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Research Publications (Food Safety)

This page tracks research articles published in national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. Research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies (requires login) and FDA Grant Funding Agencies (requires login) are also tracked in Scopus.

Displaying 76 - 100 of 179

  1. Salting‐out assisted liquid‐liquid extraction method optimized by design of experiments for the simultaneous HPLC analysis of perampanel and stiripentol in mouse matrices

    • Journal of Separation Science
    • This work reports an HPLC method development able to simultaneously determine perampanel and stiripentol, two third‐generation antiepileptics whose therapeutic spectrum can potentially be extended, in several mouse matrices. A salting‐out assisted liquid‐liquid extraction optimized by a design of experiments approach was adopted for samples preparation. Isopropanol and magnesium sulfate were the extraction solvent and salting‐out agent, respectively.

  2. Application of biocharcoal aerogel sorbent for solid‐phase microextraction of polycyclic aromatic hydrocarbons in water samples

    • Journal of Separation Science
    • A facile method was introduced for preparing a biocharcoal aerogel, which was derived from pomelo peel as the only raw material. The inner spongy layer of pomelo peel was freeze‐dried for maintaining three‐dimensional structure, further carbonized under high temperature and oxygen‐limited conditions. The morphological structure and graphitization degree of biocharcoal aerogel were characterized by scanning electron microscope and Raman spectrum.

      • Chemical contaminants
  3. Monitoring of priority pollutants chlorophenols in water and milk by headspace solid phase microextraction based on electrospun polycaprolactam nanofibers decorated with cadmium oxide‐carbon nanotubes

    • Journal of Separation Science
    • Priority pollutants chlorophenols are broadly used chemicals that are persistent in the environment and causing serious human health hazards. The current study introduces a novel adsorbent for the extraction of chlorophenols from river water, surface water, and milk by headspace solid phase microextraction coupled with GC.

      • Heavy Metals
      • Chemical contaminants
  4. Non‐invasive sorptive extraction for the separation of human skin surface chemicals using comprehensive gas chromatography coupled to time‐of‐flight mass spectrometry: A mosquito‐host biting site investigation

    • Journal of Separation Science
    • Variation in inter‐human attractiveness to mosquitoes, and the preference of mosquitoes to bite certain regions on the human host, are possible avenues for identifying lead compounds as potential mosquito attractants or repellents.

      • Heavy Metals
      • Chemical contaminants
  5. Multidimensional liquid chromatography approaches for analysis of food contaminants

    • Journal of Separation Science
    • In the last years, multidimensional liquid chromatography technique became very widespread for the complete separation of non‐volatile analytes in complex matrices. The main advantage of these techniques, especially when coupled with mass spectrometry, is the enhancement of separation power or peak capacity, due to an increase in selectivity and sensitivity of the two systems.

  6. Pharmacokinetic comparison of nine bioactive components in rat plasma following oral administration of raw and wine‐processed Ligustri Lucidi Fructus by ultra‐high‐performance liquid chromatography coupled with triple quadrupole mass spectrometry

    • Journal of Separation Science
    • An accurate and sensitive ultra‐high‐performance liquid chromatography coupled with triple quadrupole mass spectrometry method was established and validated for the determination of 9 bioactive compounds of Ligustri Lucidi Fructus in rat plasma. Separation was performed on Halo® C18 column with a mobile phase of acetonitrile and 0.1% formic acid in water. The eluate was detected by multiple‐reaction monitoring scanning operating in the negative ionization mode.

  7. Trace determination of parabens in cosmetics and personal care products using fabric‐phase sorptive extraction and high‐performance liquid chromatography with UV detection

    • Journal of Separation Science
    • A simple, fast, and sensitive analytical protocol using fabric‐phase sorptive extraction followed by high performance liquid chromatography with ultraviolet detection has been developed and validated for the extraction of five parabens including methylparaben, ethylparaben, propylparaben, butylparaben, and benzylparaben. In the present work, sol‐gel polyethylene glycol coated fabric‐phase sorptive extraction membrane is used for the preconcentration of parabens (polar) from complex matrices.

      • Produce Safety
      • Ethylene Sensitive
  8. Determination of trace polycyclic aromatic hydrocarbons in water and milk using solid‐phase extraction packed with graphene/chitosan composite aerogel prior to gas chromatography‐mass spectrometry

    • Journal of Separation Science
    • Polycyclic aromatic hydrocarbons, ubiquitous compounds which result from incomplete combustion or pyrolysis of natural and man‐made combustion sources, can adversely affects human health due to their well‐known toxicity.

