Research Publications from Peer-Reviewed Journals

The Research Publications track research that is published across national and international peer-reviewed journals. The most recent articles are available ahead of print and searchable by Journal Title, Subject, USDA Grant Funding Agencies or FDA Grant Funding Agencies. The research publications are tracked across five subject areas: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, and Viruses.

Wed, 09/16/2020 - 16:00
Regulation of the environmental stress response and virulence of Shigella flexneri may involve multiple signaling pathways; however, these mechanisms are not well-defined. In bacteria, small regulatory RNAs (sRNAs) regulate bacterial growth, metabolism, virulence, and environmental stress response. Therefore, identifying novel functional sRNAs in S. flexneri could help elucidate pathogenic...
Wed, 09/16/2020 - 12:01
Inorganic arsenic (iAs) is a recognized environment-related factor for bladder cancer (BCa). Arsenic (+3 oxidation state) methyltransferase (AS3MT) gene might influence BCa by regulating iAs metabolism. The aim of the present study was to explore whether AS3MT polymorphisms could affect BCa susceptibility. We systematically reviewed eligible case-control studies about AS3MT polymorphisms and BCa...
Wed, 09/16/2020 - 12:01
Polychlorinated biphenyls (PCBs) are ubiquitously detected and have been linked to metabolic diseases. Gut microbiome is recognized as a critical regulator of disease susceptibility; however, little is known how PCBs and gut microbiome interact to modulate hepatic xenobiotic and intermediary metabolism. We hypothesized the gut microbiome regulates PCB-mediated changes in the metabolic...
Wed, 09/16/2020 - 12:01
Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. The metabolic bioactivation of drugs to chemically reactive metabolites (CRMs) contribute to liver-associated adverse drug reactions in humans that often goes undetected in conventional animal toxicology studies. A...
Wed, 09/16/2020 - 12:01
Early risk assessment of drug-induced liver injury (DILI) potential for drug candidates remains a major challenge for pharmaceutical development. We have previously developed a set of rat liver transcriptional biomarkers in short-term toxicity studies to inform the potential of drug candidates to generate a high burden of chemically reactive metabolites that presents higher risk for human DILI....
Wed, 09/16/2020 - 12:00
Traditional methods for cancer risk assessment are resource-intensive, retrospective, and not feasible for the vast majority of environmental chemicals. In this study, we investigated whether quantitative genomic data from short-term studies may be used to set protective thresholds for potential tumorigenic effects. We hypothesized that gene expression biomarkers measuring activation of the key...
Wed, 09/16/2020 - 12:00
Cadmium (Cd) is a heavy metal and an environmental pollutant. However, the full spectrum of its neurotoxicity and the underlying mechanisms are not completely understood. Our previous studies demonstrated that Cd exposure impairs adult hippocampal neurogenesis and hippocampus-dependent memory in mice. This study aims to determine if these adverse effects of Cd exposure can be mitigated by...
Wed, 09/16/2020 - 10:02
ABSTRACT The bacterial and fungal community involved in ambrosia beetle fungiculture remains poorly studied compared to the famous fungus-farming ants and termites. Here we studied microbial community dynamics of laboratory nests, adults, and brood during the life cycle of the sugarcane shot hole borer, Xyleborus affinis. We identified a total of 40 fungal and 428 bacterial operational taxonomic...
Wed, 09/16/2020 - 08:02
by Guillaume Lhermie, Pierre Sauvage, Loren William Tauer, Leslie Verteramo Chiu, Karun Kanyiamattam, Ahmed Ferchiou, Didier Raboisson, Harvey Morgan Scott, David R. Smith, Yrjo Tapio Grohn The rising public health threat of antimicrobial resistance, the influence of food service companies, as well as the overall lack of positive image of using medical products in intensive farming are major...
Wed, 09/16/2020 - 08:02
by Pankaj Dhaka, Satya Veer Singh Malik, Jay Prakash Yadav, Manesh Kumar, Sukhadeo B. Barbuddhe, Deepak B. Rawool Coxiella burnetii is a highly infectious zoonotic pathogen infecting wide range of mammals, including humans. In the present study, a total of 711 blood samples from bovines [cattle (n = 543) and buffaloes (n = 168)] from eight farms at different geographical locations in India were...
