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International Journal of Antimicrobial Agents

Tue, 07/16/2019 - 01:05
Available online 7 June 2019 Author(s): Maya L. Nadimpalli, Agathe de Lauzanne, Thong Phe, Laurence Borand, Jan Jacobs, Laetitia Fabre, Thierry Naas, Simon Le Hello, Marc SteggerABSTRACTEscherichia coli ST410 (Ec-ST410) is an emerging, multidrug-resistant clone. Recent investigations of its global epidemiology and evolution have been based almost exclusively on isolates from Europe and North...
Tue, 07/16/2019 - 01:05
Available online 13 July 2019 Author(s): Yuan Lin, Hongjuan Zhang, Weibao Song, Shuyi Si, Yanxing Han, Jiandong JiangAbstractThe current outbreak of Zika virus (ZIKV) is the impetus for novel, safe and efficacious anti-ZIKV agents. ZIKV non-structural protein 5 (NS5) RNA-dependent RNA polymerase (RdRp) is essential for viral replication and is logically regarded as an attractive drug target. In...
Sun, 06/16/2019 - 01:12
Available online 14 June 2019 Author(s): Yu-Lin Lee, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Yen-Hsu Chen, Shu-Hsing Cheng, Wen-Chien Ko, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Chao-Nan Lin, Yu-Hui Chen, Wang-Huei ShengAbstractWe performed multicentre surveillance of the antimicrobial...
Thu, 06/13/2019 - 01:17
Available online 11 June 2019 Author(s): Qingqing Xu, Jianping Jiang, Zhenhan Zhu, Teng Xu, Zi-Ke Sheng, Meiping Ye, Xiaogang Xu, Minggui WangAbstractKlebsiella pneumoniae is one of the common pathogens causing urinary tract infections (UTIs). Nitrofurantoin (NIT), with high therapeutic concentrations in urine, is recommended as first-line drug for both empiric treatment and chemoprophylaxis of...
Sun, 04/28/2019 - 01:13
Available online 26 April 2019 Author(s): Bao-Tao Liu, Xuyong Li, Qidi Zhang, Hu Shan, Ming Zou, Feng-Jing SongAbstractThe presence of mobilized colistin resistance (mcr) genes is a global concern. However, data concerning mcr in fresh vegetables, a reservoir for antibiotic resistance genes, is still rare. In this study, mcr genes were analyzed among 528 vegetable samples from 53 supermarkets or...
Sun, 04/07/2019 - 01:13
Available online 6 April 2019 Author(s): Chengtao Sun, Baoli Chen, Anette Hulth, Stefan Schwarz, Xing Ji, Lennart E. Nilsson, Shizhen Ma, Qiang Sun, Zhenwang Bi, Yang Wang, Zhenqiang Bi, Congming Wu, Stefan BörjessonAbstractLivestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is an increasingly important public health concern worldwide; however, data on LA-MRSA from Asian...
Mon, 03/18/2019 - 01:12
Available online 16 March 2019 Author(s): Aimee K. Murray, Lihong Zhang, Jason Snape, William H. GazeAbstractBacterial communities are exposed to a cocktail of antimicrobial agents, including antibiotics, heavy metals and biocidal antimicrobials such as quaternary ammonium compounds (QACs). The extent to which these compounds may select or co-select for antimicrobial resistance (AMR) is not fully...
Sat, 03/16/2019 - 01:14
Available online 14 March 2019 Author(s): Gang Zhang, Kaiwen Sun, Guomin Ai, Jianjuan Li, Na Tang, Yuqin Song, Chao Wang, Jie FengAbstractIntrinsic resistance of bacteria to antibiotics plays an increasingly significant role in antibiotic resistance. However, the breadth of intrinsic resistance has not been fully elucidated. Here we identified a novel class of chloramphenicol acetyltransferase (...
