Chemical contaminants

Thu, 07/30/2020 - 18:02
Bisphenol A (BPA) is an environmental endocrine disruptor and a risk factor for prostate cancer. The cystic fibrosis transmembrane conductance regulator (CFTR) is proposed to be a prostate cancer suppressor in some recent researches. However, the potential role and mechanism of CFTR in BPA-induced prostate cancer cells has not been well identified. In this study, BPA decreased the viability of...
Thu, 07/30/2020 - 16:00
Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae pose significant treatment and infection prevention challenges. Escherichia coli sequence type (ST) 131 associated with the blaCTX-M-15 gene has been the dominant lineage of ESBL-producing E. coli in the US and worldwide. In this study, our objective was to determine the β-lactamase profile, means of dissemination, prevalence, and...
Thu, 07/30/2020 - 02:04
Abstract Chickpea (Cicer arietinum) belonging to the Fabaceae family is a major legume crop and is a good source of protein and carbohydrates. Industrialization has resulted in soil contamination with heavy metals such as cadmium. Adsorption of cadmium by plants can lead to reduced yields and heavy metal toxicity. In the current study, changes in the anatomical, morphological features and...
Thu, 07/30/2020 - 02:02
The present study focuses on the simultaneous analysis of metallic species and radionuclide data from January 2009 to December 2011 in the dust deposited on filters in Málaga (Spain). Some metallic elements (Ca, Fe, K, Mg, Na, Zn, Pb, Cu, Ni) and radionuclides (7Be and 210Pb) have been determined by inductively coupled plasma-mass spectroscopy and gamma spectrometry, respectively. For this...
Wed, 07/29/2020 - 22:14
Peptide sequencing is critical to the quality control of peptide drugs and functional studies of active peptides. A combination of peptidase digestion and mass spectrometry technology is common for peptide sequencing. However, such methods often cannot obtain the complete sequence of a peptide due to insufficient amino acid sequence information. Here, we developed a method of generating full...
Wed, 07/29/2020 - 14:06
The purpose of this research was to determine the occurrence of 15 + 1 European priority polycyclic aromatic hydrocarbons (EUPAHs) in various types of tea purchased on Hangzhou city market in China in order to control their safety. The results indicated that the incidence rate of EUPAHs compounds was 97.4%. The total EUPAHs levels ranged from 1.2 μg/kg to 155.6 μg/kg, with a median of 27.1 μg/kg...
Wed, 07/29/2020 - 04:02
Cholesterol is a major carbon source for Mycobacterium tuberculosis (Mtb) during infection, and cholesterol utilization plays a significant role in persistence and virulence within host macrophages. Elucidating the mechanism by which cholesterol is degraded may permit the identification of new therapeutic targets. Here, we characterized EchA19 (Rv3516), an enoyl-CoA hydratase involved in...
Wed, 07/29/2020 - 02:03
Phytoremediation is an ecologically and economically feasible technique to remove heavy metal from soil. The aim of the study was to examine cadmium (Cd) toxicity and phytoremediation aptitude of Brassica juncea. In the present study, plants survived when exposed to different levels of Cd (0, 25, 50 and 100 mg/kg soil) and accumulated a large amount of Cd in its root and shoot. Translocation...
Tue, 07/28/2020 - 22:19
Babesia ovis is a tick‐transmitted protozoan haemoparasite causing ovine babesiosis in sheep and goats leading to considerable economic loss in Turkey and neighbouring countries. There are no vaccines available, therapeutic drugs leave toxic residues in meat and milk, and tick vector control entails environmental risks. A panel of eight mini‐ and micro‐satellite marker loci was developed and...
Tue, 07/28/2020 - 16:00
Previous studies proved that heavy metals could increase the risk of disease by acting on the gut microbiota. Meanwhile, gut microbiota played important roles in detoxifying heavy metals. However, the response of gut microbiota to heavy metals and which microbes dominated this detoxification processes are still unclear. This study investigated the difference of high-fat-diet (HFD) and normal-diet...
