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Research Publications (Food Safety)

This page tracks research articles published in national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. Research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies (requires login) and FDA Grant Funding Agencies (requires login) are also tracked in Scopus.

Displaying 76 - 100 of 615

  1. A Selective Medium for Screening Ceftazidime/Avibactam Resistance in Carbapenem-Resistant Enterobacterales

    • Frontiers in Microbiology
    • Ceftazidime/avibactam (CZA) is an alternative antibiotic used for the treatment of infections caused by carbapenem-resistant Enterobacterales (CRE). However, the CZA-resistant CRE strains have been detected worldwide. Therefore, it is critical to screen CZA-resistant CRE strains in colonized patients or a specific population so as to rapidly implement infection control measures to limit their transmission.

      • Bacterial pathogens
      • Salmonella
      • Shigella
  2. Outbreak of sexually transmitted, extensively drug-resistant Shigella sonnei in the UK, 2021–22: a descriptive epidemiological study

    • The Lancet Infectious Diseases
    • Background Shigellosis, traditionally a foodborne and waterborne infection, causes substantial morbidity globally.

      • Bacterial pathogens
      • Shigella
  3. Bacteriophages Isolated From Turkeys Infecting Diverse Salmonella Serovars

    • Frontiers in Microbiology
    • Salmonella is one of the leading causes of foodborne illnesses worldwide. The rapid emergence of multidrug-resistant Salmonella strains has increased global concern for salmonellosis.

      • Bacterial pathogens
      • Salmonella
      • Shigella
  4. Characterization of Extended-Spectrum β-Lactamase-Producing Shigella sonnei in Spain: Expanding the Geographic Distribution of Sequence Type 152/CTX-M-27 Clone

    • Antimicrobial Agents and Chemotherapy
    • Antimicrobial Agents and Chemotherapy, Ahead of Print. We describe the first occurrence in Spain of community cases of CTX-M-27-producing Shigella sonnei sequence type 152 (ST152), resistant to quinolones and azithromycin. The cases included adult males and also one pediatric case. The isolates were clustered together with an Australian isolate and differed from other outbreak-causing strains in England by more than 50 alleles.

      • Bacterial pathogens
      • Shigella
  5. Microbial Antagonism in Food-Enrichment Culture: Inhibition of Shiga Toxin-Producing Escherichia coli and Shigella Species

    • Frontiers in Microbiology
    • Bacterial pathogens, such as Shiga toxin-producing Escherichia coli (STEC) and Shigella spp., are important causes of foodborne illness internationally. Recovery of these organisms from foods is critical for food safety investigations to support attribution of illnesses to specific food commodities; however, isolation of bacterial cultures can be challenging. Methods for the isolation of STEC and Shigella spp.

      • Bacterial pathogens
      • Escherichia coli O157:H7
      • Shigella
  6. Functional Role of YnfA, an Efflux Transporter in Resistance to Antimicrobial Agents in Shigella flexneri

    • Antimicrobial Agents and Chemotherapy
    • Antimicrobial Agents and Chemotherapy, Ahead of Print.

      • Bacterial pathogens
      • Shigella
  7. CT295 Is Chlamydia trachomatis’ Phosphoglucomutase and a Type 3 Secretion Substrate

    • Frontiers in Cellular and Infection Microbiology
    • The obligate intracellular bacteria Chlamydia trachomatis store glycogen in the lumen of the vacuoles in which they grow. Glycogen catabolism generates glucose-1-phosphate (Glc1P), while the bacteria can take up only glucose-6-phosphate (Glc6P). We tested whether the conversion of Glc1P into Glc6P could be catalyzed by a phosphoglucomutase (PGM) of host or bacterial origin. We found no evidence for the presence of the host PGM in the vacuole. Two C.

      • Bacterial pathogens
      • Shigella
  8. Physicochemical characterization of ten newly isolated phages against the foodborne pathogen Shigella flexneri

    • Journal of Food Processing and Preservation
    • Journal of Food Processing and Preservation, Accepted Article. Ten bacteriophages with lytic activity against Shigella flexneri were tested for their resistance to physicochemical conditions found in food matrices. Phage viability and activity were evaluated at different temperatures, pH values and NaCl concentrations. In addition, challenge tests with each individual phage against ATCC12022 were conducted to evaluate their use as biocontrol agents.

