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Sample Search: Osteomyelitis

Are there alternatives to the painful or distressful procedures being employed in the research on the effects of L-fucose or arachidonic acid in the establishment of acute (trauma-induced) osteomyelitis caused by S. aureus in rats?

Set Terms Items
1 osteomyelit* 23636
2 "L fucose" OR "arachidonic acid" 54910
3 #1 AND #2 5
4 acute NEAR/3 (osteomyelitis OR osteomyelitic) 1554
5 "staph aureus" OR "s aureus" OR "staphylococcal aureus" 39743
6 #4 AND #5 75
7 trauma* OR posttrauma* 348717
8 #7 AND #5 374
9 #8 AND #1 57
10 vitro OR culture OR (isolated NEAR/4 (bone OR tibia)) 2689101
11 #10 AND #1 1673
12 #11 AND #5 196
13 ketamine OR xylazine OR acepromazine OR buprenorphine OR yohimbine 41546
14 #13 AND #1 7
15 #13 AND #2 83
16 imaging OR noninvasive OR "non invasive" OR biomarker* 934240
17 #16 AND #1 2973
18 model* OR mouse OR mice OR rat OR rats OR rabbit* OR pig OR pigs OR rodent* OR rabbit* 8398084
19 #17 AND #18 119

Databases Searched: Agricola, Medline, Biosis, CAB Abstracts

 Example Citations:

Set 3

Arachidonic acid facilitates experimental chronic osteomyelitis in rats. Rissing, J.P.; Buxton, T.B.; Fisher, J.; Harris, R.; Shockley, R.K.
Infection and immunity, 1985, 49 (1), 141-144. PMCID: PMC262070

Synergy of HBO2 and a local antibiotic carrier for experimental osteomyelitis due to Staphylococcus aureus in rats. Mendel, V.; Simanowski, H.-.; Scholz, H.C.
Undersea & hyperbaric medicine, 2004, 31 (4), 407-416

Set 6

A porcine model of acute, haematogenous, localized osteomyelitis due to Staphylococcus aureus: a pathomorphological study. Johansen, L.K.; Frees, D.; Aalbaek, B.; Koch, J.; Iburg, T.; Nielsen, O.L.; Leifsson, P.S.; Jensen, H.E.
Apmis, 2011, 119 (2), 111-118. PMCID: PMC3040840

Efficacy of the new cephalosporin ceftaroline in the treatment of experimental methicillin-resistant Staphylococcus aureus acute osteomyelitis. Jacqueline, C.; Amador, G.; Caillon, J.; Mabecque, V.L.; Batard, E.; Miègeville, A.F.; Biek, D.; Ge, Y.G.; Potel, G.; Hamel, A.
Journal of antimicrobial chemotherapy, 2010, 65 (8), 1749-1752. 

An acute osteomyelitis model in traumatized rat tibiae involving sand as a foreign body, thermal injury, and bimicrobial contamination. McPherson, J.C.; Runner, R.R.; Shapiro, B.; Walsh, D.S.; Stephens-DeValle, J.; Buxton, T.B.
Comparative medicine, 2008, 58 (4), 369-74. PMCID: PMC2706036

Internalization of Staphylococcus aureus by cultured osteoblasts. Nousiainen, M.T.; Frankenburg, K.P.; Ramp, W.K.; Hudson, M.C.
Abstracts of the general meeting of the american society for microbiology, 1996, 96 (0), 212. DOI: 10.1006/mpat.1995.0075

Scintigraphic imaging using technetium-99m-labeled ceftizoxime in an experimental model of acute osteomyelitis in rats. Diniz, S.O.; Rezende, C.M.; Serakides, R.; Ferreira, R.L.; Ribeiro, T.G.; Martin-Comin, J.; Cardoso, V.N.
Nuclear medicine communications, 2008, 29 (9), 830-6. DOI: 10.1097/MNM.0b013e3283000514

Set 9

Osteoblasts express the inflammatory cytokine interleukin-6 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue. Marriott, I.; Gray, D.L.; Tranguch, S.L.; Fowler, V.G.; Stryjewski, M.; Scott Levin, L.; Hudson, M.C.; Bost, K.L.
The American Journal of Pathology, 2004, 164 (4), 1399-406. PMCID: PMC1615361

Osteomyelitis: a current challenge. Jorge, L.S.; Chueire, A.G.; Rossit, A.R.
Brazilian Journal of Infectious Diseases, 2010, 14 (3), 310-315. DOI: 10.1590/S1413-86702010000300020

A non-traumatic staphylococcus aureus osteomyelitis model in pigs . Jensen, H.E.; Nielsen, O.L.; Agerholm, J.S.; Iburg, T.; Johansen, L.K.; Johannesson, E.; Moller, M.; Jahn, L.; Munk, L.; Aalbaek, B.; Leifsson, P.S.
In Vivo, 2010, 24 (3), 257-264.