Wed, 09/16/2020 - 08:02
by Jenell T. Larsen Tempel, Shannon Atkinson Endocrine profiling is an increasingly utilized tool for detecting pregnancies in wild populations of mammals. Given the difficulty in calculating reproductive rates of Pacific walruses (Odobenus rosmarus divergens) the use of endocrine techniques for determining pregnancy rates could be particularly useful for management of the population. The goals...
Wed, 09/16/2020 - 06:08
Author(s): Abraham Fikru Mechesso, Dong Chan Moon, Su-Jeong Kim, Hyun-Ju Song, Hee Young Kang, Seok Hyeon Na, Ji-Hyun Choi, Ha-Young Kim, Soon-Seek Yoon, Suk-Kyung Lim Food-producing animals are considered a leading source of human Salmonella infections in Korea. However, there is a lack of comprehensive and up-to-date data regarding the diversity and resistance profiles of Salmonella serotypes...
Wed, 09/16/2020 - 06:08
Author(s): Shen Yang, Jian Li, Jude Juventus Aweya, Zijin Yuan, Wuyin Weng, Yueling Zhang, Guang-Ming Liu Antimicrobial peptides are being explored for use as food preservatives to prevent foodborne diseases. In this study, bioinformatics tools were used to screen potential antimicrobial amino acid sequences from the whey acidic protein (WAP) of large yellow croaker (Larimichthys crocea). A novel...
Wed, 09/16/2020 - 06:08
Author(s): Khatereh Shirani, Fakhri Shahidi, Seyed Ali Mortazavi Cold plasma is a novel technology for surface decontamination. Almond slices can be contaminated with different microorganisms during their production. In the current research, the atmospheric argon plasma treatment (5, 10, 15, and 20 min) was used to decontamination of almond slices surface. Microbial load, Color, peroxide value,...
Wed, 09/16/2020 - 04:02
Animal protein supplement feeds (APFs) are important raw feed materials for livestock. APFs might be susceptible to organophosphate esters (OPEs) but have not been paid attention yet. In the present study, animal-derived (meat meal, feather meal, and blood meal) and plant-derived APFs were all found to contain detectable levels of OPEs, with 16 target OPEs ranging from 12.6 ng/g dry weight (dw)...
Wed, 09/16/2020 - 02:02
Consumption of raw or unpasteurized milk is a risk for the consumers because indirect contaminations such as fecal-cross-contamination could occur and determine the presence of enteric viruses. In this study, milk was treated with several temperature and time combinations chosen by performing a preliminary experiment to evaluate the intervals needed to inactivate Hepatitis A virus (HAV) HM175...
Wed, 09/16/2020 - 00:00
Alternaria toxins are emerging mycotoxins, candidates for regulation by European Authorities. Therefore, highly sensitive, confirmatory, and reliable analytical methodologies are required for their monitoring in food. In that context, an isotope dilution LC-MS/MS method was developed for the analysis of five Alternaria toxins (Altenuene, Alternariol, Alternariol monomethylether, Tentoxin, and...
Wed, 09/16/2020 - 00:00
This study aimed to investigate the effects of dietary AFB1 on growth performance, health, intestinal microbiota communities and AFB1 tissue residues of turbot and evaluate the mitigation efficacy of yeast cell wall extract, Mycosorb® (YCWE) toward AFB1 contaminated dietary treatments. Nine experimental diets were formulated: Diet 1 (control): AFB1 free; Diets 2–5 or Diets 6...
Wed, 09/16/2020 - 00:00
Heavy metals are typical cumulative pollutants that can enter and poison the human body through the food chain. However, the molecular mechanism of heavy metal-induced oxidative stress is unclear. In this study, we characterize PvKelch-like-1 from P. vannamei and explore its antioxidant roles in immune regulation of crustaceans. PvKelch-like-1 full length contains 2107 nucleotides, consists of a...
Wed, 09/16/2020 - 00:00
Acinetobacter spp. has gained fame from their ability to resist difficult conditions and their constant development of antimicrobial resistance. This study aimed to investigate the prevalence, susceptibility testing, OXA carbapenemase-encoding genes, and RAPD-genotyping of multidrug resistant Acinetobacter baumannii incriminated in hidden community-acquired infections in Egypt. The antimicrobial...
