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Research Publications (Food Safety)

The Food Safety Publications tracks research that is published across national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. The research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies and FDA Grant Funding Agencies are also tracked.

Displaying 1 - 25 of 35

  1. The in silico and in vitro analysis of donepezil derivatives for Anopheles acetylcholinesterase inhibition

    • Thu, 11/10/2022 - 04:00
    • PLOS ONE
    • by Thankhoe A. Rants’o, Divan G. van Greunen, C. Johan van der Westhuizen, Darren L. Riley, Jenny-Lee Panayides, Lizette L. Koekemoer, Robyn L. van Zyl Current studies on Anopheles anticholinesterase insecticides are focusing on identifying agents with high selectivity towards Anopheles over mammalian targets. Acetylcholinesterase (AChE) from electric eel is often used as the bioequivalent enzyme to study ligands designed for activity and inhibition in human.

      • Chemical contaminants
      • Heavy Metals
      • Pesticide residues
  2. Proteomic analysis of T. qataranse exposed to lead (Pb) stress reveal new proteins with potential roles in Pb tolerance and detoxification mechanism

    • Thu, 10/20/2022 - 04:00
    • Frontiers in Plant Science
    • Soil lead (Pb) contamination is one of the environmental problems facing the modern world. Sources of Pb in soil include industrial activities such as mining and smelting processes, agricultural activities such as application of insecticide and municipal sewage sludges, and urban activities such as use of lead in gasoline, paints, and other materials.

      • Chemical contaminants
      • Heavy Metals
      • Pesticide residues
  3. Pesticidal Activity and Mode of Action of Monoterpenes

    • Thu, 04/07/2022 - 04:00
    • Journal of Agricultural and Food Chemistry
    • Synthetic pesticides are often associated with issues such as pest resistance, persistent residue, nontarget toxicity, and environmental issues. Therefore, the research and development of novel, safe, and effective pesticides has become a focus in pesticide discovery. Monoterpenes are secondary plant metabolites that commonly have multiple action targets and have been used in aromatherapy, alternative medicine, and food industries. Some are highly potent and stereoselective.

      • Chemical contaminants
      • Heavy Metals
      • Pesticide residues
  4. Development of Novel (+)-Nootkatone Thioethers Containing 1,3,4-Oxadiazole/Thiadiazole Moieties as Insecticide Candidates against Three Species of Insect Pests

    • Mon, 12/20/2021 - 04:00
    • Journal of Agricultural and Food Chemistry
    • To improve the insecticidal activity of (+)-nootkatone, a series of 42 (+)-nootkatone thioethers containing 1,3,4-oxadiazole/thiadiazole moieties were prepared to evaluate their insecticidal activities against Mythimna separata Walker, Myzus persicae Sulzer, and Plutella xylostella Linnaeus.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  5. Synthesis, Structural Characterization, and Antibacterial and Antifungal Activities of Novel 1,2,4-Triazole Thioether and Thiazolo[3,2-b]-1,2,4-triazole Derivatives Bearing the 6-Fluoroquinazolinyl Moiety

    • Tue, 12/14/2021 - 04:00
    • Journal of Agricultural and Food Chemistry
    • A total of 52 novel 1,2,4-triazole thioether and thiazolo[3,2-b]-1,2,4-triazole derivatives bearing the 6-fluoroquinazolinyl moiety were designed, synthesized, and evaluated as antimicrobial agents in agriculture based on the molecular hybridization strategy. Among them, molecular structures of compounds 5g and 6m were further confirmed via the single-crystal X-ray diffraction method.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  6. Quantification of Heavy Metals and Pesticide Residues in Widely Consumed Nigerian Food Crops Using Atomic Absorption Spectroscopy (AAS) and Gas Chromatography (GC)

    • Tue, 12/07/2021 - 00:00
    • Toxins
    • More still needs to be learned regards the relative contamination of heavy metals and pesticide residues, particularly those found in widely consumed Nigerian food crops like cereals, vegetables, and tubers. In this current study, the heavy metals and pesticide residues detectable in widely consumed Nigerian food crops were respectively quantified using atomic absorption spectroscopy (AAS) and gas chromatography (GC).

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  7. Preparation and Anti-Tobacco Mosaic Virus Activities of Crocetin Diesters

    • Fri, 11/12/2021 - 04:01
    • Journal of Agricultural and Food Chemistry
    • The development of antiviral agents with an original structure and noticeable effect is always in great need. Natural products are important lead compounds in the development of new pesticides. Crocin-1 and crocin-2 were effectively isolated from Gardeniae fructus and found to have higher anti-tobacco mosaic virus (TMV) activity levels than ribavirin.

