You are here

PLoS One

Wed, 02/21/2018 - 17:00
Óscar Herrero, Mónica Aquilino, Paloma Sánchez-Argüello, Rosario Planelló Bisphenol S (BPS) is an industrial alternative to the endocrine disruptor bisphenol A (BPA), and can be found in many products labeled “BPA-free”. Its use has grown in recent years, and presently it is considered a ubiquitous emerging pollutant. To date there is a lack of information on the effects of BPS on invertebrates...
Fri, 02/09/2018 - 17:00
Wiebke Jansen, Svenja Woudstra, Anja Müller, Nils Grabowski, Gundela Schoo, Bettina Gerulat, Günter Klein, Corinna Kehrenberg Though imports of products of animal origin into the European Union (EU) have to comply with legal requirements and quality standards of the community, food consignment rejections at external EU borders have been increasing in recent years. This study explored...
Fri, 02/09/2018 - 17:00
Peninah Munyua, Clayton Onyango, Lydia Mwasi, Lilian W. Waiboci, Geoffrey Arunga, Barry Fields, Joshua A. Mott, Carol J. Cardona, Philip Kitala, Philip N. Nyaga, M. Kariuki Njenga Background Influenza A virus subtypes in non-human hosts have not been characterized in Kenya. We carried out influenza surveillance in selected domestic animals and compared the virus isolates with isolates obtained in...
Wed, 02/07/2018 - 17:00
Akua Obeng Forson, Isaac Arthur, Patrick F. Ayeh-Kumi Introduction Intestinal parasitic infections (IPIs) in school children are a public health problem in most developing countries. Methods and principal findings A cross sectional survey was conducted from May to July 2016 with school children living in overcrowded urban slums in Accra, Ghana. A simple random sample of 300 children aged 2–9...
Tue, 02/06/2018 - 17:00
Assia Saltykova, Véronique Wuyts, Wesley Mattheus, Sophie Bertrand, Nancy H. C. Roosens, Kathleen Marchal, Sigrid C. J. De Keersmaecker Whole genome sequencing represents a promising new technology for subtyping of bacterial pathogens. Besides the technological advances which have pushed the approach forward, the last years have been marked considerable evolution of the whole genome sequencing...
Thu, 02/01/2018 - 17:00
Minal Mulye, Brianne Zapata, Stacey D. Gilk Coxiella burnetii is an obligate intracellular bacterial pathogen and a causative agent of culture-negative endocarditis. While C. burnetii initially infects alveolar macrophages, it has also been found in lipid droplet (LD)-containing foamy macrophages in the cardiac valves of endocarditis patients. In addition, transcriptional studies of C. burnetii-...
Wed, 01/31/2018 - 17:00
Ibrahim Hamad, Rita Abou Abdallah, Isabelle Ravaux, Saadia Mokhtari, Hervé Tissot-Dupont, Caroline Michelle, Andreas Stein, Jean-Christophe Lagier, Didier Raoult, Fadi Bittar Research on the relationship between changes in the gut microbiota and human disease, including AIDS, is a growing field. However, studies on the eukaryotic component of the intestinal microbiota have just begun and have...
Wed, 01/31/2018 - 17:00
Ziyao Zhou, Furui Liu, Xinyue Zhang, Xiaoxiao Zhou, Zhijun Zhong, Huaiyi Su, Jin Li, Haozhou Li, Fan Feng, Jingchao Lan, Zhihe Zhang, Hualin Fu, Yanchun Hu, Suizhong Cao, Weigang Chen, Jiabo Deng, Jianqiu Yu, Wenping Zhang, Guangneng Peng Surfactin secreted Bacillus subtilis can confer strong, diverse antipathogenic effects, therebenefitting the host. Carbon source is an important factor for...
