Heavy Metals

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Sun, 02/21/2021 - 06:11
Author(s): Ju Tang, Weixia Duan, Ping Deng, Huijuan Li, Cong Liu, Yu Duan, Min Feng, Shangcheng Xu Cadmium (Cd) is a ubiquitous environmental and occupational pollutant that is considered a high-risk factor for neurodegenerative diseases. However, the mechanism underlying Cd-induced neurotoxicity has not been fully elucidated. Abnormal mitochondrial distribution and excessive mitochondrial...
Sun, 02/21/2021 - 04:02
Triglyceride (TG) is a class of neutral lipids, which functions as an energy storage depot and is important for cellular growth, metabolism, and function. The composition and content of TG molecular species are crucial factors for nutritional aspects in food chemistry and are directly associated with several diseases, including atherosclerosis, diabetes, obesity, stroke, etc. As a result of the...
Sat, 02/20/2021 - 22:09
Journal of the Science of Food and Agriculture, Accepted Article. Lead (Pb2+) is one of the most toxic heavy metals, which can be found in various quantities in the environment. The five native probiotic bacteria and inulin were used to assess in vitro lead nitrate and lead acetate binding capacities and removal potentials.
Sat, 02/20/2021 - 06:31
Author(s): Yi Zhou, Wenlong Jiang, Xinyu Guo, Yun Zhao, Baoqiang Xu, Jiarong Li, Bin Yang Noble lead, which is produced by the reduction smelting of lead anode slime, contains copious rare and precious metals. The vacuum distillation procedure for processing noble lead exhibits the advantages of efficiency and simplicity, and has been industrialized in most of China’s lead, copper and precious...
Sat, 02/20/2021 - 02:03
This study focuses on heavy metal contamination in soils due to recreational shooting within the Tonto National Forest, Arizona. The main research questions are: (1) Have some soils within the Tonto National Forest (NF) been contaminated with lead (Pb) due to recreational shooting? (2) How far downslope have the soils been contaminated? Soils in permitted shooting areas were tested for lead (Pb...
Fri, 02/19/2021 - 16:00
Rice, a staple crop for nearly half the planet’s population, tends to absorb and accumulate excessive cadmium (Cd) when grown in Cd-contaminated fields. Low levels of Cd can degrade the quality of rice grains, while high levels can inhibit the growth of rice plants. There is genotypic diversity in Cd distribution and Cd tolerance in different rice varieties, but their underlying genetic...
Fri, 02/19/2021 - 08:03
Acid-sensing ion channels (ASICs) are expressed in the nervous system, activated by acidosis, and implicated in pain pathways. Mambalgins are peptide inhibitors of ASIC1 and analgesic in rodents via inhibition of centrally expressed ASIC1a and peripheral ASIC1b. This activity has generated interest in mambalgins as potential therapeutics. However, most mechanism...
Fri, 02/19/2021 - 02:04
Cadmium (Cd) in soil–plant system can abridge plant growth by initiating alterations in root zones. Hydroponics and rhizoboxes are useful techniques to monitor plant responses against various natural and/or induced metal stresses. However, soil based studies are considered more appropriate in order to devise efficient food safety and remediation strategies. The present research evaluated the Cd-...
Fri, 02/19/2021 - 02:03
Jumping ability determines the likelihood of survival and reproduction of amphibians. To study the toxic effect of lead (Pb) on the jumping ability of amphibians, Pelophylax nigromaculata were treated with 0, 1 and 10 mg/L Pb for 10 days and 20 days each. The results showed that for both treatment time (10 days and 20 days), compared to the control group, the 1 mg/L Pb treatment had no...
Thu, 02/18/2021 - 16:00
New anti-infective approaches are urgently needed to control multidrug-resistant (MDR) pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA). Sortase A (SrtA) is a membrane-bound cysteine transpeptidase that plays an essential role in the catalysis of covalent anchoring of surface proteins to the cell wall of Staphylococcus aureus (S. aureus). The present study reports...
Thu, 02/18/2021 - 10:02
Schistosomiasis poses a serious threat to human health and remains a major tropical and parasitic disease in more than 70 countries. Praziquantel (PZQ) has been the primary treatment for schistosomiasis for nearly 4 decades. However, its efficacy against migratory-stage schistosomula is limited. Radicicol (RAD), a β-resorcylic acid lactone derived from Paecilomyces sp. strain SC0924, was...
