Heavy Metals

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Fri, 04/30/2021 - 02:02
Intensified vehicular traffic causes increased heavy metal contamination of the environment. We investigated the heavy metal chemistry of soils located under silver fir stands in the vicinity of Poland’s S7 roadway. Three sampling sites were located in fir stands in central Poland. Fieldwork included soil sampling of the organic (O) horizon and mineral (A) topsoil. We analyzed the soil pH, carbon...
Thu, 04/29/2021 - 16:00
Rice poses a major source of the toxic contaminant cadmium (Cd) for humans. Here, we elucidated the role of Cd storage forms (i.e., the chemical Cd speciation) on the dynamics of Cd within rice. In a pot trial, we grew rice on a Cd-contaminated soil in upland conditions and sampled roots and shoots parts at flowering and maturity. Cd concentrations, isotope ratios, Cd speciation (X-ray absorption...
Thu, 04/29/2021 - 12:07
Author(s): Qi Tao, Bing Li, Yixuan Chen, Junwen Zhao, Qiquan Li, Yulan Chen, Quanhui Peng, Shu Yuan, Huanxiu Li, Rong Huang, Changquan Wang The recycling of agricultural waste is a global challenge to the sustainable development of agriculture. By using corn stalks, we studied the feasibility of combining anaerobic fermentation and pyrolysis processes to produce both fermentated liquid feed and...
Thu, 04/29/2021 - 12:05
Author(s): Jian Zhang, Qingqing Xiao, Pengcheng Wang Cadmium (Cd) is among the most toxic heavy metals in soils. The ways by which tomato plants inoculated with a phosphate-solubilizing bacterium (PSB) respond to Cd and regulate gene expression remain unclear. We investigated hormone metabolism and genes involved in Cd resistance in tomato seedlings inoculated with the PSB strain N3. Cd inhibited...
Thu, 04/29/2021 - 12:05
Author(s): MeiYan Guan, MingXue Chen, ZhenZhen Cao Management of nitrogen fertilizer is a good strategy for controlling cadmium (Cd) accumulation in plants. Some progress has already been made but much remains to be done. Here, we show that mutants with loss of function of nitrate transporter1.1 (NRT1.1) or nitrate transporter2.1 (NRT2.1) had lower Cd concentrations than wild-type plants under...
Wed, 04/28/2021 - 10:02
ABSTRACT The evolution of pathogens in response to selective pressures present during chronic infections can influence their persistence and virulence and the outcomes of antimicrobial therapy. Because subpopulations within an infection can be spatially separated and the host environment can fluctuate, an appreciation of the pathways under selection may be most easily revealed through the...
Wed, 04/28/2021 - 10:02
We investigated the prevalence and transmission of NDM-producing Enterobacteriaceae in fecal samples of geese and environmental samples from a goose farm in southern China. The samples were cultivated on MacConkey agar plates supplemented with meropenem. Individual colonies were examined for blaNDM, and blaNDM-positive bacteria were characterized based on whole-genome sequencing (WGS) data from...
Wed, 04/28/2021 - 06:11
Author(s): Ping Zhang, Yue Cai, Lingjie Zhang, Yuting Mao, Mingxue Xiang, Zhongbang Zhu, Youqin Zou Selective removal of metal ions, especially lead (Pb2+), is of enormous importance for environmental protection. A major challenge is to rational design capture agent for Pb2+ with high efficiency and excellent selectivity. Here we recycled the organic layered wastes to prepare a novel sulfate-...
Mon, 04/26/2021 - 08:04
Lead (Pb) contamination in environment has been identified as a threat to human health and ecosystems. In an effort to reduce the health and ecological risks associated with Pb mining wastes, a field study was conducted to stabilize Pb using phosphate (P)-enriched biosolid amendments in the contaminated mining wastes (average of 1004 mg Pb kg−1) located within the Jasper County Superfund Site,...
Sat, 04/24/2021 - 08:04
by Hongke Wu, Ming Wang, Jay D. Raman, Alicia C. McDonald Exposures to heavy metals have been linked to prostate cancer risk. The relationship of these exposures with serum prostate-specific antigen (PSA), a marker used for prostate cancer screening, is unknown. We examined whether total urinary arsenic, urinary dimethylarsonic acid, blood cadmium, blood lead, and total blood mercury levels are...