Mon, 01/29/2018 - 17:00
Hannah A. DeBerg, Mussaret B. Zaidi, Matthew C. Altman, Prasong Khaenam, Vivian H. Gersuk, Freddy D. Campos, Iza Perez-Martinez, Mario Meza-Segura, Damien Chaussabel, Jacques Banchereau, Teresa Estrada-Garcia, Peter S. Linsley Globally, diarrheal diseases are a leading cause of death in children under five and disproportionately affect children in developing countries. Children who contract...
Fri, 01/26/2018 - 17:00
Lisa Ciesinski, Sebastian Guenther, Robert Pieper, Martin Kalisch, Carmen Bednorz, Lothar H. Wieler High levels of zinc oxide are used frequently as feed additive in pigs to improve gut health and growth performance and are still suggested as an alternative to antimicrobial growth promoters. However, we have recently described an increase of multi-resistant E. coli in association to zinc feeding...
Tue, 01/23/2018 - 17:00
Natalie L. Adams, Tanith C. Rose, Jeremy Hawker, Mara Violato, Sarah J. O’Brien, Benjamin Barr, Victoria J. K. Howard, Margaret Whitehead, Ross Harris, David C. Taylor-Robinson Background The association between socioeconomic status (SES) and health is well-documented; however limited evidence on the relationship between SES and gastrointestinal (GI) infections exists, with published studies...
Tue, 01/23/2018 - 17:00
Bo Cui, Chunxin Wang, Xiang Zhao, Junwei Yao, Zhanghua Zeng, Yan Wang, Changjiao Sun, Guoqiang Liu, Haixin Cui Poorly water-soluble and photosensitive pesticide compounds are difficult to formulate as solvent-free nanoformulations with high efficacy. A avermectin solid nanodispersion with a mean particle size of 188 nm was developed microprecipitation and lyophilisation techniques. The...
Mon, 01/22/2018 - 17:00
Walaa Darwiche, Jérôme Gay-Quéheillard, Stéphane Delanaud, Hiba El Khayat El Sabbouri, Hassan Khachfe, Wissam Joumaa, Véronique Bach, Wiam Ramadan The widely used organophosphorus pesticide chlorpyrifos (CPF) is often detected in food. CPF inhibits acetylcholinesterase and can modify muscle contractility and respiratory patterns. We studied the effects of chronic exposure to CPF on respiratory...
Thu, 01/11/2018 - 17:00
Guixin Yan, Xin Xiao, Nian Wang, Fugui Zhang, Guizhen Gao, Kun Xu, Biyun Chen, Jiangwei Qiao, Xiaoming Wu The glyoxalase pathway is composed of glyoxalase I (GLYI) and glyoxalase II (GLYII) and is responsible for the detoxification of a cytotoxic metabolite methylglyoxal (MG) into the nontoxic S-D-lactoylglutathione. The two glyoxalase enzymes play a crucial role in stress tolerance in various...
Thu, 01/11/2018 - 17:00
Christopher J. Leary, Hannah F. Ralicki, David Laurencio, Sarah Crocker-Buta, John H. Malone Amphibians inhabiting montane riparian zones in the Neotropics are particularly vulnerable to decline, but the reasons are poorly understood. Because environmental contaminants, endocrine disruption, and pathogens often figure prominently in amphibian declines it is imperative that we understand how...
Wed, 01/10/2018 - 17:00
Sophie Vacher, Patrice Castagnet, Walid Chemlali, François Lallemand, Didier Meseure, Marc Pocard, Ivan Bieche, Martine Perrot-Applanat Increasing epidemiological and animal experimental data provide substantial support for the role of aryl hydrocarbon receptor (AhR) in mammary tumorigenesis. The effects of AhR have been clearly demonstrated in rodent models of breast carcinogenesis and in...
Wed, 01/10/2018 - 17:00
Thomas Brauge, Christine Faille, Irina Sadovskaya, Alain Charbit, Thierry Benezech, Yang Shen, Martin J. Loessner, Jean Romain Bautista, Graziella Midelet-Bourdin The wall teichoic acid (WTA) is the major carbohydrate found within the extracellular matrix of the Listeria monocytogenes biofilm. We first addressed the frequency of spontaneous mutations in two genes (lmo2549 and lmo2550)...
