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Research Publications (Food Safety)

The Food Safety Publications tracks research that is published across national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. The research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies and FDA Grant Funding Agencies are also tracked.

Displaying 1 - 25 of 625

  1. Validation of a LC-MS/MS method for the quantitative analysis of four antibiotics in pig tissues and plasma to assess the risk of transfer of residues to edible matrices after exposure to cross-contaminated feed

    • Thu, 10/06/2022 - 04:00
    • Food Additives & Contaminants: Part A
      • Chemical contaminants
      • Antibiotic residues
  2. Occurrence and Risk Assessment of Fluoroquinolone Residues in Chicken and Pork in China

    • Fri, 09/23/2022 - 04:00
    • Antibiotics
    • Antibiotics, especially fluoroquinolones, have been exhaustively used in animal husbandry. However, very limited information on the occurrence and exposure assessment of fluoroquinolone residues in chicken and pork in China is available to date.

      • Chemical contaminants
      • Antibiotic residues
  3. Rapid and accurate quantification and analysis of nitrofuran metabolites residues in aquatic products by ultra-high performance liquid chromatography–tandem mass spectrometry

    • Wed, 09/21/2022 - 04:00
    • European Food Research and Technology
    • Nitrofurans, a kind of banned antibiotics for their serious toxic side effects, have often been found in aquatic products in the past and are still found nowadays which were a severe threat for human health. A rapid quantization of nitrofuran metabolites residues in aquatic products by ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method was developed in this study.

      • Chemical contaminants
      • Antibiotic residues
  4. Effects of g-C3N4 on bacterial community and tetracycline resistance genes in two typical sediments in tetracycline pollution remediation

    • Fri, 09/16/2022 - 04:00
    • Frontiers in Microbiology
    • Photocatalysis, as a novel technique, has been widely used for antibiotic pollution remediation in wastewater. In the processes of degradation and removal of antibiotics, the impact of photocatalysts on microenvironment is very important but remains poorly understood.

      • Chemical contaminants
      • Antibiotic residues
  5. Insights into the impact of manure on the environmental antibiotic residues and resistance pool

    • Fri, 09/16/2022 - 04:00
    • Frontiers in Microbiology
    • The intensive use of antibiotics in the veterinary sector, linked to the application of manure-derived amendments in agriculture, translates into increased environmental levels of chemical residues, AR bacteria (ARB) and antibiotic resistance genes (ARG). The aim of this review was to evaluate the current evidence regarding the impact of animal farming and manure application on the antibiotic resistance pool in the environment.

      • Chemical contaminants
      • Antibiotic residues
  6. Determination of Sulphonamides and Tetracycline Residues in Liver Tissues of Broiler Chicken Sold in Kinondoni and Ilala Municipalities, Dar es Salaam, Tanzania

    • Fri, 09/09/2022 - 04:00
    • Antibiotics
    • In Tanzania, the increased demand for animal-derived foods, particularly eggs, meat, and milk, has resulted in the intensification of farming systems with the use of antimicrobials, particularly sulphonamides and tetracyclines. According to the FAO/WHO Codex Alimentarius commission, concentrations of antimicrobial residues in food exceeding the acceptable daily intake (ADI) and maximum residual limit (MRL) pose a health risk to consumers.

      • Chemical contaminants
      • Antibiotic residues
  7. Rapid and sensitive analytical strategy for multi-class antibiotic residues analysis in aquatic products with amphiphilic magnetic polymer particles as an effective cleanup adsorbent

    • Thu, 09/01/2022 - 04:00
    • Food Chemistry
    • Multi-class antibiotic analysis in aquatic products is still challenging owing to the complex matrix and low co-extraction efficiency of various antibiotics. A facile and sensitive sample pretreatment method based on magnetic dispersive solid-phase extraction was thus developed via systematic optimization of extraction and purification procedure. The multi-class antibiotics can simultaneously be extracted by acetonitrile-2% acetic acid.

      • Chemical contaminants
      • Antibiotic residues
  8. Comprehensive survey and health risk assessment of antibiotic residues in freshwater fish in southeast China

    • Fri, 08/12/2022 - 04:00
    • Journal of Food Composition and Analysis
    • To assess the health risks from antibiotic residues in freshwater fish, this study analyzed residues of 65 antibiotics in 10 freshwater fish species sampled in southeast China. Eight antibiotics were detected by UPLC-MS/MS at an overall detection rate of 53.9%, with 3.48% of samples exceeding MRLs and 13.0% suggesting the misuse of human antibiotics. Quinolones, particularly enrofloxacin, were the most frequently detected residues.

      • Chemical contaminants
      • Antibiotic residues
  9. Protein Engineering of a Germacrene A Synthase From Lactuca sativa and Its Application in High Productivity of Germacrene A in Escherichia coli

    • Thu, 08/11/2022 - 04:00
    • Frontiers in Plant Science
    • Germacrene A (GA) is a key intermediate for the synthesis of medicinal active compounds, especially for β-elemene, which is a broad-spectrum anticancer drug. The production of sufficient GA in the microbial platform is vital for the precursors supply of active compounds. In this study, Escherichia coli BL21 Star (DE3) was used as the host and cultivated in SBMSN medium, obtaining a highest yield of FPP. The GA synthase from Lactuca sativa (LTC2) exhibited the highest level of GA production.

