An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Research Publications (Nutrition)

View recent food and human nutrition research articles from a selection of peer-reviewed journals. Explore publications by searching with keywords or filtering results by a journal name or nutrition category (nutrients, foods, or beverages). New articles are added daily.

Displaying 1 - 25 of 4750

  1. The effects of a green Rooibos (Aspalathus linearis) extract on metabolic parameters and adipose tissue biology in rats fed different obesogenic diets

    • Tue, 11/29/2022 - 04:00
    • Food & Function
    • Supplementation with Rooibos extract modulated metabolic markers, adipocyte size and adipose stem cell (ASC) function in rats, under different dietary conditions. This is the first in vivo/ex vivo study to demonstrate effects of Rooibos on ASCs.

      • Nutrients
  2. Urine caffeine metabolites are positively associated with cognitive performance in older adults: an analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014

    • Tue, 11/29/2022 - 04:00
    • Nutrition Research
      • Beverages
      • Nutrients
  3. Integrated lipidomic and transcriptomic analyses reveal the mechanism of large yellow croaker roe phospholipids on lipid metabolism in normal-diet mice

    • Tue, 11/29/2022 - 04:00
    • Food & Function
    • Large yellow croaker roe phospholipids were found to be able to regulate the lipid metabolism of normal-diet mice mainly through influencing the gene expression in the liver closely related to the absorption and digestion of lipids.

      • Nutrients
  4. Impact of ß-hydroxy-ß-methylbutyrate (HMB) in critically ill patients on the endocrine axis – a post-hoc cohort study of the HMB-ICU trial

    • Sun, 11/27/2022 - 04:00
    • Clinical Nutrition ESPEN
    • Background β−hydroxy-β−methylbutyrate (HMB) might improve muscle function and maintain its mass in critically ill patients. We aimed to investigate whether the administration of HMB influenced the plasma levels of growth hormone (GH)/insulin-like growth factor-1 (IGF-1), C-peptide, and 25-OH vitamin-D. Methods Post-hoc analysis of the study HMB-ICU, a randomized, placebo-controlled double-blind trial.

      • Nutrients
  5. Interplay of Broccoli/Broccoli Sprout Bioactives with Gut Microbiota in Reducing Inflammation in Inflammatory Bowel Diseases

    • Sun, 11/27/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • Inflammatory Bowel Diseases (IBD) are chronic, reoccurring, and debilitating conditions characterized by inflammation in the gastrointestinal tract, some of which can lead to more systemic complications and can include autoimmune dysfunction, a change in the taxonomic and functional structure of microbial communities in the gut, and complicated burdens in a person's daily life.

      • Foods
  6. Anti-inflammatory mechanisms of polyphenols in adipose tissue inflammation: Role of gut microbiota, intestinal barrier integrity and zinc homeostasis

    • Sun, 11/27/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • Obesity is associated with an imbalance of micro-and macro-nutrients, dysbiosis, and a “leaky” gut phenomenon. Polyphenols, such as curcumin, resveratrol, and anthocyanin may alleviate the systemic effects of obesity, potentially by improving gut microbiota, intestinal barrier integrity (IBI), and zinc homeostasis.

      • Nutrients
  7. Resveratrol alleviated 5-FU-induced cardiotoxicity by attenuating GPX4 dependent ferroptosis

    • Sun, 11/27/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • Background and purpose The clinical use of 5-fluorouracil (5-FU), a potent antitumor agent, was limited by severe cardiotoxic effects. The present study was aimed to investigate the protective effects of resveratrol (Res) on 5-FU-induced cardiotoxicity and to explore its potential mechanisms. Methods The cardiotoxicity model was intraperitoneal injection of 5-FU at the dose of 30 mg/kg for 7 consecutive days.

      • Nutrients
  8. Deep phenotyping and biomarkers of various dairy fat intakes in an 8-week randomized clinical trial and 2-year swine study

    • Sun, 11/27/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • Health effects of dairy fats (DF) are difficult to evaluate, as DF intakes are hard to assess epidemiologically and DF have heterogeneous compositions that influence biological responses.

      • Beverages
  9. Blood orange juice intake modulates plasma and PBMC microRNA expression in overweight and insulin resistance women: impact on MAPK and NFκB signaling pathways

    • Sun, 11/27/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • Blood orange consumption presents potential health benefits and may modulate epigenetic mechanisms such as microRNAs (miRNAs) expression. MiRNAs are non-coding RNAs responsible for post-transcriptional gene regulation, as well as these molecules can also be used as biomarkers in body fluids. This study aimed to investigate the effect of chronic blood orange juice (BOJ) intake on the inflammatory response and miRNA expression profile in plasma and blood cells in overweight women.

