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Food Safety Publications

The Food Safety Publications tracks research that is published across national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. The research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies and FDA Grant Funding Agencies are also tracked.

Displaying 1 - 25 of 530

  1. In Vitro Hepatoprotective and Human Gut Microbiota Modulation of Polysaccharide-Peptides in Pleurotus citrinopileatus

    • Sat, 05/21/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Pleurotus citrinopileatus, a golden oyster mushroom, is popular in Asia and has pharmacological functions. However, the effects of polysaccharide-peptides extracted from Pleurotus citrinopileatus and underlying mechanism on digestive systme have not yet been clarified. Here, we determined the composition of two polysaccharide-peptides (PSI and PSII) from P. citrinopileatus and investigated the protective effects of on hepatoprotective and gut microbiota.

      • Bacterial pathogens
      • Shigella
  2. Combined Non-Invasive Prediction and New Biomarkers of Oral and Fecal Microbiota in Patients With Gastric and Colorectal Cancer

    • Thu, 05/19/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Background

      There is no information on the commonality and specificity of oral and fecal microbiota in patients with gastric cancer (GC) and colorectal cancer (CRC).

      Methods

      • Bacterial pathogens
      • Shigella
  3. Structural Characterization, Antimicrobial, Antibiofilm, Antioxidant, Anticancer and Acute Toxicity Properties of N-(2-hydroxyphenyl)-2-phenazinamine From Nocardiopsis exhalans (KP149558)

    • Thu, 05/19/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • The present study aimed to isolate and identify potential drugs from marine actinomycete Nocardiopsis exhalans and screen them for biomedical applications. The cell-free culture of N. exhalans was extracted with ethyl acetate and the solvent extract showed six fractions in thin-layer chromatography. The fractions were subjected to column chromatography for purification and evaluated for activity against human clinical pathogens.

      • Bacterial pathogens
      • Staphylococcus aureus
  4. Gut Microbiome Characteristics in IgA Nephropathy: Qualitative and Quantitative Analysis from Observational Studies

    • Tue, 05/17/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Background

      Recent data indicate the importance of gut-kidney axis in the pathogenesis of Immunoglobulin A nephropathy (IgAN). Growing evidence suggests the alterations of diversity and composition of gut microbiome among patients with IgAN, however, the details are not yet fully understood.

      Methods

      • Bacterial pathogens
      • Shigella
  5. An Anti-MRSA Phage From Raw Fish Rinse: Stability Evaluation and Production Optimization

    • Tue, 05/17/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Accumulating evidence has denoted the danger of resistance in tenacious organisms like methicillin-resistant Staphylococcus aureus (MRSA). MRSA, a supple bacterium that adopts a variety of antibiotic resistance mechanisms, is the cause of multiple life-threatening conditions. Approaching a post-antibiotic era, bacteria-specific natural predators, bacteriophages, are now given the chance to prove eligible for joining the antibacterial weaponry.

      • Bacterial pathogens
      • Staphylococcus aureus
  6. “Alterations in the Skin Microbiota Are Associated With Symptom Severity in Mycosis Fungoides”

    • Tue, 05/17/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Cutaneous T cell lymphoma (CTCL), a non-Hodgkin lymphoma, is thought to arise from mature tissue-resident memory T cells. The most common subtypes include Mycosis Fungoides and Sezary Syndrome. The role of skin microbiota remains unclear in the symptom manifestation of MF.

      • Bacterial pathogens
      • Staphylococcus aureus
  7. Bacterial Adhesion and Biofilm Formation of Enterococcus faecalis on Zwitterionic Methylmethacrylat and Polysulfones

    • Mon, 05/16/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Biofilm-associated implant infections represent a major challenge for healthcare systems around the world due to high patient burden and enormous costs incurred. Enterococcus faecalis (E. faecalis) is the most prevalent enterococcal species identified in biofilm-associated infections. The steadily growing areas of application of implants demand a solution for the control of bacterial infections.

      • Bacterial pathogens
      • Staphylococcus aureus
  8. Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota

    • Mon, 05/16/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Several strains of lactic acid bacteria are potent probiotics and can cure a variety of diseases using different modes of actions. These bacteria produce antimicrobial peptides, bacteriocins, which inhibit or kill generally closely related bacterial strains and other pathogenic bacteria such as Listeria, Clostridium, and Salmonella. Bacteriocins are cationic peptides that kill the target cells by pore formation and the dissipation of cytosolic contents, leading to cell death.

