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Development of Chemical Methods to Provide Pure Authenticated Standards for Toxic Dehydropyrrolizidine Alkaloids (DHPAs) and their N-oxides


Demonstrate and validate a standardized method for the quantitative analysis of toxic dehydropyrrolizidine alkaloids (DHPAs) from plants poisonous to livestock and humans by ; 1) Developing extraction, identification and quantitative methods; 2) validating the analytical process in different matrices according to the AOAC International Guidelines for Single Laboratory Validation of chemical Methods for Botanicals; and 3) establish and validate response factors for “difficult to manage” DHPAs relative to “easy to manage” secondary standards. 4) provide purified DHPA’s for toxicology testing and verification.

Panter, Kip
USDA - Agricultural Research Service
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