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Research Publications (Food Safety)

The Food Safety Publications tracks research that is published across national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. The research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies and FDA Grant Funding Agencies are also tracked.

Displaying 1 - 25 of 2008

  1. Effect of the Combined Compound Probiotics with Glycyrrhinic Acid on Alleviating Cytotoxicity of IPEC-J2 Cells Induced by Multi-Mycotoxins

    • Tue, 09/27/2022 - 04:00
    • Toxins
    • Aflatoxins B1 (AFB1), deoxynivalenol (DON) and zearalenone (ZEA) are the three most prevalent mycotoxins, whose contamination of food and feed is a severe worldwide problem.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  2. Intraspecific Growth and Aflatoxin Inhibition Responses to Atoxigenic Aspergillus flavus: Evidence of Secreted, Inhibitory Substances in Biocontrol

    • Tue, 09/27/2022 - 04:00
    • Phytopathology®
    • The fungus Aspergillus flavus infects corn, peanut, and cottonseed, and contaminates seeds with acutely poisonous and carcinogenic aflatoxin. Aflatoxin contamination is a perennial threat in tropical and subtropical climates. Nonaflatoxin-producing isolates (atoxigenic) are deployed in fields to mitigate aflatoxin contamination. The biocontrol competitively excludes toxigenic A. flavus via direct replacement and thigmoregulated (touch) toxin inhibition mechanisms.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  3. An Aflatoxin-M1 biochip using graphene quantum dot-gold hybrid nanoparticles

    • Sun, 09/25/2022 - 04:00
    • Food Chemistry
    • Toxicosis through food and feed has remained a point of concern to food sectors across the globe. Although strict regulations have been implemented in developed and developing countries, their detection in food matrices is an evolving science. This study focuses on the development and fabrication of an electrochemical microfluidic biosensor that deploys aptamers to detect trace concentrations of Aflatoxin-M1 (AF-M1) in milk samples.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  4. Effects of Compound Mycotoxin Detoxifier on Alleviating Aflatoxin B1-Induced Inflammatory Responses in Intestine, Liver and Kidney of Broilers

    • Sun, 09/25/2022 - 04:00
    • Toxins
    • In order to alleviate the toxic effects of aflatoxins B1 (AFB1) on inflammatory responses in the intestine, liver, and kidney of broilers, the aflatoxin B1-degrading enzyme, montmorillonite, and compound probiotics were selected and combined to make a triple-action compound mycotoxin detoxifier (CMD). The feeding experiment was divided into two stages.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  5. High speed homogenization assisted encapsulation of synergistic essential oils formulation: Characterization, in vitro release study, safety profile, and efficacy towards mitigation of aflatoxin B1 induced deterioration in rice samples

    • Sun, 09/25/2022 - 04:00
    • Food and Chemical Toxicology
    • Application of essential oils to mitigate aflatoxin B1 (AFB1) contamination in food is a current research hotspot; however, their direct incorporation may cause toxic effects, and changes in food organoleptic properties.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  6. Prediction of Aspergillus parasiticus inhibition and aflatoxin mitigation in red pepper flakes treated by pulsed electric field treatment using machine learning and neural networks

    • Sat, 09/24/2022 - 04:00
    • Food Research International
    • Presence of aflatoxins in agricultural products is a worldwide problem. Because of their high heat stability and resistance to most of the food processing technologies, aflatoxin degradation is still a big challenge.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  7. Inhibition of Essential Oils on Growth of Aspergillus flavus and Aflatoxin B1 Production in Broth and Poultry Feed

    • Fri, 09/23/2022 - 04:00
    • Toxins
    • Aflatoxin B1 (AFB1), a common contaminant in food and feed during storage, does great harm to human and animal health. Five essential oils (thymol, carvacrol, cinnamaldehyde, eugenol, and citral) were tested for their inhibition effect against Aspergillus flavus (A. flavus) in broth and feed. Cinnamaldehyde and citral were proven to be most effective against A. flavus compared to others and have a synergistic effect when used simultaneously.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  8. Effects of Zearalenone on Production Performance, Egg Quality, Ovarian Function and Gut Microbiota of Laying Hens

    • Thu, 09/22/2022 - 04:00
    • Toxins
    • Zearalenone (ZEN) is a ubiquitous contaminant in poultry feed, since ZEN and its metabolites can interfere with estrogen function and affect the reproductive ability of animals. The estrogen-like effect of ZEN on mammal is widely reported, while little information is available, regarding the effect of relatively low dose of ZEN on estrogen function and production performance of laying hens, and the relationship between them.

