Physella acuta, an alien snail species in order to determine their ability of bioaccumulation of heavy metals in their shells, bodies, the difference in accumulation in relation to age classes, and the influence of ecological variables on the community composition and density. On the...
Wed, 09/25/2019 - 03:34
Author(s): Jaime Rodríguez-Estival, Carlos Morales-Machuca, Jennifer Pareja-Carrera, Manuel E. Ortiz-Santaliestra, Rafael MateoAbstractHere we characterize the bioaccumulation of mercury (Hg) and lead (Pb) in red swamp crayfish (Procambarus clarkii) from two river courses in Central Spain that are impacted by historical Hg and Pb mining activities, respectively. We estimate the absolute oral...
Wed, 09/25/2019 - 03:27
Cadmium (Cd) is a toxic element widely distributed in the aquatic environment and producing a wide variety of harmful effects. In this study, the acute toxicity (96 h LC50) of Cd to rainbow trout Oncorhynchus mykiss embryos and larvae was determined. The obtained results showed that hatched larvae were the most sensitive to Cd exposure. After 4 days of exposure, embryos were found to have...
Wed, 09/25/2019 - 03:27
This study investigated the effect of persistent heavy metal exposure on the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) of the freshwater snail, Lymnaea natalensis. Malondialdehyde (MDA) levels were also measured as an index of lipid peroxidation. The snails were exposed to cadmium, copper, lead and mercury for a total of 28 days at 0.1 mg/L, 0.1 mg/L...
Wed, 09/25/2019 - 03:27
The objective of the study was to evaluate the toxicity of trace elements to earthworms (Eisenia fetida) in recreational and military shooting range soils. The earthworms were exposed to soils; then mortality, growth, and reproduction endpoints were determined. In the recreational shooting range, the total Pb concentration was 6151 mg kg−1 and in the soil of the impact berm of the military...
Tue, 09/24/2019 - 03:41
by Aung B. Bo, Jae D. Kim, Young S. Kim, Hun T. Sin, Hye J. Kim, Botir Khaitov, Young K. Ko, Kee W. Park, Jung S. Choi Bioactive herbicidal compounds produced by soil microorganisms might be used to creating a bioherbicide for biological weed control. A total of 1,300 bacterial strains were isolated and screened for herbicidal activity against grass and broadleaf weeds. Among primarily selected...
Tue, 09/24/2019 - 03:37
Author(s): Lanlan Peng, Jiwang Chen, Lu Chen, Jie Cai, Wenping Ding, Yonggui Gao, Yongning Wu, Shuiyuan ChengAbstractIn this work, rice ultrafiltration albumin (RUA) and rice cadmium-binding protein (RCBP) were separated and purified from rice albumin (RA) in rice grain endosperm using ultrafiltration and ion-exchange chromatography (IEC). Physicochemical properties of RCBP were investigated,...
Tue, 09/24/2019 - 03:37
Author(s): Marco Genchi, Alice Vismarra, Chiara Lucchetti, Antonio Viglietti, Serena Crosara, Giacomo Gnudi, Cecilia Quintavalla, Roland Schaper, Laura KramerAbstractHeartworm infection (also known as dirofilariosis due to Dirofilaria immitis) in dogs causes chronic pulmonary disease that, if left untreated, can lead to right-side congestive heart failure. Currently, the only registered drug for...
Tue, 09/24/2019 - 03:37
Author(s): Wei Yang, Zhi-Kai Tian, Hui-Xin Yang, Zhao-Jun Feng, Jian-Mei Sun, Hong Jiang, Chao Cheng, Qing-Lei Ming, Chan-Min LiuAbstractFisetin, a natural flavonoid found in plants, fruits and vegetables, exerts anti-cancer, anti-oxidant, anti-inflammatory and anti-mitotic effects. The current study instigates the protective effect of fisetin against lead-induced synaptic dysfunction,...
Tue, 09/24/2019 - 03:36
Author(s): Nathan C. Twaddle, Frederick A. Beland, Daniel R. DoergeAbstractArsenic is a common toxic contaminant in food and drinking water. Metabolic activation of arsenic species produces reactive trivalent intermediates that can disrupt cellular regulatory systems by covalent binding to thiol groups. Arsenic exposures have been associated with human diseases including cancer, diabetes, lung...
