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Dose-response and Mixture Response of Pesticides In Vitro and In Vivo


This research project aims to investigate potential interactions of mixtures of pesticides.

<p>In its report on Risk Assessment of Mixtures of Pesticides and Similar Substances, the Committee on Toxicity of Chemicals in Food Consumer Products and the Environment (COT) recommended a need for investigation of the nature and dose-response relationships for combined actions of chemical mixtures.

<p>This project focuses on possible combined actions of anticholinergic pesticides.

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An in vitro model based on cholinesterase depression will be used to investigate the nature and dose-response relationships of anticholinergic carbamates and organophosphates that may be found in foodstuffs.

<p>These studies will determine whether effects are additive or otherwise. The effect of subsequent exposures will also be investigated.

<p>Should any significant interactions be observed, these will be investigated further in controlled human volunteer studies.

<p>Find more about this project and other FSA food safety-related projects at the <a href="; target="_blank">Food Standards Agency Research webpage</a>.

Health and Safety Laboratory, Derbyshire UK
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