Tue, 07/28/2020 - 14:06
Agricultural commodities are generally consumed as processed food. Therefore, it is indispensable to assess pesticide residues in processed products rather than only in the raw agricultural commodity, in order to approach a more realistic scenario of dietary exposure. Processing factors are important tools for dietary exposure risk assessments. In this study, processing factors for the baking...
Tue, 07/28/2020 - 14:06
Herein, we have successfully established a novel, rapid, and simple lateral-flow immunoassay based on time-resolved fluorescence and biotin-streptavidin to detect the residues of various antibiotics in milk. The fluorescence signal and sensitivity of immunochromatography were enhanced through biotinylated antibody coupled with streptavidin europium microspheres. Moreover, due to the use of a QR...
Tue, 07/28/2020 - 06:16
Author(s): Sufang Fan, Junmei Ma, Meirong Cao, Juan Wang, Leilei Zhang, Yan Zhang, Qiang Li, Jia Chen In this experiment, a liquid chromatography tandem mass spectrometry method was built to determine 15 pesticide residues in Chinese cabbage and cucumber samples based on online turbulent flow chromatography purification. After modified quick, easy, cheap, effective, rugged, and safe (QuEChERS)...
Tue, 07/28/2020 - 06:15
Author(s): Pei Cao, Huai-ning Zhong, Kai Qiu, Dan Li, Gang Wu, Hai-xia Sui, Yan Song This study estimated the dietary exposures to BPA, BPF and BPS from canned foods and beverages in China. A total of 151 canned product samples were collected from the supermarkets in major Chinese cities, and the substances in the product were measured and analyzed. The detection rates of BPA, BPF and BPS in...
Tue, 07/28/2020 - 02:02
In this study, a magnetic montmorillonite composite (MMC) was prepared by a coprecipitation method, evaluated as sorbent for Cd(II) ions and characterized by IR spectroscopy, SEM, EDX, VSM, and zeta potential measurement. The adsorption potential of MMC was tested in both batch and continuous modes at different initial pH levels, sorbent dosages, contact times, ionic strengths, flow rates, and...
Mon, 07/27/2020 - 06:13
Author(s): Meng Xiu, Xianyu Wang, Lidia Morawska, David Pass, Andrew Beecroft, Jochen F. Mueller, Phong Thai Emissions of hazardous organic chemicals from crumb rubber modified (CRM) asphalt mixes have been longstanding environmental and occupational health concerns. This study aimed to quantify the emissions of volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs) and total...
Sun, 07/26/2020 - 06:10
Author(s): Jia Wang, Yi Yang, Ying Huang, Xiao Zhang, Yu Huang, Wei C. Qin, Yang Wen, Yuan H. Zhao Agricultural pesticides serve as effective controls of unwanted weeds and pests. However, these same chemicals can exert toxic effects in non-target organisms. To determine chemical modes of action, the toxicity ratio (TR) and critical body residues (CBRs) of 57 pesticides were calculated for...
Sun, 07/26/2020 - 02:02
Degradation-resistant chemical contaminants of health concern such as dichlorodiphenyltrichloroethane (DDT) pesticides and polychlorinated biphenyls (PCBs) in the environment are redistributed between different environmental compartments, where they partition between biotic heterotrophic routes and abiotic features (water and immobile soil components). Their fate and the potential risk they pose...
Sat, 07/25/2020 - 22:11
BACKGROUND Sulfamethazine (SMZ), a veterinary drug widely used in animal husbandry, is harmful to human health when excess residues are present in food. In this study, a fast, reliable, and sensitive immunochromatographic assay (ICA) was developed on the basis of the competitive format by using time‐resolved fluorescent nanobeads (TRFN) as label for the detection of SMZ in egg, honey, and pork...
