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National Agricultural Library
U.S. Department of Agriculture
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  4. Evaluation of the Genotoxicity of the Phytoestrogen, Coumestrol, in Human Lymphoblast Cells that Differ in the Mutational Status of the p53 Tumor Suppressor Gene

Evaluation of the Genotoxicity of the Phytoestrogen, Coumestrol, in Human Lymphoblast Cells that Differ in the Mutational Status of the p53 Tumor Suppressor Gene

Objective

<ol>
<li>To confirm the clastogenicity of coumestrol by the micronucleus assay; </li>
<li> To confirm the mutagenicity of coumestrol at the HPRT locus; </li>
<li> To determine if coumestrol induces large scale chromosomal damage such as that detected by the Tk mutation assay; </li>
<li> To determine if the toxicity of coumestrol is due to apoptosis; </li>
<li> To determine the effect of coumestrol on the cell-cycle. </li> </ol>

Investigators
Domon, Olen
Institution
DHHS/FDA - National Center for Toxicological Research
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0705501