Heavy Metals

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Wed, 01/13/2021 - 06:07
Author(s): Huan Wang, Qi Han, Yongjie Chen, Guanghui Hu, Houjuan Xing Cadmium (Cd) is a typical pollutant and carcinogen in environment. Exposure assessment of contaminants is an important component of occupational and environmental epidemiological studies. Early studies of Cd have focused on aquatic animals, chickens and rats. However, toxicological evaluation of Cd in pigs has not been reported...
Tue, 01/12/2021 - 08:05
by Junenette L. Peters, Melissa J. Perry, Eileen McNeely, Robert O. Wright, Wendy Heiger-Bernays, Jennifer Weuve Elevated red blood cell distribution width (RDW), traditionally an indicator of anemia, has now been recognized as a risk marker for cardiovascular disease incidence and mortality. Experimental and acute exposure studies suggest that cadmium and lead individually affect red blood cell...
Mon, 01/11/2021 - 16:00
Development of novel anti-tuberculosis combination regimens that increase efficacy and reduce treatment timelines will improve patient compliance, limit side-effects, reduce costs, and enhance cure rates. Such advancements would significantly improve the global TB burden and reduce drug resistance acquisition. Bioenergetics has received considerable attention in recent years as a fertile area for...
Sun, 01/10/2021 - 06:07
Author(s): Issam Saidi, Fatma Guesmi, Oussama Kharbech, Najla Hfaiedh, Wahbi Djebali In the present work, the effect of seed pre-soaking with gallic acid (GA; 3,4,5-triphydroxyl-benzoic acid) in conferring subsequent tolerance to Cd stress in sunflower (Helianthus annuus) seedlings was investigated. Exposing sunflower seedlings to increasing Cd concentrations (5, 10 and 20 μM) caused a gradual...
Sat, 01/09/2021 - 06:18
Author(s): Jesús Sevillano Caño, Fernando Cámara Martos, Ricardo Zamora-Díaz, Jesús Salvador Sevillano–Morales Consumption of Pb-contaminated game meat is a concern for the population, as it poses a potential risk to consumer health. Thus, this study is aimed at determining Pb content in muscle tissue of migratory birds, evaluating the influence of the use of Pb ammunition on the content of this...
Sat, 01/09/2021 - 02:02
This study is aimed at investigation of various potential contaminants (arsenic, mercury and polycyclic aromatic hydrocarbons) content in soils of different landscapes of Eastern Antarctica ice-free areas. Our data not only showed that intensive human impact might result in significant direct contamination of surrounding landforms, but also revealed a specific role of ornithogenic transport in...
Sat, 01/09/2021 - 02:02
Hemp is one of the most complete plants for industrial and consumer purposes. In the food industry, the main hemp product is the seed oil, which contains a wide spectrum of compounds such as amino acids and fatty acids that are essential for human health. Given its growing consumption, systematic studies were undertaken for the quantification of toxic elements (As, Cd, and Pb) in hemp products,...
Fri, 01/08/2021 - 06:07
Author(s): Anelia G. Dobrikova, Emilia L. Apostolova, Anetta Hanć, Ekaterina Yotsova, Preslava Borisova, Ilektra Sperdouli, Ioannis-Dimosthenis S. Adamakis, Michael Moustakas The herbal plant Salvia sclarea L. (clary sage) is classified to cadmium (Cd) accumulators and considered as a potential plant for phytoremediation of heavy metal polluted soil. However, the effect of Cd only treatment on...
Fri, 01/08/2021 - 02:03
Paragonimiasis is a foodborne trematode infection that affects 23 million people, mainly in Asia. Lung fluke infections lead frequently to chronic cough with fever and hemoptysis, and are often confused with lung cancer or tuberculosis. Paragonimiasis can be efficiently treated with praziquantel, but diagnosis is often delayed, and patients are frequently treated for other conditions. To improve...
Fri, 01/08/2021 - 02:02
Minerals such as calcium, magnesium, and potassium which are available in the Ajwa dates are known to play vital roles in the regulation of blood pressure due to their interaction with the arterial resistance. The purpose of this study was to investigate the level of various ions in these date seeds and their correlation to the cardiovascular parameters. The powder was subjected to the electron...
