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Development of Encapsulated Bacteriophage for Effectively Delivery to Chicken Intestine for the Control of Food-Borne Salmonella spp


To develop bacteriophage encapsulation methodology that is optimal for chicken gastrointestinal track and investigate its efficacy to control S. typhimurium DT 104 in broiler production in comparison to non-encapsulated phages.

Our specific objectives are:

<OL> <LI> To develop a well protected encapsulated phage (Felix O1, as a model) for targeted delivery to chick intestine by oral administration.
<LI>To validate the efficacy of encapsulated phage for control of Salmonella in experimental chicks in comparison with non-encapsulated phage.

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Expected Benefits:
To provide important information towards the feasibility of using bacteriophages as a control agent against food-borne pathogens in food animal production. It may result in commercially available phage products that benefit poultry industry. The reduction of food-borne pathogens in poultry products will reduce foods safety risks and increase consumer confidence in poultry products. The poultry industry will benefit through improvement of animal health and growth. <P> For more information, please visit the <a href="; target="_blank">Ontario Ministry of Agriculture, Food & Rural Affairs (OMAFRA) Food Safety Research Program</a>.

Wang, Qi
Agriculture and Agri-Food Canada
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