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A HORMONAL MECHANISM LINKING LIVER DYSFUNCTION, HYPERKETONEMIA AND REDUCED APPETITE IN EARLY LACTATING DAIRY COWS

Investigators
Boisclair, Yv, .
Institutions
Cornell University
Start date
2020
End date
2023
Objective
We will test the hypothesis that the synthesis of the appetite-suppressing hormone GDF15 is increased in hyperketonemic, early lactating dairy cows. We propose two objectives to test our hypothesis. In objective 1, we will measure indices of GDF15 production in early lactating dairy cows during the course of experimentally induced ketosis and following its resolution. In objective 2, we will measure plasma GDF15 in a large cohort of early lactating dairy cows under commercial conditions and categorized on the basis of BHBA plasma concentration as either normal, subclinically ketotic or clinically ketotic.
Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
NYC-127946
Accession number
1023925
Categories
Natural Toxins