Tue, 09/15/2020 - 22:14
HoBi‐like pestivirus is an emerging atypical pestivirus in cattle and small ruminants, causing clinical signs similar to those observed in bovine viral diarrhea virus infections. Natural infection of HoBi‐like pestivirus has been reported in cattle herds and small ruminants in multiple countries in South America, Europe, and Asia. However, HoBi‐like pestiviruses were only identified from...
Tue, 09/15/2020 - 22:13
PEF treatment of sesame seeds provides significant reduction on aflatoxin producing fungi, Aspergillus paraciticus, as well as decomposition of aflatoxins with reduced mutagenity with preservation of physical properties and reduced acid number and peroxide value. Abstract Seed processing technologies are essential for seed safety and functionality through protection of physicochemical quality,...
Tue, 09/15/2020 - 16:01
Lead–zinc (Pb–Zn) mine tailings pose a great risk to the natural environment and human health because of their high toxicity. In this study, the responses of photosynthesis, chlorophyll fluorescence, and antioxidative enzyme of Melia azedarach and Ligustrum lucidum in the soil contaminated by Pb–Zn mine tailings were investigated. Results showed that Pb–Zn mine tailings significantly reduced net...
Tue, 09/15/2020 - 16:01
Consumption of dates has not been considered a common risk of hepatitis A virus (HAV) infection. In January 2018, an outbreak of hepatitis was identified with cases resident in all regions of Denmark. All the detected strains belonged to HAV genotype 3A. Epidemiological investigations through patients’ interviews, case-control and trace-back studies pointed toward different batches of dates from...
Tue, 09/15/2020 - 16:01
BackgroundEnterobacter cloacae is an opportunistic pathogen which is responsible for serious nosocomial infections. A gene which plays an important role in resistance to carbapenems is the New Delhi metallo-β-lactamase 1 (NDM-1). Currently, the spread of NDM-1-producing E. cloacae strains is a serious public threat.MethodsA multidrug-resistant E. cloacae ssp. dissolvens strain CBG15936 was...
Tue, 09/15/2020 - 16:01
In this work, we report the isolation and detailed functional characterization for the new non-ribosomally synthesized antibiotic 5812-A/C, which was derived from metabolites of Streptomyces roseoflavus INA-Ac-5812. According to its chemical structure, the studied 5812-A/C preliminary is composed of a cyclic peptide part covalently bounded with an arabinose residue. N-terminal amino acid...
Tue, 09/15/2020 - 16:01
Background: We conducted this retrospective study to reveal the accuracy of metagenomic next-generation sequencing (mNGS) for diagnosing osteoarticular infections from fresh abscess specimens obtained from patients in an HIV-naive population.Methods: We retrospectively analyzed hospital records at three participating TB-specialized hospitals for patients admitted with suggestive diagnoses of...
Tue, 09/15/2020 - 10:01
Members of the small multidrug resistant (SMR) efflux pump family known as SugE (more recently renamed to Gdx) are known for their narrow substrate selectivity to small guanidinium (Gdm+) compounds and disinfectant quaternary ammonium compounds (QACs). Gdx members have been identified on multidrug resistant plasmids in Gram-negative bacilli, but their functional role remains unclear as few have...
Tue, 09/15/2020 - 08:03
by Hyunhee Park, Eunsong Hwang, Miyeon Jang, Chungsik Yoon Enclosed underground excavation worksite has an environment with poor ventilation and exposure to hazardous substances from diesel engine exhaust and construction materials. The objective of this study was to evaluate the exposure level of elemental carbon (EC), organic carbon (OC), total carbon (TC), polycyclic aromatic hydrocarbons (...
Tue, 09/15/2020 - 08:03
by Rory F. Little, Markiyan Samborskyy, Peter F. Leadlay The type I polyketide SF2487/A80577 (herein referred to as tetromadurin) is a polyether tetronate ionophore antibiotic produced by the terrestrial Gram-positive bacterium Actinomadura verrucosospora. Tetromadurin is closely related to the polyether tetronates tetronasin (M139603) and tetronomycin, all of which are characterised by...
