Research Publications from Peer-Reviewed Journals

The Research Publications track research that is published across national and international peer-reviewed journals. The most recent articles are available ahead of print and searchable by Journal Title, Subject, USDA Grant Funding Agencies or FDA Grant Funding Agencies. The research publications are tracked across five subject areas: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, and Viruses.

Thu, 12/17/2020 - 12:00
Background Despite national immunization efforts, including universal childhood hepatitis A (HepA) vaccination recommendations in 2006, hepatitis A virus (HAV)–associated outbreaks have increased in the United States. Unvaccinated or previously uninfected persons are susceptible to HAV infection, yet the susceptibility in the US population is not well known. Methods Using National Health and...
Thu, 12/17/2020 - 12:00
Background Horizontal transmission of Toxoplasma gondii occurs primarily via ingestion of environmental oocysts or consumption of undercooked/raw meat containing cyst-stage bradyzoites. The relative importance of these 2 transmission routes remains unclear. Oocyst infection can be distinguished from bradyzoite infection by identification of immunoglobulin G (IgG) antibodies against T. gondii...
Thu, 12/17/2020 - 10:02
ABSTRACT The type II secretion system (T2SS) is a conserved transport pathway responsible for the secretion of a range of virulence factors by many pathogens, including Vibrio cholerae. Disruption of the T2SS genes in V. cholerae results in loss of secretion, changes in cell envelope function, and growth defects. While T2SS mutants are viable, high-throughput genomic analyses have listed these...
Thu, 12/17/2020 - 10:01
Increasing mobile colistin resistance, mediated by the mcr gene family, in Enterobacteriaceae has become a global concern. Among the 10 reported mcr genes, mcr-8 was first identified in Klebsiella pneumoniae, which could cause severe infections with high mortality. Information about the prevalence and genetic context of mcr-8 is still lacking. In this study, we found that mcr-8 was present in 9....
Thu, 12/17/2020 - 10:01
Fluoroquinolones (FQ) are crucial components of multidrug-resistant tuberculosis (MDR TB) treatment. Differing levels of resistance are associated with specific mutations within the quinolone-resistance-determining region (QRDR) of gyrA. We sequenced the QRDR from serial isolates of MDR TB patients in the Preserving Effective TB Treatment Study (PETTS) with baseline FQ resistance (FQR) or...
Thu, 12/17/2020 - 10:01
Tetracyclines are widely used in veterinary medicine and food animal production. Campylobacter members are major foodborne pathogens, and their resistance to tetracycline has been widely reported in different countries. To date, Tet(O), a ribosomal protection protein, is the only confirmed Tet resistance determinant in Campylobacter spp. Here, we reported the detection and characterization of a...
Thu, 12/17/2020 - 10:01
A healthy, intact gut microbiota is often resistant to colonization by gastrointestinal pathogens. During periods of dysbiosis, however, organisms such as Clostridioides difficile can thrive. We describe an optimized in vitro colonization resistance assay for C. difficile in stool (CRACS) and demonstrate the utility of this assay by assessing changes in colonization resistance following...
Thu, 12/17/2020 - 10:01
We previously identified a small-molecule inhibitor of capsule biogenesis (designated DU011) and identified its target as MprA, a MarR family transcriptional repressor of multidrug efflux pumps. Unlike other proposed MprA ligands, such as salicylate and 2,4-dinitrophenol (DNP), DU011 does not alter Escherichia coli antibiotic resistance and has significantly enhanced inhibition of capsule...
Thu, 12/17/2020 - 10:01
Pretomanid was approved by the U.S. FDA, via the limited population pathway for antibacterial and antifungal drugs, as part of a three-drug regimen with bedaquiline and linezolid for the treatment of extensively drug-resistant and treatment-intolerant or nonresponsive multidrug-resistant tuberculosis. The recommended dose of pretomanid is 200 mg once daily with food. The objective of this work...
Thu, 12/17/2020 - 10:01
Bacterial pathogens are rapidly evolving resistance to all clinically available antibiotics. One part of the solution to this complex issue is to better understand the resistance mechanisms to new and existing antibiotics. Here, we focus on two antibiotics. Teixobactin is a recently discovered promising antibiotic that is claimed to "kill pathogens without detectable resistance" (L. L. Ling, T....
