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PLoS Pathogens

Sat, 05/23/2015 - 01:21
Filipe Carvalho, Magda L. Atilano, Rita Pombinho, Gonçalo Covas, Richard L. Gallo, Sérgio R. Filipe, Sandra Sousa, Didier Cabanes Listeria monocytogenes is an opportunistic Gram-positive bacterial pathogen responsible for listeriosis, a human foodborne disease. Its cell wall is densely decorated with wall teichoic acids (WTAs), a class of anionic glycopolymers that play key roles in bacterial...
Fri, 05/22/2015 - 01:19
Salvador Almagro-Moreno, Kali Pruss, Ronald K. Taylor To cause the diarrheal disease cholera, Vibrio cholerae must effectively colonize the small intestine. In order to do so, the bacterium needs to successfully travel through the stomach and withstand the presence of agents such as bile and antimicrobial peptides in the intestinal lumen and mucus. The bacterial cells penetrate the viscous mucus...
Thu, 05/21/2015 - 01:21
Kareem Rashid Rumah, Yinghua Ma, Jennifer R. Linden, Myat Lin Oo, Josef Anrather, Nicole Schaeren-Wiemers, Miguel A. Alonso, Vincent A. Fischetti, Mark S. McClain, Timothy Vartanian Clostridium perfringens ε-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with characteristics of blood-brain barrier (BBB) dysfunction and white...
Sat, 05/16/2015 - 01:26
Olivier Duron, Valérie Noël, Karen D. McCoy, Matteo Bonazzi, Karim Sidi-Boumedine, Olivier Morel, Fabrice Vavre, Lionel Zenner, Elsa Jourdain, Patrick Durand, Céline Arnathau, François Renaud, Jean-François Trape, Abel S. Biguezoton, Julie Cremaschi, Muriel Dietrich, Elsa Léger, Anaïs Appelgren, Marlène Dupraz, Elena Gómez-Díaz, Georges Diatta, Guiguigbaza-Kossigan Dayo, Hassane Adakal, Sébastien...
Thu, 05/07/2015 - 01:26
Elías Barquero-Calvo, Ricardo Mora-Cartín, Vilma Arce-Gorvel, Juana L. de Diego, Carlos Chacón-Díaz, Esteban Chaves-Olarte, Caterina Guzmán-Verri, Andre G. Buret, Jean-Pierre Gorvel, Edgardo Moreno Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs), enhance their microbicidal function, and promote the survival of these leukocytes for protracted periods of...
Sat, 04/18/2015 - 01:21
Tobias Dörr, Brigid M. Davis, Matthew K. Waldor In many bacteria, inhibition of cell wall synthesis leads to cell death and lysis. The pathways and enzymes that mediate cell lysis after exposure to cell wall-acting antibiotics (e.g. beta lactams) are incompletely understood, but the activities of enzymes that degrade the cell wall (‘autolysins’) are thought to be critical. Here, we report that...
Thu, 04/16/2015 - 01:19
Sarah A. Jung, Christine A. Chapman, Wai-Leung Ng Bacteria use quorum sensing (QS) for cell-cell communication to carry out group behaviors. This intercellular signaling process relies on cell density-dependent production and detection of chemical signals called autoinducers (AIs). Vibrio cholerae, the causative agent of cholera, detects two AIs, CAI-1 and AI-2, with two histidine kinases, CqsS...
Tue, 03/31/2015 - 01:21
Bobbi Xayarath, Francis Alonzo, Nancy E. Freitag Listeria monocytogenes is a Gram-positive facultative intracellular bacterial pathogen that invades mammalian cells and escapes from membrane-bound vacuoles to replicate within the host cell cytosol. Gene products required for intracellular bacterial growth and bacterial spread to adjacent cells are regulated by a transcriptional activator known...
