An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

National Agricultural Library
U.S. Department of Agriculture
  1. Home
  2. Human Nutrition and Food Safety
  3. Research Publications (Food Safety)

Research Publications (Food Safety)

This page tracks research articles published in national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. Research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies (requires login) and FDA Grant Funding Agencies (requires login) are also tracked in Scopus.

Displaying 1 - 18 of 18

  1. Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice

    • Toxicology

    • Deoxynivalenol (DON) is a significant Fusarium toxin that has gained global attention due to its high frequency of contamination in food and feed. It was reported to have hepatotoxicity, immunotoxicity, and reproduction toxicity in organs. On the other hand, Selenomethionine (SeMet) was proven to have anti-oxidation, tissue repairing, immunity improvement, and antifungal mycotoxin infection functions. However, the molecular mechanism by which SeMet alleviates DON damage is not yet clear.

      • Natural toxins
      • Mycotoxins

  2. Ochratoxin A induces cytotoxicity through ROS-mediated endoplasmic reticulum stress pathway in human gastric epithelium cells

    • Toxicology

    • Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium species that greatly threatens human health. We previously showed that OTA induced cycle arrest, apoptosis and autophagy in human gastric epithelium cells (GES-1). However, the mechanism underlying these effects is still unclear.

      • Natural toxins
      • Mycotoxins

  3. Evaluation of okadaic acid toxicity in human retinal cells and zebrafish retinas

    • Toxicology

    • Okadaic acid (OA, C₄₄H₆₈O₁₃) is a neurotoxin and phosphatase inhibitor produced by several 

      • Natural toxins
      • Shellfish toxins

  4. The Nrf1 transcription factor is induced by patulin and protects against patulin cytotoxicity

    • Toxicology

    • Patulin is a mycotoxin produced by a variety of molds that is found in various food products. The adverse health effects associated with exposure to patulin has led to many investigations into the biological basis driving the toxicity of patulin. Nevertheless, the mechanisms through which mammalian cells resists patulin-mediated toxicity is poorly understood. Here, we show that loss of the Nrf1 transcription factor renders cells sensitive to the acute cytotoxic effects of patulin.

      • Natural toxins
      • Mycotoxins

  5. Marine toxin domoic acid induces moderate toxicological response in non-target HepG2 cells

    • Toxicology

    • Domoic acid (DA) is a marine neurotoxin produced as a defence compound by diatom Pseudo-nitzschia. Although its toxicity is well known in marine mammals and fish, data on DA cyto/genotoxicity in human non-target cells is still limited. Hence, we aimed to study the effect of DA (0.001 to 10 µg/mL) on cell viability and proliferation kinetics of human hepatocellular carcinoma (HepG2) cells as well as DNA damage induction after 4, 24 and 72 h of exposure.

      • Natural toxins
      • Shellfish toxins

  6. Close association between the synergistic toxicity of zearalenone-deoxynivalenol combination and microRNA221-mediated PTEN/PI3K/AKT signaling in HepG2 cells

    • Toxicology

    • Mycotoxins can impart different types of combined toxicity to humans and animals, therefore, it is critical to understand the underlying mechanisms to eliminate the harm. Herein a combination of zearalenone (ZEA) at 2 μM and deoxynivalenol (DON) at 0.1 μM decreased cell viability and increased ROS level in HepG2 cells, suggesting synergistic toxicity exerted by ZEA and DON even at their low toxic concentrations.

      • Natural toxins
      • Mycotoxins

  7. Toxic effects of patulin on mouse oocytes and its possible mechanisms

    • Toxicology

    • Author(s): Wen-Long Lei, Yuan-Yuan Li, Yi Hou, Chenli Liu, Wei-Ping Qian, Qing-Yuan Sun, Chun-Hui Zhang

      • Mycotoxins
      • Natural toxins

  8. Zearalenone exposure mediated hepatotoxicity via mitochondrial apoptotic and autophagy pathways: associated with gut microbiome and metabolites