Thu, 12/17/2020 - 10:01
Current guidelines recommend vancomycin and linezolid as first-line agents against methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. Telavancin is a potential new therapeutic alternative, specifically in monomicrobial MRSA pneumonia. This study compared the efficacies of telavancin versus linezolid in a porcine model of severe MRSA pneumonia. In 18 mechanically ventilated...
Thu, 12/17/2020 - 10:01
Silver gulls carry phylogenetically diverse Escherichia coli, including globally dominant extraintestinal pathogenic E. coli (ExPEC) sequence types and pandemic ExPEC-ST131 clades; however, our large-scale study (504 samples) on silver gulls nesting off the coast of New South Wales identified E. coli ST457 as the most prevalent. A phylogenetic analysis of whole-genome sequences (WGS) of 138 ST457...
Thu, 12/17/2020 - 10:01
Monitoring of Plasmodium falciparum sensitivity to antimalarial drugs in Africa is vital for malaria elimination. However, the commonly used ex vivo/in vitro 50% inhibitory concentration (IC50) test gives inconsistent results for several antimalarials, while the alternative ring-stage survival assay (RSA) for artemisinin derivatives has not been widely adopted. Here, we applied an alternative two...
Thu, 12/17/2020 - 08:03
Formamidinium lead iodide (CH(NH2)2PbI3, FAPI) thin films have been deposited on glass substrates at 150 °C using ambient pressure aerosol assisted chemical vapour deposition (AACVD). The films have been analysed by a range of techniques including powder X-ray diffraction (pXRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, and UV–Vis–NIR absorption spectroscopy...
Thu, 12/17/2020 - 08:03
by Stéphane Pont, Nathan Fraikin, Yvan Caspar, Laurence Van Melderen, Ina Attrée, François Cretin Bacterial bloodstream infections (BSI) are a major health concern and can cause up to 40% mortality. Pseudomonas aeruginosa BSI is often of nosocomial origin and is associated with a particularly poor prognosis. The mechanism of bacterial persistence in blood is still largely unknown. Here, we...
Thu, 12/17/2020 - 06:11
Author(s): Babar Hussain, Muhammad Jawad Umer, Jumei Li, Yibing Ma, Yawar Abbas, Muhammad Nadeem Ashraf, Nazia Tahir, Aman Ullah, Nirmali Gogoi, Muhammad Farooq A high concentration of toxic heavy metal cadmium (Cd) in the paddy soils and its translocation and subsequent accumulation in the rice grain and the food chain is a global environmental issue. Mechanistic understanding of soil properties...
Thu, 12/17/2020 - 06:11
Author(s): Carlota Gamboa-Cruz, Sílvia Barros, Ana Sofia Vila Pouca, Jorge Barbosa, Andreia Freitas, Fernando Ramos The use of antibiotics in livestock production has become a common practice. In the EU, the use of antibiotics as growth promoters is forbidden. However, the (mis)use of antibiotics may lead to antimicrobial resistance, which adversely affects humans, animals and the environment....
Thu, 12/17/2020 - 06:11
Author(s): Shu-Chuan Kuo, Yih-Ming Weng In Taiwan, food safety courses are taught to Grade 6 schoolchildren at elementary school. However, no report discussed the relationship and these changes among knowledge, attitudes, and practices concerning food safety in Taiwan before. Therefore, the aim of this study was to determine the association of food safety education with a combination of knowledge...
Thu, 12/17/2020 - 06:10
Author(s): Jordana Alves Ferreira, Sonia C.N. Queiroz Several pesticides are used in the cultivation of coconut palm, hence evaluation of the residues from these substances must be analyzed in the fruit, to provide and ensure the food safety. Therefore, the development and validation of comprehensive and effective methods becomes crucial, given the complexity of the matrix. Thus, a novel method...
Thu, 12/17/2020 - 06:10
Author(s): Mohit Bansal, Nitin Dhowlaghar, Ramakrishna Nannapaneni, Divya Kode, Sam Chang, Chander S. Sharma, Christopher McDaniel, Aaron Kiess The objective of this study was to determine if the adaptation at planktonic stage to subinhibitory concentrations (SIC) of sodium hypochlorite (NaOCl) could modulate the biofilm forming ability of five Listeria monocytogenes strains V7, Scott A, FSL-N1-...