Thu, 02/18/2021 - 06:29
Author(s): Ziyang Luo, Hanying Duan, Yuncheng Yang, Wentao Zhang, Hosahalli S. Ramaswamy, Weibin Bai, Chao Wang Cadmium (Cd) ranks seventh in the World Health Organization (WHO) priority list of hazardous toxic substances. In this study, a high-pressure extraction (HPE) method was explored for Cd decontamination in rice, and the process was compared with the traditional washing method. Optimal...
Thu, 02/18/2021 - 06:26
Author(s): Lucas Suchecki Barnet, Dirce Pozebon, Valderi L. Dressler, Daiane Cioato A methodology for As speciation in rice using liquid chromatography-inductively coupled plasma mass spectrometry (LC-ICP-MS) was optimised and validated. Chromatographic separation and elution of As(III), DMA(V) (dimethylarsenic acid), MMA(V) (monomethylarsenic acid) and As(V) were achieved in less than 8 min...
Thu, 02/18/2021 - 04:02
Effective strategies are needed to deal with invasive fungal infections caused by drug-resistant fungi. Previously, we designed a series of antifungal benzocyclane derivatives based on the drug repurposing of haloperidol. Herein, further structural optimization and antifungal mechanism studies were performed, leading to the discovery of new piperidol derivative B2 with improved synergistic...
Thu, 02/18/2021 - 02:02
Cadmium (Cd) is considered one of the heavy metals disturbing plant biophysiological functions. The potential role of phosphorus (P) nutrition in the attenuation of Cd effects on photosynthetic efficiency, plant growth, and cadmium uptake has been investigated in hydroponically grown tomato. Two P nutrition regimes (P15: 15 mg l-1; P30: 30 mg l-1) were assessed in the presence or absence of Cd (...
Tue, 02/16/2021 - 06:24
Author(s): Yuanyuan Fang, Lili Lu, Yuan Liang, Dongjie Peng, Michael Aschner, Yueming Jiang Lead is a heavy metal pollutant that is widely present in the environment. It affects every organ system, yet the nervous system appears to be the most sensitive and primary target. Although many countries have made significant strides in controlling Pb pollution, Pb poisoning continuous to be a major...
Mon, 02/15/2021 - 06:11
Author(s): Jingzeng Cai, Haoyue Guan, Xing Jiao, Jie Yang, Xiaoming Chen, Haoran Zhang, Yingying Zheng, Yue Zhu, Qi Liu, Ziwei Zhang Cadmium (Cd) chloride, as widely distributed toxic environmental pollutants by using in industry, severely imperils animal and human health. Pyroptosis is a Cas1-dependent pro-inflammatory programmed cell death and involves in various types of diseases. Nevertheless...
Sat, 02/13/2021 - 22:28
Seafood is capable of bioaccumulating heavy metals (HM), making it a potentially major dietary source of HM for humans. Presently, little data exists on seafood from the eastern‐most boundary of the Mediterranean Sea. This study aims to provide exposure insight of the Israeli population to HM through the consumption of locally caught seafood by assessing the levels of arsenic, mercury, cadmium,...
Sat, 02/13/2021 - 04:02
Two proteases produced by the SARS-CoV-2 virus, the main protease and papain-like protease, are essential for viral replication and have become the focus of drug development programs for treatment of COVID-19. We screened a highly focused library of compounds containing covalent warheads designed to target cysteine proteases to identify new lead scaffolds for both Mpro and PLpro proteases. These...
Sat, 02/13/2021 - 02:03
Atmospheric deposition of cadmium (Cd) and lead (Pb) was investigated together with the accumulation, distribution and health risks from potentially toxic metals in soils, vegetables and human hair at a mining area in southwest China. Annual atmospheric deposition of Cd and Pb were 41.1 and 192 g ha− 1, respectively, and consisted mainly of dry deposition. Agricultural soils experienced high...
