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Research Publications (Food Safety)

This page tracks research articles published in national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. Research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies (requires login) and FDA Grant Funding Agencies (requires login) are also tracked in Scopus.

Displaying 51 - 75 of 179

  1. Moisture‐sensitive metal–organic framework constructed from cobalt and 4‐(4‐pyridyl) benzoic acid for dispersive solid phase extraction of polycyclic aromatic hydrocarbons in apple

    • Journal of Separation Science
    • Journal of Separation Science, Accepted Article. A moisture‐sensitive metal‐organic framework CoII(pybz)2·2DMF was synthesized and applied as the adsorbent of dispersive solid phase extraction. The structure changed after water treatment due to the fact that two chelate carboxylate groups on the skeleton were transformed to monodentate because of the coordination of water molecules.

      • Chemical contaminants
  2. A proof‐of‐concept of parallel single drop microextraction for the rapid and sensitive biomonitoring of pesticides in urine

    • Journal of Separation Science
    • Journal of Separation Science, Accepted Article. In this study, a lab‐made Parallel‐Single Drop Microextraction methodology using the magnetic ionic liquid trihexyltetradecylphosphonium tetrachloromanganate (II) as extraction solvent was developed to determine the pesticides tebuconazole, pendimethalin, dichlorodiphenyltrichloroethane, and dichlorodiphenyldichloroethylene in human urine samples.

      • Pesticide residues
      • Chemical contaminants
  3. A thin‐layer solid‐phase extraction–liquid film elution technique used for the enrichment of polycyclic aromatic hydrocarbons in water

    • Journal of Separation Science
    • Journal of Separation Science, Accepted Article. In this paper, we propose a novel micro‐solid‐phase extraction and elution technique, which we called the thin‐layer solid‐phase extraction–liquid film elution technique.

      • Chemical contaminants
  4. Boron nitride modified reduced graphene oxide as solid‐phase microextraction coating material for the extraction of seven polycyclic aromatic hydrocarbons from water and soil samples

    • Journal of Separation Science
    • A novel hexagonal boron nitride modified reduced graphene oxide material was synthesized and used as the adsorbent for the solid‐phase microextraction of seven polycyclic aromatic hydrocarbons from water and soil samples prior to their detection by gas chromatography‐flame ionization detector. Under optimal conditions, the linear response range of the analytes for water sample is 0.25‐50 ng mL−1 with the correlation coefficients (r) ranging between 0.9953 and 0.9996.

      • Chemical contaminants
  5. Front Cover: Automated micro‐solid‐phase extraction clean‐up of polycyclic aromatic hydrocarbons in food oils for analysis by gas chromatography–orbital ion trap mass spectrometry

    • Journal of Separation Science
    • DOI: 10.1002/jssc.202000720 The cover picture shows the automated clean‐up process for polycyclic aromatic hydrocarbons in sunflower oil with a PAL system and further analysis with gas chromatography‐quadrupole‐orbitrap‐mass spectrometry (GC‐Q‐Orbitrap‐MS) and the resulting data depicted as a chromatogram. An animated picture of the PAL system is shown.

      • Chemical contaminants
  6. Particle packed mixed‐mode chromatographic stationary phase for the separation of peptide in liquid chromatography

    • Journal of Separation Science
    • A particle based stationary phase has been prepared for the separation of five synthetic peptides and a mixture containing tryptic digest of cytochrome C in liquid chromatography. Particles originating from silica monolith were differentially sedimented to obtained particles in 1 to 2 μm range.

      • Chemical contaminants
  7. A green molecular imprinted solid phase extraction protocol for Bisphenol A monitoring with HPLC‐UV to guarantee the quality and safety of walnuts under different storage conditions

    • Journal of Separation Science
    • Monitoring the residual toxicant concentrations in foods is the key step for minimizing potential hazards. The huge interest about food contamination and exposure to endocrine disruptors such as Bisphenol A has emerged the development of sensitive analytical methodologies to guarantee the safety and quality of foods. In this work, a green molecularly imprinted solid phase extraction protocol coupled with HPLC‐UV was optimized following the principles of Green Analytical Chemistry.

      • Chemical contaminants
  8. Multi‐residue extraction to determine organic pollutants in mussel haemolymph

    • Journal of Separation Science
    • This study assesses the extraction of 11 pharmaceuticals, 5 pesticides, 5 perfluoroalkyl substances and 2 illicit drugs in haemolymph from (Mytilus Galloprovincialis). Four extraction procedures using Phree™ Phospholipid Removal cartridges were tested using different volumes of methanol (400 μl and 600 μl) and acetonitrile (300 μl and 450 μl). The pollutants were determined by HPLC‐MS/MS.