      • Bacterial pathogens
      • Shigella
  9. The AraC/XylS Protein MxiE and Its Coregulator IpgC Control a Negative Feedback Loop in the Transcriptional Cascade That Regulates Type III Secretion in Shigella flexneri

    • Journal of Bacteriology
    • Journal of Bacteriology, Ahead of Print. Members of the AraC family of transcriptional regulators (AFTRs) control the expression of many genes important to cellular processes, including virulence. In Shigella species, the type III secretion system (T3SS), a key determinant for host cell invasion, is regulated by the three-tiered VirF/VirB/MxiE transcriptional cascade. Both VirF and MxiE belong to the AFTRs and are characterized as positive transcriptional regulators.

      • Bacterial pathogens
      • Shigella
  10. Akkermansia muciniphila Alters Gut Microbiota and Immune System to Improve Cardiovascular Diseases in Murine Model

    • Frontiers in Microbiology
    • The gut microbiota plays an important role in a variety of cardiovascular diseases. The probiotics screened based on microbiota can effectively improve metabolism and immune function of the body, which is of great value in the field of cardiovascular disease treatment. Abdominal aortic aneurysms (AAA) refer to the lesion or injury of the abdominal aortic wall resulting in a localized bulge, which is one of the cardiovascular diseases with pulsing mass as the main clinical symptom.

      • Bacterial pathogens
      • Shigella
  11. Therapeutic Effect of Buyang Huanwu Decoction on the Gut Microbiota and Hippocampal Metabolism in a Rat Model of Cerebral Ischemia

    • Frontiers in Cellular and Infection Microbiology
    • Buyang Huanwu decoction (BHD) is a well-known Chinese herbal prescription. It has been widely used in the clinical treatment of cerebral ischemia (CI) in China. However, the mechanism underlying the treatment of CI with BHD remains to be elucidated. In this study, we combined microbiomic and metabolomic strategies to explore the therapeutic effects of BHD on middle cerebral artery occlusion (MCAO) in rats.

      • Bacterial pathogens
      • Shigella
  12. Enteric Illness Outbreaks Reported Through the National Outbreak Reporting System—United States, 2009–2019

    • Clinical Infectious Diseases
    • Background The National Outbreak Reporting System (NORS) captures data on foodborne, waterborne, and enteric illness outbreaks in the United States. This study describes enteric illness outbreaks reported during 11 years of surveillance. Methods We extracted finalized reports from NORS for outbreaks occurring during 2009–2019.

      • Bacterial pathogens
      • Campylobacter
      • Salmonella
      • Shigella
      • Viruses
      • Norovirus
  13. icaR and icaT are Ancient Chromosome Genes Encoding Substrates of the Type III Secretion Apparatus in Shigella flexneri

    • mSphere
    • mSphere, Ahead of Print. Shigella is an Escherichia coli pathovar that colonizes the cytosol of mucosal cells in the human large intestine. To do this, Shigella uses a Type III Secretion Apparatus (T3SA) to translocate several proteins into host cells. The T3SA and its substrates are encoded by genes of the virulence plasmid pINV or by chromosomal genes derived thereof.

      • Bacterial pathogens
      • Shigella
  14. Immunization of Rabbits with a Quadrivalent Shigella Bioconjugate Vaccine Induces Functional Antibodies Reactive with Shigella Isolates from Kenya

    • mSphere
    • mSphere, Ahead of Print. Diarrheal diseases are a leading cause of global morbidity and mortality, disproportionately affecting children in resource-limited settings. Although improvements in hygiene and access to clean water are helpful, vaccines are considered essential due to the low infectious dose of Shigella species and increasing antibiotic resistance.

      • Bacterial pathogens
      • Shigella
  15. The Shigella Spp. Type III Effector Protein OspB Is a Cysteine Protease

    • mBio
    • mBio, Ahead of Print. The type III secretion system is required for virulence of many pathogenic bacteria. Bacterial effector proteins delivered into target host cells by this system modulate host signaling pathways and processes in a manner that promotes infection. Here, we define the activity of the effector protein OspB of the human pathogen Shigella spp., the etiological agent of shigellosis and bacillary dysentery.

      • Bacterial pathogens
      • Shigella
  16. Similar Carcass Surface Microbiota Observed Following Primary Processing of Different Pig Batches

    • Frontiers in Microbiology
    • Bacterial contamination during meat processing is a concern for both food safety and for the shelf life of pork meat products. The gut microbiota of meat-producing animals is one of the most important sources of surface contamination of processed carcasses. This microbiota is recognized to vary between pigs from different farms and could thus be reflected on the bacterial contamination of carcasses at time of processing.