Fri, 02/12/2021 - 04:02
The metabolism of chlorogenic acid (CGA) through the intestinal tract was studied. As cadmium is a well-known toxic heavy metal, this study was carried out to investigate the comparative protective effect of CGA and its representative intestinal metabolite (3-(3-hydroxyphenyl) propionic acid, HPPA) against Cd-induced erythrocyte cytotoxicity in vitro and in vivo. We found that CGA and its...
Thu, 02/11/2021 - 22:11
Environment and food contamination with cadmium (Cd) can cause serious toxicity, posing a severe threat to agricultural production and human health. However, how amino acids contribute to defenses against oxidative stress caused by Cd in cells is not fully understood. As a model eukaryote with a relatively clear genetic background, Saccharomyces cerevisiae has been commonly used in Cd toxicity...
Thu, 02/11/2021 - 08:07
by Chunjiang Yang, Aobo Chen, Yashuo Chen The COVID-19 pandemic has unhinged the lives of people across the globe. In particular, more than 30 million Chinese college students are home-schooling, yet there is little understanding of how academic workload, separation from school, and fears of contagion lead to a decrease in their health. This study examined the relationships between Chinese...
Thu, 02/11/2021 - 06:21
Author(s): Coline Monchanin, Amaury Blanc-Brude, Erwann Drujont, Mohammed Mustafa Negahi, Cristian Pasquaretta, Jérôme Silvestre, David Baqué, Arnaud Elger, Andrew B. Barron, Jean-Marc Devaud, Mathieu Lihoreau Pollutants can have severe detrimental effects on insects, even at sublethal doses, damaging developmental and cognitive processes involved in crucial behaviours. Agrochemicals have been...
Thu, 02/11/2021 - 06:20
Author(s): Yongqiang You, Li Wang, Chang Ju, Gen Wang, Fang Ma, Yujiao Wang, Dongguang Yang Arbuscular mycorrhizal fungi (AMF) play an important role in improving plant tolerance and accumulation of zinc (Zn) and cadmium (Cd). The growth, physiology and absorption of elements and transport in Phragmites australis (P. australis) were investigated under Zn and Cd stress to identify the transport...
Thu, 02/11/2021 - 06:20
Author(s): Yaping Li, Mingjie Sun, Wei He, Hui Wang, Hong Pan, Quangang Yang, Yanhong Lou, Yuping Zhuge Cadmium is a common heavy metal pollutant. In some plants, its absorption is inhibited by exogenous phosphorus. Here, the effect of P supplementation on the growth of tall fescue exposed to Cd was evaluated in a hydroponic culture experiment. Plants were exposed to five concentrations of P (0,...
Wed, 02/10/2021 - 08:02
by Roger Pamphlett, Philip A. Doble, David P. Bishop Objective Mercury and other toxic metals have been suggested to be involved in thyroid disorders, but the distribution and prevalence of mercury in the human thyroid gland is not known. We therefore used two elemental bio-imaging techniques to look at the distribution of mercury and other toxic metals in the thyroid glands of people over a wide...
Wed, 02/10/2021 - 02:04
Abstract Pollution with the heavy metal cadmium (Cd2+) is a global problem. Cadmium adversely affects living organisms, highlighting the need to develop new methods for removal of this pollutant from the environment. In this study, we used a novel biomaterial based on calcium-crosslinked alginate-encapsulated bacteria to precipitate Cd2+ in polluted water. Our results show that calcium-...
Wed, 02/10/2021 - 02:04
Accumulation and transfer of Cd by Sonchus asper intercropped with a legume crop, Vicia faba were determined via 112Cd as a tracer to assess the potential of Sonchus asper as a hyperaccumulator. In this study, Sonchus asper and Vicia faba were planted side by side in soils amended with arbuscular mycorrhizae, and 112Cd was applied to either Sonchus asper or Vicia faba planted soils while the...
Tue, 02/09/2021 - 18:02
In this study, the level of arsenic (As), lead (Pb) and cadmium (Cd) and also essential elements in beer samples consumed in Turkey were investigated using the inductively coupled plasma mass spectrometry (ICP-MS) method. The heavy metal-induced non-carcinogenic and carcinogenic risks were calculated. For essential elements, the calculated estimated daily intake of iron (Fe), copper (Cu),...
