Research Publications (Food Safety)

The TMA/TMAO pathway represents one of many microbe‐dependent pathways that will ultimately be linked to CHD pathogenesis Molecular docking results found that baicalein, fisetin, acacetin, and myricetin in flavonoid aglycones, and baicalin, naringin and hesperidin in flavonoid glycosides had good binding effects on TMA‐lyase, which were the most active and could be used as lead compounds for structural modification.

A surplus of unused parts of vegetables (e.g., white cabbage cores and outer leaves) is generated daily by factories of fresh‐cut vegetables. Anaerobic fermentation of these vegetable residues with protease (Sumizyme FP) and Pediococcus pentosaceus did not produced l‐ornithine, however, when eggshell was added to them, large amounts of l‐ornithine were stably produced. These fermented products are sustainable food ingredients with the potential health benefits of l‐ornithine.

Journal of Food Biochemistry, EarlyView. Black ginseng (BG) shows beneficial effects on liver injury, but the related mechanism has not been fully revealed. This study attempted to investigate the protective effects and associated mechanisms of BG against nonalcoholic steatohepatitis (NASH). Twelve ginsenosides in BG were annotated by ultrahigh performance liquid chromatography combined with high resolution mass spectrometry (UHPLC-HRMS).

Journal of Food Biochemistry, EarlyView. Copper II-Albumin complex (Cu-II-Albumin complex) is a novel therapeutic target that has been used as anti-inflammatory, antioxidant, and anti-gastrointestinal toxicity.

Journal of Food Biochemistry, EarlyView. This study reports the protective role of the aqueous extract of Syzygium aromaticum (ESA) against lead (Pb)-induced neurotoxicity in mice. Thirty male mice weighing between 18 g and 25 g were randomly divided into five groups.

Journal of Food Biochemistry, EarlyView.

Journal of Food Biochemistry, EarlyView. Abstract

Journal of Food Biochemistry, EarlyView. Lead nitrate (LN) and cadmium chloride (CdCl2), regarded as environmental contaminants, are toxic heavy metals. Sesamol is a dietary phytochemical found in sesame oil. We aimed to analyze the hepatotoxic and nephrotoxic effects of LN and CdCl2 and to evaluate the possible protective effect of sesamol. LN (90 mg/kg bw per day), CdCl2 (3 mg/kg bw per day), and sesamol (50 mg/kg bw per day) were given to rats via gavage for 28 days.

Journal of Food Biochemistry, EarlyView. Bisphenol A (BPA) is used as a plasticizer in polycarbonate plastics. It has been used in consumer products and epoxy resins for decades as protective coatings and linings for food and beverage bottles. This can trigger human reactions to BPA which interferes with estrogen receptors. Our study explored the ameliorative effects of selenium (Se) in male rats on liver damage caused by BPA.

Journal of Food Biochemistry, EarlyView. 3‐Monochloropropane‐1,2‐diol (3‐MCPD) as a byproduct of food processing and a carcinogenic agent has attracted much attention in the last decades. Kidney is the main target organ that is sensitive to the toxicity of 3‐MCPD.

Scheme summarizing the protective properties of Chrysin against testicular toxicity caused by lead acetate in rats. Abstract In the present study, the protective effects of chrysin (CHR) against testicular damage caused by lead acetate (PbAc) were examined. In this way, 30 min after rats were given 25 and 50 mg/kg/b.w CHR orally for seven consecutive days, 30 mg/kg/b.w PbAc was administered orally.

The multi‐target activity of curcumin makes it a promising pharmacological lead for structural modifications focused on the preparation of new therapeutics with improved bioavailability. A possible modification is to “decompose” the parent curcumin structure into constituent units and to build up curcumin analogues with biphenyl structural moiety.

Moringa oleifera Lam. extract (MOE) led to the activation of the detoxifying enzyme systems in the Pb (II)‐intoxicated rodents. Administration of MOE offers protection against PbAc‐intoxicated rodents’ brain tissues by inhibiting oxidative stress, apoptosis and inflammation, via attenuating NF‐κB signaling pathways. Abstract In this study, we investigate the potential protective effect of Moringa oleifera Lam. extract (MOE) against lead‐induced neurotoxicity.

