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<ol><li> Determine the inhibitory concentration of thymol-beta-D-glucopyranoside (called beta-D-thymol) needed to achieve efficacious reductions of Campylobacter coli, Salmonella spp., and E. coli in laboratory and animal feeding studies.</li> <li> Evaluate the potential of beta-D-thymol to co-select for antibiotic-resistant Campylobacter coli, Salmonella spp., and generic E. coli or to make resistant strains of these bacteria more sensitive to antibiotics when grown in mixed populations of porcine gut bacteria.</li></ol>
<p>A series of laboratory and live animal studies will be conducted to test the effects of a novel antimicrobial compound, thymol-beta-D-glucopyranoside, on the survivability and antimicrobial susceptibility of zoonotic pathogens.</p>