Tue, 02/09/2021 - 08:07
The ultrafast polarization response to incident light and ensuing exciton/carrier generation are essential to outstanding optoelectronic properties of lead halide perovskites (LHPs). A large number of mechanistic studies in the LHP field to date have focused on contributions to polarizability from organic cations and the highly polarizable inorganic lattice. For...
Tue, 02/09/2021 - 02:03
Abstract Serpentine has weak immobilization capacity for Pb(II), especially under acidic conditions. In order to improve its application potential, a new biological modification method was adopted, i.e., the serpentine powder was weathered by Aspergillus niger and the fungus-serpentine aggregation (FSA) formed was investigated for its Pb(II) immobilization potential and underlying mechanism....
Tue, 02/09/2021 - 02:03
We investigated cadmium (Cd) accumulation in muscles, gills and hepatopancreas of Litopenaeus vannamei following 48 h exposure to 5.25 mg/L, and depuration of Cd in these tissues on 1, 5 and 15 d post exposure. We also detected the expressions of metallothionein (MT), caspase-3 and p53 in hepatopancreas of shrimp exposed to 0, 5.25 and 10.5 mg/L Cd (the 24 h median lethal concentration, 24 h LC50...
Sun, 02/07/2021 - 02:03
People living near abandoned mines are at increased risk of exposure to toxic metals. We surveyed 4500 inhabitants with the mean age of 68.5 years old (male: 1768, female: 2732) living near 104 abandoned metal mines from 2013 to 2017 (the 2nd phase health survey in Korea). We conducted personal interviews, blood and urine sampling, and analyzed the concentrations of lead (Pb) and cadmium (Cd) in...
Sat, 02/06/2021 - 06:18
Author(s): Qi Li, Yingna Xing, Xiaowen Fu, Lei Ji, Tianyuan Li, Jianing Wang, Guanhong Chen, Zhichong Qi, Qiang Zhang The effects of Bacillus subtilis inoculation on the growth and Cd uptake of alfalfa were evaluated in this research using pot experiments, and the relevant biochemical mechanisms were first investigated by combined microbial diversity and nontarget metabolomics analyses. The...
Sat, 02/06/2021 - 02:02
In this study, we investigated effects of lead on growth response and antioxidant defense protection in a new identified strain isolated from a soil, in the rhizosphere of Sainfoin Hedysarum coronarium L. Different concentrations of lead (0, 0.2, 1.5 and 3 g L−1) added to Bacillus simplex strain 115 cultures surprisingly did not inhibit its growth. However, a resulting oxidative stress as...
Sat, 02/06/2021 - 02:02
Fresh snow and lichens (Cladonia rangiferina) were collected along two ~300-km transects in a regional survey around two smelter areas in Northern Ontario, i.e., the Sudbury and Timmins areas, in 2009–2010, as a part of a monitoring program. The samples were analyzed for Pb isotope ratios in snow from 47 sites, and in lichens from 28 sites, for background airborne lead and to determine the...
Fri, 02/05/2021 - 08:03
by Masato Ogura, Kumiko Endo, Toshiyuki Suzuki, Yoshimi Homma Interleukin-31 (IL-31) is involved in excessive development of cutaneous sensory nerves in atopic dermatitis (AD), leading to severe pruritus. We previously reported that PQA-18, a prenylated quinolinecarboxylic acid (PQA) derivative, is an immunosuppressant with inhibition of p21-activated kinase 2 (PAK2) and improves skin lesions in...
Fri, 02/05/2021 - 06:09
Author(s): Xinxin Li, Xiang Lan, Xiuwei Feng, Xiaoyu Luan, Xiufeng Cao, Zhaojie Cui The biosorption and bioaugmentation performances of Mucor circinelloides were investigated under different contact time, initial metal(loid) concentration and species. The microbe-plant interaction appeared synergistic with enhancing plant growth and alleviating oxidative damages induced by lead, cadmium and...
Thu, 02/04/2021 - 16:00
Cereals are the major contributors to global food supply, accounting for more than half of the total human calorie requirements. Sustainable availability of quality cereal grains is an important step to address the high-priority issue of food security. High concentrations of heavy metals specifically lead (Pb) in the soil negatively affect biochemical and physiological processes regulating grain...
