Human Pharmacokinetics of Bisphenol A

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<ol>
<li>Measure deuterated BPA from blood and urine samples from adult humans after a single oral dose of 100 µg/kg bw in order to resolve uncertainty regarding human metabolism, pharmacokinetics (PK), and mass balance of BPA.</li>
<li>Integrate these new human PK and mass-balance data with the PK data from experimental animal models (e.g., mouse, rat, and monkey) along with human urinary biomonitoring data to refine a physiologically based pharmacokinetic (PBPK) model for BPA. </li></ol></p>