An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

National Agricultural Library
U.S. Department of Agriculture
  1. Home
  2. Research Tools
  3. Food Safety Research Projects Database
  4. Biomarkers of Low Dose Immunotoxicity of Deoxynivalenol in Mice

Biomarkers of Low Dose Immunotoxicity of Deoxynivalenol in Mice

Objective

Develop methods to lessen the toxicity of foodborne fungal toxins in humans.

More information

APPROACH: Develop animal models that are increasingly relevant to humans, in exposure dose and potential biomarkers. Use suppression of peripheral blood lymphocyte (PBL) counts as a sensitive biomarker for dietary DON exposure. Feed mice varying amounts of DON for 2 and 4 weeks, and assess PBL total and subpopulation counts to determine the utility of PBL counts as biomarkers of DON exposure that could be readily adapted to human epidemiology of DON toxicity.

Investigators
Walker-Simmons, M. Kay
Institution
Iowa State University
USDA - Agricultural Research Service
Start date
2006
End date
2009
Funding Source
Nat'l. Inst. of Food and Agriculture
Project number
0500-00053-002-61G
Accession number
410624
Categories
Natural Toxins
Mycotoxins
Prevention and Control
Sanitation and Quality Standards
View this project