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Food Safety Publications

The Food Safety Publications tracks research that is published across national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. The research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies and FDA Grant Funding Agencies are also tracked.

Displaying 1 - 25 of 105

  1. Repurposing the Kinase Inhibitor Mavelertinib for Giardiasis Therapy

    • Thu, 06/16/2022 - 04:00
    • Antimicrobial Agents and Chemotherapy
    • Antimicrobial Agents and Chemotherapy, Ahead of Print. A phenotypic screen of the ReFRAME compound library was performed to identify cell-active inhibitors that could be developed as therapeutics for giardiasis. A primary screen against Giardia lamblia GS clone H7 identified 85 cell-active compounds at a hit rate of 0.72%. A cytotoxicity counterscreen against HEK293T cells was carried out to assess hit compound selectivity for further prioritization.

      • Parasites
      • Giardia lamblia
  2. Label-free detection and enumeration of Giardia cysts in agitated suspensions using in situ microscopy

    • Sun, 06/12/2022 - 04:00
    • Journal of Microbiological Methods
    • Laboratory procedures performed in water treatment studies frequently require the characterization of (oo)cyst suspensions. Standard methods commonly used are laborious, expensive and time-consuming, besides requiring well-trained personnel to prepare samples with fluorescent staining and perform analysis under fluorescence microscopy.

      • Parasites
      • Giardia lamblia
  3. Prevalence and multilocus genotyping of Giardia duodenalis in zoo animals in three cities in China

    • Wed, 06/08/2022 - 04:00
    • Parasitology Research
    • Giardia duodenalis is a flagellated parasitic microorganism that parasitizes in the intestines of humans and animals. Although asymptomatic infections commonly exist in both humans and animals, some enteric symptoms have been reported in immunocompromised individuals, posing a threat to public health. Children could be infected with G. duodenalis through an environment contaminated by infective animals. Thus, the investigation of the prevalence and genotypes of G.

      • Parasites
      • Giardia lamblia
  4. Evaluation of the efficacy of gold nanoparticles on Giardia lamblia infection in experimental animals

    • Tue, 05/24/2022 - 04:00
    • Experimental Parasitology
    • Giardia lamblia (G. lamblia) is an important cause of severe malabsorption, weight loss, physical and mental retardation especially in infants and children throughout the world. Metronidazole (MTZ) is the standard drug used for their treatment which possesses several drawbacks with low efficacy. Gold nanoparticles possess a broad-spectrum antimicrobial activity and could be considered as a future alternative to many microbial agents.

      • Parasites
      • Giardia lamblia
  5. Prevalence and molecular characterization of Giardia duodenalis in small ruminants of Shiraz, southwestern Iran: A zoonotic concern

    • Fri, 05/13/2022 - 04:00
    • Comparative Immunology, Microbiology and Infectious Diseases
    • Livestock are commonly affected by gastrointestinal protozoan parasites, including Giardia duodenalis. In small ruminants, G. duodenalis infection may decrease carcass weight and dressing percentage. Current study was done to determine the prevalence, assemblage distribution, and zoonotic significance of Giardia infection in sheep and goats in Shiraz, southwestern Iran.

      • Parasites
      • Giardia lamblia
  6. Machine Learning and Its Applications for Protozoal Pathogens and Protozoal Infectious Diseases

    • Fri, 04/29/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • In recent years, massive attention has been attracted to the development and application of machine learning (ML) in the field of infectious diseases, not only serving as a catalyst for academic studies but also as a key means of detecting pathogenic microorganisms, implementing public health surveillance, exploring host-pathogen interactions, discovering drug and vaccine candidates, and so forth.

      • Parasites
      • Cryptosporidium parvium
      • Giardia lamblia
      • Toxoplasma gondii
  7. The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment

    • Fri, 04/29/2022 - 04:00
    • PLOS Pathogens
    • by William R. Hardin, Germain C. M. Alas, Nikita Taparia, Elizabeth B. Thomas, Melissa C. Steele-Ogus, Kelli L. Hvorecny, Aaron R. Halpern, Pavla Tůmová, Justin M. Kollman, Joshua C. Vaughan, Nathan J. Sniadecki, Alexander R. Paredez Attachment to the intestinal epithelium is critical to the lifestyle of the ubiquitous parasite Giardia lamblia. The ventrolateral flange is a sheet-like membrane protrusion at the interface between parasites and attached surfaces.

      • Parasites
      • Giardia lamblia
  8. Dual RNA Sequencing Reveals Key Events When Different Giardia Life Cycle Stages Interact With Human Intestinal Epithelial Cells In Vitro

    • Thu, 04/28/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Giardia intestinalis is a protozoan parasite causing diarrheal disease, giardiasis, after extracellular infection of humans and other mammals’ intestinal epithelial cells (IECs) of the upper small intestine. The parasite has two main life cycle stages: replicative trophozoites and transmissive cysts.

