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Research Publications (Food Safety)

The Food Safety Publications tracks research that is published across national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. The research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies and FDA Grant Funding Agencies are also tracked.

Displaying 1 - 25 of 287

  1. The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection

    • Thu, 09/22/2022 - 04:00
    • mBio
    • mBio, Ahead of Print. Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in, e.g., sterol biosynthesis and protein prenylation, as well as longer “polyprenyl” diphosphates, used in ubiquinone and menaquinone biosynthesis.

      • Parasites
      • Toxoplasma gondii
  2. Metabolic flexibilities and vulnerabilities in the pentose phosphate pathway of the zoonotic pathogen Toxoplasma gondii

    • Tue, 09/20/2022 - 04:00
    • PLOS Pathogens
    • by Ningbo Xia, Xuefang Guo, Qinghong Guo, Nishith Gupta, Nuo Ji, Bang Shen, Lihua Xiao, Yaoyu Feng Metabolic pathways underpin the growth and virulence of intracellular parasites and are therefore promising antiparasitic targets.

      • Parasites
      • Toxoplasma gondii
  3. Detection of Toxoplasma gondii oocysts in soil and risk mapping in an Island environment in the Northeast of Brazil

    • Sun, 09/18/2022 - 04:00
    • Transboundary and Emerging Diseases
    • Transboundary and Emerging Diseases, Accepted Article. Toxoplasmosis is an emerging and re-emerging infectious disease that can be transmitted through a contaminated environment. Environmental contamination is an emergency health issue and determining its occurrence is fundamental to a One Health approach. In this study we addressed the extent of environmental contamination and viability of T. gondii oocysts in soil in different environments on Fernando de Noronha Island, Brazil.

      • Parasites
      • Toxoplasma gondii
  4. In vitro and in vivo anti−Toxoplasma activities of HDAC inhibitor Panobinostat on experimental acute ocular toxoplasmosis

    • Mon, 09/12/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Ocular toxoplasmosis (OT) is retinochoroiditis caused by Toxoplasma gondii infection, which poses a huge threat to vision. However, most traditional oral drugs for this disease have multiple side effects and have difficulty crossing the blood-retinal barrier, so the new alternative strategy is required to be developed urgently. Histone deacetylases (HDAC) inhibitors, initially applied to cancer, have attracted considerable attention as potential anti-Toxoplasma gondii drugs.

      • Parasites
      • Toxoplasma gondii
  5. Separate To Operate: the Centriole-Free Inner Core of the Centrosome Regulates the Assembly of the Intranuclear Spindle in Toxoplasma gondii

    • Thu, 09/08/2022 - 04:00
    • mBio
    • mBio, Ahead of Print. Centrosomes are the main microtubule-organizing center of the cell. They are normally formed by two centrioles, embedded in a cloud of proteins known as pericentriolar material (PCM). The PCM ascribes centrioles with their microtubule nucleation capacity. Toxoplasma gondii, the causative agent of toxoplasmosis, divides by endodyogeny. Successful cell division is critical for pathogenesis.

      • Parasites
      • Toxoplasma gondii
  6. Isolation and characterization of Toxoplasma gondii isolates from human congenital toxoplasmosis cases reveal a new virulent genotype in São Paulo, Brazil

    • Sat, 09/03/2022 - 04:00
    • Parasitology Research
    • Toxoplasma gondii causes severe disease in congenitally infected fetuses. The severity of fetal infection is related to the gestational stage at the time of maternal infection, parasite burden, and genotypic characteristics. South America has a high incidence of congenital toxoplasmosis and has the highest genotypic diversity of the parasite.

      • Parasites
      • Toxoplasma gondii
  7. In Vitro Biological Activity of Natural Products from the Endophytic Fungus Paraboeremia selaginellae against Toxoplasma gondii

    • Wed, 08/31/2022 - 04:00
    • Antibiotics
    • Toxoplasma gondii is an apicomplexan pathogen able to infect a wide range of warm-blooded animals, including humans, leading to toxoplasmosis. Current treatments for toxoplasmosis are associated with severe side-effects and a lack efficacy to eradicate chronic infection. Thus, there is an urgent need for developing novel, highly efficient agents against toxoplasmosis with low toxicity.

      • Parasites
      • Toxoplasma gondii
  8. Role of landscape context in Toxoplasma gondii infection of invasive definitive and intermediate hosts on a World Heritage Island

    • Wed, 08/31/2022 - 04:00
    • International Journal for Parasitology: Parasites and Wildlife
    • Free-ranging cats are invasive species threatening biodiversity worldwide. They may also impose an environmental risk to humans and livestock through the transmission of zoonotic diseases. We investigated antibody levels against Toxoplasma gondii in free-ranging cats and black rats (definitive and representative intermediate hosts) by ELISA and determined their relationships with landscape environmental factors on Tokunoshima Island, Japan, the Natural World Heritage site.