Sat, 07/25/2020 - 18:02
This research deals with a highly efficient, selective, low-cost, and recyclable adsorbent for the fast removal of lead (Pb)(II) ions from aqueous solutions, and an investigation of the related adsorption mechanisms. Three types of materials were prepared from pea peels waste using simple, energy-efficient and environmentally friendly treatment. Obtained adsorbents were characterized by elemental...
Sat, 07/25/2020 - 04:02
Xanthomonas oryzae pv. oryzae (Xoo) is an offensive phytopathogen that can invade a wide range of plant hosts to develop bacterial diseases, including the well-known rice bacterial leaf blight. However, few agrochemicals have been identified to effectively prevent and eliminate Xoo-induced diseases. Thus, designing novel antibacterial compounds on the basis of the potential targets from Xoo may...
Sat, 07/25/2020 - 04:02
Amphotericin B (AmB, 1) is the drug of choice for treating the most serious systemic fungal or protozoan infections. Nevertheless, its application is limited by low solubility in aqueous media and serious side effects such as infusion-related reactions, hemolytic toxicity, and nephrotoxicity. Owing to these limitations, it is essential to search for the polyene derivatives with better...
Sat, 07/25/2020 - 02:02
Creosote is a multicomponent oil classified as a dense non-aqueous phase liquid (DNAPL) produced from coal tar distillation. The concept of phase distribution is critical in decision-making to remediate contaminated sites. The creosote mass transfer between sorbed, aqueous, vapor, and DNAPL phases is controlled by physicochemical characteristics, geology of the site, and environment conditions....
Fri, 07/24/2020 - 08:02
Antibiotic residues are major contaminants in milk because of their frequent use in agriculture and animal husbandry. In particular, streptomycin, an aminoglycoside antibiotic, is a potential risk to consumers because of its ototoxicity, anaphylaxis, and growth inhibition. Herein, monoclonal antibodies for streptomycin were conjugated with europium microspheres to serve as detection probes for...
Fri, 07/24/2020 - 02:02
Quantum dots (QDs), such as cadmium selenide (CdSe) and lead selenide (PbSe) exhibit excellent optical, magnetic and chemical properties due to their extremely size (ca. 1–10 nm) and are attractive semiconductor nanomaterials for optical studies and energy storage. In this study, aqueous synthesis of CdSe and PbSe QDs in a size range of 2–10 nm was described. Synthesized QDs were characterized...
Fri, 07/24/2020 - 02:02
Pentachlorophenol (PCP), commonly used as a wood preservative, pesticide, and fungicide, is the most toxic of all chlorophenols and can accumulate in living organisms. It is of great significance to construct a sensitive method for the detection of PCP in real samples. In this study, a simple, novel, and sensitive electrochemical sensor for pentachlorophenol (PCP) was constructed by modifying...
Fri, 07/24/2020 - 02:02
Phytoremediation is a cost-effective and relatively cleaner method for remediating contaminated areas using plants. Certain plants, including some sunflower species, have already been identified as potential phytoremediation candidates because of their ability to accumulate heavy metals. This study investigated the ability of Tithonia rotundifolia (red sunflower) to accumulate lead from lab-...
Thu, 07/23/2020 - 22:14
A sample pretreatment method based on the combination of a three‐phase solvent extraction system and deep eutectic solvent‐based dispersive liquid–liquid microextraction has been introduced for the extraction of four organochlorine pesticides in cocoa samples before their determination by gas chromatography–electron capture detection. A mixture of sodium chloride, acetonitrile, and potassium...
Thu, 07/23/2020 - 10:01
Alveolar echinococcosis (AE), caused by the larval stage of the cestode Echinococcus multilocularis, is a lethal disease in humans. Novel therapeutic options are urgently needed since the current chemotherapy displays limited efficiency in AE treatment. In this study, we assessed the in vitro and in vivo effects of the epidermal growth factor receptor (EGFR)/MEK/extracellular signal-regulated...
Thu, 07/23/2020 - 10:01
Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite Cryptosporidium parvum in vitro with limited cytotoxicity (50% effective concentration [EC50] = 120 nM versus 50% cytotoxic concentration [TC50] = 988 nM), and its application disrupted the parasite morphology. This study expands the spectrum of...