Thu, 12/17/2020 - 06:09
Author(s): Beatriz Ferrer, Lisa M. Prince, Alexey A. Tinkov, Abel Santamaria, Marcelo Farina, João Batista Rocha, Aaron B. Bowman, Michael Aschner Several studies have demonstrated that heavy metals disrupt energy homeostasis. Leptin inhibits food intake and decreases body weight through activation of its receptor in the hypothalamus. The impact of heavy metals on leptin signaling in the...
Thu, 12/17/2020 - 06:08
Author(s): Jeyakumar Balakrishnan, Prakash Ganapathi, Suganya Kannan, Murugan Marudhamuthu, Kathiresan Shanmugam Fatty acid methyl esters (FAMEs) from marine microalgae have been reported to possess antimicrobial activities against several Gram positive and Gram negative bacteria, but a majority of them needs to be explored. The objective of this study was to investigate the antibacterial...
Thu, 12/17/2020 - 06:08
Author(s): Elżbieta Maćkiw, Dorota Korsak, Joanna Kowalska, Benjamin Felix, Monika Stasiak, Katarzyna Kucharek, Jacek Postupolski The aim of the present study is to investigate the prevalence and genetic diversity of Listeria monocytogenes in various fresh and frozen vegetable products available in Poland. The samples were collected at retail market within the framework of national official...
Thu, 12/17/2020 - 06:08
Author(s): Fan Li, Qinghua Ye, Moutong Chen, Baoqing Zhou, Xinran Xiang, Chufang Wang, Yuting Shang, Jumei Zhang, Rui Pang, Juan Wang, Liang Xue, Shuzhen Cai, Yu Ding, Qingping Wu The abundant information provided by the pan-genome analysis approach reveals the diversity among Listeria monocytogenes serotypes. The objective of this study was to mine novel target genes using pan-genome analysis...
Thu, 12/17/2020 - 06:08
Author(s): Guillaume Legrand Ngolong Ngea, Qiya Yang, William Tchabo, Raffaello Castoria, Xiaoyun Zhang, Hongyin Zhang This research aimed to isolate lactic acid bacteria (LAB) from apple surface and to reveal their potential to inhibit the growth of Penicillium expansum. Besides, their ability to detoxify fruit juices contaminated with mycotoxin patulin, produced by this fungi, was also studied...
Thu, 12/17/2020 - 06:07
Author(s): Chao Zhao, Chao Peng, Pengfei Wang, Sigang Fan, Lulu Yan, Lihua Qiu Cell division cycle 37 (Cdc37) is an important cytoplasmic phosphoprotein, which usually functions as a complex with heat shock protein 90 (Hsp90), to effectively reduce the damage caused by heavy metals, such as cadmium (Cd), in aquatic animals. The high toxicity of Cd in aquatic systems generally has a deleterious...
Thu, 12/17/2020 - 06:07
Author(s): Xingyuan Li, Ting Geng, Wenjie Shen, Jingru Zhang, Yongzhang Zhou Cadmium (Cd) is a highly toxic heavy metal that occurs widely in the environment and poses extensive threats to human health, animals, and plants. This study aims to identify and apportion multi-source and multi-phase Cd pollution from natural and anthropogenic inputs using ensemble models that include random forest (RF...
Thu, 12/17/2020 - 06:07
Author(s): Ann Abraham, Leanne J. Flewelling, Kathleen R. El Said, William Odom, Stephen P. Geiger, April A. Granholm, Jennifer T. Jackson, Dean Bodager Brevetoxins were confirmed in urine specimens from patients diagnosed with neurotoxic shellfish poisoning (NSP) after consumption of gastropods that were recreationally harvested from an area previously affected by a Karenia brevis bloom. Several...
Wed, 12/16/2020 - 22:09
Coxiellosis or Q fever is an important global occupational zoonotic disease caused by one of the most contagious bacterial pathogens‐ Coxiella burnetii, which ranks one among the 13 global priority zoonoses. The detection of C. burnetii infection is exhibiting an increasing trend in high‐ risk personnel around the globe. It has increasingly been detected from foods of animal origin (including...