    • Toxicology

    • Author(s): Yuanliang Li, Jiangnan Yi, Qiwen Zeng, Yingwei Liu, Bijing Yang, Bingxian Liu, Yangwei Li, Khalid Mehmood, Riaz Hussain, Zhaoxin Tang, Hui Zhang, Ying Li

      • Mycotoxins
      • Natural toxins

  9. Exosomes mediated the delivery of ochratoxin A-induced cytotoxicity in HEK293 cells

    • Toxicology

    • Author(s): Liye Zhu, Haomiao Wang, Jieyu Yuhan, Boyang Zhang, Hongyu Li, Charles Asakiya, Kunlun Huang, Xiaoyun He, Wentao Xu

      • Mycotoxins
      • Natural toxins

  10. Aflatoxin B1 interferes with embryonic liver development: involvement of p53 signaling and apoptosis in zebrafish

    • Toxicology

    • Author(s): Ya-Chih Cheng, Ting-Shuan Wu, Ying-Tzu Huang, Yung Chang, Jiann-Jou Yang, Feng-Yih Yu, Biing-Hui Liu

      • Aflatoxins
      • Natural toxins

  11. Metabolomics analysis underlay mechanisms in the renal impairment of mice caused by combination of aflatoxin M1 and ochratoxin A

    • Toxicology

    • Author(s): Ziwei Wang, Yanan Gao, Xin Huang, Shengnan Huang, Xue Yang, Jiaqi Wang, Nan Zheng

      • Aflatoxins
      • Mycotoxins
      • Natural toxins

  12. Non-cytotoxic dosage of fumonisin B1 aggravates ochratoxin A-induced nephrocytotoxicity and apoptosis via ROS-dependent JNK/MAPK signaling pathway

    • Toxicology

    • Author(s): Haolei Li, Mengmeng Wang, Weili Kang, Ziman Lin, Fang Gan, Kehe Huang

      • Natural toxins
      • Mycotoxins

  13. Neurotoxicity of zearalenone’s metabolites and beauvericin mycotoxins via apoptosis and cell cycle disruption

    • Toxicology

    • Author(s): Fojan Agahi, Cristina Juan, Guillermina Font, Ana Juan-García

      • Mycotoxins
      • Natural toxins

  14. Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A

    • Toxicology

    • Author(s): Qipeng Zhang, Wenying Chen, Boyang Zhang, Chen Li, Xunyao Zhang, Qian Wang, Yan Wang, Qian Zhou, Xiaohong Li, Xiao Li Shen

      • Mycotoxins
      • Natural toxins

  15. Microphysiological System Modeling of Ochratoxin A-Associated Nephrotoxicity

    • Toxicology

    • Author(s): Tomoki Imaoka, Jade Yang, Lu Wang, Matthew G. McDonald, Zahra Afsharinejad, Theo K. Bammler, Kirk Van Ness, Catherine K. Yeung, Allan E. Rettie, Jonathan Himmelfarb, Edward J. Kelly

      • Mycotoxins
      • Natural toxins

  16. Effects of zearalenone-induced oxidative stress and Keap1–Nrf2 signaling pathway-related gene expression in the ileum and mesenteric lymph nodes of post-weaning gilts

    • Toxicology

    • Author(s): Qun Cheng, Shuzhen Jiang, Libo Huang, Yuxi Wang, Weiren Yang, Zaibin Yang, Jinshan Ge

      • Mycotoxins
      • Natural toxins

  17. Amelioration of ochratoxin-A induced cytotoxicity by prophylactic treatment of N-Acetyl-L-Tryptophan in human embryonic kidney cells

    • Toxicology

    • Author(s): Prerna Agarwal, Darshana Singh, S. Raisuddin, Raj Kumar

      • Natural toxins
      • Mycotoxins

  18. Zearalenone induces NLRP3-dependent pyroptosis via activation of NF-κB modulated by autophagy in INS-1 cells

    • Toxicology

    • Author(s): Xue Wang, Liping Jiang, Limin Shi, Kun Yao, Xiance Sun, Guang Yang, Lijie Jiang, Cong Zhang, Ningning Wang, Hongying Zhang, Yan Wang, Xiaofang Liu

      • Mycotoxins
      • Natural toxins