Research Publications (Food Safety)

Author(s): Jingwen Yang, Qing Xie, Yongmin Wang, Juan Wang, Yongjiang Zhang, Cheng Zhang, Dingyong Wang

Exposure to lead-based paints is a major threat to the health of painters. This study aimed to evaluate the blood concentration of lead (Pb) in painters of buildings and cars. The present study was a cross-sectional study in which a semi-structured questionnaire was used to collect the socio-demographic information. Lead concentration in blood samples was determined using the atomic absorption spectrometry method. A total of 32 male painters were selected based on inclusion criteria.

Due to the prevalence of hypertension (one of the major risk factors of CVD) in the population, it is necessary to explore the adverse effects of daily tolerable and “safe” dose of bisphenol A (BPA) under hypertensive conditions. The current study exposed the Nω-nitro-l-arginine methyl ester (L-NAME, 40 mg/kg b.w/day) induced hypertensive Wistar rats to BPA (50 μg/kg b.w/day) by oral administration along with appropriate controls for 30 days period.

In this study, the dihydropteroate synthase of Staphylococcus aureus was obtained, and its recognition mechanisms for 31 sulfonamide drugs were studied. Results showed that their core structure matched well with the binding pocket of para-aminobenzoic acid, and all the sulfonamide side chains were out of the binding pocket. Hydrogen bonds and hydrophobic interactions were the main intermolecular forces, and the key amino acids were Gly171 and Lys203.

Seventeen organochlorine pesticides (OCPs) and seven indicator polychlorinated biphenyls (PCBs) residues in 80 sediment samples from four cage aquaculture farms on the Volta Basin were determined to find out the extent of their contamination as well as their risk to biota in the aquatic ecosystem. The extracted residues of the OCPs and PCBs were analysed on a gas chromatograph equipped with an electron capture detector and mass spectrometer, respectively.

Although the prevalence of elevated childhood blood lead levels (BLLs) has been declining, there are still an estimated 500,000 children (1 to 5 years) with BLLs above the CDC’s reference value (≥ 5 μg/dL). The objective of this study was to evaluate the ecological association between soil lead (Pb) concentrations in greenspaces in Brooklyn, NY and elevated BLLs of children aged 1 to 5 years old.

This study aimed to investigate the testicular function of Mugil cephalus that inhabit Wadi El-Rayan lakes. Testes of fish inhabiting the upper lake (site 2) and the lower lake (site 3) of Wadi El-Rayan showed significant decreases in gonadosomatic index, high accumulation levels of six metals, and eight organochlorine pesticide residues.

Human exposure to cadmium (Cd) may induce severe effects in different organs. Recent studies suggest that long non-coding RNAs (lncRNAs) are closely involved in the pathophysiological mechanisms of Cd-related diseases.

Fungal fatty acid (FA) synthase and desaturase enzymes are essential for the growth and virulence of human fungal pathogens. These enzymes are structurally distinct from their mammalian counterparts, making them attractive targets for antifungal development. However, there has been little progress in identifying chemotypes that target fungal FA biosynthesis. To accomplish this, we applied a whole-cell-based method known as Target Abundance-based FItness Screening using Candida albicans.

Microfluidic chip analysis has great potential advantages such as high integration, fast speed analysis, and automatic operation and is widely used not only in biological fields but also in many other analytical areas such as agriculture and food safety. Herein, a fully automatic multi-class multi-residue analysis of veterinary drugs simultaneously in an integrated chip-mass spectrometry (chip-MS) platform was developed.

In all organisms, splicing occurs through the formation of spliceosome complexes, and splicing auxiliary factors are essential during splicing. U2AF65 is a crucial splicing cofactor, and the two typical RNA-recognition motifs at its center recognize and bind the polypyrimidine sequence located between the intron branch site and the 3′-splice site.

The existence of polycyclic aromatic hydrocarbons (PAHs) in contaminated environment is multifarious. At present, studies of metabolic regulation focus on the degradation process of single PAH. The global metabolic regulatory mechanisms of microorganisms facing coexisting PAHs are poorly understood, which is the major bottleneck for efficient bioremediation of PAHs pollution. Naphthalene (NAP) significantly enhanced the biodegradation of phenanthrene (PHE) by Pseudomonas sp. SL-6.

Due to the biomagnifying effect in the food chains, heavy metals will cause serious harm to the food produced in paddy soil, and then threaten human health. The remediation of soil heavy metals by the addition of amendments is a common method. However, the combination of the two amendments has been less studied and its effect is unknown.

by Ali Bahrami Rad, Conner Galloway, Daniel Treiman, Joel Xue, Qiao Li, Reza Sameni, Dave Albert, Gari D. Clifford

Background

Author(s): Hao Tang, Shu Zhang, Hongwei Pang, Jiaqi Wang, Xiangxue Wang, Gang Song, Shujun Yu

Mandipropamid (MDP) is a widely used chiral fungicide to control oomycete pathogens with two enantiomers. In this study, the enantioselective bioactivity, toxicity, and degradation of MDP were investigated for the first time. The bioactivity of S-MDP was 118–592 times higher than that of R-MDP and 1.14–1.67 times higher than that of Rac-MDP against six phytopathogens.

Endophytic bacteria play potentially important roles in the processes of plant adaptation to the environment. Understanding the composition and dynamics of endophytic bacterial communities under heavy metal (HM) stress can reveal their impacts on host development and stress tolerance. In this study, we investigated root endophytic bacterial communities of different rice cultivars grown in a cadmium (Cd)-contaminated paddy field.

Author(s): Katarina Baralić, Dragica Bozic, Katarina Živančević, Milan Milenković, Dragana Javorac, Đurđica Marić, Evica Antonijević Miljaković, Aleksandra Buha Djordjevic, Predrag Vukomanović, Marijana Ćurčić, Zorica Bulat, Biljana Antonijević, Danijela Đukić-Ćosić

Author(s): Xulu Chang, Meiru Kang, Yihao Shen, Lili Yun, Guokun Yang, Lei Zhu, Xiaolin Meng, Jianxin Zhang, Xi Su

Author(s): Yanling Li, Weiping Chen, Yang Yang, Tianqi Wang, Yating Dai

Succinate dehydrogenase (SDH) is known as an ideal target for the investigations of fungicides. To develop novel SDH inhibitors, 30 novel thiophene/furan-1,3,4-oxadiazole carboxamide derivatives were designed and synthesized. In the in vitro antifungal assay, a majority of the target compounds demonstrated fair to potent antifungal activity against seven tested phytopathogenic fungi.

Polycyclic aromatic hydrocarbons (PAHs), as indicators of anthropogenic activities, existed in sediments may pose potential risk to environment. In the present study, we assessed occurrence, composition, and risk assessment of PAHs in Wei River Basin. It was found that the total concentration (∑16PAHs) of selected PAHs in sediments for the main stream of Wei River and its tributaries ranged from n.d.

Author(s): Mohammad Al-Harahsheh, Sanad Altarawneh, Mohammad Al-Omari, Mohammednoor Altarawneh, Sam Kingman, Chris Dodds

Abstract