Alternatives to Antibiotics: Neonatal Immunomodulation to Improve Disease Resilience in Food Animals - ISU

Our overall goal is to utilize innate training as an approach to enhance disease resistance in a manner that is highly relevant to agriculture. Thus, one objective to meet the goal is to identify molecular mechanisms of induced training to develop additional approaches to induce innate training in food animals. The efficacy of Bacille Calmette-Guerin (BCG) as an immunomodulator will be evaluated in pigs and samples will be collected for molecular analysis to identify molecular mechanisms of training. Cooperator will assist in data analysis, includeing ATAC-Seq, ChIP-seq, and RNA-seq data, with integration of various datasets to identify relationships between DNA accessibility and gene expression related to innate training. Cooperator will also finish analysis of already collected data from porcine and bovine samples.