Research Publications (Food Safety)

Epidemiological evidence links polychlorinated biphenyls (PCBs) to skeletal toxicity, however mechanisms whereby PCBs affect bone are poorly studied. In this study, coplanar PCB 126 (5 μmol/kg) or corn oil vehicle was administered to N = 5 and 6 male and female, wild type (WT) or AhR −/− rats via intraperitoneal injection. Animals were sacrificed after 4 weeks. Bone length was measured; bone morphology was assessed by microcomputed tomography and dynamic histomorphometry.

Author(s): A.M. Api, F. Belmonte, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G.A. Burton, J. Buschmann, M.A. Cancellieri, M.L. Dagli, M. Date, W. Dekant, C. Deodhar, A.D. Fryer, S. Gadhia, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, D.C. Liebler

Exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) through food, water, and air occurred during the life, which may change telomere length (TL) in peripheral blood leukocytes. The present study was designed to investigate the association between TL and serum levels of PCBs and OCPs in Tehran male’s population. Whole blood samples were randomly taken from 300 adult males, aged between 25 and 40 years.

Author(s): Yuchang Tao, Xiaozhuan Liu, Lingling Cui, Xinxin Liu, Yao Chen, Zhidong He, Mengmeng Ji, Zhan Gao, Ning Li, Zhongxiao Wan, Zengli Yu As a common birth defect, Cleft palate can be caused by the disturbance during the developmental process of the palatal shelves. The 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) is a well-known environmental teratogenic agent for cleft palate and Aryl hydrocarbon receptor (AhR) pathway can be activated by dioxins.

Author(s): Yunyun Deng, Pingan Peng, Lijuan Jia, Haowen Yin, Jianfang Hu, Wanlian Mao

To discover natural-product-based pesticides, 7β-oxycarbonylandrographolide derivatives were stereoselectively constructed from a labdane diterpenoid andrographolide.

by Lucille Rey-Cadilhac, Ronan Cariou, Anne Ferlay, Catherine Jondreville, Carole Delavaud, Yannick Faulconnier, Sébastien Alcouffe, Pascal Faure, Philippe Marchand, Bruno Le Bizec, Stefan Jurjanz, Sylvain Lerch Food safety crises involving persistent organic pollutants [POPs, e.g. dioxins, polychlorinated biphenyls (PCBs), organochlorine pesticides] lead to systematic slaughter of livestock to prevent their entry into the food chain.

by Sylvain Lerch, Lucille Rey-Cadilhac, Ronan Cariou, Yannick Faulconnier, Catherine Jondreville, Denis Roux, Gaud Dervilly-Pinel, Bruno Le Bizec, Stefan Jurjanz, Anne Ferlay

Author(s): Kailun Yu, Xiuli Zhang, Xuemei Tan, Mengmeng Ji, Yao Chen, Zhongxiao Wan, Zengli Yu

Author(s): Marion Hulin, Véronique Sirot, Paule Vasseur, Aurelie Mahe, Jean-Charles Leblanc, Julien Jean, Philippe Marchand, Anaïs Venisseau, Bruno LE. Bizec, Gilles Riviere A total diet study (TDS) was conducted between 2010 and 2016 to characterize the health risk related to chemical residues in food of French not breastfed children under three years of age (infant TDS).

Author(s): Keqi Hu, Hang Yu, Zihuan Li, Guifang Jin, Hansi Jia, Meiqi Song, Yungang Liu

The levels of persistent organic pollutants, polychlorinated biphenyls (PCBs), were investigated in influent, effluent, and sludge of five wastewater treatment plants (WWTPs) in Jordan. Concentrations of 12 dioxin-like PCBs were determined. The extraction of PCBs from wastewater samples was done by solvent extraction using dichloromethane/hexane 1:1 mixture.