Fri, 01/08/2021 - 02:01
Heavy metals release from contaminated sediments is one of the most important chemical processes affecting overlying water quality in river, lake, and ocean. The objective of this study was to determine the leaching properties, kinetic rate, and leaching amount of zinc (Zn) and cadmium (Cd) from the river sediment contaminated by gold mining. Speciation of Zn and Cd in the sediments was extracted...
Fri, 01/08/2021 - 02:01
Exogenous regulation of plant physiology is a kind of effective approach to help plant grow under Cd (cadmium)-contaminated environment. CA (cinnamaldehyde) is an environmental friendly natural compound with medicinal properties and antimicrobial activities. In this work, we found that CA was able to confer plant Cd tolerance by priming defense in the root of B. rapa. Pretreatment with CA...
Fri, 01/08/2021 - 02:01
The research was aimed at checking the possibility of using the Chrysanthemum (Chrysanthemum indicum) as a sorbent for the removal of heavy metals. The chrysanthemum was divided into flower petals, stems, and leaves to check the affinity for the metals tested. In the work, equilibrium and kinetic modeling of the process was carried out by selecting nonlinear models with the best fit. The tested...
Thu, 01/07/2021 - 06:13
Author(s): Chunyan Zhang, Xia Jia, Yonghua Zhao, Lu Wang, Kemeng Cao, Ningjing Zhang, Yunfeng Gao, Ziwei Wang Flavonoids participate in several plant processes such as growth and physiological protection in adverse environments. In this study, we investigated the combined effects of eCO2 and cadmium (Cd)-contaminated soils on the total flavonoid and monomer contents in the leaves of Robinia...
Thu, 01/07/2021 - 06:13
Author(s): Ying Yan, Qianqian Sun, Jingjie Yang, Xiaowen Zhang, Boli Guo Cd contamination in rice grains has become a topic of great concern because of the high health risks associated with the long-term consumption of Cd-contaminated rice. Identification of Cd sources in rice grains by scientific methods is important for controlling heavy metal pollution and protecting human health. Here, the Cd...
Thu, 01/07/2021 - 02:02
Abstract In this study, we firstly reported the large-scale screening and isolation of endophytic fungi from nine wild and six cultivated soybeans in the cold regions of China. We totally isolated 302 endophytic fungal strains, of which 215 strains are isolated from the wild soybeans and 87 are identified from cultivated soybeans. Among these endophytic fungal strains, in the roots, stems, and...
Wed, 01/06/2021 - 04:03
4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) has been recognized as one of the most promising targets in the field of herbicide innovation considering the severity of weed resistance currently. In a persistent effort to develop effective HPPD-inhibiting herbicides, a structure-guided strategy was carried out to perform the structural optimization for triketone-quinazoline-2,4-diones...
Wed, 01/06/2021 - 00:00
Scorpion toxins represent a variety of tools to explore molecular mechanisms and cellular signaling pathways of many biological functions. These toxins are also promising lead compounds for developing treatments for many neurological diseases. In the current study, we purified a new scorpion toxin designated as BmK NSPK (Buthus martensii Karsch neurite-stimulating peptide targeting Kv channels)...
Wed, 01/06/2021 - 00:00
Riboswitches reside in the untranslated region of RNA and regulate genes involved in the biosynthesis of essential metabolites through binding of small molecules. Since their discovery at the beginning of this century, riboswitches have been regarded as potential antibacterial targets. Using fragment screening, high-throughput screening and rational ligand design guided by X-ray crystallography,...
Tue, 01/05/2021 - 12:00
Cadmium is toxic to the ovaries in animal studies, but its association with diminished ovarian reserve in women is not established. We investigated urinary cadmium, a biomarker of long-term exposure, in relation to diminished ovarian reserve, as indicated by elevated serum follicle-stimulating hormone concentrations (≥10 IU/L), in women aged 35–49 years (unweighted n = 1,681). Using data from the...
Tue, 01/05/2021 - 12:00
In this issue of the Journal, Upson et al. (Am J Epidemiol. 2021;190(1):116–124) assess urinary cadmium level as a potential environmental influence on ovarian reserve, as measured using serum follicle-stimulating hormone, in data from 1,681 US women (1988–1994). They compare 3 methods for modeling urinary proxy exposures—standardization, covariate adjustment, and covariate-adjusted...