Tue, 09/15/2020 - 02:01
Abstract Aims This research aimed to establish how Hordeum vulgare responds to abiotic and biotic stress affecting in tandem. Methods Plants were inoculated with Heterodera filipjevi and treated with cadmium (Cd) concentration (5 μM) that can occur in the cultivated soil. To verify the hypothesis about participation of increased antioxidative defence in H. vulgare under stress, biochemical and...
Tue, 09/15/2020 - 00:00
The emergence of B. cereus as an opportunistic food-borne pathogen has intensified the need to distinguish strains of public health concern. The heterogeneity of the diseases associated with B. cereus infections emphasizes the versatility of these bacteria strains to colonize their host. Nevertheless, the molecular basis of these differences remains unclear. Several toxins are involved in...
Tue, 09/15/2020 - 00:00
We investigated ochratoxin A (OTA) contamination in raisin samples purchased from Slovak markets and determined the diversity of black-spored aspergilli as potential OTA and fumonisin (FB1 and FB2) producers. The taxonomic identification was performed using sequences of the nuclear ITS1-5.8s-ITS2 region, the calmodulin and beta-tubulin genes. We obtained 239 isolates from eight fungal genera, of...
Tue, 09/15/2020 - 00:00
Bitis arietans is a snake of medical importance, as it is responsible for more accidents in humans and domestic animals than all other African snakes put together. The accidents are characterized by local and systemic alterations, such as inflammation, cardiovascular and hemostatic disturbances, which can lead victims to death or permanent disability. However, little is known about the...
Mon, 09/14/2020 - 22:11
Clostridium difficile (C.difficile) can cause antibiotic‐associated diarrhea or pseudo‐membranous colitis in humans and animals. Currently, the various methods such as microbiological culture,cytotoxic assay, ELISA and PCR have been used to detect Clostridium difficile infection (CDI). These conventional methods, however, require long detection time and professional staff. The paper is to...
Mon, 09/14/2020 - 06:10
Author(s): Miao Li, Haiming Wang, Jiadi Sun, Jian Ji, Yongli Ye, Xin Lu, Yinzhi Zhang, Xiulan Sun Aflatoxin M1 (AFM1), a frequently occurring mycotoxin in milk and dairy products, causes acute and chronic poisoning. In this study, we developed a time-resolved fluorescence microsphere immunochromatographic test strip (TRFM–ICTS) combined with ultraviolet light for the rapid and quantitative...
Mon, 09/14/2020 - 06:09
Author(s): L.C. Eastwood, T.M. Taylor, J.W. Savell, K.B. Gehring, A.N. Arnold Effect of various antimicrobial interventions on pork carcass cuts – skin-on and skinless, non-chilled and chilled – was studied. Carcass pieces were inoculated with Salmonella enterica, Shiga toxin-producing Escherichia coli (STEC), Escherichia coli pathogen surrogates or Campylobacter spp. Inoculated pieces were...
Mon, 09/14/2020 - 02:02
Toxoplasmosis represents an important public health issue, with the consumption of raw or undercooked meat being a major way of human infection. The role of beef in the transmission of the parasite to humans is questioned due to lower quantity of tissue cysts compared with other meat-producing species. However, the habit of consuming raw beef is regionally diffused, and the risk posed by...
Sun, 09/13/2020 - 06:10
Author(s): Federica Giacometti, Annalisa Pezzi, Giorgio Galletti, Marco Tamba, Giuseppe Merialdi, Silvia Piva, Andrea Serraino, Silva Rubini The current study presents data on the antimicrobial resistance (AMR) patterns of 102 S. enterica subsp. enterica (72 Salmonella ser. Typhimurium and 30 monophasic S. Typhimurium serovar) and 79 Escherichia coli (and their phylogenetic group determination)...
Sun, 09/13/2020 - 06:08
Author(s): Agata Los, Dana Ziuzina, Daniela Boehm, Paula Bourke The safety and quality of cereal grain supplies are adversely impacted by microbiological contamination, with novel interventions required to maximise whole grains safety and stability. The microbiological contaminants of wheat grains and the efficacy of Atmospheric Cold Plasma (ACP) for potential to control these risks were...