      • Natural toxins
      • Mycotoxins
  9. Development and Validation of LC-Q-TOF-MS Methodology to Determine Mycotoxin Biomarkers in Human Urine

    • Wed, 09/21/2022 - 04:00
    • Toxins
    • Mycotoxin contamination of foodstuffs is a health concern worldwide and monitoring human exposure to mycotoxins is a key concern. Most mycotoxins and their metabolites are excreted in urine, but a reliable detection method is required, considering the low levels present in this biological sample.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  10. Unveiling ochratoxin a controlling and biodetoxification molecular mechanisms: Opportunities to secure foodstuffs from OTA contamination

    • Wed, 09/21/2022 - 04:00
    • Food and Chemical Toxicology
    • Anarchic growth of ochratoxin A (OTA) producing fungi during crop production, prolonged storage, and processing results in OTA contamination in foodstuffs. OTA in food exacerbates the risk of health and economic problems for consumers and farmers worldwide. Although the toxic effects of OTA on human health have not been well established, comprehensive preventive and remedial measures will be essential to eliminate OTA from foodstuffs.

      • Natural toxins
      • Mycotoxins
  11. Investigation of ochratoxin A in commercial cheeses and pork meat products by liquid chromatography–tandem mass spectrometry

    • Wed, 09/21/2022 - 04:00
    • Journal of Food Science
    • Journal of Food Science, EarlyView. Ochratoxin A (OTA) is a mycotoxin produced by several species of Aspergillus and Penicillium and commonly detected in a wide range of foodstuffs. The purpose of this work was to monitor the presence of OTA in cheeses and pork meat products.

      • Natural toxins
      • Mycotoxins
  12. Human exposure to ochratoxin A and its natural occurrence in spices marketed in Chile (2016–2020): A case study of merkén

    • Wed, 09/21/2022 - 04:00
    • Journal of Food Composition and Analysis
    • The potential ingestion of food products contaminated with ochratoxin A (OTA) is cause of concern for public health. Currently, several detection methods are available to detect OTA in singles spices but not in spice mixtures such as merkén. The present study modified, optimized, and validated a method for successful OTA quantification in merkén, paprika, and chili.

      • Natural toxins
      • Mycotoxins
  13. Genomic footprints related with adaptation and fumonisins production in Fusarium proliferatum

    • Wed, 09/21/2022 - 04:00
    • Frontiers in Microbiology
    • Fusarium proliferatum is the principal etiological agent of rice spikelet rot disease (RSRD) in China, causing yield losses and fumonisins contamination in rice. The intraspecific variability and evolution pattern of the pathogen is poorly understood. Here, we performed whole-genome resequencing of 67 F. proliferatum strains collected from major rice-growing regions in China. Population structure indicated that eastern population of F.

      • Natural toxins
      • Mycotoxins
  14. Functional analysis of the bZIP-type transcription factors AtfA and AtfB in Aspergillus nidulans

    • Tue, 09/20/2022 - 04:00
    • Frontiers in Microbiology
    • Transcription factors (TFs) with the basic leucin zipper domain are key elements of the stress response pathways in filamentous fungi. In this study, we functionally characterized the two bZIP type TFs AtfA and AtfB by deletion (Δ) and overexpression (OE) of their encoding genes in all combination: ΔatfA, ΔatfB, ΔatfAΔatfB, ΔatfAatfBOE, ΔatfBatfAOE, atfAOE, atfBOE and atfAOEatfBOE in Aspergillus nidulans.

      • Natural toxins
      • Mycotoxins
  15. Fusarium verticillioides Pex7/20 mediates peroxisomal PTS2 pathway import, pathogenicity, and fumonisin B1 biosynthesis

    • Tue, 09/20/2022 - 04:00
    • Applied Microbiology and Biotechnology
    • Fusarium verticillioides, a well-known fungal pathogen that causes severe disease in maize and contaminates the grains with fumonisin B1 (FB1) mycotoxin, affects the yield and quality of maize worldwide. The intrinsic roles of peroxisome targeting signal (PTS)–containing proteins in phytopathogens remain elusive.

      • Natural toxins
      • Mycotoxins
  16. A stem-loop like aptasensor for sensitive detection of aflatoxin based on graphene oxide/AuNPs nanocomposite platform

    • Tue, 09/20/2022 - 04:00
    • Food Chemistry
    • Aflatoxin as the potent carcinogenic mycotoxin had been received great attention for detection in food industry and safety. Due to low quantity of aflatoxin in food samples, there is a need to develop a sensitive method toward its detection. In the present study, an aflatoxin B1 (AFB1) specific aptasensor with internal complementary sequence was developed for detection of AFB1.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  17. Identification of a UDP‐glucosyltransferase conferring deoxynivalenol resistance in Aegilops tauschii and wheat

    • Tue, 09/20/2022 - 04:00
    • Plant Biotechnology Journal
    • Plant Biotechnology Journal, Accepted Article. Aegilops tauschii is the diploid progenitor of the wheat D subgenome and a valuable resource for wheat breeding, yet, genetic analysis of resistance against Fusarium head blight (FHB) and the major Fusarium mycotoxin deoxynivalenol (DON) is lacking. We treated a panel of 147 Ae. tauschii accessions with either F.