Thu, 04/22/2021 - 06:16
Author(s): Hao Wu, Shufang Zheng, Jinxi Zhang, Shiwen Xu, Zhiruo Miao Cadmium (Cd), an environmental pollutant, causes several adverse reactions in animals. High dose of Cd has serious cytotoxicities, including the induction of programmed cell necrosis, autophagy and apoptosis, which has aroused wide public concern. The balance of cytokine network is affected by Th1/Th2 balance which is closely...
Thu, 04/22/2021 - 02:02
The research aims to analyse the treatment possibility of Cd-polluted soil using electrokinetics driven by solar power in comparison with driving by direct current power. Meanwhile, the effects of electrolyte on electrokinetics were investigated. Five runs of electrokinetics were carried out using different electrolytes and energy sources. Experimental results showed that the combined application...
Thu, 04/22/2021 - 02:02
Abstract Aims There is little information available on the potential influence of soil micro-arthropods on the phytoremediation of metal-contaminated soils using hyperaccumulator plants. We hypothesized that soil micro-arthropods may promote organic matter decomposition, thereby releasing nitrogen and enhancing the growth of and metal uptake by hyperaccumulators and thereby increase...
Wed, 04/21/2021 - 04:03
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that is frequently found in the airways of cystic fibrosis (CF) patients due to the dehydrated mucus that collapses the underlying cilia and prevents mucociliary clearance. During this life-long chronic infection, P. aeruginosa cell accumulates mutations that lead to inactivation of the mucA gene that results in the constitutive...
Wed, 04/21/2021 - 04:03
The humoral immune response plays a key role in suppressing the pathogenesis of SARS-CoV-2. The molecular determinants underlying the neutralization of the virus remain, however, incompletely understood. Here, we show that the ability of antibodies to disrupt the binding of the viral spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor on the cell, the key molecular event...
Wed, 04/21/2021 - 02:03
Lead (Pb) not only negatively alters plant growth and yield but may also have potentially toxic risks to human health. Nevertheless, the interaction between rice (Oryza sativa L.) plants and the molecular cell dynamics induced by lead-methyl jasmonate (MJ) remains unknown. Here, plants were hydroponically exposed to Pb (150 and 300 µM) alone or in combination with 0.5 and 1 µM MJ. The application...
Sat, 04/17/2021 - 02:03
Abstract Bacterial cell has always been an attractive target for anti-infective drug discovery. MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) enzyme of Escherichia coli (E.coli) is crucial for peptidoglycan biosynthetic pathway, as it is involved in the early stages of bacterial cell wall biosynthesis. In the present study we aim to identify novel chemical structures targeting the MurA...
Sat, 04/17/2021 - 02:03
Pollutants emitted into the air not only have local effect but can also affect areas further from the source. The goal of this study was to assess a method for identifying the sources of element pollution in rainwater using enrichment factors supported by Weather Research and Forecasting (WRF) model. In this study, we collected nineteen rainwater samples at the two locations of Durham and Chimney...
Fri, 04/16/2021 - 18:03
The organochlorine insecticide dichlorodiphenyltrichloroethane (DDT) and heavy metal cadmium (Cd) are widespread environmental pollutants. They are persistent in the environment and can accumulate in organisms. Although the individual toxicity of DDT and Cd has been well documented, their combined toxicity is still not clear. Since liver is their common target, in this study, the individual and...
Fri, 04/16/2021 - 08:03
by Katja Pirc, Vesna Hodnik, Tina Snoj, Tea Lenarčič, Simon Caserman, Marjetka Podobnik, Hannah Böhm, Isabell Albert, Anita Kotar, Janez Plavec, Jure Borišek, Martina Damuzzo, Alessandra Magistrato, Boris Brus, Izidor Sosič, Stanislav Gobec, Thorsten Nürnberger, Gregor Anderluh The lack of efficient methods to control the major diseases of crops most important to agriculture leads to huge...