      • Beverages
      • Foods
  10. Creatine supplementation to improve the peripheral and central inflammatory profile in Cerebral Palsy

    • Sat, 11/26/2022 - 04:00
    • Clinical Nutrition ESPEN
    • This opinion paper presents a brief review on the potential use of Creatine (Cr) to improve the inflammatory profile in individuals with Cerebral Palsy (CP). CP is a condition that causes muscle atrophy followed by reduced strength and altered muscle tone. The prevalence of chronic diseases is higher in people with CP due to this, which are often associated with peripheral inflammation, but there are no studies that have evaluated central inflammation in this condition.

      • Nutrients
  11. Effects of a dietary intervention with Mediterranean vs lacto-ovo vegetarian diets on HDL function: results from the CARDIVEG study

    • Sat, 11/26/2022 - 04:00
    • Nutrition, Metabolism and Cardiovascular Diseases
    • Background and Aim HDL-cholesterol efflux capacity (CEC) has been shown to be a better cardiovascular (CVD) risk marker than serum HDL concentration. Several foods and nutrients have been shown to improve HDL functions, however no effective dietetic nor pharmacological strategy is available to increase CEC.

      • Nutrients
  12. Deep Shotgun metagenomic and 16S rRNA analysis revealed the microbial diversity of Lactic acid bacteria in traditional fermented foods of eastern Hainan, China

    • Fri, 11/25/2022 - 04:00
    • Food & Function
    • The eastern part of Hainan, China, has a flat terrain and a suitable climate with abundant sunshine and rain. The unique environment makes the tropical microbial resources of natural fermented food unique and rich.

      • Foods
      • Nutrients
  13. Plasma omega-3 fatty acids are positively associated with appendicular muscle mass index only in adults with low protein intake: Results from NHANES 2011-2012

    • Fri, 11/25/2022 - 04:00
    • Clinical Nutrition
    • Background Omega-3 (ω-3) fatty acids may indirectly increase muscle protein synthesis making the muscle more sensitive to amino acids uptake; therefore, ω-3 could promote benefits on muscle mass mainly when protein intake is low.

      • Nutrients
  14. Aspartame consumption during pregnancy impairs placenta growth in mice through sweet taste receptor-reactive oxygen species-dependent pathway

    • Fri, 11/25/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • The prevalence of obesity has risen dramatically over recent years, and so has the prevalence of adverse obesity-associated pregnancy outcomes. To combat obesity, the calorie contents of many foods and beverages may be reduced by the use of artificial sweeteners, such as aspartame. However, animal studies suggest that aspartame and its metabolites may exhibit toxicity, and the effects of aspartame on pregnancy are largely unknown.

      • Foods
  15. PERINATAL IRON DEFICIENCY CAUSES SEX-DEPENDENT ALTERATIONS IN RENAL RETINOIC ACID SIGNALING AND NEPHROGENESIS

    • Fri, 11/25/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • Long-term alterations in kidney structure and function have been observed in offspring exposed to perinatal stressors such as iron deficiency (ID), albeit the mechanism underlying this remains unclear. Here, we assessed how perinatal ID alters renal vitamin A metabolism, an important mediator of nephrogenesis, in the developing kidney.

      • Nutrients
  16. Berry consumption mitigates the hypertensive effects of a high-fat, high-sucrose diet via attenuation of renal and aortic AT1R expression resulting in improved endothelium-derived NO bioavailability

    • Fri, 11/25/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • Dysregulation of the renin-angiotensin system (RAS) is a contributor to high-fat diet-related blood pressure (BP) increases. Deleterious effects of dysregulated RAS result in an overproduction of reactive oxygen species and a decrease in endothelial nitric oxide (NO) bioavailability due to increased NADPH oxidase (NOX) expression. Dietary polyphenols have been shown to mitigate the imbalance in the redox state and protect against endothelial dysfunction induced by a high-fat diet.

      • Foods
      • Nutrients
  17. Integration of transcriptomic and proteomic analyses reveals protective mechanisms of N-acetylcysteine in indomethacin-stimulated enterocytes

    • Fri, 11/25/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • Intestinal health is critical for the growth and development of humans and animals. Our previous study has demonstrated that indomethacin (IDMT) could induce intestinal injury in piglets, and N-acetylcysteine (NAC) supplementation contributed to alleviating intestinal injury induced by various stimuli. In this study, we investigated the mechanism of IDMT-induced cell death in IPEC-1 cell lines and explored the role of NAC by using transcriptomic and proteomic analyses.