Wed, 12/16/2020 - 22:09
Furan, a significant food contaminant, was found in many cooked foods. In most cooked foods, furan has been found to be coexisted with some alkylated derivatives such as 2‐methylfuran. 2‐methylfuran was found to be potent hepatotoxins. Little toxicological data is available for 2‐methylfuran. The objective of this study was to investigate metabolite changes in the liver samples from mice fed with...
Wed, 12/16/2020 - 22:08
Production and world consumption of spices are constantly increasing. Although the antimicrobial properties of some spices are well documented, their use in the agri‐food industry is also responsible for microbial contamination and spoilage. Bacterial spores introduced by spices can withstand different preparation processes, particularly thermal treatments, leading to food alterations during...
Wed, 12/16/2020 - 22:06
Tomato is a climacteric fruit susceptible to rapid softening and ripening after harvest. In this study, the changes of physicochemical characters, cell wall degrading enzymes, cell wall compositions and ethylene production of ‘Hisar Arun’ and ‘BSS‐488’ tomato fruits were investigated under the influence of salicylic acid treatment. Salicylic acid treatment effectively delayed firmness decline and...
Wed, 12/16/2020 - 16:00
Gastrointestinal bacteria that harbor antibiotic resistance genes (ARG) become enriched with antibiotic use. Livestock manure application to cropland for soil fertility presents a concern that ARG and bacteria may proliferate and be transported in the environment. In the United States, manure applications typically occur during autumn with slow mineralization until spring planting season. A...
Wed, 12/16/2020 - 16:00
High concentrations of heavy metal (HM) ions impact agronomic staple crop production in acid soils (pH ≤ 5) due to their cytotoxic, genotoxic, and mutagenic effects. Among cytotoxic ions, the trivalent aluminum cation (Al3+) formed by solubilization of aluminum (Al) into acid soils, is one of the most abundant and toxic elements under acidic conditions. In recent years, several studies have...
Wed, 12/16/2020 - 16:00
Salmonella enterica serovar Typhi (S. Typhi) is the causative agent of typhoid fever, a disease that kills an estimated 200,000 people annually. Previously, we discovered an antimicrobial pathway dependent on Rab32 and BLOC-3 (BRAM) that is critical to kill S. Typhi in murine macrophages. The BLOC-3 complex is comprised of the two sub-units HPS1 and HPS4 and exhibits guanine-nucleotide exchange...
Wed, 12/16/2020 - 10:01
Campylobacter jejuni is a zoonotic pathogen and is one of the leading causes of human gastroenteritis worldwide. C. jejuni IA3902 (representative of the sheep abortion clone) is genetically similar to C. jejuni W7 (representative of strain type NCTC 11168); however, there are significant differences in the ability of luxS mutants of these strains to colonize chickens. LuxS is essential for the...
Wed, 12/16/2020 - 10:01
A critical facet of mammalian innate immunity involves the hosts’ attempts to sequester and/or limit the availability of key metabolic products from pathogens. For example, nutritional immunity encompasses host approaches to limit the availability of key heavy metal ions such as zinc and iron. Previously, we identified several hundred genes in a multidrug-resistant isolate of Acinetobacter...
Wed, 12/16/2020 - 08:02
Human sapoviruses (HuSaVs) cause acute gastroenteritis similar to human noroviruses. Although HuSaVs were discovered four decades ago, no HuSaV has been grown in vitro, which has significantly impeded the understanding of viral biology and the development of antiviral strategies. In this study, we identified two susceptible human cell lines, that...
Wed, 12/16/2020 - 06:07
Author(s): Karen Jaqueline Haselroth, Poline Wilke, Ingrid Miotto Dalla Costa, Victor Manuel Lustoza Rotta, Adriana Fiorini Rosado, Eliane Hermes Little is known about the use of microbial lipases for the treatment of beef industry effluent. It is essential to develop techniques for the sustainable management of this waste, given its high polluting potential, especially due to the high...
Wed, 12/16/2020 - 06:05
Author(s): L.H.B. Hansen, B. Nielsen, E.J. Boll, L. Skjøt-Rasmussen, A. Wellejus, L. Jørgensen, C. Lauridsen, N. Canibe Enterotoxigenic Escherichia coli (ETEC), being the major cause of post-weaning diarrhoea (PWD) in newly weaned piglets, induces poor performance and economic losses in pig production. This functional in vitro screening study investigated probiotic strains for use in suckling...
