Friday, July 31, 2020
HHS. NIH. The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

July 24, NICEATM released an update of the Integrated Chemical Environment (ICE). ICE provides data and tools to help develop, assess, and interpret chemical safety tests. This update adds the following features to these ICE tools:

  • Search: query results can now be sent directly to the EPA CompTox Chemicals Dashboard.
  • In Vitro to In Vivo Extrapolation (IVIVE): assays can be selected based on mode of action; results can be filtered by mode of action or toxicity endpoint annotation.
  • Chemical Characterization: principal component analysis plots provide an additional option for visualization of chemical properties.

Other new resources in ICE 3.1 include:

  • New Chemical Quick Lists: U.S. Environmental Protection Agency (EPA) List of Active Ingredients and EPA List of Inert Ingredients Food and Nonfood Use.
  • Additional metadata provided in results downloads.
  • New tooltips and information buttons to help users set up queries.

ICE is available at

Friday, July 31, 2020
HHS. NIH. The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

The Department of Health and Human Services (HHS) has released the 2020 Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Omnibus Grant Solicitations. These solicitations will be used by the National Institutes of Health and other offices within HHS to fund researcher-initiated projects in health, medicine, and life sciences.

Projects being funded by the National Institute of Environmental Health Sciences (NIEHS) under this solicitation include development of toxicity screening, testing, and modeling approaches that support Tox21 and other NTP goals. Areas of high priority include development of:

  • Metabolically competent in vitro assay systems for various tissue types.
  • Computational approaches for predictive toxicology.

The first deadline for applications under this announcement is September 5. More information is available on the NICEATM website at

NIEHS has also reissued the Funding Opportunity Announcement for its Commercialization Readiness Pilot program. These grants support commercialization of previously funded SBIR and STTR Phase II and Phase IIB projects by funding activities not typically supported through Phase II or Phase IIB grants or contracts. Small businesses that have had an active National Institutes of Health SBIR or STTR Phase II or Phase IIB award within the last 36 months are eligible to apply. Awardees will receive up to $300,000. Standard SBIR/STTR application deadlines apply for these grants; the next deadline is September 5. More information is available at

Monday, July 27, 2020
USDA. APHIS. Animal Care.
Wednesday, July 15, 2020
HHS. NIH. The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

new report presents the findings of a National Academies of Sciences, Engineering, and Medicine study to evaluate the use of dogs in biomedical research. Conducted at the request of the U.S. Department of Veterans Affairs (VA), the study assessed whether laboratory dogs are or will continue to be necessary for biomedical research related to the VA’s mission. Former NICEATM Director Warren Casey is a coauthor of the report. It is available at

The report concludes that using laboratory dogs in research at the VA is scientifically necessary for only a few areas of current biomedical research. The report recommends that the VA adopt an expanded set of criteria for determining when it is scientifically necessary to use laboratory dogs in VA biomedical research and promote the development and use of alternatives to laboratory dogs. It also highlights opportunities for the VA to enhance the welfare of laboratory dogs that are being used in necessary biomedical research areas.

Friday, May 29, 2020
HHS. NIH. Office of Laboratory Animal Welfare.

Earn 9 RACE credits by attending the 3Rs Symposium! Are you a veterinary medical professional struggling to find RACE credits during the COVID-19 pandemic?

The 7th Annual 3Rs Symposium: Practical Solutions and Success Stories, sponsored by Johns Hopkins University Center for Alternative to Animal Testing (JHU CAAT), NIH OLAW, and USDA AWIC has been approved to offer 9 American Association of Veterinary State Boards RACE credits for the event! The virtual symposium takes place next week, June 4 – 5, so learn more and register here Link to Non-U.S. Government Site - Click for Disclaimer soon!  

Tuesday, March 24, 2020
USDA. Animal and Plant Health Inspection Service.
Tuesday, February 18, 2020
USDA. APHIS. Animal Care.
Information on EPA’s Inaugural Conference on New Approach Methods for Reducing Animal Testing for Chemical Safety
Tuesday, December 10, 2019
U.S. Environmental Protection Agency
Office of Pollution Prevention and Toxics Update

On December 17, 2019, the U.S. Environmental Protection Agency (EPA) will host its first annual conference to discuss alternative test methods and strategies to reduce animal testing. This conference will take place in Washington, D.C. The public can register to participate via webinar at:

EPA’s conference will bring together some of the leading voices in environmental and health research to discuss efforts to reduce testing on mammals. Specifically, the conference will focus on the New Approach Methods (NAMs) and will feature presentations by U.S. and international scientific experts on advancements in the field. On-site participants will have the opportunity to exchange information about scientific advancements in the NAMs field in order to develop a better understanding of the state of the science, discuss approaches for developing scientific confidence in using alternatives, and summarize existing studies characterizing the uncertainties in results from animal testing.

EPA’s conference is an important step in implementing Administrator Wheeler’s commitment in his “Directive to Prioritize Efforts to Reduce Animal Testing.” Issued in September 2019, the directive announced EPA’s efforts to aggressively pursue a reduction in animal testing. In his directive, Administrator Wheeler calls for the agency to reduce its requests for, and funding of, mammalian studies by 30 percent by 2025 and eliminate all mammalian study requests and funding by 2035. Any mammalian studies requested or funded by EPA after 2035 will require administrator approval on a case-by-case basis. The directive also champions scientific advancements that allow scientists to better predict potential hazards for risk assessment purposes without using traditional animal testing methods. 

Over the past several years, EPA has made significant scientific advancements in NAMs and led efforts to reduce, replace, and refine its animal testing requirements. Just last week, EPA updated the list of NAMs that it developed pursuant to the Toxic Substances Control Act (TSCA), as amended by the 2016 Lautenberg Chemical Safety Act. The agency will continue to lead the way among federal agencies in the United States and internationally.

Thursday, September 26, 2019
HHS. National Institutes of Health.