An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Host stress-induced mutations drive bacterial pathogen evolution


Campylobacter jejuni is responsible for millions of cases of diarrhea per year and is associated with Guillain-Barré syndrome, the leading cause of flaccid paralysis in the post-polio era. Chickens are a primary reservoir for C. jejuni, and most human infections are the result of direct or indirect contact with contaminated poultry products.The fundamental goal of this proposal is to gain a better understanding of C. jejuni growth and adaptation in the intestine of the natural animal host (chickens). Our working hypothesis is that host-induced DNA damage results in mutations that provide C. jejuni with enhanced in vivo fitness. It is critical to gain insight into the mechanisms C. jejuni utilizes to achieve a high level of chicken colonization (host adaptation) to develop strategies to mitigate the adaptive processes associated with human infections.

Konkel, Michael
Washington State University
Start date
End date
Project number
Accession number