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Research Publications (Food Safety)

This page tracks research articles published in national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. Research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies (requires login) and FDA Grant Funding Agencies (requires login) are also tracked in Scopus.

Displaying 101 - 125 of 665

  1. Application of non-target analysis and high resolution mass spectrometry for the identification of thermal transformation products of oxytetracycline in pacific white shrimp

    • Oxytetracycline is an antibiotic authorized for use in aquaculture and is often detected in seafood products, especially shrimp. Previous studies investigating the fate of oxytetracycline in shrimp tissues after cooking were limited to quantification of parent compound residues, and did not describe any potential transformation products formed. Hence, the main objective of this study was to apply a non-target analysis workflow to study the fate of oxytetracycline in shrimp muscle.

      • Chemical contaminants
      • Antibiotic residues
  2. Antimicrobial Resistance Development Pathways in Surface Waters and Public Health Implications

    • Antibiotics
    • Human health is threatened by antibiotic-resistant bacteria and their related infections, which cause thousands of human deaths every year worldwide. Surface waters are vulnerable to human activities and natural processes that facilitate the emergence and spread of antibiotic-resistant bacteria in the environment. This study evaluated the pathways and drivers of antimicrobial resistance (AR) in surface waters.

      • Chemical contaminants
      • Antibiotic residues
  3. Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition

    • mSystems
    • mSystems, Ahead of Print. Antibiotics used as growth promoters in livestock and animal husbandry can be detected in animal-derived food. Epidemiological studies have indicated that exposure to these antibiotic residues in food may be associated with childhood obesity. Herein, the effect of exposure to a residual dose of tylosin—an antibiotic growth promoter—on host metabolism and gut microbiota was explored in vivo.

      • Chemical contaminants
      • Antibiotic residues
  4. Protein-Ligand Identification and In Vitro Inhibitory Effects of Cathine on 11 Major Human Drug Metabolizing Cytochrome P450s

    • International Journal of Toxicology
    • Cathine is the stable form of cathinone, the major active compound found in khat (Catha edulis Forsk) plant. Khat was found to inhibit major phase I drug metabolizing cytochrome P450 (CYP) enzyme activities in vitro and in vivo. With the upsurge of khat consumption and the potential use of cathine to combat obesity, efforts should be channelled into understanding potential cathine-drug interactions, which have been rather limited.

      • Chemical contaminants
      • Antibiotic residues
  5. Novel Quorum Quenching YtnP Lactonase From Bacillus paralicheniformis Reduces Pseudomonas aeruginosa Virulence and Increases Antibiotic Efficacy in vivo

    • Frontiers in Microbiology
    • Bacterial infections have become increasingly difficult to treat due to the occurrence of antibiotic-resistant strains. A promising strategy to increase the efficacy of therapy is to combine antibacterials with agents that decrease pathogen virulence via the modulation of the quorum sensing (QS). Lactonases inhibit acylated homoserine lactone (AHL)-mediated QS in Gram-negative bacteria, including the leading nosocomial pathogen Pseudomonas aeruginosa.

      • Chemical contaminants
      • Antibiotic residues
  6. The Role of Probiotics in Alleviating Postweaning Diarrhea in Piglets From the Perspective of Intestinal Barriers

    • Frontiers in Cellular and Infection Microbiology
    • Early weaning of piglets is an important strategy for improving the production efficiency of sows in modern intensive farming systems. However, due to multiple stressors such as physiological, environmental and social challenges, postweaning syndrome in piglets often occurs during early weaning period, and postweaning diarrhea (PWD) is a serious threat to piglet health, resulting in high mortality.

      • Chemical contaminants
      • Antibiotic residues
  7. Targeting the Plasmodium falciparum’s Thymidylate Monophosphate Kinase for the Identification of Novel Antimalarial Natural Compounds

    • Frontiers in Cellular and Infection Microbiology
    • Recent reports of resistance to artemisinin-based combination drugs necessitate the need to discover novel antimalarial compounds. The present study was aimed at identifying novel antimalarial compounds from natural product libraries using computational methods. Plasmodium falciparum is highly dependent on the pyrimidine biosynthetic pathway, a de novo pathway responsible for the production of pyrimidines, and the parasite lacks the pyrimidine salvage enzymes. The P.

      • Chemical contaminants
      • Antibiotic residues
      • Heavy Metals
  8. Rational Framework for the design of Trp- and Arg-rich peptide antibiotics against multidrug-resistant bacteria

    • Frontiers in Microbiology
    • The threat of antibiotic resistance warrants the discovery of agents with novel antimicrobial mechanisms. Antimicrobial peptides (AMPs) directly disrupting bacterial membranes may overcome resistance to traditional antibiotics. AMP development for clinical use has been mostly limited to topical application to date.