Wed, 12/16/2020 - 06:05
Author(s): Selçuk Kılıç, Bekir Çelebi, Meral Turan Brucella melitensis and Brucella abortus account for almost all cases of brucellosis in Turkish population. We developed a fourplex quantitative real-time PCR (qPCR) assay for the electrophoresis-free, rapid and cost-effective differentiation of B. abortus and B. melitensis from the other Brucella spp. The 4-plex species differentiation assay was...
Wed, 12/16/2020 - 04:01
In the fight against the spread of antibiotic resistance (ABR), authorities usually require that strains “intentionally added into the food chain” be tested for their antibiotic susceptibility. This applies to strains used in starter or adjunct cultures for the production of fermented foods, such as many strains of Pediococcus pentosaceus . The European Food Safety Authority (EFSA) recommends...
Wed, 12/16/2020 - 04:01
As part of the National Antimicrobial Resistance Monitoring System (NARMS) activities, the United States Department of Agriculture (USDA) Food Safety Inspection Service (FSIS) collected cecal samples from food animal slaughter facilities throughout the country between 2014 and 2018. Of the 26,780 cecal samples from cattle, swine, chicken and turkey , 6,350 (23.71%) tested positive for Salmonella...
Wed, 12/16/2020 - 04:01
Vegetables in Cambodia are commonly sold in informal markets lacking food safety standards and controls. Currently, data on microbial contamination of vegetables in Cambodian informal markets are limited. The purpose of this study was to investigate Salmonella enterica and indicator organisms (generic Escherichia coli and coliforms) on the surface of fresh vegetables sold in informal markets in...
Wed, 12/16/2020 - 04:01
Butter adulteration practices and their health risks were assessed along the supply chains in the central highlands and south-western midlands of Ethiopia. Purposive sampling technique was used to select 1101 respondents. Based on the result of the cross-sectional study, fatty acid profiles of butter samples collected from retailers’ shops were investigated to determine the extent of adulteration...
Wed, 12/16/2020 - 02:01
Amendment with treated biosolids can increase soil fertility and plant nutrition to the soil, but the fertilization value compared with other commercial soil amendments on the soil ecosystem is poorly understood. The effects of different proportions (0%, 5%, 10%, and 15%) of thermal and pH-treated biosolid applications on the growth performance, nutrient contents, and toxicity performance of...
Wed, 12/16/2020 - 00:00
Aflatoxin B1 (AFB1) is a mycotoxin that frequently contaminates cereals and cereal byproducts. This study investigates the effect of AFB1 on the mesenteric lymph nodes (MLNs) of piglets and evaluates if a diet containing grape seed meal (GSM) can counteract the negative effect of AFB1 on inflammation and oxidative stress. Twenty-four weaned piglets were fed the following diets: Control, AFB1...
Tue, 12/15/2020 - 22:09
Since 2013, H5N6 highly pathogenic avian influenza viruses have caused considerable economic losses in the poultry industry and have caused 24 laboratory‐confirmed human cases. In this study, we isolated nine (B1–B9) H5N6 viruses from healthy ducks in Guangdong Province, Southern China from December 2018 to April 2019. Phylogenetic analysis revealed that B1, B2, B3, B4, B5, B7, B8, and B9...
Tue, 12/15/2020 - 22:09
The present study envisages the potential application of chitosan‐coated Zingiber zerumbet essential oil nanoemulsion (ZEO‐CsNE) as green antimicrobial preservative against Aspergillus flavus, aflatoxin B1 (AFB1), and lipid peroxidation of stored functional foods. GC‐MS analysis of ZEO exhibited the abundance of cis‐geraniol (15.53%) as the major component. ZEO‐CsNE showed biphasic release...
Tue, 12/15/2020 - 22:09
The operating environment for food safety interventions in nations such as Saudi Arabia, with limited local agricultural productivity, high reliance on foreign food imports and observance of Islamic laws, is remarkably challenging for the national control and regulatory institutions, since compliance to the mandatory food safety regulations and the local religious Halal standards must be ensured...

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