Thu, 02/04/2021 - 16:00
Serious infections caused by multidrug-resistant Staphylococcus aureus clearly urge the development of new antimicrobial agents. Drug repositioning has emerged as an alternative approach that enables us to rapidly identify effective drugs. We first reported a guanidine compound, isopropoxy benzene guanidine, had potent antibacterial activity against S. aureus. Unlike conventional antibiotics,...
Thu, 02/04/2021 - 04:03
Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis affecting human populations, yet CL remains largely ignored in drug discovery programs. CL causes disfiguring skin lesions and often relapses after “clinical cure” using existing therapeutics. To expand the pool of anti-CL lead candidates, we implemented an integrated screening platform comprising three progressive Leishmania...
Wed, 02/03/2021 - 06:11
Author(s): Wen Li, Yinyuan Chen, Tao Wang Cadmium in food and drinking water poses a serious threat to human health. In this study, a strain of lactic acid bacteria (LAB), namely, Weissella viridescens ZY-6 was utilized to remove Cd2+ from aqueous solution. Its Cd2+ binding capacity was assessed in different conditions, the underlying mechanism was investigated, and its use for removal of Cd2+...
Wed, 02/03/2021 - 06:11
Author(s): Jomana Elaridi, Hani Dimassi, Osama Al Yamani, Maria Estephan, Hussein F. Hassan Infant formula is a common source of food and nutrition for many infants and toddlers. However, the presence of contaminants, such as toxic metals, may pose increased health risks to infants. An investigation on the occurrence of the toxic metals: lead (Pb), cadmium (Cd) and arsenic (As) in baby formula...
Tue, 02/02/2021 - 22:13
Cadmium (Cd) is a common toxic heavy metal in the environment, and bacteria have evolved different strategies to deal with Cd‐toxicity. Here, a bacterium designated Pseudoalteromonas sp. MT33b possessing strong Cd‐resistance was isolated from the Mariana Trench sediments. Supplement of cysteine significantly increased bacterial Cd‐resistance and removal rate. Biofilm formation was demonstrated to...
Tue, 02/02/2021 - 08:04
by Jeremy D. Baker, Rikki L. Uhrich, Gerald C. Kraemer, Jason E. Love, Brian C. Kraemer Effective SARS-CoV-2 antiviral drugs are desperately needed. The SARS-CoV-2 main protease (Mpro) appears as an attractive target for drug development. We show that the existing pharmacopeia contains many drugs with potential for therapeutic repurposing as selective and potent inhibitors of SARS-CoV-2 Mpro. We...
Tue, 02/02/2021 - 04:03
Limited therapeutic options are available for the treatment of human schistosomiasis caused by the parasitic Schistosoma flatworm. The B cell lymphoma-2 (BCL-2)-regulated apoptotic cell death pathway in schistosomes was recently characterized and shown to share similarities with the intrinsic apoptosis pathway in humans. Here, we exploit structural differences in the human and schistosome BCL-2 (...
Mon, 02/01/2021 - 06:09
Author(s): Kuiju Niu, Ran Zhang, Ruiting Zhu, Yong Wang, Dan Zhang, Huiling Ma Perennial ryegrass (Lolium perenne L.), a grass species with superior tillering capacity, plays a potential role in the phytoremediation of cadmium (Cd)-contaminated soils. Tiller production is inhibited in response to serious Cd stress. However, the regulatory mechanism of Cd stress-induced inhibition of tiller...
Sun, 01/31/2021 - 06:10
Author(s): Christelle Douillet, Jinglin Ji, Immaneni Lakshmi Meenakshi, Kun Lu, Fernando Pardo-Manuel de Villena, Rebecca C. Fry, Miroslav Stýblo Arsenic methyltransferase (AS3MT) is the key enzyme in the pathway for the methylation of inorganic arsenic (iAs), a potent human carcinogen and diabetogen. AS3MT converts iAs to mono- and dimethylated arsenic species (MAs, DMAs) that are excreted...
Sat, 01/30/2021 - 18:03
Background:Ischemic heart disease (IHD) is the major cause of duty-related fatalities in the fire service. Age and career length are not only important risk factors associated with IHD, but are also highly correlated. The aim of this secondary analyses was to assess the relationship between age, career length, and IHD, based on ischemic severity, to identify whether age or career length had a...

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