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ADDEND: Micronucleus and Gene Mutation Analysis in F344 Big Blue Rats Administered Leucomalachite Green in the Diet for 4, 16, and 32 weeks


Malachite and leucomalachite green are currently being tested for carcinogenicity under the National Institute of Environmental Health Sciences Interagency Agreement (IAG). The objective of this project is to assess the mutagenicity ofleucomalachite green in relation to DNA adduct formation in tissues of Big Blue rats.

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FY 2000 Accomplishments: This proposal was approved to begin in FY 2001.
FY 2001 Plans: Evaluate leucomalachite green genotoxicity in Big Blue rats: Four doses and threetime points will be used and the lacI mutant frequency in the liver tissue will bedetermined along with the Hprt mutant frequency in the lymphocyte andmicronucleus assay in the bone marrow.</p>

Manjanatha, Mugimane
DHHS/FDA - National Center for Toxicological Research
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