Developing physiologically-based pharmacokinetic models for ivermectin and doramectin in food animals for new world screwworm emergency response

The objective of this proposal is to help combat the new world screwworm (NWS) outbreak by developing novel physiologically based pharmacokinetic (PBPK) models to predict withdrawal intervals of ivermectin and doramectin in food-producing animals following extralabel use for various routes of administration, doses, and dosing frequencies. There are three Aims. Aim 1 is todevelop a PBPK model for ivermectin and doramectin in cattle. Aim 2 is to developa generic PBPK model for ivermectin and doramectin in cattle, swine, sheep, and goats. Aim 3 is todevelop a generic PBPK model for ivermectin in broiler chickens and laying hens.