Amoxicillin and lincomycin have been identified as having toxicological significanceby the CVM, NCTR, and the U.S. Department of Agriculture (USDA) and have been scheduled for incurred-residue FDA method trials. Methods of analysis have been developed and validated for amoxicillin in catfish and salmon and lincomycin in salmon. <OL> <LI> Validation of the above methods for incurred residues of amoxicillin in salmon and tilapia and lincomycin in salmon are needed. <LI> Documentation of incurred-residue confirmation methods by Liquid Chromatography/Mass Spectrometry (LC/MS) are also needed for these regulatory methods.
FY 2000 Accomplishments: One manuscript related to this work has been published under E0693611.
<br>FY 2001 Plans:The final phases of E0693601 and E0693611 (methods development) represent theinter-laboratory collaboration to evaluate the ruggedness of these analytic techniques.