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Identification of Immune Subsets that Contribute to IFNgamma- Dependent Protection against S. Typhimurium In Vivo


The aim of this work is to identify the cell subsets that contribute to IFNg-dependent immunity to Salmonella typhimurium infection during primary and subsequent rechallenge infections. There are three main objectives addressed by this proposal. <OL> <LI> Determination of the anti- Salmonella mechanism(s) mediated by natural killer (NK) cells <LI> The minimal requirement for T cell subsets and the IFNg- mediated anti-Salmonella response <LI> The interaction between different T cell subsets and the IFNg-mediated anti- Salmonella response.

Institute for Animal Health
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