      • Parasites
      • Toxoplasma gondii
  9. Investigation of Toxoplasma gondii, Neospora caninum and Tritrichomonas foetus in abortions of cattle, sheep and goats in Turkey: Analysis by real-time PCR, conventional PCR and histopathological methods

    • Mon, 08/29/2022 - 04:00
    • Comparative Immunology, Microbiology and Infectious Diseases
    • The aim of this study was to identify three parasitic major abortion agents in all cattle aborted fetus samples and N. caninum and T. gondii in sheep and goat aborted fetus sent to Elazig Veterinary Control Institute during two years. Total genomic DNAs were obtained using a commercial kit. Real-time PCR analysis was performed separately for each agent. Conventional PCR was set up for confirmation of positive samples.

      • Parasites
      • Toxoplasma gondii
  10. Antimicrobial, Antivirulence, and Antiparasitic Potential of Capsicum chinense Jacq. Extracts and Their Isolated Compound Capsaicin

    • Sat, 08/27/2022 - 04:00
    • Antibiotics
    • Bacterial, fungal, and parasitic infections increase morbimortality rates and hospital costs. This study aimed to assess the antimicrobial and antiparasitic activities of the crude extract from the seeds and peel of the pepper Capsicum chinense Jacq. and of the isolated compound capsaicin and to evaluate their ability to inhibit biofilm formation, eradicate biofilm, and reduce hemolysin production by Candida species.

      • Parasites
      • Toxoplasma gondii
  11. An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii

    • Tue, 08/23/2022 - 04:00
    • PLOS Pathogens
    • by Jonathan Munera Lopez, Isadonna F. Tengganu, Jun Liu, John M. Murray, Luisa F. Arias Padilla, Ying Zhang, Peter T. Brown, Laurence Florens, Ke Hu The phylum Apicomplexa includes thousands of species of unicellular parasites that cause a wide range of human and animal diseases such as malaria and toxoplasmosis. To infect, the parasite must first initiate active movement to disseminate through tissue and invade into a host cell, and then cease moving once inside.

      • Parasites
      • Toxoplasma gondii
  12. High prevalence of Toxoplasma gondii in Nigerian wild rats by molecular detection

    • Tue, 08/23/2022 - 04:00
    • Veterinary Parasitology: Regional Studies and Reports
    • Toxoplasmosis has been reported in Nigeria using several diagnostic tools with high prevalence in humans and some food animals. Rodents have been recognised as vital intermediate hosts of Toxoplasma gondii. However, there is paucity of information on the occurrence of T. gondii in wild rats found in Nigeria. This study aimed at molecular detection of T.

      • Parasites
      • Toxoplasma gondii
  13. The first apicoplast tRNA thiouridylase plays a vital role in the growth of Toxoplasma gondii

    • Mon, 08/15/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Toxoplasmosis caused by the protozoan Toxoplasma gondii is one of the most common parasitic diseases in humans and almost all warm-blooded animals. Lys, Glu, and Gln-specific tRNAs contain a super-modified 2-thiourea (s2U) derivatives at the position 34, which is essential for all living organisms by maintaining the structural stability and aminoacylation of tRNA, and the precision and efficiency of codon recognition during protein translation.

      • Parasites
      • Toxoplasma gondii
  14. Biogenic silver nanoparticles (AgNp-Bio) restore testosterone levels and increase TNF-α and IL-6 in Leydig cells infected with Toxoplasma gondii

  15. Evaluation of anti-parasitic activities of new quinolones containing nitrofuran moiety against Toxoplasma gondii

    • Thu, 08/04/2022 - 04:00
    • Experimental Parasitology
    • Toxoplasmosis is a disease with a worldwide prevalence that is caused by Toxoplasma gondii. Pyrimethamine and sulfadiazine are two pharmacological agents commonly used to treat of this infection. However, they are accompanied by some side effects. Therefore, the identifying of new drugs with low toxocytosis seems to be a matter of vital importance.

      • Parasites
      • Toxoplasma gondii
  16. A Role for Basigin in Toxoplasma gondii Infection

    • Tue, 08/02/2022 - 04:00
    • Infection and Immunity
    • Infection and Immunity, Ahead of Print. The role of specific host cell surface receptors during Toxoplasma gondii invasion of host cells is poorly defined. Here, we interrogated the role of the well-known malarial invasion receptor, basigin, in T. gondii infection of astrocytes. We found that primary astrocytes express two members of the BASIGIN (BSG) immunoglobulin family, basigin and embigin, but did not express neuroplastin.

      • Parasites
      • Toxoplasma gondii
  17. Molecular occurrence and risk factors for Toxoplasma gondii infection in equids in Jilin, China

    • Sun, 07/31/2022 - 04:00
    • Scientific Reports
    • Toxoplasma gondii, one of the important zoonotic parasites, has been detected in lots of hosts including humans, with a widespread prevalence. The products of equids, such as meat and milk, have been closely related to humans’ life. As the intermediate hosts, little is known about equids toxoplasmosis in Jilin province. Therefore, the present study aimed to evaluate the occurrence and risk factors of Toxoplasma gondii infections in equids from Jilin, northeastern China.