Wed, 01/10/2018 - 17:00
Simson Tarigan, Michael Haryadi Wibowo, Risa Indriani, Sumarningsih Sumarningsih, Sidna Artanto, Syafrison Idris, Peter A. Durr, Widya Asmara, Esmaeil Ebrahimie, Mark A. Stevenson, Jagoda Ignjatovic Although vaccination of poultry for control of highly pathogenic avian influenza virus (HPAIV) H5N1 has been practiced during the last decade in several countries, its effectiveness under field...
Wed, 01/10/2018 - 17:00
Helka M. Heikkilä, Tarja S. Jokinen, Pernilla Syrjä, Jouni Junnila, Anna Hielm-Björkman, Outi Laitinen-Vapaavuori Objective To investigate the clinical, cytological, and histopathological adverse effects of intra-articularly injected botulinum toxin A in dogs and to study whether the toxin spreads from the joint after the injection. Methods A longitudinal, placebo-controlled, randomized clinical...
Fri, 01/05/2018 - 17:00
Yumi Matsushita, Miki Manabe, Naoki Kitamura, Izumi Shibuya Transient receptor potential vanilloid type 1 (TRPV1) is a polymodal receptor channel that responds to multiple types of stimuli, such as heat, acid, mechanical pressure and some vanilloids. Capsaicin is the most commonly used vanilloid to stimulate TRPV1. TRPV1 channels are expressed in dorsal root ganglion neurons that extend to Aδ-...
Thu, 01/04/2018 - 17:00
Yen-Te Liao, Irwin A. Quintela, Kimberly Nguyen, Alexandra Salvador, Michael B. Cooley, Vivian C. H. Wu Shiga toxin-producing E. coli (STEC) causes approximately 265,000 illnesses and 3,600 hospitalizations annually and is highly associated with animal contamination due to the natural reservoir of ruminant gastrointestinal tracts. Free STEC-specific bacteriophages against STEC strains are also...
Fri, 12/22/2017 - 17:00
Claudia Jäckel, Jens A. Hammerl, Jörg Rau, Stefan Hertwig Campylobacter jejuni and C. coli are important food-borne pathogens that are widespread in animal husbandry. To combat Campylobacter along the food chain, the application of lytic phages has been shown to be a promising tool. Campylobacter phages are currently classified into three groups, of which group II and group III phages are the...
Thu, 12/21/2017 - 17:00
Ryosuke Goto, Tsuyoshi Miki, Nao Nakamura, Mayuka Fujimoto, Nobuhiko Okada Mucosal barrier formed cationic antimicrobial peptides (CAMPs) is believed to be crucial for host protection from pathogenic gut infection. However, some pathogens can develop resistance to the CAMPs to survive in hosts. Salmonella enterica is a common cause of acute diarrhea. During the course of this disease, the...
Wed, 12/20/2017 - 17:00
Saemee Song, Seokho Hong, Jinyang Jang, Ji-Hyun Yeom, Nohra Park, Jaejin Lee, Yeri Lim, Jun-Yeong Jeon, Hyung-Kyoon Choi, Minho Lee, Nam-Chul Ha, Kangseok Lee RNase E has a pivotal role in the degradation and processing of RNAs in Escherichia coli, and protein inhibitors RraA and RraB control its enzymatic activity. The halophilic pathogenic bacterium Vibrio vulnificus also expresses orthologs...
Wed, 12/20/2017 - 17:00
Kristina Attoff, Anda Gliga, Jessica Lundqvist, Ulf Norinder, Anna Forsby Despite its high relevance, developmental neurotoxicity (DNT) is one of the least studied forms of toxicity. Current guidelines for DNT testing are based on in vivo testing and they require extensive resources. Transcriptomic approaches using relevant in vitro models have been suggested as a useful tool for identifying...
