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Development of Methods for Analysis of Volatile and Nonvolatile N-nitrosamines in Relevant Cosmetics and Nitrite Cured Meat Products


1) To develop methods for extraction, cleanup, and analysis of non-volatile N-nitrosaminesin cosmetics and meat products using combined liquid chromatography (LC) detection methods with confirmation by compatible mass spectrometry (MS) ionization methods. 2) To investigate the applicability of Liquid Chromatography-electron spray ionization/mass sprectroscopy (LC-ESI/MS) and/or (LC-APCI/MS) as a multi-residue, trace-level, quantitative technique for analysis of volatile, semi-volatile, and non-volatile N-nitrosamines in these consumer products.

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FY 2000 Accomplishments: 1) The results of this project have been reported at the 48th American Society of Mass Spectrometry (ASMS) conference. 2) The manuscript has been submitted for publication.
<p>FY 2001 Plans:This project has ended.

Billedeau, Stanley
DHHS/FDA - National Center for Toxicological Research
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