      • Parasites
      • Toxoplasma gondii
  18. Hypothetical bromodomain-containing protein 5 is required for the growth of Toxoplasma gondii

    • Sat, 07/23/2022 - 04:00
    • Veterinary Parasitology
    • Bromodomain (BRD) is a highly conserved structural module domain, found in various proteins, including chromatin-related proteins, nucleus acetyltransferases, and transcription-associated proteins. Toxoplasma gondii, a zoonotic 

      • Parasites
      • Toxoplasma gondii
  19. Molecular and serological detection of Toxoplasma gondii infection in mammals in the Taipei Zoo

    • Wed, 07/20/2022 - 04:00
    • Zoonoses and Public Health
    • Zoonoses and Public Health, EarlyView. Toxoplasmosis caused by Toxoplasma gondii affects both conservation and public health efforts. In the Taipei Zoo, toxoplasmosis was diagnosed in ring-tailed lemurs and a meerkat in 2019 while a freeze–thaw meat strategy had been applied to carnivores before the event.

      • Parasites
      • Toxoplasma gondii
  20. Comparison of a commercial ELISA and indirect hemagglutination assay with the modified agglutination test for detection of Toxoplasma gondii antibodies in giant panda (Ailuropoda melanoleuca)

    • Sun, 07/17/2022 - 04:00
    • International Journal for Parasitology: Parasites and Wildlife
    • Toxoplasma gondii is a worldwide-distributed zoonotic protozoan parasite which causes toxoplasmosis and has a significant effect on public health. In the giant panda (Ailuropoda melanoleuca), toxoplasmosis can cause asymptomatic infections, reproductive disorder and even death, which poses a serious threat to the conservation of this rare protected species. Therefore, serological investigation of T.

      • Parasites
      • Toxoplasma gondii
  21. Metabolomics study of cat small intestine during the early stage of Toxoplasma gondii oocyst formation identifies potential biomarkers

    • Sun, 07/17/2022 - 04:00
    • Veterinary Parasitology
    • Toxoplasma gondii (T. gondii) is a zoonotic intracellular protozoan parasite that can invade, replicate and survive in almost all cells of warm-blooded animals. T. gondii infection threatens the life of the fetus or can cause morbidity in the infant. As the only definitive host of T.

      • Parasites
      • Toxoplasma gondii
  22. Activity of isoflavone biochanin A in chronic experimental toxoplasmosis: impact on inflammation

    • Wed, 07/13/2022 - 08:00
    • Parasitology Research
    • Toxoplasma gondii is a worldwide prevalent parasite. The infection has been linked to variable inflammatory effects including neuroinflammation. Biochanin A (BCA) is an isoflavone, known for its anti-inflammatory and anti-oxidative properties. In this study, we examined the effect of BCA on the brain and liver inflammatory lesions in a murine model with chronic toxoplasmosis.

      • Parasites
      • Toxoplasma gondii
  23. A new adenine nucleotide transporter located in the ER is essential for maintaining the growth of Toxoplasma gondii

    • Thu, 07/07/2022 - 04:00
    • PLOS Pathogens
    • by Senyang Li, Jiahui Qian, Ming Xu, Jing Yang, Zhengming He, Tongjie Zhao, Junlong Zhao, Rui Fang The lumen of the endoplasmic reticulum (ER) is the subcellular site where secretory protein folding, glycosylation and sulfation of membrane-bound proteins, proteoglycans, and lipids occur. The protein folding and degradation in the lumen of the ER require high levels of energy in the form of ATP.

      • Parasites
      • Toxoplasma gondii
  24. Microfluidic model for in vitro acute Toxoplasma gondii infection and transendothelial migration

    • Thu, 07/07/2022 - 04:00
    • Scientific Reports
    • The protozoan parasite Toxoplasma gondii (T. gondii) causes one of the most common human zoonotic diseases and infects approximately one-third of the global population. T. gondii infects nearly every cell type and causes severe symptoms in susceptible populations. In previous laboratory animal studies, T. gondii movement and transmission were not analyzed in real time.

      • Parasites
      • Toxoplasma gondii
  25. Abortion outbreak in a sheep flock caused by Toxoplasma gondii clonal type III

    • Sat, 07/02/2022 - 04:00
    • Parasitology Research
    • Toxoplasma gondii is a major cause of reproductive losses in small ruminants in several countries. We describe here an outbreak of T. gondii-associated abortion in sheep in Southern Brazil. The flock was comprised of 55 adult sheep, and late-term abortions and stillbirths were detected in 15/36 (41.66%) gestating ewes. Serum samples collected from 45 sheep were tested for T.

      • Parasites
      • Toxoplasma gondii