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Effect of Ethanol on the Tumorigenicity ofUrethane (Ethyl Carbamate) in B6C3F1 Mice


To determine the effect of ethanol on the tumorigenicity of urethane (ethyl carba-mate)in B6C3F1 mice.

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FY 2000 Accomplishments:1) Draft pathology report completed.2) Metabolism/adduct study continued.3) Two papers on mass spectrometry methods for the detection of etheno DNAadducts submitted.FY 2001 Plans:1) Prepare draft NTP final report.2) Complete mechanistic studies associated with bioassay.2) Initiate oncogene analyses.

Beland, Frederick
DHHS/FDA - National Center for Toxicological Research
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