      • Pesticide residues
      • Chemical contaminants
  9. Combination of solvent extraction with deep eutectic solvent‐based dispersive liquid‐liquid microextraction for the analysis of aflatoxin M1 in cheese samples using response surface methodology optimization

    • Journal of Separation Science
    • A new extraction procedure based on combination of a solvent extraction and deep eutectic solvent‐based dispersive liquid–liquid microextraction has been introduced for the extraction of aflatoxin M1 from cheese samples. In this method, acetonitrile, deionized water, and n‐hexane are added onto the sample and vortexed.

      • Aflatoxins
      • Natural toxins
  10. A semi‐automatic solid phase extraction system based on MIL‐101(Cr) foam‐filled syringe for detection of triazines in vegetable oils

    • Journal of Separation Science
    • In this study, several metal‐organic framework‐melamine foam columns were first developed and used as a laboratory‐made semi‐automatic solid phase extraction packed in syringe adsorber for the extraction of six triazine herbicides from vegetable oil samples coupled to high‐performance liquid chromatography‐tandem mass spectrometry.

      • Chemical contaminants
  11. Pipette tip micro‐solid phase extraction (octyl‐functionalized hybrid silica monolith) and ultra‐high‐performance liquid chromatography‐tandem mass spectrometry to determine cannabidiol and tetrahydrocannabinol in plasma samples

    • Journal of Separation Science
    • This manuscript describes the development of an innovative method to determine cannabinoids (cannabidiol and tetrahydrocannabinol) in human plasma samples by pipette‐tip micro‐SPE and LC‐MS/MS. An octyl‐functionalized hybrid silica monolith, which had been synthesized and characterized, was used as a selective stationary phase. The octyl‐functionalized hybrid silica monoliths presented high permeability and adequate mechanical strength.

  12. Development and evaluation of poly adenosine 5'‐diphosphate‐ribose polymerase 1 immobilization‐based receptor chromatography

    • Journal of Separation Science
    • Yanghe decoction is a traditional Chinese medicine prescription and has been used for breast cancer treatment for many years. However, the effective ingredients in the decoction have not been identified. The expression of poly (ADP‐ribose) polymerase‐1 is highly related to breast cancer. Using poly (ADP‐ribose) polymerase‐1 as a probe, we expressed the haloalkane dehalogenase‐tagged protein in E.

      • Heavy Metals
      • Bacterial pathogens
      • Chemical contaminants
  13. Risk screening of mycotoxins and their derivatives in dairy products using a stable isotope dilution assay and LC–MS/MS

    • Journal of Separation Science
    • An LC–MS/MS method coupled with a stable isotope dilution assay was established for the simultaneous detection of 17 mycotoxins and their derivatives (aflatoxins B1, B2, G1, G2, M1, and M2; fumonisins B1 and B2; ochratoxin A; zearalenone; zearalanone; α‐zearalanol; α‐zearalenol; T‐2 toxin; deoxynivalenol; deepoxy‐deoxynivalenol; and sterigmatocystin) in milk and dairy products.

      • Aflatoxins
      • Mycotoxins
      • Natural toxins
  14. Research progress on sample pretreatment methods for migrating substances from food contact materials

    • Journal of Separation Science
    • Excessive absorbtion of migrating substances from food contact materials can affect human health. Thus it is essential to analyze the migration of contaminant from food contact materials. However, comprehensive analysis has been challenged by low concentration of migrating substances, manifold and complex matrix interference of food contact materials.

  15. A challenging choice of aptamer for selective enrichment of ochratoxin A

    • Journal of Separation Science
    • In a recent study conducted by Zhang et al. (2019), the adenosine monophosphate‐specific aptamer has been applied for the rapid extraction of ochratoxin A. Although several publications have already reported the selection of adenosine monophosphate, adenosine triphosphate, and adenosine, there is no report on the detection of ochratoxin A using this aptamer. The data of Zhang et al.

      • Mycotoxins
      • Natural toxins
  16. Hydroxypropyl‐β‐cyclodextrin encapsulated stationary phase based on silica monolith particles for enantioseparation in liquid chromatography

    • Journal of Separation Science
    • Hydroxypropyl‐β‐cyclodextrin‐encapsulated stationary phase incorporated on silica monolith particles was prepared by physical embedding, providing a new method for the development of chiral stationary phase for enantioseparation in liquid chromatography. Ground silica monolith particles of about 2.0 μm were prepared via sol‐gel reaction followed by differential sedimentation.

      • Chemical contaminants
  17. Polyethyleneimine‐modified magnetic carbon nanotubes as solid‐phase extraction adsorbent for the analysis of multi‐class mycotoxins in milk via LC‐MS/MS

    • Journal of Separation Science
    • Polyethyleneimine‐modified magnetic multi‐walled carbon nanotubes were developed to extract 10 mycotoxins. Simple modification of polyethyleneimine was achieved on the magnetic substrate by using an epoxy‐containing silane agent as a linker. The resultant magnetic adsorbent was integrated with reverse phase and anion exchange interaction sites. Under optimal extraction conditions, only 20.0 mg adsorbent was used to extract the mycotoxins from 50.0 mL loading solution.

