Comparative Proteomics

The development of proteomics for the analysis of changes to the proteome under different physiological and environmental conditions in bacteria, humans and plants is core to many of the advanced scietific activities of the Institute. In particular, Campylobacter, human cell lines and plants are key systems that are being studied by comparative proteomics. <P>
In addition to detecting proteins that change in abundance, a key goal is to characterise the nature of post- translational modifications. This technology is clearly key to most genomics-based projects and underpins the Institutes System Biology activities. <P>
It is our intention to develop a flagship project using Campylobacter as the model, where transcriptomic, proteomic and metabolomic analyses will be performed in parallel and an important effort will be made to integrate the results from each technology to determine how information feeds down from the transcriptome to the proteome and thereby affects the metabolome. <P>
A similar project will be developed for Arabidopsis as a model, in collaboration with the JIC, leading to joint grant proposals in this area.