This research project aims to investigate potential interactions of mixtures of pesticides.
<p>In its report on Risk Assessment of Mixtures of Pesticides and Similar Substances, the Committee on Toxicity of Chemicals in Food Consumer Products and the Environment (COT) recommended a need for investigation of the nature and dose-response relationships for combined actions of chemical mixtures.
<p>This project focuses on possible combined actions of anticholinergic pesticides.
An in vitro model based on cholinesterase depression will be used to investigate the nature and dose-response relationships of anticholinergic carbamates and organophosphates that may be found in foodstuffs.
<p>These studies will determine whether effects are additive or otherwise. The effect of subsequent exposures will also be investigated.
<p>Should any significant interactions be observed, these will be investigated further in controlled human volunteer studies.
<p>Find more about this project and other FSA food safety-related projects at the <a href="http://www.food.gov.uk/science/research/" target="_blank">Food Standards Agency Research webpage</a>.