Sun, 02/03/2019 - 01:12
Available online 1 February 2019 Author(s): Dee Shortridge, Leonard R. Duncan, Michael A. Pfaller, Robert K. FlammAbstractCeftolozane-tazobactam (C-T) is a combination of an antipseudomonal cephalosporin and a β-lactamase inhibitor. C-T was approved by the US Food and Drug Administration in 2014 and by the European Medicine Agency in 2015 for use in adults to treat complicated urinary tract...
Mon, 12/31/2018 - 01:11
Available online 29 December 2018 Author(s): Philip G. Drennan, Evan J. Begg, Sharon J. Gardiner, Carl M.J. Kirkpatrick, Steve T. ChambersAbstractWe have evaluated the literature to review optimal dosing and monitoring of intravenous vancomycin in adults, in response to evolving understanding of targets associated with efficacy and toxicity. The area under the total concentration-time curve (0 -...
Sun, 11/04/2018 - 01:10
Available online 3 November 2018 Author(s): Agnès B. Jousset, Sandrine Bernabeu, Remy A. Bonnin, Elodie Creton, Garance Cotellon, Aimie Sauvadet, Thierry Naas, Laurent DortetAbstractPlasmid-mediated colistin resistance is increasingly described worldwide in Enterobacteriaceae from animal and from human isolates. Diffusion of these resistance traits among carbapenem-resistant enterobacterial...
Fri, 10/12/2018 - 01:12
Available online 10 October 2018 Author(s): Bruce C. Koppen, Patrick P.G. Mulder, Leonie de Boer, Martijn Riool, Jan W. Drijfhout, Sebastian A.J. ZaatABSTRACTAntibiotic resistance and biofilm formation are the major reasons for failure in treatment of bacterial infections. We therefore aimed to identify synergistic combinations of conventional antibiotics and novel Synthetic Antimicrobial and...
Fri, 10/05/2018 - 01:12
Available online 2 October 2018 Author(s): Shuaiyin Chen, Huiying Liu, Wenjuan Liang, Lijuan Hong, Bing Zhang, Lu Huang, Xiangjiao Guo, Guangcai DuanAbstractMultidrug resistances Shigella is an enormous threat of public health. The resistance genes always located in plasmids, phages and integrons, which get into bacteria cells by horizontal gene transfer (HGT). CRISPR-Cas systems are adaptive...
Sun, 09/02/2018 - 01:11
Available online 31 August 2018 Author(s): Karolina A. Lis, Corinna Kehrenberg, Annika Boulaaba, Maren von Köckritz-Blickwede, Sylvia Binder, Yangfang Li, Julia L. Zimmermann, Yvonne Pfeifer, Birte AhlfeldAbstractObjectiveTo investigate the impact of cold atmospheric pressure plasma (CAP) produced by a Surface-Micro-Discharge (SMD) plasma source as a new strategy to combat the transmission of...
Sat, 08/25/2018 - 01:08
Available online 24 August 2018 Author(s): Chih-Cheng Lai, Yi-Tsung Lin, Yu-Tzu Lin, Min-Chi Lu, Zhi-Yuan Shi, Yao-Shen Chen, Lih-Shinn Wang, Shu-Hui Tseng, Chao-Nan Lin, Yen-Hsu Chen, Wen-Chien Ko, Fu-Der Wang, Po-Ren Hsueh, Infection Control Society of TaiwanABSTRACTIn 2017, this nationwide surveillance was conducted to investigate the prevalence and clinical characteristics of patients with...
Sat, 08/04/2018 - 01:13
Available online 3 August 2018 Author(s): Amira Klibi, Abderrazek Maaroufi, Carmen Torres, Ahlem JouiniAbstractThe prevalence of methicillin-resistant (MR) and methicillin-susceptible (MS) coagulase-negative staphylococci (CNS) and the implicated mechanisms of resistance and virulence were investigated in milk of mastitis cows. In addition the presence of SCCmec type is analyzed in MR...