      • Parasites
      • Giardia lamblia
  9. An Overview of Mucosa-Associated Protozoa: Challenges in Chemotherapy and Future Perspectives

    • Tue, 04/26/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Parasitic infections caused by protozoans that infect the mucosal surfaces are widely neglected worldwide. Collectively, Entamoeba histolytica, Giardia lamblia, Cryptosporidium spp. and Trichomonas vaginalis infect more than a billion people in the world, being a public health problem mainly in developing countries. However, the exact incidence and prevalence data depend on the population examined.

      • Parasites
      • Cryptosporidium parvium
      • Giardia lamblia
  10. Multilocus Genotyping of Giardia duodenalis in Alpine Musk Deer (Moschus chrysogaster) in China

    • Wed, 04/20/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Giardia duodenalis is the underlying cause of a significant number of outbreaks of gastrointestinal illness in humans and animals worldwide. The purpose of this study was to elucidate the prevalence and genetic diversity of G. duodenalis in captive alpine musk deer (Moschus chrysogaster) in China. A total of 202 fecal samples were collected from three farms in Gansu Province, China. Identification of G.

      • Parasites
      • Giardia lamblia
  11. Occurrence, genetic characterization, and zoonotic importance of Giardia duodenalis in various species of rodents (Mus musculus, Rattus norvegicus, and Rattus rattus)

    • Sun, 04/10/2022 - 04:00
    • Comparative Immunology, Microbiology and Infectious Diseases
    • Giardia duodenalis is a well-known flagellated parasite and the causative agent of protozoal diarrhea in animals and humans worldwide. Current study was aimed at determination of G. duodenalis prevalence, genetic variation and zoonotic significance in various species of rodents in Shiraz, southwestern Iran.

      • Parasites
      • Giardia lamblia
  12. Current status of intestinal parasitosis among patients attending teaching hospitals in Zagazig district, Northeastern Egypt

    • Fri, 04/01/2022 - 04:00
    • Parasitology Research
    • Almost 80% of health problems in the developing world are due to malnutrition and infectious diseases, which are mainly parasitic. Updated records on the prevalence of parasitic infections and the potential risk factors are essential to enhancing control strategies. Therefore, this study was conducted to evaluate the current situation of intestinal parasitism among patients attending teaching hospitals in Zagazig district, Northeastern Egypt. The study involved five hundred cases.

      • Parasites
      • Giardia lamblia
  13. Enhanced detection of Giardia duodenalis mixed assemblage infections in pre-weaned dairy calves using next generation sequencing

    • Wed, 03/30/2022 - 04:00
    • Veterinary Parasitology
    • Giardia duodenalis is one of the most common parasitic causes of gastrointestinal illness in humans worldwide with widespread infections in mammalian hosts. It frequently infects cattle, producing a high number of cysts. Cattle can harbor both host-adapted assemblage E and human pathogenic assemblages A and B.

      • Parasites
      • Giardia lamblia
  14. Different Drugs, Same End: Ultrastructural Hallmarks of Autophagy in Pathogenic Protozoa

    • Tue, 03/29/2022 - 04:00
    • Frontiers in Microbiology
    • Protozoan parasites interact with a wide variety of organisms ranging from bacteria to humans, representing one of the most common causes of parasitic diseases and an important public health problem affecting hundreds of millions of people worldwide. The current treatment for these parasitic diseases remains unsatisfactory and, in some cases, very limited.

      • Parasites
      • Giardia lamblia
  15. Disc and actin-associated Protein 1 influences attachment in the intestinal parasite Giardia lamblia

    • Sat, 03/26/2022 - 04:00
    • PLOS Pathogens
    • by Melissa C. Steele-Ogus, Ava M. Obenaus, Nathan J. Sniadecki, Alexander R. Paredez The deep-branching eukaryote Giardia lamblia is an extracellular parasite that attaches to the host intestine via a microtubule-based structure called the ventral disc. Control of attachment is mediated in part by the movement of two regions of the ventral disc that either permit or exclude the passage of fluid under the disc.

      • Parasites
      • Giardia lamblia
  16. Disease burden from simultaneous exposure of Cryptosporidium sp. and Giardia sp. and land use vulnerability assessment in a Costa Rican drinking water system.

    • Tue, 03/22/2022 - 09:15
    • Microbial Risk Analysis
    • Human and animal feces are one of the main pollutants in drinking water systems (DWS). Both sources of fecal pollution are related to environmental conditions, such as poor land use management and little micro-basin protection. Cryptosporidium sp. and Giardia sp. are zoonotic protozoan water and foodborne transmitted parasitic pathogens and a frequent cause of diarrhea in children in low- and middle-income countries.

