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U.S. Department of Agriculture
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  3. Research Publications (Food Safety)

Research Publications (Food Safety)

This page tracks research articles published in national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. Research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies (requires login) and FDA Grant Funding Agencies (requires login) are also tracked in Scopus.

Displaying 1 - 25 of 230

  1. Epigenome-wide perspective of cadmium-associated DNA methylation and its mediation role in the associations of cadmium with lipid levels and dyslipidemia risk

    • Food and Chemical Toxicology

    • Background 

      Studies demonstrated the associations of cadmium (Cd) with lipid levels and dyslipidemia risk, but the mechanisms involved need further exploration.

      Objectives

      • Chemical contaminants
      • Heavy Metals

  2. Toxicity assessment of lead, nickel and cadmium on zebra fish augmented with Bacillus xiamenensis VITMSJ3: An insight on the defense mechanism against oxidative stress due to heavy metals

    • Food and Chemical Toxicology

    • Increase urbanization in recent years has let to discharge of heavy metals into the environment which has caused severe impacts on soil as well as water.

      • Chemical contaminants
      • Heavy Metals

  3. Gestational cadmium exposure disrupts fetal liver development via repressing estrogen biosynthesis in placental trophoblasts

    • Food and Chemical Toxicology

    • Cadmium (Cd), commonly found in diet and drinking water, is known to be harmful to the human liver. Nevertheless, the effects and mechanisms of gestational Cd exposure on fetal liver development remain unclear.

      • Chemical contaminants
      • Heavy Metals

  4. The contribution of cacao consumption to the bioaccessible dietary cadmium exposure in the Belgian population

    • Food and Chemical Toxicology

    • Since 2019, EU limits apply to cadmium (Cd) concentrations in cacao-derived food products. The dietary risk assessment leading to that regulation used consumption surveys aggregated to a limited number of chocolate product categories and did not consider differences in Cd bioaccessibility. Here, the cacao-related dietary Cd exposure in the Belgian population was estimated with higher resolution and accounting for bioaccessibility.

      • Chemical contaminants
      • Heavy Metals

  5. Antioxidant activity and protective effect of the outer scales hydroalcoholic extract of Allium cepa L. var. Tropea on toxicity damage induced by Cadmium in Caco-2 cells

    • Food and Chemical Toxicology

    • The characterization of bioactive metabolites and the protective effects against Cadmium (Cd) of the hydroalcoholic extract from Allium cepa var. Tropea (Tropea red onion) in human Caco-2 colon adenocarcinoma cells and in vitro antioxidant effects were investigated. Tropea red onion extract showed high levels of bioactive compounds and a strong activity as radical scavenger and inhibitor of lipid peroxidation.

      • Chemical contaminants
      • Heavy Metals

  6. Lactobacillus plantarum WSJ-06 alleviates neurobehavioral injury induced by lead in mice through the gut microbiota

    • Food and Chemical Toxicology

    • Chronic lead exposure can result in cognitive dysfunction and behavioral disorders. However, the current treatments for alleviating lead poisoning have many side effects. Previous studies have suggested that probiotics may have the potential to ameliorate neurotoxicity caused by lead exposure.

      • Chemical contaminants
      • Heavy Metals

  7. Trivalent arsenic impairs the effector response of human CD4+ and CD8+ T cells to influenza A virus ex vivo

    • Food and Chemical Toxicology

    • Arsenic is a persistent environmental contaminant that humans are exposed to primarily through contaminated water supplies. Arsenic has been shown to have numerous immunomodulatory effects, including deleterious effects on T cell function. However, the effect of arsenic on human T cell function in the context of influenza infection remains poorly characterized.

      • Chemical contaminants
      • Heavy Metals

  8. Maternal genetic effect on apoptosis of ovarian granulosa cells induced by cadmium

    • Food and Chemical Toxicology

    • To investigate the maternal genetic effects of cadmium (Cd) -induced apoptotic in ovarian granulosa cells (OGCs). Herein, pregnant Sprague-Dawley (SD) rats were treated with CdCl2 from day 1 to day 20, F1 and F2 female rats were mated with untreated males to produce F2 and F3 generations. Under this model, significant apoptotic changes were observed in F1 OGCs induced by Cd (Liu et al., 2021).

      • Chemical contaminants
      • Heavy Metals

  9. Cadmium induces the expression of Interleukin-6 through Heme Oxygenase-1 in HK-2 cells and Sprague-Dawley rats

    • Food and Chemical Toxicology

    • Cadmium is toxic to the kidney through mechanisms involving oxidative stress and inflammation. We studied reciprocal crosstalk among the oxidative stress, inflammation, and the nuclear Nrf2 pathway in cadmium-induced nephrotoxicity on HK-2 human renal proximal tubular epithelial cells.

      • Chemical contaminants
      • Heavy Metals

  10. Occurrence and human health risk assessment of mineral elements and pesticides residues in bee pollen

    • Food and Chemical Toxicology

    • Bee pollen contains a diversity of bioactive components. Nevertheless, since pollen is retrieved from a variety of plants, including the cultivated ones which are subjected to agrochemical treatments, its contamination is unavoidable. In this context, 45 samples of pollen were analysed with optimized analytical methods for trace and macro elements (ICP-MS), pesticides and metabolites residues (LC & GC-MS/MS) content.