Tue, 01/05/2021 - 10:03
ABSTRACT SARS-CoV-2 uses human angiotensin-converting enzyme 2 (ACE2) as the primary receptor to enter host cells and initiate the infection. The critical binding region of ACE2 is an ~30-amino-acid (aa)-long helix. Here, we report the design of four stapled peptides based on the ACE2 helix, which is expected to bind to SARS-CoV-2 and prevent the binding of the virus to the ACE2 receptor and...
Mon, 01/04/2021 - 02:02
Cadmium (Cd) threatens rice quality and human health, yet this risk remains uncertain in paddy fields with high geological background of transportation and deposition. In this study, we collected 31 pairs of soil and rice grain samples in Doumen and Xinhui Districts in Guangdong province, China and investigated which factors controlled Cd bioavailability in soil and accumulation in rice. Soil...
Sun, 01/03/2021 - 02:03
Abstract Main conclusion Cadmium-sensitive yeast screening resulted in the isolation of protein translation factor SaeIF1 from the hyperaccumulator Sedum alfredii which has both general and special regulatory roles in controlling cadmium accumulation. Abstract The hyperaccumulator of Sedum alfredii has the extraordinary ability to hyperaccumulate cadmium (Cd) in shoots. To investigate...
Sun, 01/03/2021 - 02:02
Alluvial soils are rich in mineral nutrients, and contain high heavy metals, especially Cd. The interactions of mineral nutrients with Cd in soil-rice grain systems on natural condition of alluvial plain are highlighted in this study. 110 pairs of rice grain and soil (0–20 cm) samples from the Pearl River Delta were investigated and measured. The results indicated that pH, organic matter, cation...
Sun, 01/03/2021 - 02:02
We utilized lead (Pb) stable isotopes to identify the source of acute Pb poisoning in a Tundra Swan (Cygnus columbianus) and evaluated overall Pb exposure. Upon necropsy, we obtained samples of blood, liver, kidney, heart, thigh, breast, femur, and metallic objects (i.e., fishing sinker, spring and swivels) from the gizzard for Pb isotopic analysis. Pb isotope ratios of blood and soft tissues...
Sat, 01/02/2021 - 22:10
Aims A Cadmium (Cd)‐tolerant Bacillus megaterium strain A14 was used to investigate the effects and mechanisms of bacterial inoculation on peanut growth, Cd accumulation in grains, and Cd fixation in Cd‐contaminated soil. Methods and Results Spectroscopic analysis showed that A14 has many functional groups (‐OH, ‐NH2 and ‐COO et al.) distributed on its surface. The pot experiment indicated that...
Sat, 01/02/2021 - 06:17
Author(s): Qingfeng He, Yunjing Luo, Ziqi Xie This study aimed to assess the ameliorative effect and mechanisms of sulforaphane (SFN) on cadmium (Cd)-induced hepatotoxicity. Four in vitro free radical scavenging tests, HepG2 cell viability analysis, and cadmium chloride (CdCl2) indeced liver injured mice mode were employed. SFN scavenged the free radicals in vitro, and mitigated the oxidative...
Sat, 01/02/2021 - 06:12
Author(s): Huiping Dai, Shuhe Wei, Marta Pogrzeba, Jacek Krzyżak, Szymon Rusinowski, Qing Zhang Bidens pilosa L. is a widely distributed Cd-hyperaccumulator species in the world with large biomass and fast growth rate. The Cd accumulating differences between different ecotypes of B. pilosa is not clear. This experiment firstly compared the Cd concentrations and relative physio-biochemical indices...
Fri, 01/01/2021 - 08:02
by Ji Yoon Choi, Da-An Huh, Kyong Whan Moon Imbalances in thyroid-stimulating hormone (TSH) levels are associated with metabolic syndrome (MetS), and the underlying mechanism is partly in alignment with that of lead exposure causing MetS. Many studies have reported the association between lead exposure and MetS, but no study has considered the possibility of TSH mediating lead's effect on MetS....