Mon, 12/18/2017 - 17:00
Ali Akgul, Nawar Al-Janabi, Bhaskar Das, Mark Lawrence, Attila Karsi Listeria monocytogenes is a Gram-positive foodborne pathogen and the causative agent of listeriosis. L. monocytogenes lapB gene encodes a cell wall surface anchor protein, and mutation of this gene causes Listeria attenuation in mice. In this work, the potential role of Listeria LapB protein in catfish fillet attachment was...
Fri, 12/15/2017 - 17:00
Meena Shekhar, Nirupma Singh, Ram Dutta, Shrvan Kumar, Vinay Mahajan An attempt was made to compare between easy and inexpensive qualitative method (ammonia vapour test) and analytical methods (thin layer chromatography and enzyme-linked immunosorbent assay) for identification of aflatoxigenic isolates of Aspergillus flavus in maize. In this comparative study the toxicity level of A. flavus...
Wed, 12/13/2017 - 17:00
Débora Maria Pires Gonçalves Barreira, Túlio Machado Fumian, Marco André Loureiro Tonini, Lays Paula Bondi Volpini, Rodrigo Pratte Santos, Anézia Lima Chaves Ribeiro, José Paulo Gagliardi Leite, Márcia Terezinha Baroni de Moraes e Souza, Patrícia Brasil, Denise Cotrim da Cunha, Marize Pereira Miagostovich, Liliana Cruz Spano Noroviruses are the leading cause of acute gastroenteritis (AGE) in all...
Wed, 12/13/2017 - 17:00
Ethan C. Rath, Hunter Gill, Yongsheng Bai The shelf-life of fresh carcasses and produce depends on the chemical and physical properties of antimicrobials currently used for treatment. For many years the gold standard of these antimicrobials has been Cetylpyridinium Chloride (CPC) a quaternary ammonium compound (QAC). CPC is very effective at removing bacterial pathogens from the surface of...
Fri, 12/08/2017 - 17:00
Tiago Rusin, Wilma Maria Coelho Araújo, Cristiane Faiad, Helio de Carvalho Vital Although food irradiation has been used to ensure food safety, most consumers are unaware of the basic concepts of irradiation, misinterpreting information and demonstrating a negative attitude toward food items treated with ionizing radiation. This research is aimed at developing a tool to assess the awareness on...
Fri, 12/08/2017 - 17:00
Fouzia Nahid, Rabaab Zahra, Linus Sandegren Carbapenem resistant Klebsiella pneumoniae (CR-KP) infections are an ever-increasing global issue, especially in the Indian subcontinent. Here we report genetic insight into a blaOXA-181 harbouring Klebsiella pneumoniae, belonging to the pandemic lineage ST147, that represents an intermediate stage towards pan-drug resistance. The CR-KP isolate DA48896...
Tue, 12/05/2017 - 17:00
Christina Herland Fløtre, Kristin Varsi, Thea Helm, Bjørn Bolann, Anne-Lise Bjørke-Monsen Background The toxic trace elements mercury (Hg), lead (Pb), cadmium (Cd) and antimony (Sb) are transferred over the placenta to the fetus and secreted into the breastmilk. All four elements bioaccumulate in the body and as maternal age at delivery is increasing in industrialized countries, the burden of...
Thu, 11/30/2017 - 17:00
Paulina Cortes-Hernandez, Lenin Domínguez-Ramírez Periplasmic Binding Proteins (PBPs) trap nutrients for their internalization into bacteria ABC transporters. Ligand binding triggers PBP closure bringing its two domains together like a Venus flytrap. The atomic determinants that control PBP opening and closure for nutrient capture and release are not known, although it is proposed that opening...