      • Chemical contaminants
      • Heavy Metals
      • Pesticide residues
  8. The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host

    • Thu, 09/09/2021 - 08:03
    • PLOS Pathogens
    • by Zhaojiang Guo, Shi Kang, Qingjun Wu, Shaoli Wang, Neil Crickmore, Xuguo Zhou, Alejandra Bravo, Mario Soberón, Youjun Zhang

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  9. Association Between Gestational Exposure to Toxicants and Autistic Behaviors Using Bayesian Quantile Regression

    • Wed, 09/01/2021 - 12:00
    • American Journal of Epidemiology
    • Autism spectrum disorder, which is characterized by impaired social communication and stereotypic behaviors, affects 1%–2% of children. Although prenatal exposure to toxicants has been associated with autistic behaviors, most studies have been focused on shifts in mean behavior scores. We used Bayesian quantile regression to assess the associations between log2-transformed toxicant concentrations and autistic behaviors across the distribution of behaviors.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  10. Deciphering the Behavioral Response of Meloidogyne incognita and Fusarium oxysporum Toward Mustard Essential Oil

    • Thu, 08/26/2021 - 16:00
    • Frontiers in Plant Science
    • Environmental concerns related to synthetic pesticides and the emphasis on the adoption of an integrated pest management concept as a cardinal principle have strengthened the focus of global research and development on botanical pesticides. A scientific understanding of the mode of action of biomolecules over a range of pests is key to the successful development of biopesticides.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  11. Characterization of Emerging Pathogens Carrying blaKPC-2 Gene in IncP-6 Plasmids Isolated From Urban Sewage in Argentina

    • Tue, 08/24/2021 - 16:00
    • Frontiers in Cellular and Infection Microbiology
    • Untreated wastewater is a reservoir for multidrug-resistant bacteria, but its role in the spread of antibiotic resistance in the human population remains poorly investigated. In this study, we isolated a KPC-2-producing ST2787 Klebsiella quasipneumoniae subsp. quasipneumoniae (WW14A), recovered from raw sewage at a wastewater treatment plant in Argentina in 2018 and determined its complete genome sequence. Strain WW14A was resistant to all β-lactams, ciprofloxacin and amikacin.

      • Heavy Metals
      • Pesticide residues
      • Bacterial pathogens
      • Chemical contaminants
  12. Design, Synthesis, and Evaluation of Novel Isothiazole-Purines as a Pyruvate Kinase-Based Fungicidal Lead Compound

    • Sat, 08/07/2021 - 04:03
    • Journal of Agricultural and Food Chemistry
    • Target identification is one of the most important bases for novel pesticide development; pyruvate kinase (PK) was discovered as a potent fungicide target in our previous studies. To continue the PK-based fungicide development, novel isothiazole-purine derivatives were rationally designed and synthesized.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  13. Concentrations and related health risk assessment of pesticides, phthalates and heavy metals in strawberry from Shanghai, China

    • Thu, 08/05/2021 - 04:03
    • Journal of Food Protection
    • In the present study, a risk assessment of pesticides, phthalates and heavy metals in strawberries (n = 335) in recent years was conducted by determining the out estimate dietary intake (EDI), target hazard quotient (THQ) and hazard index (HI) . 128 Pesticides, 18 phthalates and 3 heavy metals were determined in this determination.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  14. Novel Inhibitors of an Insect Pest Chitinase: Design and Optimization of 9-O-Aromatic and Heterocyclic Esters of Berberine

    • Mon, 07/05/2021 - 04:03
    • Journal of Agricultural and Food Chemistry
    • OfChi-h, a lepidopteran-exclusive glycoside hydrolase family 18 (GH18) chitinase from the agricultural insect pest Ostrinia furnacalis, is a promising molecular target candidate for pest control and management. Berberine (BER), a traditional Chinese medicine, binds to a wide variety of glycosyl hydrolases via an identical mechanism, showing potential as a pesticide lead compound. In this work, we found that BER was a moderate inhibitor of OfChi-h with a Ki of 16.1 μM.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  15. The Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant Monophasic Salmonella Typhimurium Circulating in Europe

    • Fri, 05/21/2021 - 16:00
    • Frontiers in Microbiology
    • The European epidemic monophasic variant of Salmonella enterica serovar Typhimurium (S. 1,4,[5],12:i:-) characterized by the multi locus sequence type ST34 and the antimicrobial resistance ASSuT profile has become one of the most common serovars in Europe (EU) and the United States (US). In this study, we reconstructed the time-scaled phylogeny and evolution of this Salmonella in Europe. The epidemic S.

      • Salmonella
      • Heavy Metals
      • Pesticide residues
      • Bacterial pathogens
      • Chemical contaminants
  16. Analysis of Microbiological and Chemical Hazards in Edible Insects Available to Canadian Consumers

    • Fri, 05/07/2021 - 04:02
    • Journal of Food Protection
    • Edible insects are a novel food in most countries; their popularity is growing because of their high protein/low fat content, ease of cultivation, and small environmental impact. To our knowledge, this is the first report that addresses both microbiological and chemical hazards in edible insects. Samples were collected from retail stores or purchase through e-commerce. A total of 51 samples of dried whole insects or insect powders were tested for generic Escherichia coli ( E.