Sat, 08/04/2018 - 01:13
Available online 3 August 2018 Author(s): Losasso Carmen, Di Cesare Andrea, Mastrorilli Eleonora, Patuzzi Ilaria, Cibin Veronica, Eckert Ester M, Fontaneto Diego, Vanzo Angiola, Ricci Antonia, Corno GianlucaAbstractThe massive use of antimicrobials in animal farming is considered as the greatest contributor to the phenomenon of antimicrobial resistant bacteria (ARB) presence in food of animal...
Mon, 07/30/2018 - 01:13
Available online 29 July 2018 Author(s): Bojana Beović, Céline Pulcini, Catherine Dumartin, Guillaume Béraud, Barbara Nerat, Cristina Maurel, May Doušak, Milan Čižman, the LEASH Study Group on behalf of ESCMID Study Group for Antimicrobial StewardshiP (ESGAP)AbstractAntimicrobial stewardship (AMS) is the cornerstone activity in the combat against antimicrobial resistance. In order to ensure...
Fri, 07/06/2018 - 01:14
Available online 16 May 2018 Author(s): Ignacio Gutiérrez-del-Río, Javier Fernández, Felipe LombóAbstractSynthetic food additives generate a negative perception in consumers. Therefore, food manufacturers search for safer natural alternatives as those involving phytochemicals and plant essential oils. These bioactives have antimicrobial activities widely proved in in vitro tests. Foodborne...
Fri, 07/06/2018 - 01:14
Available online 23 May 2018 Author(s): Su-Chen Lim, Grace O. Androga, Daniel R. Knight, Peter Moono, Niki F. Foster, Thomas V. RileyAbstractWe recently reported a high prevalence of Clostridium difficile in retail vegetables, compost and lawn in Western Australia (WA). The objective of this study was to investigate the antimicrobial susceptibility of previously isolated food and environmental C...
Fri, 07/06/2018 - 01:14
Available online 30 May 2018 Author(s): Abdullah Ibn Mafiz, Liyanage Nirasha Perera, Yingshu He, Wei Zhang, Shujie Xiao, Weilong Hao, Shi Sun, Kequan Zhou, Yifan ZhangABSTRACTUrban agricultural soils can be an important reservoir of antibiotic resistance, and have great food safety and public health indications. This study investigated antibiotic-resistant bacteria and antibiotic resistance genes...
Fri, 07/06/2018 - 01:14
Publication date: June 2018 , Volume 51, Issue 6Author(s): Carla Andrea Alonso, Gerardo Cortés-Cortés, Elaa Maamar, Mariana Massó, Rosa del Carmen Rocha-Gracia, Carmen Torres, Daniela Centrón, María Paula QuirogaAbstractIntegrons are genetic platforms able to excise, integrate and express antibiotic resistance gene cassettes (GCs). Here we investigated the complete genetic organisation, genetic...
Fri, 07/06/2018 - 01:14
Publication date: June 2018 , Volume 51, Issue 6Author(s): Delfino Vubil, Clara Balleste-Delpierre, Rita Mabunda, Sozinho Acácio, Marcelino Garrine, Tacilta Nhampossa, Pedro Alonso, Inacio Mandomando, Jordi VilaAbstractThe objective of this study was to assess antibiotic resistance and the molecular epidemiology of shigella isolates from a case–control study of diarrhoea, conducted from 2007 to...
Fri, 07/06/2018 - 01:14
Publication date: July 2018 , Volume 52, Issue 1Author(s): Qiuxia Ma, Yong Huang, Jian Wang, Xuebin Xu, Jane Hawkey, Chaojie Yang, Beibei Liang, Xiaofeng Hu, Fuli Wu, Xiaoxia Yang, Jinyan Wang, Rongrui Li, Peng Li, Jing Xie, Leili Jia, Ligui Wang, Rongzhang Hao, Yigang Tong, Kathryn E. Holt, Shaofu QiuAbstractSince the plasmid-mediated polymyxin resistance gene mcr-1 was first reported in...