      • Chemical contaminants
  9. Capillary liquid chromatography as an effective method for the determination of seven neonicotinoid residues in honey samples

    • Journal of Separation Science
    • A new analytical method based on capillary LC with diode array detection has been developed for the simultaneous quantification of seven neonicotinoid insecticides commercially available (imidacloprid, thiacloprid, clothianidin, thiamethoxam, acetamiprid, nitenpyram and dinotefuran) in honey samples.

      • Chemical contaminants
  10. The Separation and Identification of Synthetic Cathinones by Portable Low Microflow Liquid Chromatography with Dual Capillary Columns in Series and Dual Wavelength Ultraviolet Detection

    • Journal of Separation Science
    • This study ascertained the viability of a portable liquid chromatograph, operating at low μL/min flow, for the analysis of seized drugs at remote sites as well as in laboratory settings. Synthetic cathinones were screened using dual capillary columns in series, C8 and biphenyl, with on‐column ultraviolet detection at 255 nm and 275 nm.

  11. Preparation of porous polymers based on high internal phase emulsion for enrichment of estrogens in urine

    • Journal of Separation Science
    • In this work, graphene oxide‐hybridized high internal emulsion polymers with crosslinking and open‐cell structure was prepared and applied for separation and enrichment of estrogens. The prepared graphene oxide‐hybridized high internal emulsion polymer monoliths had hydrophobicity, porosity and stability, which were just obtained by one step in‐situ emulsion polymerization of 2‐ethylhexyl acrylate, glycidyl methacrylate and divinylbenzene after doping with graphene oxide.

  12. Simultaneous separation and determination of 32 fentanyl‐related substances, including seven sets of isomeric fentanyl analogues, by ultra‐high‐performance liquid chromatography coupled with high‐resolution mass spectrometry

    • Journal of Separation Science
    • A method for separation and determination of 32 fentanyl‐related substances, including seven sets of isomeric fentanyl analogues, was developed using ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap high‐resolution mass spectrometry. The collision energy, chromatographic column and mobile phase were optimized.

  13. Targeted analysis of 6 emerging derivatives or metabolites together with 25 common macrolides in milk using Quick, Easy, Cheap, Effective, Rugged and Safe extraction and ultra‐performance liquid chromatography quadrupole/electrostaticfield orbitrap...

    • Journal of Separation Science
    • An analytical method for the determination of 6 emerging derivatives or metabolites together with 25 common macrolides antibiotics in milk by ultra‐performance liquid chromatography quadrupole/electrostaticfield orbitrap mass spectrometry was established. The samples were purified with optimized Quick, Easy, Cheap, Effective, Rugged, Safe methods.

  14. Combination of continuous digestion by peptidase and spectral similarity comparisons for peptide sequencing

    • Journal of Separation Science
    • Peptide sequencing is critical to the quality control of peptide drugs and functional studies of active peptides. A combination of peptidase digestion and mass spectrometry technology is common for peptide sequencing. However, such methods often cannot obtain the complete sequence of a peptide due to insufficient amino acid sequence information. Here, we developed a method of generating full peptide ladders and comparing their MS2 spectral similarities.

      • Chemical contaminants
      • Antibiotic residues
  15. Using magnetic covalent organic framework material with large specific surface area as an effective adsorbent for the extraction and determination of six fluoroquinolones antibiotics by HPLC in milk samples

    • Journal of Separation Science
    • A magnetic covalent organic framework material was synthesized with a core‐shell structure using a simple solvothermal method. It was prepared with Fe3O4 as the magnetic core, covalent organic framework as the shell, which synthesized from 1,3,5‐triformylphloroglucinol and p‐phenylenediamine by Schiff base reaction.

  16. A three‐phase solvent extraction system combined with deep eutectic solvent‐based dispersive liquid‐liquid microextraction for extraction of some organochlorine pesticides in cocoa samples prior to gas chromatography‐electron capture detector

    • Journal of Separation Science
    • A sample pretreatment method based on the combination of a three‐phase solvent extraction system and deep eutectic solvent‐based dispersive liquid–liquid microextraction has been introduced for the extraction of four organochlorine pesticides in cocoa samples before their determination by gas chromatography–electron capture detection. A mixture of sodium chloride, acetonitrile, and potassium hydroxide solution is added to cocoa bean or powder.