Sun, 09/13/2020 - 06:07
Author(s): Congcong Wang, Jiaying He, Tongfei Xu, Hongyu Han, Zhimin Zhu, Lingxue Meng, Qihua Pang, Ruifang Fan The analogues of biphenol A (BPA), including bisphenol S (BPS) and bisphenol B (BPB), are commonly used to replace the application of BPA in containers and wrappers of daily life. However, their safeties are questioned due to their similar chemical structure and possible physiological...
Sun, 09/13/2020 - 06:06
LWT
Author(s): Haiying Cui, Hong Li, Changzhu Li, Mohamed A. Abdel-Samie, Lin Lin As a natural antibacterial agent, moringa oil (MO, containing palmitic acid, stearic acid and oleic acid as the dominant components) performs promising potential to ensure microbiological safety in food industry. Nevertheless, the antibacterial mechanism of MO is still unclear. In this study, we explored the...
Sun, 09/13/2020 - 02:02
The study reports protective role of potential probiotic cultures against infection by biofilm forming Cronobacter sakazakii in Caenorhabditis elegans model system. Among the fifteen indigenous potential probiotics, the cell free supernatant of Lactobacillus gastricus BTM7 possessed highest antimicrobial action and biofilm inhibition against C. sakazakii. The competitive exclusion assays revealed...
Sun, 09/13/2020 - 02:02
Fish consumption from contaminated water-bodies is a serious health issue. This study conducted to reveal the presence of heavy metals and bisphenols in Vembanad lake, an exploiting tourist spot in Kerala, receiving untreated agricultural, domestic, municipal, and industrial effluents. We evaluated aquatic contaminant impact on hepatic stress markers in Etroplus suratensis from fragile Vembanad...
Sun, 09/13/2020 - 02:02
The use of antimicrobial agents in livestock breeding is inevitable for prophylactic and treatment purposes, in order to maintain health and improve production of food products. However, this practice resulted in development of community resistance to antimicrobials due to residues found in livestock products. Milk is a key nutritional product that’s widely consumed for its high nutritional value...
Sun, 09/13/2020 - 02:01
Snack samples like potato crisp, fried potato, popcorn, and Cheetos have been known as carbohydrate- and protein-rich food. These tasty foods have high potential to contain acrylamide. Genotoxic and carcinogenic effect of acrylamide on human health cause to specific focus for measuring of acrylamide in food samples (Esposito et al. Food Chem Toxicol 108:249–256, 2017). In the present research,...
Sun, 09/13/2020 - 00:00
There are limited data on exposure to mycotoxins in Pakistan. Here, we measured exposure to deoxynivalenol (DON), a common contaminant of wheat, and aflatoxin B1 (AFB1), a known contaminant of rice, using biomarkers of exposure. Wheat (n = 195) and rice (n = 62) samples were analyzed for AFB1 and DON levels, and the corresponding urinary biomarkers were analyzed in urine samples from a rural...
Sat, 09/12/2020 - 22:11
Significance and Impact of the Study: Due to the resistance of the Plasmodium parasite to antimalarial drugs, only a few attempts have been made to use nanocarriers with the specific targeting approach in malaria treatment. In this article, we verified the antioxidant and anti‐inflammatory activity of silver nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the...
Sat, 09/12/2020 - 22:11
The emergence of novel resistant markers hampers the efficacy of beta‐lactam antibiotics to treat infections caused by microrganisms carrying such resistances. This study investigated the antimicrobial susceptibility pattern, the carpapenem associated determinants and the molecular epidemiology of Klebsiella pneumoniae showing a New Delhi (NDM) metallo‐β‐lactamase phenotype, isolated from a...
Sat, 09/12/2020 - 22:11
Significance and Impact of the Study: Surfactants with emulsifying bioactivity are known to be produced by Bacillus subtilis. Here, a colorimetric assay for methylene blue active substances is adapted for use in bacterial plaque to describe surfactant bioactivity, and supplemental salts of calcium during culture are shown to enrich cultured plaque for said bioactivity. Where B. subtilis is...

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