Fri, 07/06/2018 - 01:14
Publication date: July 2018 , Volume 52, Issue 1Author(s): Manjulika Shukla, Isha Soni, Karen Matsuyama, Tran Tran, Mary Tanga, Leyi Gong, Sidharth ChopraAbstractMultidrug-resistant Acinetobacter baumannii (MDR-Ab) is one of the most significant nosocomial pathogens that is being increasingly isolated in healthcare settings worldwide. Owing to its inherent drug-resistant nature, coupled with its...
Sun, 04/15/2018 - 11:33
Publication date: Available online 13 April 2018 Author(s): Anna Mae Scott, Elaine Beller, Paul Glasziou, Justin Clark, Respati W. Ranakusuma, Oyungerel Byambasuren, Mina Bakhit, Stephen W. Page, Darren Trott, Chris Del Mar Background Large quantities of antimicrobials are given to food animals, especially in feed, potentially risking increased antimicrobial resistance in...
Sun, 04/15/2018 - 11:33
Publication date: Available online 14 April 2018 Author(s): Elaa Maamar, Carla Andrea Alonso, Sana Ferjani, Ali Jendoubi, Zaineb Hamzaoui, Alia Jebri, Mabrouka Saidani, Salma Ghedira, Carmen Torres, Ilhem Boutiba-Ben Boubaker Gastrointestinal colonization by carbapenem-resistant Acinetobacter baumannii (CRAB), is a critical step before nosocomial infection. Our objective...
Mon, 04/09/2018 - 11:54
Publication date: Available online 7 April 2018 Author(s): Vanesa García, Isidro García-Meniño, Azucena Mora, Saskia C. Flament-Simon, Dafne Díaz-Jiménez, Jesús E. Blanco, María Pilar Alonso, Jorge Blanco Colistin is an antimicrobial polypeptide commonly employed for controlling and treating neonatal and post-weaning diarrhoea (PWD) diseases caused by Enterotoxigenic and...
Wed, 03/21/2018 - 12:18
Publication date: April 2018 , Volume 51, Issue 4 Author(s): Michael A. Pfaller, Robert K. Flamm, Mariana Castanheira, Helio S. Sader, Rodrigo E. Mendes Background Osteomyelitis is a difficult-to-treat infection that regularly involves prolonged use of systemic antibiotics. Dalbavancin has demonstrated activity against Gram-positive isolates, and has been considered as a candidate...
Mon, 03/19/2018 - 12:13
Publication date: Available online 19 March 2018 Author(s): Euna Oh, Junghee Bae, Ankit Kumar, Hyo-Jick Choi, Byeonghwa Jeon Biofilms of methicillin-resistant Staphylococcus aureus (MRSA) have serious clinical implications. However, it is difficult to eradicate MRSA biofilms due to the increased tolerance to antimicrobials of biofilms. In this study, we investigated the synergistic...
Mon, 03/19/2018 - 12:13
Publication date: Available online 19 March 2018 Author(s): Lúcia Santos, Fernando Ramos Aquaculture is a rapidly growing industry that currently accounts for almost half of the fish used for human consumption worldwide. Intensive and semi-intensive practices are used to produce large stocks of fish, but frequent disease outbreaks occur, and the use of antimicrobials has become a...
Fri, 03/09/2018 - 10:54
Publication date: March 2018 , Volume 51, Issue 3 Author(s): Fernanda Teixeira Subtil, Anne Drumond Villela, Bruno Lopes Abbadi, Valnês S. Rodrigues-Junior, Cristiano Valim Bizarro, Luis Fernando Saraiva Macedo Timmers, Osmar Norberto de Souza, Kenia Pissinate, Pablo Machado, Alexandre López-Gavín, Griselda Tudó, Julian González-Martín, Luiz Augusto Basso, Diógenes...
Wed, 02/28/2018 - 10:39
Publication date: Available online 28 February 2018 Author(s): Manjulika Shukla, Isha Soni, Karen Matsuyama, Tran Tran, Mary Tanga, Leyi Gong, Sidharth Chopra Introduction Multidrug-resistant Acinetobacter baumannii (MDR-AB) is one of the most significant nosocomial pathogens, that is increasingly being isolated in healthcare settings worldwide. Owing to its inherent drug-...