      • Nutrients
  18. Early life exposure to high fructose diet induces metabolic dysregulation associated with sex-specific cognitive impairment in adolescent rats.: Running title: impact of early life fructose diet on adolescent behavior

    • Fri, 11/25/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • The incidence of adolescent mental health disorders is on the rise. Epidemiological studies suggest that poor nutrition is a significant contributor to this public health crisis, specifically through exposure to high level of dietary sugar, including fructose, during critical periods of development. Previous studies have shown that elevated fructose exposure during adolescence disrupts mental health.

      • Nutrients
  19. Dietary selenomethionine attenuates obesity by enhancing beiging process in white adipose tissue

    • Fri, 11/25/2022 - 04:00
    • The Journal of Nutritional Biochemistry
    • Imbalanced nutrient intake causes abnormal energy metabolism, which results in obesity. There is feasible evidence that selenium-rich (Se-rich) foods may alleviate obesity and enhance general public health, but the underlying mechanisms remain elusive. Herein we examined the effect of Se supplementation on white adipose tissue beiging process.

      • Nutrients
  20. Protective effects of Lycium barbarum L. berry extracts against oxidative stress-induced damages on the retina of aging mouse and ARPE-19 cells

    • Fri, 11/25/2022 - 04:00
    • Food & Function
    • In this study, we investigated the preventive effect of L. barbarum berry extract on age-related macular degeneration (AMD) and its main material basis for antioxidant activity. An AMD mice model was developed by feeding 18-month-old mice with a 1% hydroquinone diet. Meanwhile, the model mice were treated with water extract (LBW) and alcohol extract (LBE) of L. barbarum berry respectively for 3 months.

      • Foods
      • Nutrients
  21. Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide

    • Fri, 11/25/2022 - 04:00
    • Food & Function
    • The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years. In this study, a homogeneous polysaccharide, PCP1, was extracted from P. cyrtonema Hua rhizomes and purified. Monosaccharide composition analysis showed that PCP1 is primarily composed of fructose, glucose, and mannose.

      • Beverages
      • Nutrients
  22. Formation of Amadori compounds in LIGAO (concentrated pear juice) processing and the effects of Fru-Asp on cough relief and lung moisturization in mice

    • Fri, 11/25/2022 - 04:00
    • Food & Function
    • LIGAO (concentrated pear juice) has been used for more than 1000 years to treat respiratory complaints such as cough and expectoration in China, but the study of the mechanism of its antitussive effects and ability to moisten the lungs is limited. This study found that the content of Amadori compounds (ACs) and other nutrients changed during LIGAO processing.

      • Beverages
      • Foods
  23. Curcumol Inhibited Breast Cancer Growth Via NCL/ERα36 and PI3K/AKT Pathway

    • Thu, 11/24/2022 - 04:00
    • Food & Function
    • Background: Breast cancer (BC) is the most common malignancy worldwide. ERα36 (ERα66 variant) is expressed in many breast cancer cells, especially highly expressed in tamoxifen (TAM)-resistant cell lines and triple-negative breast cancer and our previous work revealed that nucleolin (NCL) is a protein target of curcumol.

      • Nutrients
  24. The modulatory effect of encapsulated bioactives and probiotics on gut microbiota: Improving health status through functional food.

    • Thu, 11/24/2022 - 04:00
    • Food & Function
    • The gut microbiota can be a determining factor of the health status of the host by its association with some diseases. It is known that dietary intake can modulate this microbiota through the consumption of compounds like essential oils, unsaturated fatty acids, non-digestible fiber, and probiotics, among others. However, these kinds of compounds can be damaged in the gastrointestinal tract as they pass through it to reach the intestine.

      • Foods
      • Nutrients
  25. Anti-obesity effects of red pepper (Capsicum annuum L.) leaf extract on 3T3-L1 preadipocytes and high fat diet-fed mice

    • Thu, 11/24/2022 - 04:00
    • Food & Function
    • Patients with the obesity mostly have metabolic syndrome and can lead to multiple health problems. In the present study evaluated the anti-obesity effect of water-soluble pepper leaf extract (PLE) on 3T3-L1 adipocytes and high-fat diet (HFD)-fed mice. The adipocyte lipid content was determined using Oil Red O staining, which revealed that 100 μg/mL PLE markedly reduced fat accumulation without affecting cell viability.

      • Foods
      • Nutrients