Fri, 01/01/2021 - 06:08
Author(s): Bo Song, Guiya Xiong, Huan Luo, Zhenzi Zuo, Zhijun Zhou, Xiuli Chang Cadmium (Cd) is a toxic heavy metal and widely exists in the environment. Extensive studies have revealed that Cd exposure can elicit neurotoxicity and potentially interfere with neurogenesis. However, underlying mechanisms by which Cd exposure affects neurogenesis remain unclear. In this study, we performed single-...
Fri, 01/01/2021 - 04:02
Fungal infections could cause tremendous decreases in crop yield and quality. Natural products, including flavonoids and (iso)quinolines, have always been an important source for lead discovery in medicinal and agricultural chemistry. To promote the discovery and development of new fungicides, a series of 3-(iso)quinolinyl-4-chromenone derivatives was designed and synthesized by the active...
Wed, 12/30/2020 - 08:02
by Paweł Staniszewski, Maciej Bilek, Wojciech Szwerc, Robert Tomusiak, Paweł Osiak, Ryszard Kocjan, Tadeusz Moskalik The aim of this study was to determine the effect of the age of trees, daily sap volume as well as the term of tapping birch sap collected in the forest environment on the content of selected minerals (zinc, copper and manganese) and heavy metals (lead, nickel, chromium and cadmium...
Wed, 12/30/2020 - 08:02
RNAs have important functions that are dictated by their structure. Indeed, small molecules that interact with RNA structures can perturb function, serving as chemical probes and lead medicines. Here we describe the development of a fragment-based approach to discover and optimize bioactive small molecules targeting RNA. We extended the target...
Wed, 12/30/2020 - 08:02
The Aster proteins (encoded by the Gramd1a-c genes) contain a ligand-binding fold structurally similar to a START domain and mediate nonvesicular plasma membrane (PM) to endoplasmic reticulum (ER) cholesterol transport. In an effort to develop small molecule modulators of Asters, we identified 20α-hydroxycholesterol (HC) and U18666A as lead compounds. Unfortunately,...
Wed, 12/30/2020 - 06:07
Author(s): Xusheng Li, Haiwei Li, Dongbao Cai, Ping Li, Jietian Jin, Xinwei Jiang, Zhenhua Li, Lingmin Tian, Guobing Chen, Jianxia Sun, Weibin Bai Cadmium (Cd) is a potentially toxic trace element frequently existed in foods, water, and air, threatening liver function from its continuous bioaccumulation and induction of oxidative stress and inflammation. However, the hepatotoxicity of Cd during...
Wed, 12/30/2020 - 06:07
Author(s): Manoswini Chakrabarti, Anita Mukherjee Plants as sessile organisms have developed some unique strategies to withstand environmental stress and adaptive response (AR) is one of them. In the present study Cadmium (Cd)-induced AR was evaluated to ameliorate the genotoxicity of a known chemical mutagen ethyl methanesulphonate (EMS) based on cytotoxicity, genotoxicity and oxidative stress...
Wed, 12/30/2020 - 06:06
Author(s): Lizhi He, Jun Meng, Yan Wang, Xianjin Tang, Xingmei Liu, Caixian Tang, Lena Q. Ma, Jianming Xu Heavy-metal contamination is widespread in agricultural soils worldwide, especially paddy soils contaminated by Cd. Amendment-induced immobilization of heavy metals is an attractive and effective technique, provided that cost-effective materials are used. This field experiment compared three...
Wed, 12/30/2020 - 06:06
Author(s): Temoor Ahmed, Muhammad Noman, Natasha Manzoor, Muhammad Shahid, Muhammad Abdullah, Liaqat Ali, Gang Wang, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Abdulaziz A. Alqarawi, Elsayed Fathi Abd_Allah, Bin Li Cadmium and drought are the most destructive of the abiotic stresses with negative consequences in terms of impaired metabolism, restricted nutrient use efficiency and disruptive...
Mon, 12/28/2020 - 22:13
Scheme summarizing the protective properties of Chrysin against testicular toxicity caused by lead acetate in rats. Abstract In the present study, the protective effects of chrysin (CHR) against testicular damage caused by lead acetate (PbAc) were examined. In this way, 30 min after rats were given 25 and 50 mg/kg/b.w CHR orally for seven consecutive days, 30 mg/kg/b.w PbAc was administered...