Author(s): Yan Bao, Lei Zhang, Xin Liu, Lei Shi, Jingguang Li, Guimin Meng, Yunfeng Zhao, Yongning Wu

Landfills are repository for complex microbial diversity responsible for bio-degradation of solid waste. To elucidate this complexity, samples from three different landfill sites of North India (sample V: Bhalswa near Karnal byepass road, New Delhi, India; sample T: Chandigarh, India and sample S3: Una, H.P., India) were analyzed using metagenomic approach. Selected landfill sites had different geographical location, varied in waste composition, size of landfill and climate zone.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental contaminant in the environment. The developmental period is more sensitive to TCDD and there is a possibility that maternal exposure to TCDD may affect in adulthood. Adult female Wistar rats were exposed to 0.5, 1.0, and 2.0 µg/kg TCDD during the critical stage of organogenesis, that is, on GD15.

Author(s): Jinzhong Yang, Haibin Yu, Zhen Xie, Yufei Yang, Xiaoyan Zheng, Jingxing Zhang, Qifei Huang, Tao Wen, Jianyuan Wang The thermal processes of cement kilns are sources of polybrominated dibenzofurans and dioxins (PBDD/Fs); however, when co-processing decabromodiphenyl ether (BDE-209) soil in cement kilns, very few reports have investigated the mechanism of PBDD/Fs formation from BDE-209.

Seaweed is a source of protein that can help overcome the anticipated challenges of a growing world population and the current challenges for finding alternatives for animal proteins in the Western diet. Thus far, data on the safety of seaweed for feed and food purposes in the Western world are scattered.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental pollutant and also a strong teratogen for cleft palate (CP). But up to now, the underlying molecular mechanisms of TCDD-induced CP are largely unknown. More recently, accumulating evidences are revealing important roles of long noncoding RNAs (lncRNAs) in all kinds of diseases including CP. However, the role and molecular mechanism of lncRNAs in TCDD-induced CP are still largely unexplored.

The authors regret that the affiliation of authors is wrong. Correct affiliation is:

Public Health College of Zhengzhou University, No. 100 of Science Road, Zhengzhou, 450001, China.

Department of surgery, the first affiliated medical college of Zhengzhou University, No. 1 of Jianshe East Road, Zhengzhou, 450052, China.

*Corresponding authors: Professor Zengli Yu, Public Health College of Zhengzhou University, No. 100 of Science Road, Zhengzhou, 450001, China.

Endocrine disrupting chemicals (EDCs) are defined as exogenous substances that can alter the development and functioning of the endocrine system. The Wnt signaling pathway is an evolutionarily conserved pathway consisting of proteins that transmit cell-to-cell receptors through cell surface receptors, regulating important aspects of cell migration, polarity, neural formation, and organogenesis, which determines the fate of the cell during embryonic development.

Polychlorinated biphenyls (PCBs) are highly persistent and ubiquitously distributed environmental pollutants. Based on their chemical structure, PCBs are classified into non-ortho-substituted and ortho-substituted congeners. Non-ortho-substituted PCBs are structurally similar to dioxin and their toxic effects and mode of action are well-established. In contrast, very little is known about the effects of ortho-substituted PCBs, particularly, during early development.

Author(s): Zheng Peng, Roland Weber, Yong Ren, Jianwei Wang, Yangzhao Sun, Lifang Wang

Author(s): Xiaozhuan Liu, Xue Li, Yuchang Tao, Ning Li, Mengmeng Ji, Xiuli Zhang, Yao Chen, Zhidong He, Kailun Yu, Zengli Yu

Author(s): Lili Yang, Fen Jin, Guorui Liu, Yang Xu, Minghui Zheng, Cui Li, Yuanping Yang

Context-specific GEnome-scale metabolic Network REconstructions (GENREs) provide a means to understand cellular metabolism at a deeper level of physiological detail. Here, we use transcriptomics data from chemically-exposed rat hepatocytes to constrain a GENRE of rat hepatocyte metabolism and predict biomarkers of liver toxicity using the Transcriptionally Inferred Metabolic Biomarker Response algorithm.