Thu, 07/23/2020 - 02:03
Abstract Bisphenol S (BPS) is a major alternative to Bisphenol A (BPA) newly applied in food packing material and disrupts reproductive and developmental endpoints through endocrine pathways. This study aimed to develop a rapid, sensitive, and accurate chemiluminescence immunoassay (CLIA) for the detection of BPS in canned beverage. Anti-BPS monoclonal antibody (mAb) was generated by immunizing...
Wed, 07/22/2020 - 16:00
Metallothioneins (MTs) are low molecular weight, Cys-rich proteins that sequester both essential and non-essential metal ions. Despite being highly conserved in the Pseudomonas genus of Gram-negative bacteria, knowledge of their physiological function in this species is scarce. Using the strain P. fluorescens Q2-87 as a model organism, we investigated the role of a conserved MT in zinc...
Wed, 07/22/2020 - 16:00
Antibiotic resistance is a public health problem of growing concern. Animal manure application to soil is considered to be a main cause of the propagation and dissemination of antibiotic residues, antibiotic-resistant bacteria (ARB), and antibiotic resistance genes (ARGs) in the soil-water system. In recent decades, studies on the impact of antibiotic-contaminated manure on soil microbiomes have...
Wed, 07/22/2020 - 14:05
Processing Factors (PFs) reflect the concentration or dilution of pesticide residues resulting from food processing. PFs are key elements to demonstrate the compliance of processed foods with Maximum residue levels (MRLs) as set by Regulation 396/2005. While efforts have been made by the European Food Safety Authority (EFSA) and by national authorities to compile PFs from processing studies, such...
Wed, 07/22/2020 - 08:02
Although the Flint, Michigan, water crisis renewed concerns about lead (Pb) in city drinking water, little attention has been paid to Pb in private wells, which provide drinking water for 13% of the US population. This study evaluates the risk of Pb exposure in children in households relying on private...
Wed, 07/22/2020 - 06:13
Author(s): Hamdy A. Abdel-Gawwad, Samah A. Sanad, Mona S. Mohammed Hazardous wastes produced from different industrial activities mainly contribute to serious environmental problems, notably their negative impact on the human health. Therefore, there is a great need to implement an innovative protocol for the safe disposal of these wastes in the production of widely-used materials. This study...
Wed, 07/22/2020 - 06:11
Author(s): Gengfu Wang, Yingpei Li, Yun Li, Jiaxiang Zhang, Chengfan Zhou, Changhao Wu, Qixing Zhu, Tong Shen Bisphenol A (BPA) exposure can increase the risk of immune-related diseases in later life. Vitamin D3 (Vit D3) has been shown to have multiple immunomodulatory actions and has been used to treat immune diseases. However, the potential beneficial effects of Vit D3 on BPA-induced adverse...
Wed, 07/22/2020 - 02:03
Mycoremediation holds great potential in remedying toxic environments contaminated with polyaromatic organic pollutants. To harness the natural process for practical applications, understanding the genetic and molecular basis of the remediation process is prerequisite. Compared to known bacterial degradation pathways of aromatic pollutants, however, the fungal degradation system is less studied...
Tue, 07/21/2020 - 22:15
Acrylamide is a known neurotoxin and probable carcinogen in humans. Researchers reported that foods rich in carbohydrates could generate high amounts of acrylamide at high temperatures. In recent years, hydrocolloids are applied to reduce acrylamide in thermally processed foods and the effect has been well proved. The present work was to investigate the effect of sodium alginate as the coating...
Tue, 07/21/2020 - 22:14
The objective of this study was to investigate the impact of Soxhlet extraction (SE) and ultrasound‐assisted extraction (UAE) on the yield and quality parameters of sunflower seeds oil.Ultrasound‐extraction sunflower oil(UESO) was further opted to frying behavior, which includedUESO which was heated without any product (blank sunflower oil, that is, BSO) and UESO, which was used to fry potato...
