An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Biomarkers of Low Dose Immunotoxicity of Deoxynivalenol in Mice


Develop methods to lessen the toxicity of foodborne fungal toxins in humans.

More information

APPROACH: Develop animal models that are increasingly relevant to humans, in exposure dose and potential biomarkers. Use suppression of peripheral blood lymphocyte (PBL) counts as a sensitive biomarker for dietary DON exposure. Feed mice varying amounts of DON for 2 and 4 weeks, and assess PBL total and subpopulation counts to determine the utility of PBL counts as biomarkers of DON exposure that could be readily adapted to human epidemiology of DON toxicity.

Walker-Simmons, M. Kay
Iowa State University
USDA - Agricultural Research Service
Start date
End date
Project number
Accession number