Fri, 04/16/2021 - 06:09
Author(s): Yilu Gao, Jiameng Hong, Yuke Guo, Mengxu Chen, Alan K. Chang, Lei Xie, Xueping Ying Cadmium (Cd) has been widely used in industry and can accumulate in the water, soil, and food. Meretrix meretrix is one of the marine shellfishes cultivated for economic purpose in China. The increasing Cd levels in coastal marine water could adversely affect the economic benefits of shellfish...
Thu, 04/15/2021 - 06:18
Author(s): Xin Wang, Yiwei Xu, Yahui Li, Yanxiao Li, Zhihua Li, Wen Zhang, Xiaobo Zou, Jiyong Shi, Xiaowei Huang, Chao Liu, Wenting Li This work presents an electrochemical device based on a composite modification of amine functionalized Zr(IV) metal–organic framework (UiO-66-NH2) and multi-walled carbon nanotubes (MWCNTs) for voltammetry determination of cadmium ions (Cd2+). The UiO-66-NH2@...
Thu, 04/15/2021 - 06:15
Author(s): Anna Maria Cybulska, Szymon Grochans, Magdalena Sylwia Kamińska, Mateusz Bosiacki, Karolina Skonieczna-Żydecka, Elżbieta Grochans The aim of this systematic review was to assess if cadmium and lead levels are linked to anxiety and depression. A systematic literature search was conducted to identify observational trials evaluating the impact of cadmium and lead on the incidence and...
Thu, 04/15/2021 - 06:15
Author(s): Xueying Zong, Juanjuan Zhang, Jinwei Zhu, Linyu Zhang, Lijuan Jiang, Ying Yin, Hongyan Guo Microplastics are widespread in freshwater environments, their biological effects and combined effects of other pollutants have attracted extensive attention. In this study, we investigated the adsorption properties of heavy metals onto polystyrene (PS) microplastics as well as the...
Thu, 04/15/2021 - 04:03
Here we have described a systematic structure activity relationship (SAR) of a set of compounds inspired from cladosporin, a tool compound that targets parasite (Plasmodium falciparum) lysyl tRNA synthetase (KRS). Four sets of analogues, synthesized based on point changes in the chemical scaffold of cladosporin and other logical modifications and hybridizations, were assessed using high...
Wed, 04/14/2021 - 16:00
An increase in environmental pollution resulting from toxic heavy metals and metalloids [e.g., cadmium (Cd), arsenic (As), and lead (Pb)] causes serious health risks to humans and animals. Mitigation strategies need to be developed to reduce the accumulation of the toxic elements in plant-derived foods. Natural and genetically-engineered plants with hyper-tolerant and hyper-accumulating capacity...
Wed, 04/14/2021 - 16:00
Quorum sensing (QS) is a signaling mechanism governed by bacteria used to converse at inter- and intra-species levels through small self-produced chemicals called N-acylhomoserine lactones (AHLs). Through QS, bacteria regulate and organize the virulence factors’ production, including biofilm formation. AHLs can be degraded by an action called quorum quenching (QQ) and hence QQ strategy can...
Wed, 04/14/2021 - 06:12
Author(s): Azimeh Zamani, Sara Eavani, Ezzat Rafiee The hazardous effects of PbCrO4 were the motivation for investigation of the possible us of low-lead leaching PbCrO4 based pigments. Eggshell, as the strong low-cost adsorbent of lead, is a suitable choice for the synthesis of low-lead leaching PbCrO4/eggshell composite pigments. Starting from this point, in this work, a series of composite...
Wed, 04/14/2021 - 02:02
The effectiveness of water management in reducing cadmium (Cd) accumulation in rice grain has mainly been investigated in slightly and moderately contaminated soils but seldom in heavily contaminated soils. In addition, how soil physicochemical properties influence the effectiveness of water management merits investigation. In this study, a pot experiment was performed using six soils of slight (...
Tue, 04/13/2021 - 12:01
Lead (Pb) is a highly toxic heavy metal that broadly exists in our living environment. Although Pb has been shown to influence the development of immune cells, to date, the impact of Pb on hematopoietic stem cells (HSCs) in the bone marrow (BM) remains unknown. As people are ubiquitously exposed to Pb and HSC are essential for human health, understanding the impact of Pb on HSC is significant for...