Thu, 11/30/2017 - 17:00
Christina Bronowski, Kasem Mustafa, Ian Goodhead, Chloe E. James, Charlotte Nelson, Anita Lucaci, Paul Wigley, Tom J. Humphrey, Nicola J. Williams, Craig Winstanley, for the ENIGMA Consortium Background Water serves as a potential reservoir for Campylobacter, the leading cause of bacterial gastroenteritis in humans. However, little is understood about the mechanisms underlying variations in...
Tue, 11/28/2017 - 17:00
Masafumi Natsuike, Rui Saito, Amane Fujiwara, Kohei Matsuno, Atsushi Yamaguchi, Naonobu Shiga, Toru Hirawake, Takashi Kikuchi, Shigeto Nishino, Ichiro Imai The eastern Bering Sea has a vast continental shelf, which contains various endangered marine mammals and large fishery resources. Recently, high numbers of toxic A. tamarense resting cysts were found in the bottom sediment surface of the...
Tue, 11/21/2017 - 17:00
Victoria Martínez-Sernández, María J. Perteguer, Mercedes Mezo, Marta González-Warleta, Teresa Gárate, M. Adela Valero, Florencio M. Ubeira MF6p/FhHDM-1 is a small cationic heme-binding protein which is recognized the monoclonal antibody (mAb) MF6, and abundantly present in parenchymal cells and secreted antigens of Fasciola hepatica. Orthologs of this protein (MF6p/HDMs) also exist in other...
Wed, 11/15/2017 - 17:00
Ryan D. Oliveira, Michelle R. Mousel, Kristy L. Pabilonia, Margaret A. Highland, J. Bret Taylor, Donald P. Knowles, Stephen N. White Coxiella burnetii is a globally distributed zoonotic bacterial pathogen that causes abortions in ruminant livestock. In humans, an influenza-like illness results with the potential for hospitalization, chronic infection, abortion, and fatal endocarditis. Ruminant...
Tue, 11/14/2017 - 17:00
Aristos Ioannou, Constantinos Varotsis High performance liquid chromatography (HPLC) coupled with a Fraction Collector was employed to isolate Maillard reaction products (MRPs) formed in model systems comprising of asparagine and monosaccharides in the 60–180°C range. The primary MRP which is detected at 60°C is important for Acrylamide content and color/aroma development in foods and also in...
Fri, 11/10/2017 - 17:00
Lukas Schimunek, Rafael Serve, Michel P. J. Teuben, Philipp Störmann, Birgit Auner, Mathias Woschek, Roman Pfeifer, Klemens Horst, Tim-P. Simon, Miriam Kalbitz, Ramona Sturm, Hans-C. Pape, Frank Hildebrand, Ingo Marzi, Borna Relja In their post-traumatic course, trauma patients suffering from multiple injuries have a high risk for immune dysregulation, which may contribute to post-injury...
Wed, 11/08/2017 - 17:00
Julia Straub, Helga Paula, Michaela Mayr, David Kasper, Ojan Assadian, Angelika Berger, Judith Rittenschober-Böhm Introduction Diagnosis of neonatal sepsis remains a major challenge in neonatology. Most molecular-based methods are not customized for neonatal requirements. The aim of the present study was to assess the diagnostic accuracy of a modified multiplex PCR protocol for the detection of...
Wed, 11/08/2017 - 17:00
Alice Maserati, Ryan C. Fink, Antonio Lourenco, Matthew L. Julius, Francisco Diez-Gonzalez Salmonella can survive for long periods under extreme desiccation conditions. This stress tolerance poses a risk for food safety, but relatively little is known about the molecular and cellular regulation of this adaptation mechanism. To determine the genetic components involved in Salmonella’s cellular...
Wed, 11/08/2017 - 17:00
Daniela Mavrici, Jaszemyn C. Yambao, Bertram G. Lee, Beatriz Quiñones, Xiaohua He The rapid spreading of polymyxin E (colistin) resistance among bacterial strains through the horizontally transmissible mcr-1 and mcr-2 plasmids has become a serious concern. The emergence of these genes in Shiga toxin-producing Escherichia coli (STEC), a group of human pathogenic bacteria was even more worrisome,...