      • Chemical contaminants
      • Antibiotic residues
  10. Design and Evaluation of Short Bovine Lactoferrin-Derived Antimicrobial Peptides against Multidrug-Resistant Enterococcus faecium

    • Thu, 08/11/2022 - 04:00
    • Antibiotics
    • Enterococcus faecium has become an important drug-resistant nosocomial pathogen because of widespread antibiotic abuse. We developed short and chemically simple antimicrobial peptides (AMPs) with a selective amino acid composition, fixed charge, and hydrophobicity ratio based on the core antimicrobial motif of bovine lactoferrin (LfcinB6). Among these peptides, 5L and 6L (both 12 residues long) demonstrated a narrow spectrum and high antibacterial activity against drug-resistant E.

      • Chemical contaminants
      • Antibiotic residues
  11. A Review on Recent Trends in Advancement of Bio-Sensory Techniques Toward Pesticide Detection

    • Wed, 08/10/2022 - 04:00
    • Food Analytical Methods
    • India has achieved its food security through the green revolution and technological revolution, although food safety is still not realized. Subsequently, agricultural runoffs, industrial wastes and domestic sewages continuously contaminate the water and the associated livelihood through several contaminants. Pesticides and their residues, which function as endocrine disrupting chemicals (EDCs), influence the food web through water resources, among other things.

      • Chemical contaminants
      • Antibiotic residues
      • Pesticide residues
  12. Abridged validation of charm II screening tests for the detection of veterinary drug residues in fish farmed in Cameroon

    • Thu, 08/04/2022 - 04:00
    • Food Additives & Contaminants: Part A
    • The intensification of aquaculture in Cameroon requires efficient screening methods to control veterinary drug residues in fish. This is why the charm II radio receptor technique for the detection of antimicrobial residues in aquaculture fish initiated in Belgium was transferred to Cameroon according to Commission Decision 2002/657/EC.

      • Chemical contaminants
      • Antibiotic residues
  13. ‘Mechanistic insights into 5-lipoxygenase inhibition by active principles derived from essential oils of Curcuma species: Molecular docking, ADMET analysis and molecular dynamic simulation study

    • Sat, 07/23/2022 - 04:00
    • PLOS ONE
    • by Ayushman Gadnayak, Budheswar Dehury, Ananya Nayak, Sudipta Jena, Ambika Sahoo, Pratap Chandra Panda, Asit Ray, Sanghamitra Nayak Inflammation is caused by a cascade of events, one of which is the metabolism of arachidonic acid, that begins with oxidation by the enzyme 5-lipoxygenase.

      • Chemical contaminants
      • Antibiotic residues
  14. Regulatory mechanism of montmorillonite on antibiotic resistance genes in Escherichia coli induced by cadmium

    • Sat, 07/23/2022 - 04:00
    • Applied Microbiology and Biotechnology
    • The emergence and spread of antibiotic resistance genes (ARGs) induced by the overuse of antibiotics has become a serious threat to public health. Heavy metals will bring longer-term selection pressure to ARGs when the concentration of their residues is higher than that of antibiotics in environmental media.

      • Chemical contaminants
      • Antibiotic residues
      • Heavy Metals
  15. Associations of typical antibiotic residues with elderly blood lipids and dyslipidemia in West Anhui, China

    • Wed, 07/20/2022 - 04:00
    • Ecotoxicology and Environmental Safety
    • Growing evidence has indicated the association of clinical antibiotic use with abnormal blood lipid levels; however, no epidemiological study has examined the relationship of antibiotic exposure, probably derived from food chains, with blood lipid levels. This study investigated the relationships of urinary antibiotic levels with blood lipid levels and dyslipidemias in the older population.

      • Chemical contaminants
      • Antibiotic residues
  16. Development and Validation of a Multiresidue Method for the Determination of Macrocyclic Lactones, Monensin, and Fipronil in Bovine Liver by UHPLC-MS/MS Using a QuEChERS Extraction

    • Sun, 07/17/2022 - 04:00
    • Food Analytical Methods
    • Macrocyclic lactones (MLs) are widely used as antiparasitic agents in the livestock, monensin (ionophore antibiotics) is recommended in cattle feed as growth-promoting additives, and fipronil is a drug prescripted in animal production to control ectoparasitic infestations. However, the use of these drugs in food-producing animals may lead to the appearance of their residues in meat and offals.

      • Chemical contaminants
      • Antibiotic residues
  17. Development of a droplet digital PCR assay to detect illicit glucocorticoid administration in bovine

    • Sat, 07/16/2022 - 04:00
    • PLOS ONE
    • by Sara Divari, Matteo Cuccato, Antonella Fanelli, Francesca Tiziana Cannizzo Glucocorticoids are often used illegally in food-producing animals for the growth promotion of livestock animals. In accordance to official chemical methods for glucocorticoid detection, an animal is declared as non-compliant when a residue is identified in the sample.