      • Bacterial pathogens
      • Salmonella
  9. In Vitro Activity of MRX-8 and Comparators Against Clinical Isolated Gram-Negative Bacilli in China

    • Fri, 05/13/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • To evaluate in vitro antibacterial activity of MRX-8 against gram-negative bacteria recently isolated from China, 765 clinical isolates were collected randomly from 2017 to 2020, including Enterobacterales and P. aeruginosa and A. baumannii, S. maltophilia, B. cepacia, Alcaligenes app. and Haemophilus spp. isolates. All strains were performed with antimicrobial susceptibility testing by broth microdilution method according to the CLSI 2021.

      • Bacterial pathogens
      • Shigella
  10. Description of Staphylococcal Strains from Straw-Coloured Fruit Bat (Eidolon helvum) and Diamond Firetail (Stagonopleura guttata) and a Review of their Phylogenetic Relationships to Other Staphylococci

    • Thu, 05/12/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • The phylogenetic tree of the Staphylococcus aureus complex consists of several distinct clades and the majority of human and veterinary S. aureus isolates form one large clade. In addition, two divergent clades have recently been described as separate species. One was named Staphylococcus argenteus, due to the lack of the “golden” pigment staphyloxanthin. The second one is S. schweitzeri, found in humans and animals from Central and West Africa.

      • Bacterial pathogens
      • Staphylococcus aureus
  11. Inhibition of Toxoplasma gondii Growth by Dihydroquinine and Its Mechanisms of Action

    • Thu, 05/12/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Toxoplasma gondii is a zoonotic parasite that infects the brain of humans and causes cerebral toxoplasmosis. The recommended drugs for the treatment or prophylaxis of toxoplasmosis are pyrimethamine (PY) and sulfadiazine (SZ), which have serious side effects. Other drugs available for toxoplasmosis are poorly tolerated.

      • Chemical contaminants
      • Heavy Metals
      • Parasites
      • Toxoplasma gondii
  12. Ampicillin Treatment of Intracellular Listeria monocytogenes Triggers Formation of Persistent, Drug-Resistant L-Form Cells

    • Thu, 05/12/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Listeria monocytogenes is an opportunistic intracellular pathogen causing an infection termed listeriosis. Despite the low incidence of listeriosis, the high mortality rate in individuals at risk makes this bacterium one of the most dangerous foodborne pathogens. Reports about a relapse of infection after antibiotic treatment suggest that the bacteria may be able to evade antibiotic treatment and persist as a dormant, antibiotic-tolerant subpopulation.

      • Bacterial pathogens
      • Listeria monocytogenes
  13. Phenol-Soluble Modulins From Staphylococcus aureus Biofilms Form Complexes With DNA to Drive Autoimmunity

    • Wed, 05/11/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • The bacterial amyloid curli, produced by Enterobacteriales including Salmonella species and Escherichia coli, is implicated in the pathogenesis of several complex autoimmune diseases. Curli binds to extracellular DNA, and these complexes drive autoimmunity via production of anti-double-stranded DNA autoantibodies. Here, we investigated immune activation by phenol-soluble modulins (PSMs), the amyloid proteins expressed by Staphylococcus species.

      • Bacterial pathogens
      • Salmonella
      • Staphylococcus aureus
  14. Fecal Microbiota Transplantation Alters the Outcome of Hepatitis B Virus Infection in Mice

    • Wed, 05/04/2022 - 05:00
    • Frontiers in Cellular and Infection Microbiology
    • The susceptibility of mice to hepatitis B virus (HBV) infection depends on their genetic background. The gut microbiota modulates the antiviral immune response in the liver and plays a protective role against HBV infection. However, whether HBV infection outcomes depend on the gut microbiota remains unclear. In this study, we assessed the gut microbiota composition in naïve BALB/c and C57BL/6 mice using 16S rRNA gene sequencing.

      • Viruses
      • Hepatitis
  15. Attenuation of Yersinia pestis fyuA Mutants Caused by Iron Uptake Inhibition and Decreased Survivability in Macrophages

    • Wed, 05/04/2022 - 05:00
    • Frontiers in Cellular and Infection Microbiology
    • Yersinia pestis is the etiological agent of plague, a deadly infectious disease that has caused millions of deaths throughout history. Obtaining iron from the host is very important for bacterial pathogenicity. Y. pestis possesses many iron uptake systems. Yersiniabactin (Ybt) plays a major role in iron uptake in vivo and in vitro, and in virulence toward mice as well. FyuA, a β-barrel TonB-dependent outer membrane protein, serves as the receptor for Ybt.

      • Bacterial pathogens
      • Yersinia
  16. Toxoplasma gondii’s Basal Complex: The Other Apicomplexan Business End Is Multifunctional

    • Sat, 04/30/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • The Apicomplexa are famously named for their apical complex, a constellation of organelles at their apical end dedicated to invasion of their host cells. In contrast, at the other end of the cell, the basal complex (BC) has been overshadowed since it is much less prominent and specific functions were not immediately obvious. However, in the past decade a staggering array of functions have been associated with the BC and strides have been made in understanding its structure.

