Research Publications (Food Safety)

Amanitin poisoning still has no particular, effective antidote. Erdosteine has been shown to protect numerous tissues, particularly those in the liver. This study investigates the potential therapeutic effects of erdosteine on alpha-, beta- and gamma-amanitin-induced hepatotoxicity in in vitro models.

Background Botulinum neurotoxins (BoNTs) are used to treat spastic disorders. Depending on muscle size, one or multiple injections are recommended according to labels to target neuromuscular junctions (NMJ).

Osteoarthritis (OA) is the most common cause to lead to chronic pain. Sensitization of pain pathways including central sensitization and peripheral sensitization has been regarded as a major cause of OA pain refractory to treatment. Addressing peripheral sensitization or central sensitization alone may not adequately treat OA pain.

Zingerone1 (Zing) is one of the bioactive compounds of ginger rhizome (Zingiber officinale), whose beneficial effects have been reported previously on reproductive organ complications.

A paralytic shellfish toxin binding protein (PST-BP) was extracted and purified from the viscera of oyster (Crassostrea hongkongensis) that accumulates paralytic shellfish toxin (PST), and the amino acid sequence of the protein was detected via HPLC-MS-MS. The structure of the PST-BP was built by homology modeling, and the interaction between PST and PST-BP was studied using molecular docking. The results showed that the purity of PST-BP was more than 99.8% after the purification.

Chili (Capsicum annum) and chili powder are widely consumed in south India. The inherent and eco physiological factors with unusual nutritional characteristics of chili favors the growth of molds, during harvest and post-harvest processing.

Mycotoxins are toxic metabolites produced by mold fungi, which commonly contaminate cereal crops. These compounds include zearalenone (ZEA), which may disturb the proper functioning of the endocrine system in mammals. The metabolism of ZEA plays a key role in its toxic properties. The type and amount of produced metabolites may contribute to both the reduction and increase in its pathogenic effect.

Zearalenone (ZEN) is a worldwide fusarotoxin that poses a threat to the consumer due to its chronic toxicity.

Ochratoxin A (OTA), one of the most important mycotoxins, is mainly produced by fungi in the genera Aspergillus and Penicillium, and commonly found in food and agricultural products. In addition to causing significant economic loss, the occurrence of OTA in foods poses a serious threat to human health. Therefore, it is very important to develop approaches to control or detoxify OTA contamination and thus ensure food safety.

The aim of the study was to evaluate the possible involvement of transient receptor potential (TRP) channels, Acid-sensing ion channels (ASIC) and N-Methyl-D-aspartate receptor (NMDAR) in the orofacial antinociceptive behaviour effect of botulinum toxin type A (BoNT/A) in adult zebrafish. Initially, the open field test was performed to evaluate the effect of BoNT/A on the locomotor activity of zebrafish.

Aspergillus nomiae is the most important contaminant in Brazil nut due to its high incidence in these nuts and its strong production of carcinogenic metabolites: aflatoxins (AF). Aflatoxin biosynthesis pathway in A. nomiae is poorly studied. Thus, in present investigation, aflatoxin production and gene cluster (aflC, aflQ, aflU, and aflX) expression profile were evaluated on two strains of A.

Trichothecenes (TCNs) are the mycotoxins produced by many fungal species such as Fusarium, 

Aflatoxicosis can induce largescale toxicities in predisposed populations. Food fortification with adequate antioxidant sources may reduce the toxic burden from aflatoxicosis. We examined the individual and combined effect of Caffeic acid (CA) on the aflatoxin B1 (AFB1)-induced hepatic and renal injury in male rats.

Patulin (PAT) is a kind of mycotoxins that is universally found at rotten fruits, especially apples and apple products. Previous studies have shown that PAT has hepatotoxicity and nephrotoxicity. However, cardiotoxicity of PAT is rarely reported. Present study aimed at investigate the cardiotoxicity and relevant mechanisms of PAT on H9c2 cells. Cytotoxicity of PAT were evaluated by MTT assay and LDH.

Author(s): Solomon E. Owumi, Chioma E. Irozuru, Uche O. Arunsi, Adegboyega K. Oyelere

Author(s): Baigang Zhang, Chenghui Huang, Qikun Lu, Dongmei Xu, Hairong Liang, Jinliang Li

Author(s): Baigang Zhang, Hairong Liang, Ke Huang, Jinliang Li, Dongmei Xu, Chenghui Huang, Yi Li

Author(s): Dietrich Mebs, Julio V. Schneider, Oskar Schröder, Mari Yotsu-Yamashita, John R. Harley, Linda Mogk, Gunther Köhler

Author(s): Enjie Diao, Kun Ma, Shiquan Qian, Hui Zhang, Peng Xie, Ruifeng Mao, Huwei Song

Author(s): Tomohisa Kodama, Koichi Ikeda, Osamu Arakawa, Yusuke Kondo, Manabu Asakawa, Kentaro Kawatsu, Susumu Ohtsuka

Author(s): Cecilia Montero, Gricel Riquelme, Miguel del Campo, Néstor Lagos

Author(s): Luciane A. Chimetto Tonon, Cintia Rua, Camila M. Crnkovic, Darlon I. Bernardi, Osmindo R. Pires Junior, Célio F.B. Haddad, Carolina da S. G. Pedrosa, Leticia R.Q. Souza, Stevens K. Rehen, Gustavo P.R. de Azevedo, Cristiane C. Thompson, Fabiano L. Thompson, Roberto G.S. Berlinck

Author(s): Dimitrios Varvarousis, Christina Martzivanou, Dimitris Dimopoulos, Georgios Dimakopoulos, George I. Vasileiadis, Avraam Ploumis

Author(s): Kun Ma, Enjie Diao, Hui Zhang, Shiquan Qian, Peng Xie, Ruifeng Mao, Huwei Song, Liming Zhang

Author(s): Carolina de Miguel, Alejandra Cirera