Tue, 09/24/2019 - 03:35
Author(s): Chuang Ma, Fu-Yong Liu, Bin Hu, Ming-Bao Wei, Ji-Hong Zhao, Ke Zhang, Hong-Zhong ZhangAbstractA field experiment was conducted to assess the atmospheric deposition effects on lead (Pb) contamination in wheat by two contrasting treatments: wheat exposed or not to atmospheric deposition. Plants were housed in a shed during wheat greening for the non-exposed treatment. The Pb contents of...
Tue, 09/24/2019 - 03:31
A multidisciplinary approach was carried out in order to study the biodeterioration and the associated microbiome of a XVIII Century wax seal coloured with minium. A small wax seal fragment was observed by scanning electron microscopy combined with energy dispersive spectroscopy in non‐destructive mode. The same object was analysed by Raman and Fourier‐transform infrared spectroscopy. The...
Mon, 09/23/2019 - 03:32
In the quest for new antibacterial lead structures, activity screening against Mycobacterium tuberculosis identified antitubercular effects of gallic acid derivatives isolated from the Nigerian mistletoe Loranthus micranthus. Structure-activity relationship studies indicated that 3-O-methyl-alkylgallates comprising aliphatic ester chains with four to eight carbon atoms showed the strongest growth...
Mon, 09/23/2019 - 03:32
Salmonella genomic island 3 (SGI3) was first described as a chromosomal island in Salmonella 4,[5],12:i:–, a monophasic variant of Salmonella enterica subsp. enterica serovar Typhimurium. The SGI3 DNA sequence detected from Salmonella 4,[5],12:i:– isolated in Japan was identical to that of a previously reported one across entire length of 81 kb. SGI3 consists of 86 open reading frames...
Sun, 09/22/2019 - 03:25
Driven by the significant need for characterization of the chemical speciation of arsenic in food, this work developed a method for rapid determination of four common arsenic species, namely, arsenite, arsenate, monomethyl arsenic acid, and dimethyl arsenic acid, in vegetables using microwave‐assisted extraction, followed by detection with high‐performance liquid chromatography hyphenated to...
Sun, 09/22/2019 - 03:23
In most laboratory studies with oral exposure of terrestrial invertebrates to metals an artificial food, which is easy to handle, is used. The bioavailability of metals from this artificial food may, however, be much higher than from more field relevant food sources. Such differences may affect toxicokinetic processes in different tissues. To test the effect of bioavailability of Cd in food on Cd...
Sun, 09/22/2019 - 03:22
Leaves of five selected plants Citrus limon (Rutaceae), Ceratonia siliqua L., Olea europaea (Oleaceae), Washingtonia filifera, and Myoporum (Myoporaceae) grown in Jordan were examined for removal of heavy metals (cadmium (Cd) and lead (Pb) ions) for aqueous solutions. Cd and Pb were analyzed by atomic absorption spectrometry. A pH S-2 acidometer was used for determining the acidity of leaves–...
Sat, 09/21/2019 - 03:36
by Yasmin Chau, Fu-Shuang Li, Olesya Levsh, Jing-Ke Weng The natural product icariin inhibits human phosphodiesterase-5 (PDE5) and represents a unique pharmacophore for treating erectile dysfunction, pulmonary hypertension, and other diseases. In this study, we explore the available icariin-derived chemical scaffolds through medicinal chemistry to develop novel icariin PDE5 inhibitors with...
Sat, 09/21/2019 - 03:34
Author(s): Xiangsong Meng, Sultan Ahmed Khoso, Jianhua Kang, Jiangqiu Wu, Jiande Gao, Shangyong Lin, Meirong Wu, Wei Sun, Yuehua HuAbstractIn most of the mining industries, lime is widely used to settle flotation tailings pulp. However, this conventional method has some drawbacks, as it increases pH, organic matter content and chemical oxygen demand (COD) of tailings dam wastewater (TDW) and...
Sat, 09/21/2019 - 03:34
Author(s): Xunzhang Pan, Hailin Wang, Ziwei Wang, Lu Lin, Qi Zhang, Xinzhu Zheng, Wenying ChenAbstract:Combating global climate change calls for all countries to accelerate emissions reductions, and equity is an important guiding principle. A new indicator – the carbon Palma ratio, extended from the income Palma ratio and defined as the ratio of the total emissions of the top 10% emitters to...

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