Research Publications (Food Safety)

Aflatoxins are liver carcinogens and are common contaminants in unpackaged peanut (UPP) oil. However, the health risks associated with consuming aflatoxins in UPP oil remain unclear. In this study, aflatoxin contamination in 143 UPP oil samples from Guangdong Province were assessed via liquid chromatography–tandem mass spectrometry (LC-MS). We also recruited 168 human subjects, who consumed this oil, to measure their liver functions and lipid metabolism status.

The term toxicant-associated fatty liver disease (TAFLD) has been proposed to describe fatty liver diseases connected to toxicants other than alcohol. Aflatoxins are mycotoxins commonly found as contaminants in foods and feeds, which are known liver toxicants and potential candidates as potential causes of TAFLD.

Hepatitis B virus (HBV) infection and aflatoxin B1 (AFB1) exposure have been recognized as independent risk factors for the occurrence and development of hepatocellular carcinoma (HCC), but their combined impacts and the potential metabolic mechanisms remain poorly characterized. Here, a comprehensive non-targeted metabolomic study was performed following AFB1 exposed to Hep3B cells at two different doses: 16 μM and 32 μM.

Mycotoxigenic fungi and their toxins are a global concern, causing huge economic and health impacts in developing countries such as Ethiopia, where the mycotoxin control system is inadequate. This work aimed to review the occurrences of agriculturally essential fungi such as Aspergillus, Fusarium, and Penicillium and their major mycotoxins in Ethiopian food/feedstuffs.

The health burden of foodborne mycotoxins is considerable, but particularly for children due to their lower detoxification capacity, rapid growth and high intake of food in proportion to their weight. Through a Total Dietary Study approach, the objective was to estimate the dietary exposure and health risk caused by mycotoxins for children under 5 years living in the Lao Cai province in northern Vietnam.

Toxins, Vol. 11, Pages 205: Exposure Assessment and Risk Characterization of Aflatoxin M1 Intake through Consumption of Milk and Yoghurt by Student Population in Serbia and Greece

Toxins doi: 10.3390/toxins11040205

Authors:
Bozidar Udovicki
Ilija Djekic
Eleni P. Kalogianni
Andreja Rajkovic

Toxins, Vol. 11, Pages 17: Lactobacillus bulgaricus or Lactobacillus rhamnosus Suppresses NF-κB Signaling Pathway and Protects against AFB1-Induced Hepatitis: A Novel Potential Preventive Strategy for Aflatoxicosis?

Toxins doi: 10.3390/toxins11010017

Authors:
Yuanyuan Chen
Ruirui Li
Qiaocheng Chang
Zhihao Dong
Huanmin Yang
Chuang Xu

Publication date: Available online 20 November 2018

Food and Chemical Toxicology

Author(s): Magda Carvajal-Moreno, Manuel Vargas-Ortiz, Estela Hernández-Camarillo, Silvia Ruiz-Velasco, Francisco Rojo-Calleja

Publication date: Available online 20 November 2018

Food and Chemical Toxicology

Author(s): Blake R. Rushing, Mustafa I. Selim

Aflatoxin B1 (AFB1) and/or hepatitis B and C viruses are risk factors for human hepatocellular carcinoma (HCC). Available evidence supports the interpretation that formation of AFB1-DNA adducts in hepatocytes seeds a population of mutations, mainly G:C→T:A, and viral processes synergize to accelerate tumorigenesis, perhaps via inflammation. Responding to a need...

Publication date: Available online 27 April 2016
Food and Chemical Toxicology

Author(s): Octavio P. Luzardo, María del Mar Bernal-Suárez, María Camacho, Luis Alberto Henríquez-Hernández, Luis D. Boada, Cristian Rial-Berriel, Maira Almeida-González, Manuel Zumbado, Ricardo Díaz-Díaz