      • Chemical contaminants
      • Pesticide residues

  11. Arsenic and toxic metals in meat and fish consumed in Niger delta, Nigeria: Employing the margin of exposure approach in human health risk assessment

    • Food and Chemical Toxicology
      • Chemical contaminants
      • Heavy Metals

  12. Disruption of developmental programming with long-term consequences after exposure to a glyphosate-based herbicide in a rat model

    • Food and Chemical Toxicology
      • Chemical contaminants
      • Pesticide residues

  13. Membrane polarization in non-neuronal cells as a potential mechanism of metabolic disruption by depolarizing insecticides

    • Food and Chemical Toxicology
      • Chemical contaminants
      • Pesticide residues

  14. Ubiquitinated gasdermin D mediates arsenic-induced pyroptosis and hepatic insulin resistance in rat liver

    • Food and Chemical Toxicology
      • Chemical contaminants
      • Heavy Metals

  15. Hemoglobin adducts of acrylamide in human blood – What has been done and what is next?

    • Food and Chemical Toxicology

    • Author(s): Marie Pedersen, Efstathios Vryonidis, Andrea Joensen, Margareta Törnqvist

      • Chemical contaminants

  16. Bisphenol A induces pyroptotic cell death via ROS/NLRP3/Caspase-1 pathway in osteocytes MLO-Y4

    • Food and Chemical Toxicology

    • Author(s): Yun Zhang, Ming Yan, Weiyan Shan, Tao Zhang, Yunchen Shen, Ruirong Zhu, Jian Fang, Hongjiao Mao

      • Chemical contaminants

  17. Gestational exposure to acrylamide suppresses luteal endocrine function through dysregulation of ovarian angiogenesis, oxidative stress and apoptosis in mice

    • Food and Chemical Toxicology

    • Author(s): Dainan Yu, Xun Jiang, Wenjing Ge, Bo Qiao, Dalei Zhang, Hui Liu, Haibin Kuang

      • Chemical contaminants

  18. Integrating in silico with in vivo approach to investigate phthalate and bisphenol A mixture-linked asthma development: Positive probiotic intervention

    • Food and Chemical Toxicology

    • Author(s): Katarina Baralić, Dragica Bozic, Katarina Živančević, Milan Milenković, Dragana Javorac, Đurđica Marić, Evica Antonijević Miljaković, Aleksandra Buha Djordjevic, Predrag Vukomanović, Marijana Ćurčić, Zorica Bulat, Biljana Antonijević, Danijela Đukić-Ćosić

      • Chemical contaminants

  19. Blumea laciniata protected Hep G2 cells and Caenorhabditis elegans against acrylamide-induced toxicity via insulin/IGF-1 signaling pathway

    • Food and Chemical Toxicology

    • Author(s): Lijun Zhou, Siyuan Luo, Xiaoju Wang, Yiling Zhou, Yuan Zhang, Shuai Zhu, Tao Chen, Shiling Feng, Ming Yuan, Chunbang Ding

      • Chemical contaminants

  20. Effects of bisphenol A on the proliferation, migration, and tumor growth of colon cancer cells: In vitro and in vivo evaluation with mechanistic insights related to ERK and 5-HT3

    • Food and Chemical Toxicology

    • Author(s): Ji Hae Jun, Ju Eun Oh, Jae-Kwang Shim, Young-Lan Kwak, Jin Sun Cho

      • Chemical contaminants

  21. MiR-182–5p/TLR4/NF-κB axis contributes to the protective effect of caffeic acid phenethyl ester against cadmium-induced spleen toxicity and associated damage in mice

    • Food and Chemical Toxicology

    • Author(s): Rili Hao, Yang Jiang, Feng Li, Dongxiao Sun-Waterhouse, Dapeng Li

      • Chemical contaminants
      • Heavy Metals

  22. Bisphenol A single and repeated treatment increases HDAC2, leading to cholinergic neurotransmission dysfunction and SN56 cholinergic apoptotic cell death through AChE variants overexpression and NGF/TrkA/P75NTR signaling disruption

    • Food and Chemical Toxicology

    • Author(s): Paula Moyano, Andrea Flores, Jimena García, José Manuel García, María José Anadon, María Teresa Frejo, Emma Sola, Adela Pelayo, Javier del Pino

      • Chemical contaminants

  23. Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in food and human dietary intake: An update of the scientific literature

    • Food and Chemical Toxicology

    • Author(s): Neus González, José L. Domingo

      • Chemical contaminants
      • Dioxins

  24. Acrylamide-derived DNA adducts in human peripheral blood mononuclear cell DNA: Correlation with body mass

    • Food and Chemical Toxicology

    • Author(s): Melanie Hemgesberg, Simone Stegmüller, Alexander Cartus, Selina Hemmer, Michael Püttmann, Jean-Pierre Stockis, Dieter Schrenk

      • Chemical contaminants

  25. Bisphenol A exposure during the embryonic period: Insights into dopamine relationship and behavioral disorders in Drosophila melanogaster

    • Food and Chemical Toxicology

    • Author(s): Elize Aparecida Santos Musachio, Shanda de Freitas Couto, Marcia Rósula Poetini, Vandreza Cardoso Bortolotto, Mustafa Munir Mustafa Dahleh, Dieniffer Espinosa Janner, Stífani Machado Araujo, Bruna Piaia Ramborger, Rafael Rohers, Gustavo Petri Guerra, Marina Prigol

      • Chemical contaminants