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Fungal and Mammalian-Metabolism of Selected Pesticides Used in Food Productions for Human Consumption


<ol> <li>To determine the biotransformation of hazardous organophosphorus insecticides, parathion and methyl-parathion, and phenylurea-like herbicides, monuron and diuron, using selected a group of fungi with known biotransformation potential.
<li>To isolate and identify the metabolites of these pesticides and elucidate the metabolic pathway(s).
<li>To compare the mammalian metabolism of these compounds with fungal metabolism and ascertain the risk associated with the use of these compounds to human health and/or environmental safety.</ol>

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Pothuluri, Jairaj
DHHS/FDA - National Center for Toxicological Research
Project number