Wed, 02/28/2018 - 10:39
Publication date: Available online 28 February 2018 Author(s): Qiuxia Ma, Yong Huang, Jian Wang, Xuebin Xu, Jane Hawkey, Chaojie Yang, Beibei Liang, Xiaofeng Hu, Fuli Wu, Xiaoxia Yang, Jinyan Wang, Rongrui Li, Peng Li, Jing Xie, Leili Jia, Ligui Wang, Rongzhang Hao, Yigang Tong, Kathryn E Holt, Shaofu Qiu, Yansong Sun, Hongbin Song Since the...
Tue, 02/13/2018 - 08:59
Publication date: Available online 12 February 2018 Author(s): Delfino Vubil, Clara Balleste-Delpierre, Rita Mabunda, Sozinho Acácio, Marcelino Garrine, Tacilta Nhampossa, Pedro Alonso, Inacio Mandomando, Jordi Vila The objective of the study was to assess antibiotic resistance and the molecular epidemiology of Shigella isolates from a case-control study of diarrhea,...
Thu, 02/08/2018 - 08:53
Publication date: February 2018 , Volume 51, Issue 2 Author(s): Fabrizio Agnoletti, Romina Brunetta, Luca Bano, Ilenia Drigo, Elena Mazzolini Reliable indicators of antimicrobial consumption (AMC) measured with harmonised data and supported by indicators for antimicrobial resistance (AMR) at herd level are necessary to target antimicrobial misuse in food-producing animals. AMC data...
Thu, 02/08/2018 - 08:53
Publication date: February 2018 , Volume 51, Issue 2 Author(s): Megha Kaushik, Sanjay Kumar, Rajeev Kumar Kapoor, Jugsharan Singh Virdi, Pooja Gulati Integrons are versatile gene acquisition systems that allow efficient capturing of exogenous genes and ensure their expression. Various classes of integrons possessing a wide variety of gene cassettes are ubiquitously distributed in...
Fri, 01/12/2018 - 07:22
Publication date: Available online 11 January 2018 Author(s): Monika Kumaraswamy, Carter Do, George Sakoulas, Poochit Nonejuie, Guan Woei Tseng, Helen King, Joshua Fierer, Joe Pogliano, Victor Nizet Endocarditis is a rare but serious manifestation of Listeria monocytogenes (LM). However, the optimal treatment strategy for LM endocarditis has yet to be established. Current...
Wed, 01/03/2018 - 09:27
Publication date: Available online 3 January 2018 Author(s): Geoffroy LIEGEON, Tristan DELORY, Mathieu PICARDEAU Leptospirosis is the most common zoonotic disease and is endemic worldwide. The antibiotic susceptibilities of Leptospira isolated from both humans and animals are poorly documented. This issue is particularly important for isolates from food-producing animals which are...
Wed, 10/11/2017 - 01:15
Publication date: Available online 10 October 2017 Author(s): Nicolas Cabanel, Christiane Bouchier, Minoarisoa Rajerison, Elisabeth Carniel Emergence of antibiotic-resistant Y. pestis strains represents a public health concern. Two antibiotic-resistant Y. pestis strains isolated from Madagascar were previously identified and characterized. Both strains carried conjugative plasmids...
Wed, 09/20/2017 - 10:30
Publication date: Available online 19 September 2017 Author(s): Stefanie Kadykalo, Tara Roberts, Michelle Thompson, Jeff Wilson, Marcelo Lang, Olivier Espeisse Coccidiosis is a self-limiting disease that is universally present in poultry operations, causing extensive damage to the intestinal lining of the bird. Global economic losses from coccidiosis are estimated to be $3...
Sat, 09/16/2017 - 10:21
Publication date: Available online 14 September 2017 Author(s): Ruibai Wang, Haican Liu, Xiuqin Zhao, Jie Li, Kanglin Wan Azithromycin (AZM) is a clinically important antibiotic to Vibrio cholerae especially for inhibiting colonization of V. cholerae in intestine and the treatment of severe cholera in children and pregnant women. One IncA/C plasmid was isolated from both of the...