      • Pesticide residues
      • Chemical contaminants
  17. An Ag2S@ZnS coated fiber for efficient, long‐life solid‐phase microextraction of polycyclic aromatic hydrocarbons in water

    • Journal of Separation Science
    • Although an efficient and stable fiber coating is essential for the development of solid‐phase microextraction technique, it remains a challenging prospect. Herein, an inorganic nanocomposite material Ag2S@ZnS was prepared and used as a coating for fibers to detect polycyclic aromatic hydrocarbons in water samples in combination with a GC with flame ionization detector.

      • Chemical contaminants
  18. Mesoporous silica hybridized by ordered mesoporous carbon for in‐tube solid‐phase microextraction

    • Journal of Separation Science
    • In order to enhance the extraction performance, a mesoporous silica was modified with ordered mesoporous carbon for solid‐phase microextraction. Three stainless steel wires coated with the mesoporous material were placed in a polyetheretherketone tube for getting an extraction tube. The tube was coupled to high performance liquid chromatography with diode array detector, and the online analysis system was constructed.

      • Chemical contaminants
  19. Determination of levetiracetam in human plasma by online heart‐cutting liquid chromatography: Application to therapeutic drug monitoring

    • Journal of Separation Science
    • Levetiracetam is an antiepileptic drug for the treatment of psychiatric patients. In this study, a selective, straightforward, and rapid online heart‐cutting LC method was developed for the therapeutic drug monitoring of levetiracetam. This method allows for the determination of levetiracetam in human plasma without complex sample preparation. The mobile phases consisted of 30 mM aq. ortho‐phosphoric acid solution/methanol (70:30) at a flow rate of 1 mL/min for the first system and 10 mM aq.

  20. A novel stability‐indicating analytical method development for simultaneous determination of carboplatin and decitabine from nanoparticles

    • Journal of Separation Science
    • Drug resistance is one of the main problems of cancer treatment. For this reason, combination therapy is commonly used for years. The combination of a chemotherapeutic, carboplatin, and the epigenetic drug decitabine is a new approach to modulate drug resistance. Nanoparticulate systems can overcome the drawbacks associated with the drug combinations.

  21. The utility of silica hydride based stationary phases for dual‐mode ultra high performance liquid chromatography separation of synthetic cathinone positional isomers

    • Journal of Separation Science
    • Emerging drugs usually mimic the effects of traditional drugs, but are not always controlled due to the chemically altered structures. Positional isomers of emerging drugs are challenging to analyze because they challenge the separation and detection techniques commonly employed by forensic laboratories.

  22. Synthesis of an organic‐inorganic hybrid absorbent for in‐tube solid phase microextraction of bisphenol A

    • Journal of Separation Science
    • This research is an application of fiber‐in‐tube solid phase microextraction followed by HPLC‐UV for extraction and determination of trace amounts of bisphenol A. Nano magnetic Fe3O4 was formed on the surface of polypropylene porous hollow fibers to increase the surface area and then it was coated with polystyrene. The introduction of polystyrene improves the surface hydrophobicity and is an appropriate extractive phase because it is highly stable in aquatic media.

      • Chemical contaminants
  23. Aldehyde Oxidase Assay by CE: from off‐line, on‐line up to immobilized enzyme reactor

    • Journal of Separation Science
    • CE is a modern separation technique characterized by many benefits, which qualify it also for enzyme assays and the study of enzyme kinetics during drug development. Homogenous or heterogenous approaches can be followed for the enzymatic incubation. In this study, an immobilization procedure of aldehyde oxidase on magnetic particles was developed considering their integration with CE.

  24. Salt‐assisted acetonitrile extraction and HPLC‐QTOF‐MS/MS detection for residues of multiple classes of pesticides in human serum samples

    • Journal of Separation Science
    • Detecting pesticide residues in human serum is a challenging process. This study developed and validated a method for the extraction and recovery of residues of multiple classes of pesticides from serum using one reagent. Salt‐assisted acetonitrile extraction and HPLC with quadrupole time of flight MS/MS were used to quantitate 34 pesticides classified in nine groups of chemicals in human serum samples, which are frequently detected in food.

      • Pesticide residues
      • Chemical contaminants
  25. Rapid determination of aflatoxin B1 by an automated immunomagnetic bead purification sample pretreatment method combined with HPLC

    • Journal of Separation Science
    • The study aimed to establish a automated versatile sample preconcentration method based on the modified immunomagnetic beads, which was utilized to enrich for aflatoxin B1 from the matrices. The critical main parameters affecting the extraction efficiency, such as usage amount of immunomagnetic beads, reaction time, elution time, blending way was investigated.

      • Aflatoxins
      • Natural toxins