Tue, 07/21/2020 - 22:14
Although an efficient and stable fiber coating is essential for the development of solid‐phase microextraction technique, it remains a challenging prospect. Herein, an inorganic nanocomposite material Ag2S@ZnS was prepared and used as a coating for fibers to detect polycyclic aromatic hydrocarbons in water samples in combination with a GC with flame ionization detector. Compared with a single ZnS...
Tue, 07/21/2020 - 16:00
Selenium (Se) is an essential micronutrient for human health. Deficiency and suboptimality of Se in human populations are a potential health risk. The reduction of such health risk by biofortification of crops, particularly in wheat has drawn much attention, especially for color-grained wheat as it is rich in anthocyanins and can be used as a major source of antioxidants in diet. Herein, a two-...
Tue, 07/21/2020 - 16:00
Fusarium graminearum is a phytopathogenic fungus that causes Fusarium head blight in small-grain cereals, such as wheat, with significant yield reductions. Moreover, it contaminates the cereal grains with health-threatening mycotoxins, such as deoxynivalenol (DON), jeopardizing food and feed safety. Plant-based biopesticides, i.e. botanicals, have recently gained increased interest in crop...
Tue, 07/21/2020 - 10:02
Anaerobic degradation of polycyclic aromatic hydrocarbons has been investigated mostly with naphthalene as a model compound. Naphthalene degradation by sulfate-reducing bacteria proceeds via carboxylation to 2-naphthoic acid, formation of a coenzyme A thioester, and subsequent reduction to 5,6,7,8-tetrahydro-2-naphthoyl-coenzyme A (THNCoA), which is further reduced to hexahydro-2-naphthoyl-CoA (...
Mon, 07/20/2020 - 06:12
Author(s): Irfan Ullah Khan, Justice Kipkorir Rono, Xue Song Liu, Sheng Jun Feng, He Li, Xi Chen, Zhi Min Yang Plant metallochaperones are a class of specific metal-binding proteins that mediate metal distribution and homeostasis, but their biological functions and mechanisms underlying metal acquisition, translocation and detoxification are largely unknown. This study functionally characterized...
Mon, 07/20/2020 - 06:11
Author(s): Di Ran, Yonggang Ma, Wei Liu, Tongwang Luo, Jiaming Zheng, Dedong Wang, Ruilong Song, Hongyan Zhao, Hui Zou, Jianhong Gu, Yan Yuan, Jianchun Bian, Zongping Liu Cadmium (Cd) is one of worldwide environmental pollutants that causes bone homeostasis, which depends on the resorption of bones by osteoclasts and formation of bones by the osteoblasts (OB). However, the Cd toxicity on OB and...
Mon, 07/20/2020 - 06:10
Author(s): Jingang Wang, Junchao Zhao, Shuang Feng, Jinzhu Zhang, Shufang Gong, Kun Qiao, Aimin Zhou Cadmium (Cd), which seriously affects plant growth and crop production, is harmful to humans. Previous studies revealed ryegrass (Lolium multiflorum Lam.) exhibits Cd tolerance, and may be useful as a potential hyperaccumulator because of its wide distribution. In this study, the physiological and...
Mon, 07/20/2020 - 04:01
Previous efforts in our lab have led to the development of human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitor (NNRTI) thiophene[3,2-d]pyrimidine compound 1 (K-5a2) with promising activity against wild-type and mutant HIV-1 strains. In this work, a series of novel diarylpyrimidines derivatives carrying a structurally diverse motif at the right wing of the...
Mon, 07/20/2020 - 02:03
Furan, which has been identified as possibly carcinogenic for humans, can be induced to different food items by thermal treatment. In accordance with the previous studies and risks associated with prevalence of furan in food, it is necessary to be acknowledged of amounts of furan formed in different thermally processed foods for human awareness. In this study, Headspace Solid-Phase...

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