Tue, 11/07/2017 - 17:00
R. Boonyarittichaikij, E. Verbrugghe, D. Dekeukeleire, R. De Beelde, L. O. Rouffaer, R. Haesendonck, D. Strubbe, W. Mattheus, S. Bertrand, F. Pasmans, D. Bonte, K. Verheyen, L. Lens, A. Martel Endemic infections with the common avian pathogen Salmonella enterica subspecies enterica serovar Typhimurium (Salmonella Typhimurium) may incur a significant cost on the host population. In this study, we...
Mon, 11/06/2017 - 17:00
Chelsea M. Rochman, J. Mark Parnis, Mark A. Browne, Sebastian Serrato, Eric J. Reiner, Matthew Robson, Thomas Young, Miriam L. Diamond, Swee J. Teh We examined whether environmentally relevant concentrations of different types of microplastics, with or without PCBs, directly affect freshwater prey and indirectly affect their predators. Asian clams (Corbicula fluminea) were exposed to...
Fri, 11/03/2017 - 17:00
Izaskun Alejo-Cancho, Francesc Fernández Avilés, Alicia Capón, Cristina Rodríguez, Josep Barrachina, Pilar Salvador, Mª Eugenia Valls, Miriam J. Álvarez-Martínez, Yuliya Zboromyrska, Jordi Vila, Mª Ángeles Marcos Introduction Diarrhea is a frequent complication in hematologic patients, being an infectious cause frequently suspected. Rapid and accurate detection of gastrointestinal pathogens is...
Fri, 11/03/2017 - 17:00
Craig J. Bierle, Claudia Fernández-Alarcón, Nelmary Hernandez-Alvarado, Jason C. Zabeli, Bradley C. Janus, Dira S. Putri, Mark R. Schleiss Primary Zika virus (ZIKV) infections that occur during pregnancy can cause spontaneous abortion and profoundly disrupt fetal development. While the full range of developmental abnormalities associated with congenital Zika syndrome is not yet known, severe...
Wed, 11/01/2017 - 17:00
Yolande Bertin, Chloé Habouzit, Lysiane Dunière, Marie Laurier, Alexandra Durand, David Duchez, Audrey Segura, Delphine Thévenot-Sergentet, Federico Baruzzi, Frédérique Chaucheyras-Durand, Evelyne Forano The bovine gastrointestinal tract (GIT) is the main reservoir for enterohaemorrhagic Escherichia coli (EHEC) responsible for food-borne infections. Therefore, it is crucial to develop strategies...
Wed, 11/01/2017 - 17:00
Vinodkumar Kulangara, Neetha Nair, Asok Sivasailam, Suchithra Sasidharan, Justin Davis Kollannur, Radhika Syam Dairy cows affected with subclinical mastitis can be sources of virulent, antimicrobial-resistant Staphylococci to humans because of the excretion of the bacteria through their milk. This study focussed on the phenotypic and genotypic antibiotic resistance patterns of Staphylococci...
Mon, 10/30/2017 - 17:00
Timothy J. Sullivan, Joseph E. Neigel Infectious diseases threaten marine populations, and the extent of their impacts is often assessed prevalence of infection (the proportion of infected individuals). Changes in prevalence are often attributed to altered rates of transmission, although the rates of birth, recovery, and mortality also determine prevalence. The parasitic dinoflagellate...
Mon, 10/30/2017 - 17:00
Tomomi Sato, Masaru Usui, Noriko Konishi, Akemi Kai, Hidehito Matsui, Hideaki Hanaki, Yutaka Tamura Methicillin-resistant Staphylococcus aureus (MRSA) is a pervasive healthcare-acquired (HA) pathogen with recent emergence as a community-acquired (CA) pathogen. To elucidate whether meat mediates MRSA transmission between animals and humans in Japan, this study examined MRSA isolates from retail...

Pages