      • Natural toxins
      • Mycotoxins
  18. Mycotoxins Contamination in Rice: Analytical Methods, Occurrence and Detoxification Strategies

    • Tue, 09/20/2022 - 04:00
    • Toxins
    • The prevalence of mycotoxins in the environment is associated with potential crop contamination, which results in an unavoidable increase in human exposure. Rice, being the second most consumed cereal worldwide, constitutes an important source of potential contamination by mycotoxins.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  19. Variation of Aflatoxin Levels in Stored Edible Seed and Oil Samples and Risk Assessment in the Local Population

    • Sun, 09/18/2022 - 04:00
    • Toxins
    • Five hundred and twenty samples of edible seeds and oilseeds (sunflower, palm, peanut, sesame, cotton, and grapeseed) were purchased from markets, farmers, and superstores in the central cities of Punjab, Pakistan. A total of 125 (48.1%) edible seed samples from a 6 ≤ months storage period, and 127 (48.8%) from a 2 ≥ years storage period were found to be infested with AFs.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  20. A Stimuli-Responsive Colorimetric Aptasensor Based on the DNA Hydrogel-Coated MOF for Fumonisin B1 Determination in Food Samples

    • Sat, 09/17/2022 - 04:00
    • Food Chemistry
    • Fumonisin B1 (FB1), the most occurring fumonisin, is capable of disrupting sphingolipid metabolism and poses a serious threat to human and animal health. The high incidence and toxicity of FB1 have created an urgent need for alternative quantitative determination strategies. Herein, a colorimetric aptasensor was developed by combining the catalytical metal-organic frameworks with the polyacrylamide-DNA hydrogel.

      • Natural toxins
      • Mycotoxins
  21. Effect of environmental factors on the aflatoxin production by Aspergillus flavus during storage in upland rice seed using response surface methodology

    • Sat, 09/17/2022 - 04:00
    • LWT
    • The purpose of this study was to predict the optimal storage conditions for inhibiting aflatoxin production in upland rice seeds inoculated with Aspergillus flavus. The effects of storage conditions including moisture (A), temperature (B) and incubation time (C) on aflatoxin (AFG1, AFG2, AFB1, AFB2 and AFTOT) production in upland rice seed after inoculation of A.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  22. Analysis of the Roles of the ISLR2 Gene in Regulating the Toxicity of Zearalenone Exposure in Porcine Intestinal Epithelial Cells

    • Sat, 09/17/2022 - 04:00
    • Toxins
    • Zearalenone (ZEN) is one of the mycotoxins that pose high risks for human and animal health, as well as food safety. However, the regulators involved in ZEN cellular toxicity remain largely unknown. Herein, we showed that cell viability of porcine intestinal epithelial cells (IPEC-J2) tended to decrease with increasing doses of ZEN by the cell counting kit-8 assay.

      • Natural toxins
      • Mycotoxins
  23. A new probiotic Lactobacillus plantarum strain isolated from traditional dairy together with nanochitosan particles shows the synergistic effect on aflatoxin B1 detoxification

    • Sat, 09/17/2022 - 04:00
    • Archives of Microbiology
    • The present study aimed to evaluate the effects of new Lactobacillus plantarum strain isolated from dairy products as well as chitosan nanoparticles on reducing aflatoxin B1 (AFB1) toxicity In vitro. After collection and preparation of yogurt, cheese, milk, and whey products, lactic acid bacteria (LABs) were isolated and identified using biochemical and molecular methods. pH, bile, and salt tolerance tests were used to measure probiotic activity.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  24. Quantitative PCR (qPCR) Reveals that the Aflatoxin-Free Pistachio Samples Can Be Potentially Contaminated with Fungal Materials

    • Sat, 09/17/2022 - 04:00
    • Food Analytical Methods
    • Aflatoxins (AF) are the most potent group of mycotoxins that are produced by certain ascomycete fungi. These toxins can contaminate a large board of food commodities, thus causing a severe toxicity in animals and humans. The detection of fungal contamination of food is still challenging. This work determines whether an accurate relationship between the contamination of nut samples with AF and their contamination with fungal genomic DNA could be established.

      • Natural toxins
      • Aflatoxins
      • Mycotoxins
  25. Resveratrol Protects against Zearalenone-Induced Mitochondrial Defects during Porcine Oocyte Maturation via PINK1/Parkin-Mediated Mitophagy

    • Sat, 09/17/2022 - 04:00
    • Toxins
    • Mitochondria hold redox homeostasis and energy metabolism as a crucial factor during oocyte maturation, while the exposure of estrogenic mycotoxin zearalenone causes developmental incapacity in porcine oocyte. This study aimed to reveal a potential resistance of phytoalexin resveratrol against zearalenone during porcine oocyte maturation and whether its mechanism was related with PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy.

      • Natural toxins
      • Mycotoxins