The use of a biodegradable, load-bearing scaffold as a carrier for antibiotics in an infected open fracture model. Stewart, R.L.; Cox, J.T.; Volgas, D.; Stannard, J.; Duffy, L.; Waites, K.B.; Chu, T.
Journal of orthopaedic trauma, 2010, 24 (9), 587-91. DOI: 10.1097/BOT.0b013e3181ed1349

Management of contaminated open fractures: A comparison of two types of irrigation in a porcine model. Gaines, R.J.; DeMaio, M.; Peters, D.; Hasty, J.; Blanks, J.
Journal of Trauma and Acute Care Surgery, 2012, 72 (3), 733-736.

Set 12

A comparative 18F-FDG PET/CT imaging of experimental Staphylococcus aureus osteomyelitis and Staphylococcus epidermidis foreign-body-associated infection in the rabbit tibia. Lankinen, P.; Lehtimäki, K.; Hakanen, A.J.; Roivainen, A.; Aro, H.T.
EJNMMI Research, 2012, 2 (1), 41. DOI: 10.1186/2191-219X-2-41

Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis. Bisland, S.K.; Chien, C.; Wilson, B.C.; Burch, S.
Photochemical & photobiological sciences, 2006, 5 (1), 31-38. DOI: 10.1039/B507082A

Adjunctive use of rifampin for the treatment of Staphylococcus aureus infections: a systematic review of the literature. Perlroth, J.; Kuo, M.; Tan, J.; Bayer, A.S.; Miller, L.G.
Archives of internal medicine, 2008, 168 (8), 805-819. DOI: 10.1001/archinte.168.8.805

Safety and effectiveness of extracorporeal shockwave therapy: results of a rabbit model of chronic osteomyelitis. Gollwitzer, H.; Roessner, M.; Langer, R.; Gloeck, T.; Diehl, P.; Horn, C.; Stemberger, A.; von Eiff, C.; Gerdesmeyer, L.
Ultrasound in medicine & biology, 2009, 35 (4), 595-602. DOI: 10.1016/j.ultrasmedbio.2008.10.004

Set 15

A role for arachidonic acid in general anesthetic action. Denson, D.D.; Eaton, D.C.
Society for Neuroscience Abstracts, 1995, 21 (1-3), 1833

Set 19

Establishment of a real-time, quantitative, and reproducible mouse model of Staphylococcus osteomyelitis using bioluminescence imaging. Funao, H.; Ishii, K.; Nagai, S.; Sasaki, A.; Hoshikawa, T.; Aizawa, M.; Okada, Y.; Chiba, K.; Koyasu, S.; Toyama, Y.; Matsumoto, M.
Infection and immunity, 2012, 80 (2), 733-741. DOI: 10.1128/IAI.06166-11

Monitoring bacterial burden, inflammation and bone damage longitudinally using optical and μCT imaging in an orthopaedic implant infection in mice. Niska, J.A.; Meganck, J.A.; Pribaz, J.R.; Shahbazian, J.H.; Lim, E.; Zhang, N.; Rice, B.W.; Akin, A.; Ramos, R.I.; Bernthal, N.M.; Francis, K.P.; Miller, L.S.
PLos ONE, 2012, 7 (10), e47397. DOI: 10.1371/journal.pone.0047397

Comparison of 18F-FDG and 68Ga PET imaging in the assessment of experimental osteomyelitis due to Staphylococcus aureus. Mäkinen, T.J.; Lankinen, P.; Pöyhönen, T.; Jalava, J.; Aro, H.T.; Roivainen, A.
European journal of nuclear medicine and molecular imaging, 2005, 32 (11), 1259-68. DOI: 10.1007/s00259-005-1841-9

Evaluation of serum biochemical markers of bone metabolism for early diagnosis of nonunion and infected nonunion fractures in rabbits. Southwood, L.L.; Frisbie, D.D.; Kawcak, C.E.; McIlwraith, C.W.
American journal of veterinary research, 2003, 64 (6), 727-735.

A Novel Mouse Model of Staphylococcus aureus Chronic Osteomyelitis That Closely Mimics the Human Infection: An Integrated View of Disease Pathogenesis. Horst, S.A.; Hoerr, V.; Beineke, A.; Kreis, C.; Tuchscherr, L.; Kalinka, J.; Lehne, S.; Schleicher, I.; Koehler, G.; Fuchs, T.; Raschke, M.J.; Rohde, M.; Peters, G.; Faber, C.; Loeffler, B.; Medina, E.
American journal of pathology, 2012, 181 (4), 1206-1214. DOI: 10.1016/j.ajpath.2012.07.005