      • Parasites
      • Toxoplasma gondii
  17. Aptamer-Targeted Drug Delivery for Staphylococcus aureus Biofilm

    • Sat, 04/30/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Treatment of Staphylococcus aureus biofilm infections using conventional antibiotic therapy is challenging as only doses that are sublethal to the biofilm can be administered safely to patients. A potential solution to this challenge is targeted drug delivery. In this study, we tailored an aptamer-targeted liposomal drug delivery system for accumulation and delivery of antibiotics locally in S. aureus biofilm.

      • Bacterial pathogens
      • Staphylococcus aureus
  18. Unifying Virulence Evaluation in Toxoplasma gondii: A Timely Task

    • Fri, 04/29/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Toxoplasma gondii, a major zoonotic pathogen, possess a significant genetic and phenotypic diversity that have been proposed to be responsible for the variation in clinical outcomes, mainly related to reproductive failure and ocular and neurological signs. Different T. gondii haplogroups showed strong phenotypic differences in laboratory mouse infections, which provide a suitable model for mimicking acute and chronic infections.

      • Parasites
      • Toxoplasma gondii
  19. Machine Learning and Its Applications for Protozoal Pathogens and Protozoal Infectious Diseases

    • Fri, 04/29/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • In recent years, massive attention has been attracted to the development and application of machine learning (ML) in the field of infectious diseases, not only serving as a catalyst for academic studies but also as a key means of detecting pathogenic microorganisms, implementing public health surveillance, exploring host-pathogen interactions, discovering drug and vaccine candidates, and so forth.

      • Parasites
      • Cryptosporidium parvium
      • Giardia lamblia
      • Toxoplasma gondii
  20. Low Prevalence of Toxoplasma gondii in Dogs From Central China

    • Fri, 04/29/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Background Toxoplasma gondii can infect almost all warm-blooded animals, including humans and dogs. Humans can become infected with T. gondii by petting dogs that have eaten or contacted infected cat feces. The aim of this study was to evaluate T. gondii infections in dogs from central China. From 2015 to 2021, a total of 536 dog samples (195 fecal, 81 hearts, and 260 serum samples) from Henan Province were collected. Heart juice or serum samples (n = 341) were tested for T.

      • Parasites
      • Toxoplasma gondii
  21. Dual RNA Sequencing Reveals Key Events When Different Giardia Life Cycle Stages Interact With Human Intestinal Epithelial Cells In Vitro

    • Thu, 04/28/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Giardia intestinalis is a protozoan parasite causing diarrheal disease, giardiasis, after extracellular infection of humans and other mammals’ intestinal epithelial cells (IECs) of the upper small intestine. The parasite has two main life cycle stages: replicative trophozoites and transmissive cysts.

      • Parasites
      • Giardia lamblia
  22. Traditional Chinese Medicine Tanreqing Targets Both Cell Division and Virulence in Staphylococcus aureus

    • Wed, 04/27/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Staphylococcus aureus has been recognized as an important human pathogen and poses a serious health threat worldwide. With the advent of antibiotic resistance, such as the increased number of methicillin-resistant Staphylococcus aureus (MRSA), there is an urgent need to develop new therapeutical agents.

      • Bacterial pathogens
      • Staphylococcus aureus
  23. Microbiota-Associated Biofilm Regulation Leads to Vibrio cholerae Resistance Against Intestinal Environmental Stress

    • Wed, 04/27/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • The commensal microbes of the gut microbiota make important contributions to host defense against gastrointestinal pathogens, including Vibrio cholerae, the etiologic agent of cholera. As interindividual microbiota variation drives individual differences in infection susceptibility, we examined both host and V.

      • Bacterial pathogens
      • Vibrio
  24. An Antibiotic-Loaded Hydrogel Demonstrates Efficacy as Prophylaxis and Treatment in a Large Animal Model of Orthopaedic Device-Related Infection

    • Wed, 04/27/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Local antibiotic therapy is increasingly being recognised for its role in preventing and treating orthopaedic device-related infection (ODRI). A bioresorbable, injectable gentamicin-loaded hydrogel has been developed to deliver local antibiotics at the time of surgery with potential for both prevention and treatment of ODRI.

      • Bacterial pathogens
      • Staphylococcus aureus
  25. Campylobacter jejuni Cytolethal Distending Toxin Induces GSDME-Dependent Pyroptosis in Colonic Epithelial Cells

    • Wed, 04/27/2022 - 04:00
    • Frontiers in Cellular and Infection Microbiology
    • Background Cytolethal distending toxin (CDT) is a critical virulence factor of Campylobacter jejuni, and it induces cell death and regulates inflammation response in human epithelial cells.

      • Bacterial pathogens
      • Campylobacter