Sat, 03/21/2015 - 01:22
Mariaelena Caboni, Thierry Pédron, Omar Rossi, David Goulding, Derek Pickard, Francesco Citiulo, Calman A. MacLennan, Gordon Dougan, Nicholas R. Thomson, Allan Saul, Philippe J. Sansonetti, Christiane Gerke Shigella is the leading cause for dysentery worldwide. Together with several virulence factors employed for invasion, the presence and length of the O antigen (OAg) of the lipopolysaccharide...
Wed, 03/11/2015 - 01:22
Andrea Hodgson, Eric M. Wier, Kai Fu, Xin Sun, Hongbing Yu, Wenxin Zheng, Ho Pan Sham, Kaitlin Johnson, Scott Bailey, Bruce A. Vallance, Fengyi Wan Attaching/Effacing (A/E) pathogens including enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC) and the rodent equivalent Citrobacter rodentium are important causative agents of foodborne diseases. Upon infection, a myriad of...
Fri, 03/06/2015 - 01:22
Yuki Taguchi, Koichi Imaoka, Michiyo Kataoka, Akihiko Uda, Daiki Nakatsu, Sakuya Horii-Okazaki, Rina Kunishige, Fumi Kano, Masayuki Murata Brucella species replicate within host cells in the form of endoplasmic reticulum (ER)-derived vacuoles. The mechanisms by which the bacteria are sequestered into such vacuoles and obtain a continuous membrane supply for their replication remain to be...
Thu, 03/05/2015 - 01:25
Hirotaka Hiyoshi, Ryu Okada, Shigeaki Matsuda, Kazuyoshi Gotoh, Yukihiro Akeda, Tetsuya Iida, Toshio Kodama Vibrio parahaemolyticus is an important pathogen that causes food-borne gastroenteritis in humans. The type III secretion system encoded on chromosome 2 (T3SS2) plays a critical role in the enterotoxic activity of V. parahaemolyticus. Previous studies have demonstrated that T3SS2 induces...
Fri, 02/27/2015 - 01:26
Anne-lie Ståhl, Ida Arvidsson, Karl E. Johansson, Milan Chromek, Johan Rebetz, Sebastian Loos, Ann-Charlotte Kristoffersson, Zivile D. Békássy, Matthias Mörgelin, Diana Karpman Shiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli, which are non-invasive strains that can lead to hemolytic uremic syndrome (HUS), associated with renal failure and death. Although...
Thu, 01/29/2015 - 01:18
Matthew Darby, Corinna Schnoeller, Alykhan Vira, Fiona Culley, Saeeda Bobat, Erin Logan, Frank Kirstein, Jürgen Wess, Adam F. Cunningham, Frank Brombacher, Murray E. Selkirk, William G. C. Horsnell Innate immunity is regulated by cholinergic signalling through nicotinic acetylcholine receptors. We show here that signalling through the M3 muscarinic acetylcholine receptor (M3R) plays an important...
Fri, 01/16/2015 - 01:17
Yannick Rossez, Eliza B. Wolfson, Ashleigh Holmes, David L. Gally, Nicola J. Holden The flagellum organelle is an intricate multiprotein assembly best known for its rotational propulsion of bacteria. However, recent studies have expanded our knowledge of other functions in pathogenic contexts, particularly adherence and immune modulation, e.g., for Salmonella enterica, Campylobacter jejuni,...
Fri, 01/16/2015 - 01:17
Kemal Avican, Anna Fahlgren, Mikael Huss, Ann Kathrin Heroven, Michael Beckstette, Petra Dersch, Maria Fällman We recently found that Yersinia pseudotuberculosis can be used as a model of persistent bacterial infections. We performed in vivo RNA-seq of bacteria in small cecal tissue biopsies at early and persistent stages of infection to determine strategies associated with persistence....
Fri, 01/09/2015 - 01:18
James R. J. Haycocks, Prateek Sharma, Anne M. Stringer, Joseph T. Wade, David C. Grainger Enterotoxigenic Escherichia coli (ETEC) cause severe diarrhoea in humans and neonatal farm animals. Annually, 380,000 human deaths, and multi-million dollar losses in the farming industry, can be attributed to ETEC infections. Illness results from the action of enterotoxins, which disrupt signalling...

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