Natural phytoconstituents such as eugenol, cinnamaldehyde, alpha terpinyl acetate, piperine and cuminaldehyde have multi‐target‐directed ligand potential and can have disease modifying effects. Abstract Alzheimer's disease (AD) is a neurodegenerative disorder, and multiple factors are involved in disease progression. This is why there is an urgent need to develop novel molecules with multi‐target‐directed ligands (MTDLs) potential.

Screening of terpenoids from Azadirachta indica against the Akt showed they are potent inhibitors of the protein. The screening revealed lupeol, a triterpenoid as the lead compound. Lupeol demonstrate surpassing inhibitory potential on Akt 2 than ipatasertib in in‐silico studies Terpenoids extract downregulate Akt mRNA and demonstrated anti‐Akt downstream signaling effects; anti‐inflammatory, anti‐angiogenesis, pro‐apoptotic, and cell cycle arrest.

Shanghai smoked fish (SSF) was first prepared in this work. Volatile flavor compounds of SSF were identified via Maillard reaction. Pyrazines and furans could modify the flavor of SSF. Glucose is beneficial to enhance the aroma of SSF.

Cationic (GCP1) and anionic (GCP2) peroxidases were purified from day‐6 sprouts of garden cress. Broad substrate specificity of natural plant phenolic compounds was demonstrated for the purified peroxidases. GCP2 showed a high affinity toward sinapyl and coniferyl alcohols, which contributed in lignin synthesis. GCP2 could be used for removal of phenol and p‐chlorophenol from polluted soil as well as resisted the harmful effect of heavy metals.

Carotenoid isolated from the leaves of Spondias mombim; astaxanthin, β‐carotene‐15,15ʹ‐epoxide, and 7,7ʹ,8,8ʹ‐tetrahydro‐β‐β‐carotene demonstrate selective inhibition of XIAP by hydrophobic interactions within the domains of BIR2 and BIR3.

In this study, CTS and β‐CD were cross‐linked to synthesize a biomass membrane for adsorbing Zn2+ to reduce the Zn2+ content in wastewater via adsorption. The results show that the CTS/β‐CDP composite membrane was placed into the wastewater for effective adsorption Zn2+,which could achieve high adsorption efficiency.

Cadmium chloride evoked oxidative stress‐mediated inflammation and cell death in testis of rats. Ferulic acid acts as an antioxidant protector against CdCl2‐induced reproductive toxicity via enhancing Nrf2/ARE signaling pathway in rats. Abstract Here, we examined the protective effect of ferulic acid (FA) on cadmium chloride (CdCl2)‐mediated reproductive toxicity in male rats.

Lentil peptides fractions demonstrated antiglycation, antioxidant and antiproliferative activity. After HPLC‐MSMS sequencing, 28 novel peptides were identified. Abstract Bioactive peptides produced from natural sources are considered as strategic target for drug discovery. Hyperglycemia caused protein glycation alters the structure of many tissues that impairs their functions and lead complications diseases in human body.

The categories, properties, and applications of extremophilic enzymes in food processing and food waste valorisation are covered in this review. These enzymes' ability to maintain catalytic activities under extreme conditions opens up a broad range of applications in the food industry, including starch liquefaction/saccharification, keratin degradation, production of structured lipids, deconstruction of polymers into monomers, and degradation of toxins.

First prepare oyster peptide samples, analyze the oyster peptides by amino acid composition analysis, high‐performance liquid chromatography detection, etc. Then the oyster peptides are gavage to rats, and then analyze the rat serum indexes, related genes and protein expression, antioxidant detection, and HE staining used to study the characteristics of oyster peptides.

In this paper, the HepG2 cells were induced by high insulin to develop a insulin resistance cell model, then the function of four peptides, VLP, LLP, VA and LL, derived from pea evaluated based on this model. The results showed that pea peptides can alleviate insulin resistance by enhancing insulin signaling pathway (IRS‐1/PI3K/AKT) and reducing intracellular oxidative stress.

The effects of thiols were examined to inhibit the enzymatic browning of fresh‐cut potato during 48 hr of storage. Polyphenol oxidase (PPO) activity, residual thiol contents, ascorbic acid and antioxidant activities of treated samples were determined after 1, 24 and 48 hr. NAC (2.0%) and CYS (1.0%, 2.0%) solutions totally inhibited the activity of PPO and increased the thiol contents, ascorbic acid and antioxidant activities of potatoes, significantly.