      • Chemical contaminants
      • Antibiotic residues
  9. Monitoring and detection of antibiotic residues in animal derived foods: Solutions using aptamers

    • Trends in Food Science & Technology
    • Background

      • Chemical contaminants
      • Antibiotic residues
  10. Antimicrobial Peptides Controlling Resistant Bacteria in Animal Production

    • Frontiers in Microbiology
    • In the last few decades, antimicrobial resistance (AMR) has been a worldwide concern. The excessive use of antibiotics affects animal and human health. In the last few years, livestock production has used antibiotics as food supplementation. This massive use can be considered a principal factor in the accelerated development of genetic modifications in bacteria. These modifications are responsible for AMR and can be widespread to pathogenic and commensal bacteria.

      • Chemical contaminants
      • Antibiotic residues
  11. An Evolutionary Conservation and Druggability Analysis of Enzymes Belonging to the Bacterial Shikimate Pathway

    • Antibiotics
    • Enzymes belonging to the shikimate pathway have long been considered promising targets for antibacterial drugs because they have no counterpart in mammals and are essential for bacterial growth and virulence.

      • Chemical contaminants
      • Antibiotic residues
  12. Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1

    • Antibiotics
    • Due to their rapid evolution and their impact on healthcare, beta-lactamases, protein degrading beta-lactam antibiotics, are used as generic models of protein evolution. Therefore, we investigated the mutation effects in two distant beta-lactamases, TEM-1 and CTX-M-15. Interestingly, we found a site with a complex pattern of genetic interactions. Mutation G251W in TEM-1 inactivates the protein’s function, just as the reciprocal mutation, W251G, does in CTX-M-15.

      • Chemical contaminants
      • Antibiotic residues
  13. In vitro oxidation promoted by sarafloxacin antibiotic residues on myosin and chicken meat proteins

    • Journal of Food Composition and Analysis
    • Fluoroquinolones are widely employed to treat or prevent respiratory diseases in poultry, and their residues could be present even after slaughtering. Thus, this study aimed to assess the oxidative effect of fluoroquinolones on myosin and chicken meat proteins under in vitro conditions, using proteomics and peptidomics approaches.

      • Chemical contaminants
      • Antibiotic residues
  14. Development of 1,3,4-Oxadiazole Derived Antifungal Agents and Their Application in Maize Diseases Control

    • Frontiers in Plant Science
    • Maize is an important food crop and its fungal disease has become a limiting factor to improve the yield and quality of maize. In the control of plant pathogens, commercial fungicides have no obvious effect on corn diseases due to the emergence of drug resistance. Therefore, it is of great significance to develop new fungicides with novel structure, high efficiency, and low toxicity to control maize diseases.

      • Chemical contaminants
      • Antibiotic residues
      • Pesticide residues
  15. Inspection of antimicrobial remains in bovine milk in Egypt and Saudi Arabia employing a bacteriological test kit and HPLC-MS/MS with estimation of risk to human health

    • PLOS ONE
    • by Nora H. Al-Shaalan, Jenny Jeehan Nasr, Shereen Shalan, Areej M. El-Mahdy Veterinary medicine uses antibiotics randomly for treatment and growth promotion. Milk of dairy animals contains substantial quantities of antibiotics that have harmful effects on health. It is therefore necessary to test commercially available milk using immunological, chromatographic, or microbiological methods to confirm the absence of antibiotic residues.

      • Chemical contaminants
      • Antibiotic residues
  16. Knowledge, Attitudes, and Risk Perception of Broiler Grow-Out Farmers on Antimicrobial Use and Resistance in Oyo State, Nigeria

    • Antibiotics
    • Assessing knowledge, attitudes, and risk perception of Nigerian broiler grow-out farmers (n = 152) to antimicrobial resistance (AMR) with a five sectional purposive-structured-questionnaire: demographics; knowledge; attitudes; risk-perception; and response to regulation of antimicrobial practices. Data were analyzed using descriptive statistics, chi-square test, and binary logistic regression.

      • Chemical contaminants
      • Antibiotic residues
  17. A simple method to determine changes in the affinity between HisF and HisH in the Imidazole Glycerol Phosphate Synthase heterodimer

    • PLOS ONE
    • by Vitor M. Almeida, J. Patrick Loria, Sandro R. Marana The bi-enzyme HisF-HisH heterodimer is part of the pathway that produces histidine and purines in bacteria and lower eukaryotes, but it is absent in mammals. This heterodimer has been largely studied probing the basis of the allosteric effects and the structural stability in proteins. It is also a potential target for antibacterial drugs.