      • Chemical contaminants
      • Antibiotic residues
  18. Genome-Wide Analysis of Multidrug and Toxic Compound Extruction Transporters in Grape

    • Thu, 07/14/2022 - 04:00
    • Frontiers in Plant Science
    • Grape (Vitis vinifera L.) is an important fruit crop in the world. It is used as a table grape and is also used for raisin and wine production. Grape berries accumulate secondary metabolites, such as anthocyanins, tannins, and resveratrol, which are known as functional compounds for human health. Multidrug and toxic compound extrusion transporter (MATEs) transport secondary metabolites.

      • Chemical contaminants
      • Antibiotic residues
  19. Engineering of succinyl-CoA metabolism in view of succinylation regulation to improve the erythromycin production

    • Wed, 07/13/2022 - 08:00
    • Applied Microbiology and Biotechnology
    • As a novel protein post-translational modification (PTM), lysine succinylation is widely involved in metabolism regulation by altering the activity of catalytic enzymes. Inactivating succinyl-CoA synthetase in Saccharopolyspora erythraea HL3168 E3 was proved significantly inducing the global protein hypersuccinylation.

      • Chemical contaminants
      • Antibiotic residues
  20. Self-cleaved expression of recombinant lysostaphin from its cellulose binding domain fusion

    • Thu, 07/07/2022 - 04:00
    • Applied Microbiology and Biotechnology
    • Mature lysostaphin (mLst) is a glycineglycine endopeptidase, capable of specifically cleaving penta-glycine crosslinker in the peptidoglycan of Staphylococcus aureus cell wall. It is a very effective therapeutic enzyme to kill the multidrug-resistant S. aureus often encountered in hospital acquired infections. Fusing cellulose binding domain (CBD) to mLst significantly reduced the insoluble expression of mLst in E.

      • Bacterial pathogens
      • Staphylococcus aureus
      • Chemical contaminants
      • Antibiotic residues
  21. 3D-QSAR-Based Pharmacophore Modeling, Virtual Screening, and Molecular Dynamics Simulations for the Identification of Spleen Tyrosine Kinase Inhibitors

    • Thu, 06/30/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Spleen tyrosine kinase (SYK) is an essential mediator of immune cell signaling and has been anticipated as a therapeutic target for autoimmune diseases, notably rheumatoid arthritis, allergic rhinitis, asthma, and cancers. Significant attempts have been undertaken in recent years to develop SYK inhibitors; however, limited success has been achieved due to poor pharmacokinetics and adverse effects of inhibitors.

      • Chemical contaminants
      • Antibiotic residues
  22. Review of Antimicrobial Resistance in Wastewater in Japan: Current Challenges and Future Perspectives

    • Sat, 06/25/2022 - 04:00
    • Antibiotics
    • Antimicrobial resistance (AMR) circulates through humans, animals, and the environments, requiring a One Health approach. Recently, urban sewage has increasingly been suggested as a hotspot for AMR even in high-income countries (HICs), where the water sanitation and hygiene infrastructure are well-developed. To understand the current status of AMR in wastewater in a HIC, we reviewed the epidemiological studies on AMR in the sewage environment in Japan from the published literature.

      • Chemical contaminants
      • Antibiotic residues
  23. The thematic role of extracellular loop of VraG in activation of the membrane sensor GraS in a cystic fibrosis MRSA strain differs in nuance from the CA-MRSA strain JE2

    • Fri, 06/24/2022 - 04:00
    • PLOS ONE
    • by Junho Cho, William F. C. Rigby, Ambrose L. Cheung Patients with cystic fibrosis (CF) often suffer recurrent bronchial bacterial infections that lead to deterioration of lung function over time. The infections in CF patients are often due to S. aureus and P. aeruginosa that colonize the airways. Significantly, methicillin-resistant S.

      • Bacterial pathogens
      • Staphylococcus aureus
      • Chemical contaminants
      • Antibiotic residues
  24. A Universal LC-MS/MS Method for Simultaneous Detection of Antibiotic Residues in Animal and Environmental Samples

    • Fri, 06/24/2022 - 04:00
    • Antibiotics
    • Detecting and monitoring the usage of antibiotics is a critical aspect of efforts to combat antimicrobial resistance. Antibiotic residue testing with existing LC-MS/MS methods is limited in detection range. Current methods also lack the capacity to detect multiple antibiotic residues in different samples simultaneously. In this study, we demonstrate a methodology that permits simultaneous extraction and detection of antibiotic residues in animal and environmental samples.

      • Chemical contaminants
      • Antibiotic residues
  25. Application of non-target analysis and high resolution mass spectrometry for the identification of thermal transformation products of oxytetracycline in pacific white shrimp

    • Tue, 06/21/2022 - 04:00
    • Oxytetracycline is an antibiotic authorized for use in aquaculture and is often detected in seafood products, especially shrimp. Previous studies investigating the fate of oxytetracycline in shrimp tissues after cooking were limited to quantification of parent compound residues, and did not describe any potential transformation products formed. Hence, the main objective of this study was to apply a non-target analysis workflow to study the fate of oxytetracycline in shrimp muscle.

      • Chemical contaminants
      • Antibiotic residues