Wed, 09/06/2017 - 04:59
Publication date: Available online 5 September 2017 Author(s): Shadab Parvez, Asad U. Khan New Delhi metallo-β-lactamase (NDM)-producing Enterobacteriaceae has become a threat to public health. Hospital sewage is generally unexplored, having a potential for harbouring bacteria causing healthcare-associated infections. Hence, we initiated this study to monitor NDM-producing...
Tue, 09/05/2017 - 04:58
Publication date: Available online 5 September 2017 Author(s): Ajay Ghosh Chalasani, Utpal Roy, Sushma Nema A strong anti-methicillin resistant Staphylococcus aureus (MRSA) peptide (ASP-1) from the Bacillus subtilis URID 12.1 strain that is active against cefoxitin- and methicillin-resistant clinical isolates was purified to homogeneity by solvent extraction, silica gel-based...
Fri, 08/25/2017 - 04:34
Publication date: Available online 9 August 2017 Author(s): K.A. Clay, M.G. Hartley, P. Russell, I.H. Norville The traditional methods of measuring minimum inhibitory concentration (MIC) of antibiotics against Coxiella burnetii are time consuming and technically difficult. The discovery of axenic media for C. burnetii culture provided an opportunity to determine the feasibility of...
Fri, 08/25/2017 - 04:34
Publication date: Available online 10 August 2017 Author(s): Gayathri Upeksha Gunathilaka, Varun Tahlan, Abdullah Ibn Mafiz, Manisha Polur, Yifan Zhang A total of 29 Escherichia coli phage were isolated from wastewater samples collected from an urban wastewater treatment plant (WWTP) and characterized by host range determination, Transmission Electron Microscopy (TEM), antibiotic...
Thu, 08/03/2017 - 13:00
Publication date: Available online 3 August 2017 Author(s): Patrick N.A. Harris, M. Diletta Pezzani, Belén Gutiérrez-Gutiérrez, Pierluigi Viale, Po-Ren Hsueh, Patricia Ruiz-Garbajosa, Mario Venditti, Mario Tumbarello, Carolina Navarro-Francisco, Esther Calbo, Murat Akova, Helen Giamarellou, Antonio Oliver, Benito Almirante, Oriol Gasch, Luis Martínez-Martínez...
Tue, 07/11/2017 - 12:06
Publication date: Available online 10 July 2017 Author(s): Huping Xue, Zhaowei Wu, Dandan Qiao, Chao Tong, Xin Zhao Staphylococcus epidermidis has been suggested as a main reservoir of methicillin-resistant and virulence genes to facilitate evolution of Staphylococcus aureus as a successful pathogen. However, it remains a mystery where and how S. epidermidis obtains numerous genes...
Wed, 07/05/2017 - 11:57
Publication date: Available online 4 July 2017 Author(s): Navin B. Patel, Jignesh N. Patel, Amit C. Purohit, Vatsal M. Patel, Dhanji P. Rajani, Rosa Moo-Puc, Julio Cesar Lopez-Cedillo, Benjamin Nogueda-Torres, Gildardo Rivera A new series of N-(substituted phenyl)-2-[5-(quinoxalin-2-yloxymethyl)-[1,3,4] oxadiazol-2-ylsulfanyl]-acetamides 5a-o was designed and synthesized...
Fri, 06/30/2017 - 15:16
Publication date: Available online 28 June 2017 Author(s): Meiping Ye, Baixing Ding, Hongliang Qian, Qingqing Xu, Jianping Jiang, Jinwei Huang, Hongyu Ou, Fupin Hu, Minggui Wang Tigecycline resistance is emerging among Klebsiella pneumoniae isolates, but knowledge on in vivo development of tigecycline resistance is limited. Here, we report a new mechanism of tigecycline...

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