      • Bacterial pathogens
      • Chemical contaminants
      • Salmonella
      • Heavy Metals
      • Pesticide residues
  17. Individual and combined hepatocytotoxicity of DDT and cadmium in vitro

    • Fri, 04/16/2021 - 18:03
    • Toxicology and Industrial Health
    • The organochlorine insecticide dichlorodiphenyltrichloroethane (DDT) and heavy metal cadmium (Cd) are widespread environmental pollutants. They are persistent in the environment and can accumulate in organisms. Although the individual toxicity of DDT and Cd has been well documented, their combined toxicity is still not clear.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  18. pH-Response Quantum Dots with Orange–Red Emission for Monitoring the Residue, Distribution, and Variation of an Organophosphorus Pesticide in an Agricultural Crop

    • Tue, 03/02/2021 - 04:02
    • Journal of Agricultural and Food Chemistry
    • Development of simple, sensitive, and reliable fluorescence sensors for monitoring the residue, distribution, and variation of organophosphorus pesticides (OPs) in agricultural crops is highly urgent but remains challenging, which is ascribed to deprivation of an ideal fluorophore and ingenious detection strategy.

      • Pesticide residues
      • Heavy Metals
      • Chemical contaminants
  19. Plasmid-Mediated Ampicillin, Quinolone, and Heavy Metal Co-Resistance among ESBL-Producing Isolates from the Yamuna River, New Delhi, India

    • Fri, 11/20/2020 - 00:00
    • Antibiotics
    • Antibiotic resistance is one of the major current global health crises. Because of increasing contamination with antimicrobials, pesticides, and heavy metals, the aquatic environment has become a hotspot for emergence, maintenance, and dissemination of antibiotic and heavy metal resistance genes among bacteria.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  20. Metagenomic Analysis Reveals Bacterial and Fungal Diversity and Their Bioremediation Potential From Sediments of River Ganga and Yamuna in India

    • Fri, 10/16/2020 - 16:00
    • Frontiers in Microbiology
    • In this study, we report the presence of a microbial community of bioremediation potential in terms of relative abundance and taxonomic biodiversity in sediment samples of river Ganga and Yamuna, India at nine different sites. Metagenomic libraries were constructed using TruSeq Nano DNA Library Prep Kit and sequenced on NextSeq 500 by Illumina Next Generation Sequencing (NGS) technology.

      • Chemical contaminants
      • Heavy Metals
      • Pesticide residues
  21. Synthesis and Insecticidal Activity Evaluation of Virtually Screened Phenylsulfonamides

    • Fri, 10/09/2020 - 04:03
    • Journal of Agricultural and Food Chemistry
    • The fastest and most effective way to control pests is to use pesticides. However, with the accumulation of pesticide resistance and the difficulties of rapidly producing new pesticides, it is of great significance to create new pesticides through new synthetic methods. In this study, we report a computer-aided drug design (CADD)-assisted method to obtain two lead sulfonamides by homology modeling and virtual screening.

      • Chemical contaminants
      • Heavy Metals
      • Pesticide residues
  22. Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents

    • Tue, 08/11/2020 - 04:02
    • Journal of Agricultural and Food Chemistry
    • Plant diseases caused by viruses and fungi have posed a serious threat to global agricultural production. The discovery of new leads based on natural products is an important way to innovate pesticides. In this work, natural product luotonin A was found to have good antiviral activity against tobacco mosaic virus (TMV) for the first time. A series of luotonin A derivatives were designed, synthesized, and evaluated for their antiviral activities and fungicidal activities systematically.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  23. Design, Synthesis, and Bioactivity of a-Ketoamide Derivatives Bearing a Vanillin Skeleton for Crop Diseases

    • Sun, 06/28/2020 - 04:03
    • Journal of Agricultural and Food Chemistry
    • A series of novel α-ketoamide derivatives bearing a vanillin skeleton were designed and synthesized. Bioactivity tests on virus and bacteria were performed.

      • Heavy Metals
      • Pesticide residues
      • Chemical contaminants
  24. The Broad-Scale Analysis of Metals, Trace Elements, Organochlorine Pesticides and Polycyclic Aromatic Hydrocarbons in Wetlands Along an Urban Gradient, and the Use of a High Trophic Snake as a Bioindicator

    • Tue, 03/03/2020 - 03:15
    • Archives of Environmental Contamination and Toxicology
    • Wetlands and their biodiversity are constantly threatened by contaminant pollution from urbanisation. Despite evidence suggesting that snakes are good bioindicators of environmental health, the bioaccumulation of contaminants in reptiles is poorly researched in Australia.

      • Chemical contaminants
      • Heavy Metals
      • Pesticide residues
  25. Food safety hazards in the European seaweed chain

    • Thu, 01/30/2020 - 03:28
    • Comprehensive Reviews in Food Science and Food Safety
    • Seaweed is a source of protein that can help overcome the anticipated challenges of a growing world population and the current challenges for finding alternatives for animal proteins in the Western diet. Thus far, data on the safety of seaweed for feed and food purposes in the Western world are scattered.

      • Hepatitis
      • Heavy Metals
      • Pesticide residues
      • Dioxins
      • Bacterial pathogens
      • Norovirus
      • Salmonella
      • Chemical contaminants
      • Viruses