  18. Stability assessment of tamsulosin and tadalafil co‐formulated in capsules by two validated chromatographic methods

    • Journal of Separation Science
    • The advent of a new pharmaceutical formulation evokes the need for examining the chemical stability of their constituents and establishing proper stability‐indicating methods. Herein, the stability of the newly co‐formulated Tamsulosin and Tadalafil were examined under different stress conditions. The acidic degradation of Tamsulosin yielded its sulfonated derivative, while Tadalafil was susceptible to both acidic and basic degradation.

  19. Highly efficient solid‐phase microextraction of polycyclic aromatic hydrocarbons in water based on worm‐like nickel‐titanium oxide nanocomposites coating grown on a nickel‐titanium alloy wire by low‐voltage anodization

    • Journal of Separation Science
    • A novel worm‐like nickel‐titanium oxide nanocomposites coating was directly grown on a nickel‐titanium alloy wire by low‐voltage electrochemical anodization in alkaline ethylene glycol and water solution. The in situ growth of nickel‐titanium oxide nanocomposites greatly depended on the volume ratio of ethylene glycol to water and temperature.

      • Chemical contaminants
  20. Quantification of pyrazinamide, isoniazid, acetyl‐isoniazid and rifampicin by a high‐performance liquid chromatography method in human plasma from patients with tuberculosis

    • Journal of Separation Science
    • The aim of this study was to establish and validate an alternative high‐performance liquid chromatography (HPLC) method for simultaneous quantification of pyrazinamide, isoniazid, acetyl‐isoniazid and rifampicin in plasma of patients under treatment for tuberculosis. The performed method was lineal (r2>0.99) in the range of 2.00‐50.00 μg/mL for pyrazinamide, 0.50‐20.00 μg/mL for both acetyl‐isoniazid and isoniazid, and 1.20‐25.00 μg/mL for rifampicin.

  21. Automated micro‐solid‐phase extraction clean‐up of polycyclic aromatic hydrocarbons in food oils for analysis by gas chromatography – orbital ion trap mass spectrometry

    • Journal of Separation Science
    • Food can contain unwanted compounds and need to be analyzed for compounds like carcinogenic polycyclic aromatic hydrocarbons to ensure consumer safety. The analytes need to be extracted from the sample matrix and cleaned‐up to enable detection. However, established methods for clean‐up are labor‐intensive and have a high expenditure on organic solvents.

      • Chemical contaminants
  22. Preparation of multi‐wall carbon nanotube /urea‐formaldehyde nanocomposite as a new sorbent in solid phase extraction and its combination with deep eutectic solvent based dispersive liquid–liquid microextraction for extraction of antibiotic residues in...

    • Journal of Separation Science
    • A solid phase extraction method combined with deep eutectic solvent‐based dispersive liquid‐liquid microextraction has been developed for the extraction of three antibiotics in honey samples prior to their determination by ion mobility spectrometry. In this method, firstly, a multi‐wall carbon nanotube/urea‐formaldehyde nanocomposite was synthesized using co‐precipitation polymerization method and then it was used as a sorbent for the analytes extraction from the samples.

      • Chemical contaminants
      • Antibiotic residues
  23. A novel one‐pot strategy of preparation N‐phenylacrylamide‐styrene co‐polymer open tubular capillary column for peptides separation

    • Journal of Separation Science
    • An open tubular capillary column (100 μm internal diameter and 120 cm length) was first fabricated with N‐phenylacrylamide and styrene copolymer layer on the inner surface by in situ one‐pot strategy, while ethylene dimethacrylate was used as the cross‐linker. The pretreated silica‐fused capillary was reacted with 3‐trimethoxysilyl propyl methacrylate to attach a double bond ligand onto the inner surface of the capillary.

      • Chemical contaminants
  24. Determination of bisphenol A: Old problem, recent creative solutions based on novel materials

    • Journal of Separation Science
    • Bisphenol A is a synthetic compound widely used in industry, in the production of polycarbonate, epoxy resins and thermal paper, among others. Its annual production is estimated at millions of tons per year, demonstrating its importance. Despite its wide application in various everyday products, once in the environment (due to its disposal or leaching), it has high toxicity to humans and animal life, and this problem has been well known for years.

      • Chemical contaminants
  25. Metabolic stability studies of lead compounds supported by separation techniques and chemometrics analysis

    • Journal of Separation Science
    • With metabolism being one of the main routes of drug elimination from the body (accounting for removal of around 75% of known drugs), it is crucial to understand and study metabolic stability of drug candidates. Metabolically unstable compounds are uncomfortable to administer (requiring repetitive dosage during therapy), while overly‐stable drugs increase risk of adverse drug reactions.

      • Heavy Metals
      • Chemical contaminants