      • Chemical contaminants
      • Antibiotic residues
  18. SspH, a Novel HATPase Family Regulator, Controls Antibiotic Biosynthesis in Streptomyces

    • Antibiotics
    • Streptomyces can produce a wealth of pharmaceutically valuable antibiotics and other bioactive compounds. Production of most antibiotics is generally low due to the rigorously controlled regulatory networks, in which global/pleiotropic and cluster-situated regulatory proteins coordinate with various intra- and extracellular signals.

      • Chemical contaminants
      • Antibiotic residues
      • Pesticide residues
  19. 29 Nutritional Interventions for Intestinal Health of Nursery Pigs: Carbohydrates

    • Journal of Animal Science
    • In swine production, using feed antibiotics as antimicrobial growth promotants has been reduced; thus, feed alternatives to manage gut health are required to prevent post-weaning diarrhea. Dietary fiber, resistant starch, oligosaccharides, and exopolysaccharides are carbohydrates that together with glycoproteins are nutritional tools that may be part of managing gut health in pigs.

      • Chemical contaminants
      • Antibiotic residues
  20. 11 Determination of Milk Concentrations and Pharmacokinetics of Salicylic Acid Following Acetylsalicylic Acid (Aspirin) Administration in Postpartum Dairy Cows

    • Journal of Animal Science
    • Administration of non-steroidal anti-inflammatory drugs, such as the widely available drug aspirin, or acetylsalicylic acid (ASA), may improve health and milk production in postpartum dairy cows. However, plasma pharmacokinetic (PK) data for salicylic acid (SA), the active metabolite of ASA, are unrepresentative of lactating dairy cows and current treatment regimens, and there are currently no published milk residue and minimal pharmacodynamic data available for ASA or SA in dairy cows.

      • Chemical contaminants
      • Antibiotic residues
  21. Rapid Detection and Prediction of Norfloxacin in Fish Using Bimetallic Au@Ag Nano-Based SERS Sensor Coupled Multivariate Calibration

    • Food Analytical Methods
    • Norfloxacin is an antibiotic in the fluoroquinolone family licenced for use in animals. However, residues in animal products can have negative consequences for consumers. As a result, residue detection in various food matrices must be considered. Norfloxacin accumulates in animal-derived foods, causing deleterious consequences in humans such as foetal deformity, renal failure and drug resistance.

      • Chemical contaminants
      • Antibiotic residues
  22. Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview

    • Antibiotics
    • Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial cell membrane and periplasm and remove diverse extraneous substrates, including antimicrobials, organic solvents, toxic heavy metals, etc., from bacterial cells.

      • Chemical contaminants
      • Antibiotic residues
  23. HIV Capsid Protein Genetic Diversity Across HIV-1 Variants and Impact on New Capsid-Inhibitor Lenacapavir

    • Frontiers in Microbiology
    • The HIV p24 capsid protein has an essential, structural, and functional role in the viral replication cycle, being an interesting target for vaccine design, diagnostic tests, and new antiretroviral drugs (ARVs). The HIV-1 variability poses a challenge for the accuracy and efficiency of diagnostic and treatment tools. This study analyzes p24 diversity among HIV-1 variants and within its secondary structure in HIV-1 M, O, P, and N groups.

      • Chemical contaminants
      • Antibiotic residues
  24. Phenolic Compound Ethyl 3,4-Dihydroxybenzoate Retards Drug Efflux and Potentiates Antibiotic Activity

    • Antibiotics
    • The World Health Organization indicated that antibiotic resistance is one of the greatest threats to health, food security, and development in the world. Drug resistance efflux pumps are essential for antibiotic resistance in bacteria. Here, we evaluated the plant phenolic compound ethyl 3,4-dihydroxybenzoate (EDHB) for its efflux pump inhibitory (EPI) activity against drug-resistant Escherichia coli.

      • Chemical contaminants
      • Antibiotic residues
  25. Long-Term Exposure to the Water of Wadi El-Rayan Lakes Induced Testicular Damage and Endocrine Disruption in Mugil cephalus

    • Bulletin of Environmental Contamination and Toxicology
    • This study aimed to investigate the testicular function of Mugil cephalus that inhabit Wadi El-Rayan lakes. Testes of fish inhabiting the upper lake (site 2) and the lower lake (site 3) of Wadi El-Rayan showed significant decreases in gonadosomatic index, high accumulation levels of six metals, and eight organochlorine pesticide residues.

      • Chemical contaminants
      • Antibiotic residues
      • Pesticide residues