      • Bacterial pathogens
      • Salmonella
      • Shigella
  17. Mucosa-Colonizing Microbiota Correlate With Host Autophagy Signaling in Patients With Inflammatory Bowel Disease

    • Frontiers in Microbiology
    • Both bacteria and autophagy are implicated in inflammatory bowel disease (IBD) pathogenesis. However, how bacteria crosstalk with autophagy signaling remains largely known, especially in intestinal mucosa. This study aimed to profile the internal complex autophagy signaling cascade and their external correlation with these bacteria, and consequently provide a systematic and precise target for future IBD diagnosis and therapy.

      • Bacterial pathogens
      • Shigella
  18. In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus

    • Frontiers in Cellular and Infection Microbiology
    • Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions. However, the effects of polysaccharide-peptides extracted from Pleurotus citrinopileatus and underlying mechanism on digestive systme have not yet been clarified. Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.

      • Bacterial pathogens
      • Shigella
  19. Combined Non-Invasive Prediction and New Biomarkers of Oral and Fecal Microbiota in Patients With Gastric and Colorectal Cancer

    • Frontiers in Cellular and Infection Microbiology
    • Background

      There is no information on the commonality and specificity of oral and fecal microbiota in patients with gastric cancer (GC) and colorectal cancer (CRC).

      Methods

      • Bacterial pathogens
      • Shigella
  20. Gut Microbiome Characteristics in IgA Nephropathy: Qualitative and Quantitative Analysis from Observational Studies

    • Frontiers in Cellular and Infection Microbiology
    • Background

      Recent data indicate the importance of gut-kidney axis in the pathogenesis of Immunoglobulin A nephropathy (IgAN). Growing evidence suggests the alterations of diversity and composition of gut microbiome among patients with IgAN, however, the details are not yet fully understood.

      Methods

      • Bacterial pathogens
      • Shigella
  21. The impact of environmental pH on the gut microbiota community structure and short chain fatty acid production

    • FEMS Microbiology Ecology
    • Environmental pH is a critical parameter for maintenance of the gut microbiota. Here, the impact of pH on the gut microbiota luminal and mucosal community structure and short chain fatty acid (SCFA) production was evaluated in vitro, and data compiled to reveal a donor-independent response to an increase or decrease in environmental pH. The results found that raising environmental pH significantly increased luminal community richness and decreased mucosal community evenness.

      • Bacterial pathogens
      • Shigella
  22. In Vitro Activity of MRX-8 and Comparators Against Clinical Isolated Gram-Negative Bacilli in China

    • Frontiers in Cellular and Infection Microbiology
    • To evaluate in vitro antibacterial activity of MRX-8 against gram-negative bacteria recently isolated from China, 765 clinical isolates were collected randomly from 2017 to 2020, including Enterobacterales and P. aeruginosa and A. baumannii, S. maltophilia, B. cepacia, Alcaligenes app. and Haemophilus spp. isolates. All strains were performed with antimicrobial susceptibility testing by broth microdilution method according to the CLSI 2021.

      • Bacterial pathogens
      • Shigella
  23. Metagenome Sequencing Reveals the Microbiome of Aedes albopictus and Its Possible Relationship With Dengue Virus Susceptibility

    • Frontiers in Microbiology
    • Dengue fever virus (DENV) is a mosquito-borne flavivirus that poses a serious risk to human health. Aedes albopictus is a widely distributed vector of dengue fever in China. Based on the impact of physiological activity, the microbiome in A. albopictus will provide a novel environment-friendly approach to control DENV transmission. We performed metagenomic sequencing on A. albopictus before and after exposure to DENV blood meal to detect microbiome variation of A.

      • Bacterial pathogens
      • Shigella
  24. Modulation effects of danshen-honghua herb pair on gut microbiota of acute myocardial ischemia model rat

    • FEMS Microbiology Letters
    • In the recent years, a growing number of studies have shown that the occurrence of myocardial ischemia (MI) is closely related to the gut microbiota (GM). The Danshen-Honghua herb pair (DHHP), a classic combination in traditional Chinese herbal formulas, has been widely applied throughout history to cure cardiovascular disease, exhibiting remarkable clinical efficacy to treat ischemic heart disease (IHD). However, the intrinsic regulation mechanism of DHHP in treating MI remains unclear.

      • Bacterial pathogens
      • Shigella
  25. Phylogenetic analysis and antibiotic resistance of Shigella sonnei isolates

    • FEMS Microbiology Letters
    • Shigellosis is one of the most important gastric infections caused by different species of Shigella, and has been regarded as a serious threat to public health. Lineage/sublineage profile of Shigella sonnei is strongly associated with the antibiotic resistance and population structure of this pathogen. In this study, we determined the phylogeny and antibiotic resistance profiles of S.

      • Bacterial pathogens
      • Shigella