Assessment of Nephrotoxicity from an Exposure to Melamine, Cyanuric acid, and its combination in Newborn F344 Rats from Postnatal Day-1 to Weaning

Objective

<p>
<ol>
<li>Determine if a combined exposure to melamine and cyanuric acid in newborn F344 rats is more nephrotoxic than exposure to the individual compounds.</li>
<li>Establish the dose-response curve for the combined exposure.</li>
<li>Investigate the longer-term effects during a recovery period.</li></ol></p>

More information

Responsible Office: Biochemical Toxicology

Investigators

Gamboa da Costa, Goncalo

Institution

DHHS/FDA - National Center for Toxicological Research

DHHS/FDA - Center for Food Safety & Applied Nutrition

DHHS- National Toxicology Program

Funding Source

Nat'l. Center For Toxicological Research

Project number

E0218901