      • Cryptosporidium parvium
      • Parasites
      • Giardia lamblia
  17. Ready-to-eat salads and berry fruits purchased in Italy contaminated by Cryptosporidium spp., Giardia duodenalis, and Entamoeba histolytica

    • Fri, 03/18/2022 - 12:00
    • International Journal of Food Microbiology
    • Ready-to-eat (RTE) salads and berries are increasingly consumed in industrialized countries. These products can be contaminated by pathogenic parasites that have been responsible for foodborne outbreaks worldwide. In Italy, there are few data on contamination of RTE salads and berries with parasite transmission stages and this requires more-in-depth investigations.

      • Cryptosporidium parvium
      • Parasites
      • Giardia lamblia
  18. Giardia duodenalis in a clinically healthy population of captive zoo chimpanzees: Rapid antigen testing, diagnostic real-time PCR and faecal microbiota profiling

    • Fri, 03/18/2022 - 12:00
    • International Journal for Parasitology: Parasites and Wildlife
    • Giardia duodenalis is one of the most common intestinal parasites of humans, with a worldwide distribution. Giardia duodenalis has been reported in both wild and captive populations of non-human primates, namely chimpanzees. In this study we investigated an entire troop of clinically healthy chimpanzees (n = 21) for the presence of G. duodenalis and its association with faecal microbiota profile.

      • Parasites
      • Giardia lamblia
  19. Molecular characterization of Cryptosporidium spp. and Giardia duodenalis in pet dogs in Xinjiang, China

    • Thu, 03/03/2022 - 12:00
    • Parasitology Research
    • Cryptosporidium spp. and Giardia duodenalis are opportunistic zoonotic protozoa transmitted through several routes. In this study, a total of 604 fecal samples were collected from pet dogs in Xinjiang, China to detect the presence of Cryptosporidium spp. and G. duodenalis by PCR amplification of the small subunit (SSU) rRNA gene. The incidence rate of Cryptosporidium spp. or G. duodenalis was 5.3% (32/604).

      • Parasites
      • Cryptosporidium parvium
      • Giardia lamblia
  20. A review of the molecular epidemiology of Cryptosporidium spp. and Giardia duodenalis in the Middle East and North Africa (MENA) region

    • Fri, 01/21/2022 - 12:00
    • Infection, Genetics and Evolution
    • Cryptosporidium spp. and Giardia duodenalis are important protozoan parasites which are associated with diarrheal diseases in humans and animals worldwide. Relatively little is known about the molecular epidemiology of Cryptosporidium spp. and Giardia duodenalis in the Middle East Countries and North Africa (MENA region). Therefore, this review aimed to inspect published genotyping and subtyping studies on Cryptosporidium spp.

      • Cryptosporidium parvium
      • Parasites
      • Giardia lamblia
  21. Giardia duodenalis in colony stray cats from Italy

    • Wed, 01/12/2022 - 22:17
    • Zoonoses and Public Health
    • Zoonoses and Public Health, Volume 69, Issue 1, Page 46-54, February 2022.

      • Parasites
      • Giardia lamblia
  22. Discovery of Benzopyrrolizidines as Promising Antigiardiasic Agents

    • Wed, 01/12/2022 - 22:17
    • Frontiers in Cellular and Infection Microbiology
    • Current treatments for giardiasis include drugs with undesirable side effects, which increase the levels of therapeutic desertion and promote drug resistance in the parasites. Herein, we describe the antigiardiasic evaluation on Giardia lamblia trophozoites of a structurally diverse collection of 74 molecules.

      • Parasites
      • Giardia lamblia
  23. Discovery of Benzopyrrolizidines as Promising Antigiardiasic Agents

    • Wed, 01/12/2022 - 16:00
    • Frontiers in Cellular and Infection Microbiology
    • Current treatments for giardiasis include drugs with undesirable side effects, which increase the levels of therapeutic desertion and promote drug resistance in the parasites. Herein, we describe the antigiardiasic evaluation on Giardia lamblia trophozoites of a structurally diverse collection of 74 molecules.

      • Giardia lamblia
      • Parasites
  24. “Immunoinformatic Identification of T-Cell and B-Cell Epitopes From Giardia lamblia Immunogenic Proteins as Candidates to Develop Peptide-Based Vaccines Against Giardiasis”

    • Wed, 10/27/2021 - 16:00
    • Frontiers in Cellular and Infection Microbiology
    • Giardiasis is one of the most common gastrointestinal infections worldwide, mainly in developing countries. The etiological agent is the Giardia lamblia parasite. Giardiasis mainly affects children and immunocompromised people, causing symptoms such as diarrhea, dehydration, abdominal cramps, nausea, and malnutrition.

      • Giardia lamblia
      • Parasites
  25. Prevalence of intestinal parasitic infections and their associated risk factors among preschool and school children in Egypt

    • Thu, 09/30/2021 - 08:02
    • PLOS ONE
    • by Walid Elmonir, Haitham Elaadli, Anan Amer, Hammed El-Sharkawy, Mohamed Bessat, Samy F. Mahmoud, Mustafa Shukry Atta, Wael F. El-Tras

      • Giardia lamblia
      • Cryptosporidium parvum
      • Parasites