Sat, 12/26/2020 - 06:12
Author(s): Zhang Yiming, Yin Hang, Shao Bing, Xue Hua, Huang Bo, Liu Honggui, Li Shu Cadmium (Cd) is a toxic trace element that can enter the environment with industrial waste and accumulate in the body but the health effects of Cd on ternary pigs are still lacking in research. In order to explore the effect of Cd on the apoptosis of pig spleen and its mechanism, this study chose ternary pig as...
Fri, 12/25/2020 - 04:02
Latent Mycobacterium tuberculosis infection presents one of the largest challenges for tuberculosis control and novel antimycobacterial drug development. A series of pyrano[3,2-b]indolone-based compounds was designed and synthesized via an original eight-step scheme. The synthesized compounds were evaluated for their in vitro activity against M. tuberculosis strains H37Rv and streptomycin-starved...
Thu, 12/24/2020 - 14:05
Curcumin, used as a spice and traditional medicine in India, exerts beneficial effects against several diseases, owing to its antioxidant, analgesic, and anti-inflammatory properties. Evidence indicates that curcumin might protect against heavy metal-induced organ toxicity by targeting biological pathways involved in anti-oxidation, anti-inflammation, and anti-tumorigenesis. Curcumin has received...
Thu, 12/24/2020 - 08:04
Scientists used human white blood cell membranes to carry two drugs, an antibiotic and an anti-inflammatory, directly to infected lungs in mice. The nano-sized drug delivery method shows a potential new strategy for treating infectious diseases, including COVID-19. The researchers developed a method to essentially peel the membrane from neutrophils, the most common type of white blood cells that...
Thu, 12/24/2020 - 06:18
Author(s): Cristóbal Espinosa-Ruiz, Simona Manuguerra, Maria Morghese, José María García-Beltrán, María Ángeles Esteban, Marta Giuga, Concetta M. Messina, Andrea Santulli Chemical contaminants such as industrial and urban by-products, pharmaceuticals, drugs metabolites and, plastics, are continuously found in the oceans, affecting its quality and organism’s welfare. Although these compounds are...
Thu, 12/24/2020 - 06:18
Author(s): Hongbiao Cui, Detian Li, Xiaosheng Liu, Yuchao Fan, Xue Zhang, Shiwen Zhang, Jing Zhou, Guodong Fang, Jun Zhou While biochar is useful for environmental remediation, the effects of aging on the activation of endogenous trace metals in biochar remain unclear. In this study, three biochars with different concentrations of copper (Cu) and cadmium (Cd) were produced from the straws of...
Thu, 12/24/2020 - 06:13
Author(s): He Huang, Min Wang, Lulu Hou, Xu Lin, Shifeng Pan, Peng Zheng, Qian Zhao Lead (Pb) is a toxic heavy metal pollutants and can damage male reproductive function. Selenium (Se) possesses an ability of antagonizing Pb toxicity. However, biological events in the process of Pb toxicity and mitigative effect of Se are not well understood. The aim of present research was to investigate...
Wed, 12/23/2020 - 06:08
Author(s): Wei Fan, ChangYing Liu, Boning Cao, Shuyu Ma, Jie Hu, Zhonghuai Xiang, Aichun Zhao As a non-essential heavy metal, cadmium (Cd) is toxic to plants. In the last 15 years, over 70 transcriptome studies have been published to decipher the molecular response mechanism against Cd stress in different plants. To extract generalization results from transcriptomic data across different plants...
Tue, 12/22/2020 - 04:02
Weeds are notorious plant species exhibiting a harmful impact on crops. Biological weed control is an efficient and environmentally friendly technique, usually constitutes naturally derived compounds, including bioherbicidal metabolites produced by Streptomyces sp. The isolation and structural identification of phytotoxic compounds from Streptomyces have recently been proposed as an effective way...
Sat, 12/19/2020 - 22:12
The multi‐target activity of curcumin makes it a promising pharmacological lead for structural modifications focused on the preparation of new therapeutics with improved bioavailability. A possible modification is to “decompose” the parent curcumin structure into constituent units and to build up curcumin analogues with biphenyl structural moiety. Their antioxidant compositions with DL‐α‐...

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