Tue, 04/13/2021 - 12:01
Cadmium exposure is ubiquitous and has been linked to diseases including cancers and reproductive defects. Since cadmium is nonmutagenic, it is thought to exert its gene dysregulatory effects through epigenetic reprogramming. Several studies have implicated germline exposure to cadmium in developmental reprogramming. However, most of these studies have focused on maternal exposure, while the...
Tue, 04/13/2021 - 08:05
by Hiroko Enomoto, James Yeatts, Liliana Carbajal, B. Radha Krishnan, Jay P. Madan, Sandeep Laumas, Anthony T. Blikslager, Kristen M. Messenger There is no FDA approved therapy for the treatment of celiac disease (CeD), aside from avoidance of dietary gluten. Larazotide acetate (LA) is a first in class oral peptide developed as a tight junction regulator, which is a lead candidate for management...
Sun, 04/11/2021 - 14:05
Marine organisms are considered a cache of biologically active metabolites with pharmaceutical, functional, and nutraceutical properties. Among these, marine bioactive peptides (MBAs) present in diverse marine species (fish, sponges, cyanobacteria, fungi, ascidians, seaweeds, & mollusks) have acquired attention owing to their broad-spectrum health-promoting benefits. Nowadays, scientists are...
Sun, 04/11/2021 - 00:00
Iris lactea var. chinensis (Fisch.) (I. lactea var. chinensis) is a well-known cadmium (Cd)-tolerant plant and we have previously shown that the metallothionein gene, IlMT2a, of the plant may be playing a key role in conferring the Cd tolerance. In this study, we have identified several proteins interacting with the IlMT2a by screening yeast two-hybrid library constructed from cDNAs isolated from...
Sat, 04/10/2021 - 04:03
Natural products are one of the resources for discovering novel fungicidal leads. As a natural fungicide, osthole was used as a coumarin-based lead compound for the development of novel fungicides. Here, a series of 3,4-dichloroisothiazole-containing 7-hydroxycoumarins were rationally designed, synthesized, and characterized by introducing a bioactive substructure, 3,4-dichloroisothiazole, into...
Sat, 04/10/2021 - 04:02
Increasing multidrug resistance in Neisseria gonorrheae is a growing public health crisis. Resistance to the last line therapies, cephalosporins and azithromycin, are of particular concern, fueling the need to discover new treatments. Here, we identified the phosphoglycolipid moenomycin from a screen of microbial natural products against drug-resistant N. gonorrheae as a potent antigonococcal...
Fri, 04/09/2021 - 03:01
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has caused a pandemic with tens of millions of cases and more than a million deaths. The infection causes COVID-19, a disease of the respiratory system of divergent severity. No treatment exists. Epigallocatechin-3-gallate (EGCG), the major component of green tea, has several beneficial properties, including antiviral...
Fri, 04/09/2021 - 02:02
This study analyzed 27 surface sediment samples from the Tamaulipas Continental shelf to determine the spatial–temporal distribution of V and Cd (spring–summer 2016; summer 2017). Average V concentrations (99 ± 18 mg g−1) were similar to that previously reported values for the area, while average Cd concentrations reflect uncontaminated sediments at surface level of the shelf. Inputs of V and Cd...
Thu, 04/08/2021 - 16:00
Extreme environments are excellent places to find microorganisms capable of tolerating extreme temperature, pH, salinity pressure, and elevated concentration of heavy metals and other toxic compounds. In the last decades, extremophilic microorganisms have been extensively studied since they can be applied in several fields of biotechnology along with their enzymes. In this context, the...
Thu, 04/08/2021 - 12:00
Randomized controlled trials (RCTs) conducted by the industry are expensive, especially trials conducted for registration of new drugs for multidrug-resistant (MDR) bacteria. Lower-cost investigator-initiated trials have recently been successful in recruiting patients with severe infections caused by MDR bacteria. In this viewpoint, we contrast the aims, methods, and resulting costs of industry-...
