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Evaluation of the Genotoxicity of the Phytoestrogen, Coumestrol, in Human Lymphoblast Cells that Differ in the Mutational Status of the p53 Tumor Suppressor Gene


<li>To confirm the clastogenicity of coumestrol by the micronucleus assay; </li>
<li> To confirm the mutagenicity of coumestrol at the HPRT locus; </li>
<li> To determine if coumestrol induces large scale chromosomal damage such as that detected by the Tk mutation assay; </li>
<li> To determine if the toxicity of coumestrol is due to apoptosis; </li>
<li> To determine the effect of coumestrol on the cell-cycle. </li> </ol>

Domon, Olen
DHHS/FDA - National Center for Toxicological Research
Project number