Wed, 04/07/2021 - 16:00
Streptomyces species are the most important sources of antibacterial, antifungal, and phytotoxic metabolites. In this study, cycloheximide (CH) and acetoxycycloheximide (ACH) were isolated from the fermentation broth of Streptomyces sp. JCK-6092. The antifungal and phytotoxic activities of the two compounds (CH and ACH) and a cycloheximide derivative, hydroxycycloheximide (HCH), were compared. CH...
Sun, 04/04/2021 - 02:02
Tobacco readily accumulates cadmium (Cd), an unnecessary and poisonous element. A total of 107 soil and tobacco leaf samples were collected from South China, to clarify the quantitative relationship between soil properties and Cd content in tobacco leaves. The results showed that 86.9% of the total sampling points had soil cadmium in excess of standard value, and the ratio of active Cd content to...
Thu, 04/01/2021 - 06:18
Author(s): R. Paranthaman, J.A. Moses, C. Anandharamakrishnan This study aimed to develop and validate a powder X-ray diffraction method for the direct detection of PbCrO4 adulteration in turmeric powder. Different X-ray tube voltage (25–45 kV), tube current (25–45 mA), and scanning parameters (step size, 2θ° and time per step, s) were used and optimized on the angle of 15°–50° at 25°C with CuKα...
Thu, 04/01/2021 - 06:15
Author(s): Xiaoting Hu, Tao Li, Weihong Xu, Yourong Chai Cadmium (Cd) tolerance mechanisms in plant are mainly divided into two categories: evasion mechanism and tolerance mechanism. However, due to the complexity of the mechanism of Cd absorption and accumulation in crops, there are still disputes and controversies about Cd toxicity to plants and the mechanism of Cd tolerance in plants. The Cd...
Wed, 03/31/2021 - 04:03
The carbon–silicon switch strategy has become a key technique for structural optimization of drugs to widen the chemical space, increase drug activity against targeted proteins, and generate novel and patentable lead compounds. Flubeneteram, targeting succinate dehydrogenase (SDH), is a promising fungicide candidate recently developed in China. We describe the synthesis of novel SDH inhibitors...
Mon, 03/29/2021 - 16:00
Dental caries is a chronic oral infectious disease caused by cariogenic biofilm adhered on the tooth surface. Our previous study demonstrated that a repurposed natural compound napabucasin (NAP) showed good antimicrobial activity against oral streptococcal biofilms. The current study designed a novel small molecule, namely LCG-N25, using NAP as a lead compound, and aimed to investigate its...
Sun, 03/28/2021 - 06:09
Author(s): Leonardo Francisco Rafael Lemes, César Ricardo Teixeira Tarley This study describes the development of a new analytical method for cadmium determination in flaxseed flour based on ultrasound-assisted extraction combined with supramolecular preconcentration followed by thermospray flame furnace atomic absorption spectrometry. Cadmium from flaxseed flour was extracted by ultrasound-...
Sun, 03/28/2021 - 06:08
Author(s): Guangzhe Yang, Shan Fu, Jingjing Huang, Longying Li, Yan Long, Qiuxing Wei, Zhigang Wang, Zhiwei Chen, Jixing Xia Cadmium (Cd) is a highly toxic element to living organisms, and its accumulation in the edible portions of crops poses a potential threat for human health. The molecular mechanisms underlying Cd detoxification and accumulation are not fully understood in plants. In this...
Sun, 03/28/2021 - 06:08
Author(s): Jing Ge, Li-Li Liu, Zheng-Guo Cui, Milton Talukder, Mei-Wei Lv, Jin-Yang Li, Jin-Long Li Cadmium (Cd) is a ubiquitous environmental pollutant, which mainly input to the aquatic environment through discharge of industrial and agricultural waste, can be a threat to human and animal health. Selenium (Se) possesses a beneficial role in protecting animals and ameliorating the toxic effects...
Fri, 03/26/2021 - 06:08
Author(s): Dong Xu, Puhui Ji, Lu Wang, Xin Zhao, Xiongfei Hu, Xunrong Huang, Hanghang Zhao, Fuhao Liu In this study, a low-temperature roasting and hydrothermal methods were used to modify the fly ash resulting in two new types of adsorption materials - modified fly ash (MFA) and artificial zeolite (ZE). These modified fly ashes, as well as a natural zeolite (ZO) were applied to two types of...

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